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生物物理学杂志2007年第02期封面 购买


a sea urchin sperm flagellar adenylate kinase with triplicated catalytic domains
dual role of slp-76 in mediating t cell receptor-induced activation of phospholipase c-1
cores and ph-dependent dynamics of ferredoxin-nadp+ reductase revealed by hydrogen/deuterium exchange
caveolin-1 tyrosine phosphorylation enhances paclitaxel-mediated cytotoxicity
knockdown of mitochondrial heat shock protein 70 promotes progeria-like phenotypes in caenorhabditis elegans
structure/function analysis of the interaction of phosphatidylinositol 4,5-bisphosphate with actin-capping protein
methyltransferase that modifies guanine 966 of the 16 s rrna
a comprehensive interaction map of the human survival of motor neuron (smn) complex
characterization of myelin ligand complexes with neuronal nogo-66 receptor family members
analysis of lipolytic protein trafficking and interactions in adipocytes
-synuclein stimulates differentiation of osteosarcoma cells
mutation analysis of the short cytoplasmic domain of the cell-cell adhesion molecule ceacam1 identifies residues that orchestrate actin binding and lumen formation
identification and characterization of a schizosaccharomyces pombe rna polymerase ii elongation factor with similarity to the metazoan transcription factor ell
structural and mutational analyses of drp35 from staphylococcus aureus
an andersen-tawil syndrome mutation in kir2.1 (v302m) alters the g-loop cytoplasmic k+ conduction pathway
non-enzymatic glycation of bone collagen modifies osteoclastic activity and differentiation
convergence of p53 and transforming growth factor (tgf) signaling on activating expression of the tumor suppressor gene maspin in mammary epithelial cells
association of cd38 with nonmuscle myosin heavy chain iia and lck is essential for the internalization and activation of cd38
interferon regulatory factor-8 is indispensable for the expression of promyelocytic leukemia and the formation of nuclear bodies in myeloid cells
trehalose, a novel mtor-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and -synuclein
molecular basis of gephyrin clustering at inhibitory synapses
aup1p, a yeast mitochondrial protein phosphatase homolog, is required for efficient stationary phase mitophagy and cell survival
nonribosomal synthesis of fengycin on an enzyme complex formed by fengycin synthetases
cd44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and -2
impact of salt bridges on the equilibrium binding and adhesion of human cd2 and cd58
iron causes interactions of tak1, p21ras, and phosphatidylinositol 3-kinase in caveolae to activate ib kinase in hepatic macrophages
kinetic analysis of tubulin assembly in the presence of the microtubule-associated protein togp
caspase proteolysis of the integrin 4 subunit disrupts hemidesmosome assembly, promotes apoptosis, and inhibits cell migration
mass analysis by scanning transmission electron microscopy and electron diffraction validate predictions of stacked -solenoid model of het-s prion fibrils
med19(rox3) regulates intermodule interactions in the saccharomyces cerevisiae mediator complex
hepatitis c virus ns5a is a direct substrate of casein kinase i-, a cellular kinase identified by inhibitor affinity chromatography using specific ns5a hyperphospho..
ubiquitination and degradation of the anti-apoptotic protein arc by mdm2
an amino acid outside the pore region influences apamin sensitivity in small conductance ca2+-activated k+ channels
functional and structural characterization of a prokaryotic peptide transporter with features similar to mammalian pept1
the epidermal growth factor receptor (egfr) tyrosine kinase inhibitor ag1478 increases the formation of inactive untethered egfr dimers
third activity of bordetella adenylate cyclase (ac) toxin-hemolysin
concerted action of exonuclease and gap-dependent endonuclease activities of fen-1 contributes to the resolution of triplet repeat sequences (ctg)n- and (gaa)n-deri..
