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structural and biophysical coupling of heparin and activin binding to follistatin isoform functions
keratinocyte-specific expression of fatty acid transport protein 4 rescues the wrinkle-free phenotype in slc27a4/fatp4 mutant mice
pyrophosphate inhibits mineralization of osteoblast cultures by binding to mineral, up-regulating osteopontin, and inhibiting alkaline phosphatase activity
deubiquitinating enzyme cyld regulates the peripheral development and naive phenotype maintenance of b cells
activation properties of heterologously expressed mammalian trpv
brorin, a novel secreted bone morphogenetic protein antagonist, promotes neurogenesis in mouse neural precursor cells
gsk3 activity modifies the localization and function of presenilin 1
human polymorphic variants of the neil1 dna glycosylase
identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism
inhibition of the dopamine d1 receptor signaling by psd-95
interaction between hiv-1 rev and integrase proteins
synapsin phosphorylation by src tyrosine kinase enhances src activity in synaptic vesicles
ccaat/enhancer-binding protein deletion reduces adiposity, hepatic steatosis, and diabetes in leprdb/db mice
carbohydrate binding specificity of a fucose-specific lectin from aspergillus oryzae
the contributions of integrin affinity and integrin-cytoskeletal engagement in endothelial and smooth muscle cell adhesion to vitronectin
hypoxia-inducible expression of a natural cis-antisense transcript inhibits endothelial nitric-oxide synthase
oxygen initiation of respiration and mitochondrial biogenesis in rice
substitution of the gla domain in factor x with that of protein c impairs its interaction with factor viia/tissue factor
mice deficient in heparan sulfate 6-o-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality
glucose mediates the translocation of neurod1 by o-linked glycosylation
flippase activity detected with unlabeled lipids by shape changes of giant unilamellar vesicles
the c terminus of apolipoprotein a-v modulates lipid-binding activity
activating transcription factor-1-mediated hepatocyte growth factor-induced down-regulation of thrombospondin-1 expression leads to thyroid cancer cell invasion
constitutive/hypoxic degradation of hif- proteins by the proteasome is independent of von hippel lindau protein ubiquitylation and the transactivation activity of t..
vitamin c is an essential antioxidant that enhances survival of oxidatively stressed human vascular endothelial cells in the presence of a vast molar excess of glut..
kinetic analysis of the entire rna amplification process by q replicase
selective amino acid substitutions convert the creatine transporter to a -aminobutyric acid transporter
cell phenotype-specific down-regulation of smad3 involves decreased gene activation as well as protein degradation
the lysine-specific demethylase 1 is required for cell proliferation in both p53-dependent and -independent manners
thrombospondin-1 inhibits nitric oxide signaling via cd36 by inhibiting myristic acid uptake
tissue-specific mechanisms for ccn2/ctgf persistence in fibrotic gingiva
two yeast puf proteins negatively regulate a single mrna
peroxisome proliferator activator receptor coactivator-1 expression is reduced in obesity
corticosteroids and 2 agonists differentially regulate rhinovirus-induced interleukin-6 via distinct cis-acting elements
effect of inositol hexakisphosphate kinase 2 on transforming growth factor -activated kinase 1 and nf-b activation
toll-like receptors and type i interferons
triggering the innate antiviral response through irf-3 activation
synergism of accessory factors in functional expression of mammalian odorant receptors
eotaxin selectively binds heparin
minocycline down-regulates mhc ii expression in microglia and macrophages through inhibition of irf-1 and protein kinase c (pkc)/ii
polo-like kinase 1 facilitates chromosome alignment during prometaphase through bubr1
the nod2-rick complex signals from the plasma membrane
identification and characterization of the slowly exchanging ph-dependent conformational rearrangement in kcsa
plasticity of proton pathway structure and water coordination in cytochrome c oxidase
a putative src homology 3 domain binding motif but not the c-terminal dystrophin ww domain binding motif is required for dystroglycan function in cellular polarity ..