a comprehensive structure-function map of the intracellular surface of the human c5a receptor
regulatory cross-talk in the double par locus of plasmid pb171
plant transformation by agrobacterium tumefaciens
three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns
distinct patterns of cytokine regulation of apobec3g expression and activity in primary lymphocytes, macrophages, and dendritic cells
processing of 3‘-phosphoglycolate-terminated dna double strand breaks by artemis nuclease
the slow skeletal muscle isoform of myosin shows kinetic features common to smooth and non-muscle myosins
phosphatidylinositol 3-kinase-akt-mammalian target of rapamycin pathway is essential for neuroendocrine differentiation of prostate cancer
tim17p regulates the twin pore structure and voltage gating of the mitochondrial protein import complex tim23
a novel glycine receptor subunit splice variant predicts an unorthodox transmembrane topology
probing the importance of selected phylum-specific amino acids in a of bacteroides fragilis, a primary factor naturally devoid of an n-terminal acidic region 1.1
expression, processing, and glycosaminoglycan binding activity of the recombinant human 315-kda hyaluronic acid receptor for endocytosis (hare)
selectin ligand expression regulates the initial vascular interactions of colon carcinoma cells
erlotinib effectively inhibits jak2v617f activity and polycythemia vera cell growth
cdk5 regulates stat3 activation and cell proliferation in medullary thyroid carcinoma cells
differential helical orientations among related g protein-coupled receptors provide a novel mechanism for selectivity
in vitro fluorescence anisotropy analysis of the interaction of full-length src1a with estrogen receptors and supports an active displacement model for coregulator ..
characterization of a novel intramolecular chaperone domain conserved in endosialidases and other bacteriophage tail spike and fiber proteins
assembly of acetylcholinesterase tetramers by peptidic motifs from the proline-rich membrane anchor, prima
insulin-like growth factor 1 differentially regulates estrogen receptor-dependent transcription at estrogen response element and ap-1 sites in breast cancer cells
mitogen-activated protein kinase kinase-4 promotes cell survival by decreasing pten expression through an nfb-dependent pathway
a mutation in the mod subunit of ecop15i restriction enzyme converts the dna methyltransferase to a site-specific endonuclease
substrate specificity of rdgb protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase
different domains of the transcription factor elf3 are required in a promoter-specific manner and multiple domains control its binding to dna
actively transcribed gal genes can be physically linked to the nuclear pore by the saga chromatin modifying complex
modulation of host cell gene expression through activation of stat transcription factors by pasteurella multocida toxin
notch signaling suppresses p38 mapk activity via induction of mkp-1 in myogenesis
thrombin-activable fibrinolysis inhibitor (tafi) zymogen is an active carboxypeptidase
reversible sequestration of active site cysteines in a 2fe-2s-bridged dimer provides a mechanism for glutaredoxin 2 regulation in human mitochondria
integrity and barrier function of the epidermis critically depend on glucosylceramide synthesis
co-transcribed genes for long chain polyunsaturated fatty acid biosynthesis in the protozoon perkinsus marinus include a plant-like fae1 3-ketoacyl coenzyme a synth..
effects of ubiquitin system alterations on the formation and loss of a yeast prion
interleukin-31 and oncostatin-m mediate distinct signaling reactions and response patterns in lung epithelial cells
activation of jnk-dependent pathway is required for hiv viral protein r-induced apoptosis in human monocytic cells
rescue of a human cell line from endogenous cdk1 depletion by cdk1 lacking inhibitory phosphorylation sites
lpa4/gpr23 is a lysophosphatidic acid (lpa) receptor utilizing gs-, gq/gi-mediated calcium signaling and g12/13-mediated rho activation
arylalkylamine n-acetyltransferase: “the timezyme“
crystal structure of the rac activator, asef, reveals its autoinhibitory mechanism
mnk1 and mnk2 regulation in her2-overexpressing breast cancer lines
withaferin a strongly elicits ib kinase hyperphosphorylation concomitant with potent inhibition of its kinase activity
soluble androgen receptor oligomers underlie pathology in a mouse model of spinobulbar muscular atrophy
the crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor clec-2
passive and facilitated transport in nuclear pore complexes is largely uncoupled
substrate determinants for rna editing and editing complex interactions at a site for full-round u insertion
the hepatitis b virus x protein functionally interacts with creb-binding protein/p300 in the regulation of creb-mediated transcription
trivalent recognition unit of innate immunity system
the inner loop of tetraspanins cd82 and cd81 mediates interactions with human t cell lymphotrophic virus type 1 gag protein
regulation and function of glycogen synthase kinase-3 isoforms in neuronal survival
an insight into the mechanism of human cysteine dioxygenase
activation of nf-b by the human t cell leukemia virus type i tax oncoprotein is associated with ubiquitin-dependent relocalization of ib kinase
versatile roles of r-ras gap in neurite formation of pc12 cells and embryonic vascular development
p2x7 nucleotide receptors mediate blebbing in osteoblasts through a pathway involving lysophosphatidic acid
how tyrosine 15 phosphorylation inhibits the activity of cyclin-dependent kinase 2-cyclin a
socs3 targets siglec 7 for proteasomal degradation and blocks siglec 7-mediated responses
two tyrosine residues of toll-like receptor 3 trigger different steps of nf-b activation
molecular determinants of substrate selectivity of a novel organic cation transporter (pmat) in the slc29 family
crystal structure of human inosine triphosphatase
identification of the intracellular region of the leukotriene b4 receptor type 1 that is specifically involved in gi activation
selective inhibition of eukaryotic translation initiation factor 2 dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreat..
trans-differentiation of alveolar epithelial type ii cells to type i cells involves autocrine signaling by transforming growth factor 1 through the smad pathway
mutational analysis of cytochrome b at the ubiquinol oxidation site of yeast complex iii
effects of fibrillin-1 degradation on microfibril ultrastructure
self-chaperoning of the type iii secretion system needle tip proteins ipad and bipd
novel genomic effects of glucocorticoids in epidermal keratinocytes
5-methyltetrahydrofolate is bound in intersubunit areas of rat liver folate-binding protein glycine n-methyltransferase
chaperone properties of mammalian mitochondrial translation elongation factor tu
quantitative transcriptional control of erbb receptor signaling undergoes graded to biphasic response for cell differentiation
mutational analysis of norrin-frizzled4 recognition
protein engineering of the colony-stimulating factor-1 receptor kinase domain for structural studies
peptides derived from the c2 domain of protein kinase c (pkc) modulate pkc activity and identify potential protein-protein interaction surfaces
crystal structure of the tyrosine kinase domain of colony-stimulating factor-1 receptor (cfms) in complex with two inhibitors
site-specific lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of ib kinase activation
role of heat stress transcription factor hsfa5 as specific repressor of hsfa4
discovery and characterization of a ca2+-independent phosphatidylethanolamine n-acyltransferase generating the anandamide precursor and its congeners
glycogen synthase kinase-3 phosphorylates cdgap at a consensus erk 1 regulatory site
a c-helix residue, arg-123, has important roles in both the active and inactive forms of the camp receptor protein
functional association between three archaeal aminoacyl-trna synthetases
the role of the n-terminal domain of the complement fragment receptor c5l2 in ligand binding
ken-box-dependent degradation of the bub1 spindle checkpoint kinase by the anaphase-promoting complex/cyclosome
a potential role for multiple tissue kallikrein serine proteases in epidermal desquamation
direct interactions of runx2 and canonical wnt signaling induce fgf18
specificity of traf3 in its negative regulation of the noncanonical nf-b pathway
fluorescent na+-ca+ exchangers
alcohol regulates eukaryotic elongation factor 2 phosphorylation via an amp-activated protein kinase-dependent mechanism in c2c12 skeletal myocytes
in vitro polymerization of a functional escherichia coli amyloid protein
na+-dependent inactivation of the retinal cone/brain na+/ca2+-k+ exchanger nckx2
multiple modes of binding enhance the affinity of dc-sign for high mannose n-linked glycans found on viral glycoproteins
crystal structure of the human brd2 bromodomain
ssr2998 of synechocystis sp. pcc 6803 is involved in regulation of cyanobacterial electron transport and associated with the cytochrome b6f complex
functional dissection identifies a conserved noncoding sequence-1 core that mediates il13 and il4 transcriptional enhancement
molecular cloning and characterization of a novel -agarase, agab, from marine pseudoalteromonas sp. cy24
the eukaryotic initiation factor-2 kinase pathway facilitates differential gadd45a expression in response to environmental stress
an alix fragment potently inhibits hiv-1 budding
tristetraprolin (ttp)-14-3-3 complex formation protects ttp from dephosphorylation by protein phosphatase 2a and stabilizes tumor necrosis factor- mrna
hypoallergens for allergen-specific immunotherapy by directed molecular evolution of mite group 2 allergens
heterologous expression of the glutamine transporter snat3 in xenopus oocytes is associated with four modes of uncoupled transport
myostatin induces cyclin d1 degradation to cause cell cycle arrest through a phosphatidylinositol 3-kinase/akt/gsk-3 pathway and is antagonized by insulin-like grow..