mycobacterial uvrd1 is a ku-dependent dna helicase that plays a role in multiple dna repair events, including double-strand break repair
nfatc3 mediates chronic hypoxia-induced pulmonary arterial remodeling with -actin up-regulation
transcriptional signature of epidermal keratinocytes subjected to in vitro scratch wounding reveals selective roles for erk1/2, p38, and phosphatidylinositol 3-kina..
functional genomic studies of the intestinal response to a foodborne enteropathogen in a humanized gnotobiotic mouse model
protein kinase c-mediated phosphorylation of the calcium-sensing receptor is stimulated by receptor activation and attenuated by calyculin-sensitive phosphatase act..
inhibitory sequences within the b-domain stabilize circulating factor v in an inactive state
establishing a blueprint for ced-3-dependent killing through identification of multiple substrates for this protease
extracellular matrix-regulated gene expression requires cooperation of swi/snf and transcription factors
the mechanism of the amyloidogenic conversion of t7 endonuclease i
identification of chchd3 as a novel substrate of the camp-dependent protein kinase (pka) using an analog-sensitive catalytic subunit
identification of a flavonol 7-o-rhamnosyltransferase gene determining flavonoid pattern in arabidopsis by transcriptome coexpression analysis and reverse genetics
shedding of syndecan-1 by stromal fibroblasts stimulates human breast cancer cell proliferation via fgf2 activation
the signaling state of arabidopsis cryptochrome 2 contains flavin semiquinone
the low affinity ige receptor (cd23) is cleaved by the metalloproteinase adam10
cellular characterization of a novel focal adhesion kinase inhibitor
the lg1-3 tandem of laminin 5 harbors the binding sites of lutheran/basal cell adhesion molecule and 31/61 integrins
stringent 3q·1r composition of the snare 0-layer can be bypassed for fusion by compensatory snare mutation or by lipid bilayer modification
enhanced apoa-i-dependent cholesterol efflux by abca1 from sphingomyelin-deficient chinese hamster ovary cells
transducin activation by nanoscale lipid bilayers containing one and two rhodopsins
human topbp1 participates in cyclin e/cdk2 activation and preinitiation complex assembly during g1/s transition
the carboxyl-terminal fragment of pro-hb-egf reverses bcl6-mediated gene repression
hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance
filamin a-mediated down-regulation of the exchange factor ras-grf1 correlates with decreased matrix metalloproteinase-9 expression in human melanoma cells
overnight culture unmasks glucose-induced insulin secretion in mouse islets lacking atp-sensitive k+ channels by improving the triggering ca2+ signal
molecular cloning and characterization of tetrahydroprotoberberine cis-n-methyltransferase, an enzyme involved in alkaloid biosynthesis in opium poppy
the essential drosophila atp-binding cassette domain protein, pixie, binds the 40 s ribosome in an atp-dependent manner and is required for translation initiation
rationale for the design of shortened derivatives of the nk-lysin-derived antimicrobial peptide nk-2 with improved activity against gram-negative pathogens
the in vivo phosphorylation sites of rat brain dynamin i
two synergistic activation mechanisms of 21 integrin-mediated collagen binding
glucose modulates basement membrane fibroblast growth factor-2 via alterations in endothelial cell permeability
the sulfate groups of chondroitin sulfate- and heparan sulfate-containing proteoglycans in neutrophil plasma membranes are novel binding sites for human leukocyte e..