linked rubisco subunits can assemble into functional oligomers without impeding catalytic performance
a 2(r43q) mutation, linked to epilepsy in humans, alters gabaa receptor assembly and modifies subunit composition on the cell surface
a periplasmic iron-binding protein contributes toward inward copper supply
solution structure and backbone dynamics of an endopeptidase hyci from scherichia coli
probing the architecture of an l-type calcium channel with a charged phenylalkylamine
mechanism of substrate sensing and signal transmission within an abc transporter
hormonal regulation of nuclear permeability
a novel, non-immunogenic fyn sh3-derived binding protein with tumor vascular targeting properties
calmodulin-like protein increases filopodia-dependent cell motility via up-regulation of myosin-10
airway epithelial cell migration and wound repair by atp-mediated activation of dual oxidase 1
combined deletion of mouse dematin-headpiece and -adducin exerts a novel effect on the spectrin-actin junctions leading to erythrocyte fragility and hemolytic anemia
modulation of replicative senescence of diploid human cells by nuclear erk signaling
chondroitin sulfate n-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage
gabab receptor association with the pdz scaffold mupp1 alters receptor stability and function
the nmr solution structure of the relaxin (rxfp1) receptor lipoprotein receptor class a module and identification of key residues in the n-terminal region of the mo..
rna interference silencing of the adaptor molecules shcc and fe65 differentially affect amyloid precursor protein processing and a generation
tak1-dependent signaling requires functional interaction with tab2/tab3
urokinase receptors are required for 51 integrin-mediated signaling in tumor cells
evidence for actin cytoskeleton-dependent and -independent pathways for rela/p65 nuclear translocation in endothelial cells
cellular adhesion responses to the heparin-binding (hepii) domain of fibronectin require heparan sulfate with specific properties
structural and functional fingerprint of the mitochondrial atp-binding cassette transporter mdl1 from saccharomyces cerevisiae
a structural perspective on the interaction between lipopolysaccharide and factor c, a receptor involved in recognition of gram-negative bacteria
activation of nfatc3 down-regulates the 1 subunit of large conductance, calcium-activated k+ channels in arterial smooth muscle and contributes to hypertension
regulation of human melanocortin 1 receptor signaling and trafficking by thr-308 and ser-316 and its alteration in variant alleles associated with red hair and skin..
inhibition of hepatic phosphatidylcholine synthesis by 5-aminoimidazole-4-carboxamide-1--4-ribofuranoside is independent of amp-activated protein kinase activation
inhibition of hypoxia-inducible factor (hif) hydroxylases by citric acid cycle intermediates
association with coregulators is the major determinant governing peroxisome proliferator-activated receptor mobility in living cells
carps are ubiquitin ligases that promote mdm2-independent p53 and phospho-p53ser20 degradation
ypi1 and sds22 proteins regulate the nuclear localization and function of yeast type 1 phosphatase glc7
mitochondrial fatty acid synthesis in trypanosoma brucei
fatty acyl benzamido antibacterials based on inhibition of dnak-catalyzed protein folding
perturbation of the activity of replication origin by meiosis-specific transcription
analysis of ion interactions with the k+ -dependent na+/ca+ exchangers nckx2, nckx3, and nckx
structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates
resistance to bacillus thuringiensis toxin in caenorhabditis elegans from loss of fucose
cochlear function in mice lacking the bk channel, 1, or 4 subunits
trpm8-independent menthol-induced ca2+ release from endoplasmic reticulum and golgi
the pyrophosphate analogue foscarnet traps the pre-translocational state of hiv-1 reverse transcriptase in a brownian ratchet model of polymerase translocation
resveratrol binds to the sulfonylurea receptor (sur) and induces apoptosis in a sur subtype-specific manner
interactions of human o6-alkylguanine-dna alkyltransferase (agt) with short single-stranded dnas
functional and structural aspects of poplar cytosolic and plastidial type a methionine sulfoxide reductases
ceramide regulates atypical pkc/-mediated cell polarity in primitive ectoderm cells
role of abcg1 and abca1 in regulation of neuronal cholesterol efflux to apolipoprotein e discs and suppression of amyloid- peptide generation
peripheral effect of -melanocyte-stimulating hormone on fatty acid oxidation in skeletal muscle
atp activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages
nitric oxide mediates natural polyphenol-induced bcl-2 down-regulation and activation of cell death in metastatic b16 melanoma
compensatory mechanism for homeostatic blood pressure regulation in ephx2 gene-disrupted mice
arachidonate-derived dihomoprostaglandin production observed in endotoxin-stimulated macrophage-like cells
transglutaminase-dependent rhoa activation and depletion by serotonin in vascular smooth muscle cells
the role of the c-terminal domain of protein tyrosine phosphatase-1b in phosphatase activity and substrate binding
bisindolylmaleimide i suppresses fibroblast growth factor-mediated activation of erk map kinase in chondrocytes by preventing shp2 association with the frs2 and gab..
neuritogenic activity of chondroitin/dermatan sulfate hybrid chains of embryonic pig brain and their mimicry from shark liver
characterization of a plant-like protochlorophyllide a divinyl reductase in green sulfur bacteria
characterization of the interactome of the human mutl homologues mlh1, pms1, and pms2
real time fluorescent resonance energy transfer visualization of ferric pyoverdine uptake in pseudomonas aeruginosa
significance of the n-terminal domain for the function of chloroplast cpn20 chaperonin
multiple histone deacetylases and the creb-binding protein regulate pre-mrna 3‘-end processing
flagellin contamination of recombinant heat shock protein 70 is responsible for its activity on t cells
hxk2 regulates the phosphorylation state of mig1 and therefore its nucleocytoplasmic distribution
neutralization of acidic residues in helix ii stabilizes the folded conformation of acyl carrier protein and variably alters its function with different enzymes
analysis of nucleocytoplasmic trafficking of the hur ligand april and its influence on cd83 expression
osmotic stress-dependent repression is mediated by histone h3 phosphorylation and chromatin structure
cross-talk between histone modifications in response to histone deacetylase inhibitors
interleukin-1 receptor antagonist induction as an additional mechanism for liver receptor homolog-1 to negatively regulate the hepatic acute phase response
mechanisms involved in the protection of uv-induced protein inactivation by the corneal crystallin aldh3a1
rnase iii-dependent regulation of yeast telomerase
proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress
spontaneous cross-link of mutated 1 subunits during gabaa receptor assembly
dynamics of protein kinase c-mediated phosphorylation of the complement c5a receptor on serine 334
h2o2-induced kinetic and chemical modifications of smooth muscle myosin
functional characterization of desaturases involved in the formation of the terminal double bond of an unusual 16:39, 12, 15 fatty acid isolated from sorghum bicolo..
a novel cell-permeable antioxidant peptide, ss31, attenuates ischemic brain injury by down-regulating cd36
solution structure and alanine scan of a spider toxin that affects the activation of mammalian voltage-gated sodium channels
channeling of eukaryotic diacylglycerol into the biosynthesis of plastidial phosphatidylglycerol
amp-activated protein kinase impairs endothelial actin cytoskeleton assembly by phosphorylating vasodilator-stimulated phosphoprotein
heat shock protein 60 or 70 activates nitric-oxide synthase (nos) i- and inhibits nos ii-associated signaling and depresses the mitochondrial apoptotic cascade duri..
modulation of drak2 autophosphorylation by antigen receptor signaling in primary lymphocytes
inactivation of corynebacterium glutamicum ncgl0452 and the role of mgta in the biosynthesis of a novel mannosylated glycolipid involved in lipomannan biosynthesis
environment of the active site region of rsep, an escherichia coli regulated intramembrane proteolysis protease, assessed by site-directed cysteine alkylation
mouse and human granzyme b have distinct tetrapeptide specificities and abilities to recruit the bid pathway
curcumin opens cystic fibrosis transmembrane conductance regulator channels by a novel mechanism that requires neither atp binding nor dimerization of the nucleotid..
propionyl-l-carnitine reduces proliferation and potentiates bax-related apoptosis of aortic intimal smooth muscle cells by modulating nuclear factor-b activity
hpebp4 resists trail-induced apoptosis of human prostate cancer cells by activating akt and deactivating erk1/2 pathways
biochemical evidence that phaz gene encodes a specific intracellular medium chain length polyhydroxyalkanoate depolymerase in pseudomonas putida kt244
constitutive traffic of melanocortin-4 receptor in neuro2a cells and immortalized hypothalamic neurons
p38 mitogen-activated protein kinase plays an inhibitory role in hepatic lipogenesis
statin-induced ras activation integrates the phosphatidylinositol 3-kinase signal to akt and mapk for bone morphogenetic protein-2 expression in osteoblast differen..