the structure and transcriptional analysis of a global regulator from neisseria meningitidis
regulation of p53 nuclear export through sequential changes in conformation and ubiquitination
systematic analysis of proteoglycan modification sites in caenorhabditis elegans by scanning mutagenesis
structural organization of essential iron-sulfur clusters in the evolutionarily highly conserved atp-binding cassette protein abce1
structure of the dimeric exonuclease trex1 in complex with dna displays a proline-rich binding site for ww domains
assembly of lysine 63-linked ubiquitin conjugates by phosphorylated -synuclein implies lewy body biogenesis
solution nmr structure of the barrier-to-autointegration factor-emerin complex
axin inhibits extracellular signal-regulated kinase pathway by ras degradation via -catenin
myogenic stage, sarcomere length, and protease activity modulate localization of muscle-specific calpain
magnetic resonance spectroscopy reveals an impaired brain metabolic profile in mice resistant to cerebral malaria infected with plasmodium berghei anka
pentaketide resorcylic acid synthesis by type iii polyketide synthase from neurospora crassa
the cxcl12, periostin, and ccl9 genes are direct targets for early b-cell factor in op-9 stroma cells
oxidation and s-nitrosylation of cysteines in human cytosolic and mitochondrial glutaredoxins
hnf1 inactivation promotes lipogenesis in human hepatocellular adenoma independently of srebp-1 and carbohydrate-response element-binding protein (chrebp) activation
loss of hsulf-1 expression enhances autocrine signaling mediated by amphiregulin in breast cancer
inhibition of topoisomerase i cleavage activity by thiol-reactive compounds
structure and kinetics of monofunctional proline dehydrogenase from thermus thermophilus
microrna-21 targets the tumor suppressor gene tropomyosin 1 (tpm1)
glutathione export during apoptosis requires functional multidrug resistance-associated proteins
adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human p450 1a2
classical anticytokinins do not interact with cytokinin receptors but inhibit cyclin-dependent kinases
expression of sialidase neu2 in leukemic k562 cells induces apoptosis by impairing bcr-abl/src kinases signaling
muke and mukf form two distinct high affinity complexes
hypoxia-inducible factor-1 (hif-1) is a transcriptional activator of the trkb neurotrophin receptor gene
znt5 variant b is a bidirectional zinc transporter and mediates zinc uptake in human intestinal caco-2 cells
ca2+ signaling in microdomains
reduction of low molecular weight protein-tyrosine phosphatase expression improves hyperglycemia and insulin sensitivity in obese mice
identification of histone demethylases in saccharomyces cerevisiae
ground state structure of f1-atpase from bovine heart mitochondria at 1.9 å resolution
protein kinase c-mediated down-regulation of cyclin d1 involves activation of the translational repressor 4e-bp1 via a phosphoinositide 3-kinase/akt-independent, pr..
regulation of the interleukin-7 receptor promoter by the ets transcription factors pu.1 and ga-binding protein in developing b cells
intracellular generation of sphingosine 1-phosphate in human lung endothelial cells
coupling of the de novo fatty acid biosynthesis and lipoylation pathways in mammalian mitochondria
residues 334 and 338 in transmembrane segment 8 of human equilibrative nucleoside transporter 1 are important determinants of inhibitor sensitivity, protein folding..
arabidopsis phosphatidylinositol phosphate kinase 1 binds f-actin and recruits phosphatidylinositol 4-kinase 1 to the actin cytoskeleton
endoplasmic reticulum stress-induced death of mouse embryonic fibroblasts requires the intrinsic pathway of apoptosis
epinephrine protects cancer cells from apoptosis via activation of camp-dependent protein kinase and bad phosphorylation
activation of peroxynitrite by inducible nitric-oxide synthase
transcriptional up-regulation of inhibitory pas domain protein gene expression by hypoxia-inducible factor 1 (hif-1)
oncogenic kras activates hedgehog signaling pathway in pancreatic cancer cells
ras/erk signaling promotes site-specific ribosomal protein s6 phosphorylation via rsk and stimulates cap-dependent translation
novel interaction of the 60s ribosomal subunit export adapter nmd3 at the nuclear pore complex
two functionally divergent udp-gal nucleotide sugar transporters participate in phosphoglycan synthesis in leishmania major
assessment and application of the biotin switch technique for examining protein s-nitrosylation under conditions of pharmacologically induced oxidative stress