cathepsin cs are key for the intracellular survival of the protozoan parasite, toxoplasma gondii
inhibition of metalloprotease botulinum serotype a from a pseudo-peptide binding mode to a small molecule that is active in primary neurons
archaeal minichromosome maintenance (mcm) helicase can unwind dna bound by archaeal histones and transcription factors
the protective role of a small gtpase rhoe against uvb-induced dna damage in keratinocytes
characterization, kinetics, and crystal structures of fructose-1,6-bisphosphate aldolase from the human parasite, giardia lamblia
mechanical shedding of l-selectin from the neutrophil surface during rolling on sialyl lewis x under flow
oligomerization of the udp-glucuronosyltransferase 1a proteins
the hormonal response of estrogen receptor is decreased by the phosphatidylinositol 3-kinase/akt pathway via a phosphorylation-dependent release of creb-binding pro..
the membrane anchor r7bp controls the proteolytic stability of the striatal specific rgs protein, rgs9-2
molecular basis of cav2.3 calcium channels in rat nociceptive neurons
electron nuclear double resonance differentiates complementary roles for active site histidines in (6-4) photolyase
lysyl-trna synthetase-generated lysyl-adenylate is a substrate for histidine triad nucleotide binding proteins
oxysterol nuclear receptor lxr regulates cholesterol homeostasis and contractile function in mouse uterus
characterization of the 2-hydroxy-acid dehydrogenase mcyi, encoded within the microcystin biosynthesis gene cluster of microcystis aeruginosa pcc7806
herg is protected from pharmacological block by -1,2-glucosyltransferase function
geminin prevents rereplication during xenopus development
the novel cellular mechanism of human 5-ht6 receptor through an interaction with fyn
inhibition of b56-containing protein phosphatase 2as by the early response gene iex-1 leads to control of akt activity
protease-activating receptor-4 induces full platelet spreading on a fibrinogen matrix
epac-mediated activation of phospholipase c plays a critical role in -adrenergic receptor-dependent enhancement of ca2+ mobilization in cardiac myocytes
the n-terminal membrane occupation and recognition nexus domain of arabidopsis phosphatidylinositol phosphate kinase 1 regulates enzyme activity
functional analysis of arabidopsis thaliana rhm2/mum4, a multidomain protein involved in udp-d-glucose to udp-l-rhamnose conversion
chlamydomonas flagellar outer row dynein assembly protein oda7 interacts with both outer row and i1 inner row dyneins
microsomal prostaglandin e synthase-1 deficiency is associated with elevated peroxisome proliferator-activated receptor
tel2 is required for activation of the mrc1-mediated replication checkpoint
ectopic expression of dentin sialoprotein during amelogenesis hardens bulk enamel
defining the native disulfide topology in the somatomedin b domain of human vitronectin
src signaling regulates completion of abscission in cytokinesis through erk/mapk activation at the midbody
elucidation of the role of peptide linker in calcium-sensing receptor activation process
mechanisms of plasmin-catalyzed inactivation of factor viii
the thylakoid proton gradient promotes an advanced stage of signal peptide binding deep within the tat pathway receptor complex
biosynthesis of chondroitin and heparan sulfate in chinese hamster ovary cells depends on xylosyltransferase ii
human xylosyltransferase ii is involved in the biosynthesis of the uniform tetrasaccharide linkage region in chondroitin sulfate and heparan sulfate proteoglycans
selective up-regulation of lxr-regulated genes abca1, abcg1, and apoe in macrophages through increased endogenous synthesis of 24(s),25-epoxycholesterol
protein domain-domain interactions and requirements for the negative regulation of arabidopsis cdc48/p97 by the plant ubiquitin regulatory x (ubx) domain-containing..
regulation of human cytochrome p450 4f2 expression by sterol regulatory element-binding protein and lovastatin
inhibition of apccdh1 activity by cdh1/acm1/bmh1 ternary complex formation
nuclear and mitochondrial interaction involving mt-nd2 leads to increased mitochondrial reactive oxygen species production
a critical role for system a amino acid transport in the regulation of dendritic development by brain-derived neurotrophic factor (bdnf)
conformation state-sensitive antibodies to g-protein-coupled receptors
classical nuclear localization signals: definition, function, and interaction with importin
selective control of skeletal muscle differentiation by akt1
essential role for co-chaperone fkbp52 but not fkbp51 in androgen receptor-mediated signaling and physiology
direct interaction between usf and srebp-1c mediates synergistic activation of the fatty-acid synthase promoter
a conserved pathway that controls c-myc protein stability through opposing phosphorylation events occurs in yeast
transcriptional regulation of fasl expression and participation of stnf- in response to sertoli cell injury
prl3 promotes cell invasion and proliferation by down-regulation of csk leading to src activation
cumulus oophorus-associated glycodelin-c displaces sperm-bound glycodelin-a and -f and stimulates spermatozoa-zona pellucida binding
phosphorylation of human ctp synthetase 1 by protein kinase a
fast and selective ammonia transport by aquaporin-8
a new method of purification of proteasome substrates reveals polyubiquitination of 20 s proteasome subunits
cloning of ovocalyxin-36, a novel chicken eggshell protein related to lipopolysaccharide-binding proteins, bactericidal permeability-increasing proteins, and plunc ..