molecular and functional characterization of inositol trisphosphate receptors during early zebrafish development
endoglin differentially modulates antagonistic transforming growth factor-1 and bmp-7 signaling
nucleic acids exert a sequence-independent cooperative effect on sequence-dependent activation of toll-like receptor 9
protein phosphatase-1 modulates the function of pax-6, a transcription factor controlling brain and eye development
structure and conformational changes in the c-terminal domain of the 2-adrenoceptor
structure of aquifex aeolicus argonaute highlights conformational flexibility of the paz domain as a potential regulator of rna-induced silencing complex function
amyloid precursor protein and presenilin1 interact with the adaptor grb2 and modulate erk 1,2 signaling
dimerization is important for the gtpase activity of chloroplast translocon components attoc33 and pstoc159
genome-wide analysis of histone lysine methylation variations caused by diabetic conditions in human monocytes
non-canonical interaction of phosphoinositides with pleckstrin homology domains of tiam1 and arhgap9
the nuclear import of the human t lymphotropic virus type i (htlv-1) tax protein is carrier- and energy-independent
a germ line mutation in the death domain of dapk-1 inactivates erk-induced apoptosis
an essential cell cycle-regulated nucleolar protein relocates to the mitotic spindle where it is involved in mitotic progression in trypanosoma brucei
structure of native protein c inhibitor provides insight into its multiple functions
impaired secretion of apolipoprotein e2 from macrophages
protein c is an autocrine growth factor for human skin keratinocytes
members of the heterogeneous nuclear ribonucleoprotein h family activate splicing of an hiv-1 splicing substrate by promoting formation of atp-dependent spliceosoma..
structural and functional properties of a truncated hemoglobin from a food-borne pathogen campylobacter jejuni
zn2+-dependent redox switch in the intracellular t1-t1 interface of a kv channel
crystal structure of the t877a human androgen receptor ligand-binding domain complexed to cyproterone acetate provides insight for ligand-induced conformational cha..
phosphodiesterase 2a forms a complex with the co-chaperone xap2 and regulates nuclear translocation of the aryl hydrocarbon receptor
analysis of cd95 threshold signaling
hypoxia-inducible factor-1 inhibits self-renewal of mouse embryonic stem cells in vitro via negative regulation of the leukemia inhibitory factor-stat3 pathway
structural determinants of the c-terminal helix-kink-helix motif essential for protein stability and survival promoting activity of dj-1
lim kinase and slingshot are critical for neurite extension
dopamine receptor-interacting protein 78 acts as a molecular chaperone for g subunits before assembly with g
enhanced deacetylation of p53 by the anti-apoptotic protein hsco in association with histone deacetylase 1
a host lipase detoxifies bacterial lipopolysaccharides in the liver and spleen
guanidinylated neomycin delivers large, bioactive cargo into cells through a heparan sulfate-dependent pathway
mapping of the vitronectin-binding site on the urokinase receptor
carbonic anhydrase ii increases the activity of the human electrogenic na+/ cotransporter
role of the spätzle pro-domain in the generation of an active toll receptor ligand
coordination of steps in single-nucleotide base excision repair mediated by apurinic/apyrimidinic endonuclease 1 and dna polymerase
runx1-runx1 homodimerization modulates runx1 activity and function
the effect of mutations in -tropomyosin (e40k and e54k) that cause familial dilated cardiomyopathy on the regulatory mechanism of cardiac muscle thin filaments
cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress
identification of an interleukin 17f/17a heterodimer in activated human cd4+ t cells
role of the h domain of the histidine kinase-like protein nifl in signal transmission
the chloride dependence of the human organic anion transporter 1 (hoat1) is blunted by mutation of a single amino acid
somatostatin receptors signal through efa6a-arf6 to activate phospholipase d in clonal -cells
the rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain
amino acids at positions 3 and 4 determine the membrane specificity of pseudomonas aeruginosa lipoproteins
characterization of the pseudomonas aeruginosa lol system as a lipoprotein sorting mechanism
cyclosporin a and fk506 inhibit il-12p40 production through the calmodulin/calmodulin-dependent protein kinase-activated phosphoinositide 3-kinase in lipopolysaccha..
sufe transfers sulfur from sufs to sufb for iron-sulfur cluster assembly
heparanase enhances syndecan-1 shedding
consequences of direct versus indirect activation of epidermal growth factor receptor in intestinal epithelial cells are dictated by protein-tyrosine phosphatase 1b
clathrin adaptor gga1 polymerizes clathrin into tubules
interaction of hydroxylated collagen iv with the von hippel-lindau tumor suppressor
functional and structural characterization of the first prokaryotic member of the l-amino acid transporter (lat) family
loss of phylloquinone in chlamydomonas affects plastoquinone pool size and photosystem ii synthesis
fatty acid 2-hydroxylase, encoded by fa2h, accounts for differentiation-associated increase in 2-oh ceramides during keratinocyte differentiation
protein kinase c is required for survival of cells expressing activated p21ras
cellular recognition of trimyristoylated peptide or enterobacterial lipopolysaccharide via both tlr2 and tlr4
transient receptor potential channel a1 is directly gated by calcium ions
soluble interleukin (il)-15r is generated by alternative splicing or proteolytic cleavage and forms functional complexes with il-15
the contribution of conformational adjustments and long-range electrostatic forces to the cd2/cd58 interaction
identification by comprehensive chimeric analysis of a key residue responsible for high affinity glucose transport by yeast hxt2
specificity of l,d-transpeptidases from gram-positive bacteria producing different peptidoglycan chemotypes
the double bromodomain-containing chromatin adaptor brd4 and transcriptional regulation
7 nicotinic receptor gene promoter polymorphisms in inbred mice affect expression in a cell type-specific fashion
myosin va becomes a low duty ratio motor in the inhibited form
mitf and pu.1 recruit p38 mapk and nfatc1 to target genes during osteoclast differentiation
r-spondin1 is a high affinity ligand for lrp6 and induces lrp6 phosphorylation and -catenin signaling
gata-1 self-association controls erythroid development in vivo
trb3 inhibits the transcriptional activation of stress-regulated genes by a negative feedback on the atf4 pathway
essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by fty720 analogues
structural and mutational studies of anthocyanin malonyltransferases establish the features of bahd enzyme catalysis
rekles is an arid3-restricted multifunctional domain
def-6, a guanine nucleotide exchange factor for rac1, interacts with the skeletal muscle integrin chain 7a and influences myoblast differentiation
specific protein-membrane contacts are required for prepore and pore assembly by a cholesterol-dependent cytolysin
src-dependent phosphorylation of membrane type i matrix metalloproteinase on cytoplasmic tyrosine 57
specificity profiling of pak kinases allows identification of novel phosphorylation sites
the interaction between cap-binding complex and rna export factor is required for intronless mrna export
the lipoxin a4 receptor is coupled to shp-2 activation
kinetic and structural analysis of the early oxidation products of dopamine
secondary acylation of klebsiella pneumoniae lipopolysaccharide contributes to sensitivity to antibacterial peptides
early photocycle structural changes in a bacteriorhodopsin mutant engineered to transmit photosensory signals
lysophosphatidic acid facilitates proliferation of colon cancer cells via induction of krüppel-like factor 5
isolation and characterization of proteins associated with histone h3 tails in vivo
substrate recognition and ubiquitination of scfskp2/cks1 ubiquitin-protein isopeptide ligase
mutational analysis reveals that all tailoring region genes are required for production of polyketide antibiotic mupirocin by pseudomonas fluorescens
non-aug translation initiation of a fungal ring finger repressor involved in photocarotenogenesis
histone deacetylase inhibitor trichostatin a sustains sodium pervanadate-induced nf-b activation by delaying ib mrna resynthesis
targeting sumo e1 to ubiquitin ligases
dentin matrix protein 4, a novel secretory calcium-binding protein that modulates odontoblast differentiation
the bcl-2 regulator fkbp38-calmodulin-ca2+ is inhibited by hsp90
a novel dna damage response
naadp controls cross-talk between distinct ca2+ stores in the heart
rin1 interacts with signal-transducing adaptor molecule (stam) and mediates epidermal growth factor receptor trafficking and degradation
the nucleoside analog sangivamycin induces apoptotic cell death in breast carcinoma mcf7/adriamycin-resistant cells via protein kinase c and jnk activation
regulation of the rab5 gtpase-activating protein rn-tre by the dual specificity phosphatase cdc14a in human cells
a novel corepressor, bcor-l1, represses transcription through an interaction with ctbp
glucose is necessary for embryonic pancreatic endocrine cell differentiation
integrin 91 directly binds to vascular endothelial growth factor (vegf)-a and contributes to vegf-a-induced angiogenesis
association of protein-tyrosine phosphatase meg2 via its sec14p homology domain with vesicle-trafficking proteins
engineered monomeric human histidine triad nucleotide-binding protein 1 hydrolyzes fluorogenic acyl-adenylate and lysyl-trna synthetase-generated lysyl-adenylate
characterization of the outer membrane receptor shua from the heme uptake system of shigella dysenteriae
ckap2 is a spindle-associated protein degraded by apc/c-cdh1 during mitotic exit
structural basis for recognition of cd20 by therapeutic antibody rituximab
intrinsic disorder and autonomous domain function in the multifunctional nuclear protein, mecp2
regulation of histone h3 lysine 56 acetylation in schizosaccharomyces pombe
protein kinase c is involved in interferon regulatory factor 3 activation and type i interferon- synthesis
fibroblast growth factor inducible 14 (fn14) is required for the expression of myogenic regulatory factors and differentiation of myoblasts into myotubes
selectin blocking activity of a fucosylated chondroitin sulfate glycosaminoglycan from sea cucumber
a critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity
crystal structure of rsr, an ortholog of the antigenic ro protein, links conformational flexibility to rna binding activity
regulation of heparan sulfate 6-o-sulfation by -secretase activity
thyroid transcription factor-1 facilitates cerebrospinal fluid formation by regulating aquaporin-1 synthesis in the brain
the role of disulfide bonds and -helical coiled-coils in the biosynthesis of type xiii collagen and other collagenous transmembrane proteins
mechanism of regulation of prokaryotic tubulin-like gtpase ftsz by membrane protein ezra
sp-1 binds promoter elements that are regulated by retinoblastoma and regulate ctp:phosphocholine cytidylyltransferase- transcription
rip1-mediated aip1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ask1-jnk/p38 activation
protein kinase d induces transcription through direct phosphorylation of the camp-response element-binding protein
fast dissociation of nitric oxide from ferrous pseudomonas aeruginosa cd1 nitrite reductase
identification of a novel arabinofuranosyltransferase aftb involved in a terminal step of cell wall arabinan biosynthesis in corynebacterianeae, such as corynebacte..
interaction of the mitochondria-targeted antioxidant mitoq with phospholipid bilayers and ubiquinone oxidoreductases
mice lacking protein phosphatase 5 are defective in ataxia telangiectasia mutated (atm)-mediated cell cycle arrest
context-dependent gata factor function
mdm2 binding induces a conformational change in p53 that is opposed by heat-shock protein 90 and precedes p53 proteasomal degradation
human t-cell lymphotrophic virus type i rex and p30 interactions govern the switch between virus latency and replication
quantifying rhoa facilitated trafficking of the epithelial na+ channel toward the plasma membrane with total internal reflection fluorescence-fluorescence recovery ..
the structure of the macrophage signal regulatory protein (sirp) inhibitory receptor reveals a binding face reminiscent of that used by t cell receptors
activation of a novel calcineurin-mediated insulin-like growth factor-1 receptor pathway, altered metabolism, and tumor cell invasion in cells subjected to mitochon..
wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing ccaat/enhancer-binding protein and peroxisome proliferator-activated receptor
targeted metabolomics analysis of campylobacter coli vc167 reveals legionaminic acid derivatives as novel flagellar glycans
molecular basis for substrate discrimination by glycine transporters
v1 and v0 domains of the human h+-atpase are linked by an interaction between the g and a subunits
distinctive types of atp-dependent clp proteases in cyanobacteria
a hydrophobic pocket in the active site of glycolytic aldolase mediates interactions with wiskott-aldrich syndrome protein
structural and mechanistic analyses of endo-glycoceramidase ii, a membrane-associated family 5 glycosidase in the apo and gm3 ganglioside-bound forms
critical role of electrostatic interactions of amino acids at the cytoplasmic region of helices 3 and 6 in rhodopsin conformational properties and activation
nmr structural studies of interactions of a small, nonpeptidyl tpo mimic with the thrombopoietin receptor extracellular juxtamembrane and transmembrane domains
hyaluronan mixed esters of butyric and retinoic acid drive cardiac and endothelial fate in term placenta human mesenchymal stem cells and enhance cardiac repair in ..
a mutant ii-spectrin designed to resist calpain and caspase cleavage questions the functional importance of this process in vivo
prolonged treatment of primary hepatocytes with oleate induces insulin resistance through p38 mitogen-activated protein kinase
mitochondria are a major source of paraquat-induced reactive oxygen species production in the brain
the rtt109-vps75 histone acetyltransferase complex acetylates non-nucleosomal histone h3
up-regulation of met expression by -melanocyte-stimulating hormone and mitf allows hepatocyte growth factor to protect melanocytes and melanoma cells from apoptosis
hyperphosphorylation of the c-terminal repeat domain of rna polymerase ii facilitates dissociation of its complex with mediator
a structural switch of presenilin 1 by glycogen synthase kinase 3-mediated phosphorylation regulates the interaction with -catenin and its nuclear signaling
hulc, a histone h2b ubiquitinating complex, modulates heterochromatin independent of histone methylation in fission yeast
sequence dependence and differential expression of g5 subunit isoforms of the heterotrimeric g proteins variably processed after prenylation in mammalian cells
atp binding to the ktn/rck subunit ktra from the k+-uptake system ktrab of vibrio alginolyticus
the chromatin remodeling factor mi-2 acts as a novel co-activator for human c-myb
an archaeal protein with homology to the eukaryotic translation initiation factor 5a shows ribonucleolytic activity
the immunoglobulin heavy chain constant region affects kinetic and thermodynamic parameters of antibody variable region interactions with antigen
glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations
cd8 raft localization is induced by its assembly into cd8 heterodimers, not cd8 homodimers
auto-inhibition of the dbl family protein tim by an n-terminal helical motif
desmoglein versus non-desmoglein signaling in pemphigus acantholysis
kruppel-like factor 4 regulates endothelial inflammation
complementation analysis demonstrates that insulin cross-links both subunits in a truncated insulin receptor dimer
epigallocatechin gallate, a green tea polyphenol, mediates no-dependent vasodilation using signaling pathways in vascular endothelium requiring reactive oxygen spec..
amyloidogenesis of type iii-dependent harpins from plant pathogenic bacteria
molecular insights into quorum sensing in the human pathogen pseudomonas aeruginosa from the structure of the virulence regulator lasr bound to its autoinducer
molecular basis of selectivity of nucleoside triphosphate incorporation opposite o6-benzylguanine by sulfolobus solfataricus dna polymerase dpo
irak-4 kinase activity is required for interleukin-1 (il-1) receptor- and toll-like receptor 7-mediated signaling and gene expression
functional analysis of hairpin ribozyme active site architecture
real time measurements of water flow in amphibian gastric glands
interaction of human immunodeficiency virus type 1 integrase with cellular nuclear import receptor importin 7 and its impact on viral replication
activation of histidine decarboxylase through post-translational cleavage by caspase-9 in a mouse mastocytoma p-815
identification and characterization of the human set1b histone h3-lys4 methyltransferase complex
regulation of ionizing radiation-induced apoptosis by mitochondrial nadp+-dependent isocitrate dehydrogenase
dual role for sumo e2 conjugase ubc9 in modulating the transforming and growth-promoting properties of the hmga1b architectural transcription factor
interaction between heat shock transcription factors (hsfs) and divergent binding sequences
leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to cyclin d1 promoter via activatio..
transcription factor phox2a regulates the human 3 nicotinic receptor subunit gene promoter
initial steps in the anoxic metabolism of cholesterol by the denitrifying sterolibacterium denitrificans
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