two novel ubiquitin-fold modifier 1 (ufm1)-specific proteases, ufsp1 and ufsp2
a proteasome-regulated glycogen synthase kinase-3 modulates disease response in plants
organization and function of the ysia regulon of bacillus subtilis involved in fatty acid degradation
regulation of schizosaccharomyces pombe atf1 protein levels by sty1-mediated phosphorylation and heterodimerization with pcr1
cd40 ligand binds to 51 integrin and triggers cell signaling
a unique protease-sensitive high density lipoprotein particle containing the apolipoprotein a-imilano dimer effectively promotes atp-binding cassette a1-mediated ce..
the mycobacterium tuberculosis cell-surface glycoprotein apa as a potential adhesin to colonize target cells via the innate immune system pulmonary c-type lectin su..
direct assessment of cxcr4 mutant conformations reveals complex link between receptor structure and gi activation
assembly of an sap97-akap79-camp-dependent protein kinase scaffold at the type 1 psd-95/dlg/zo1 motif of the human 1-adrenergic receptor generates a receptosome inv..
the rate of c-fos transcription in vivo is continuously regulated at the level of elongation by dynamic stimulus-coupled recruitment of positive transcription elong..
functional architecture of atrophins
mitochondrial dysfunction induced by a cytotoxic adenine dinucleotide produced by adp-ribosyl cyclases from cadpr
molecular basis for nitric oxide dynamics and affinity with alcaligenes xylosoxidans cytochrome
the central role of pdr1 in the foundation of yeast drug resistance
the c2a-c2b linker defines the high affinity ca2+ binding mode of rabphilin-3a
microenvironmental regulation of membrane type 1 matrix metalloproteinase activity in ovarian carcinoma cells via collagen-induced egr1 expression
the tottori (d7n) and english (h6r) familial alzheimer disease mutations accelerate a fibril formation without increasing protofibril formation
structural basis of peroxide-mediated changes in human hemoglobin
rock1 phosphorylates and activates zipper-interacting protein kinase
targeting and stability of na/ca exchanger 1 in cardiomyocytes requires direct interaction with the membrane adaptor ankyrin-b
a chemogenomic screen in saccharomyces cerevisiae uncovers a primary role for the mitochondria in farnesol toxicity and its regulation by the pkc1 pathway
human endoplasmic reticulum mannosidase i is subject to regulated proteolysis
tumor-specific and proliferation-specific gene expression typifies murine transgenic b cell lymphomagenesis
transforming growth factor-3 increases the invasiveness of endometrial carcinoma cells through phosphatidylinositol 3-kinase-dependent up-regulation of x-linked inh..
protein inhibitor of activated stat1 interacts with and up-regulates activities of the pro-proliferative transcription factor krüppel-like factor 5
site-specific acetylation of p53 directs selective transcription complex assembly
14-3-3 protein interacts with huntingtin-associated protein 1 and regulates its trafficking
ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase b for degradation
structural and biophysical studies on two promoter recognition domains of the extra-cytoplasmic function factor c from mycobacterium tuberculosis
differential effects of endoplasmic reticulum stress-induced autophagy on cell survival
synergistic and differential modulation of immune responses by hsp60 and lipopolysaccharide
the effect of class a scavenger receptor deficiency in bone
in vivo membrane topology of escherichia coli seca atpase reveals extensive periplasmic exposure of multiple functionally important domains clustering on one face o..
a novel sorting sequence in the 2-adrenergic receptor switches recycling from default to the hrs-dependent mechanism
hexameric calgranulin c (s100a12) binds to the receptor for advanced glycated end products (rage) using symmetric hydrophobic target-binding patches
hydroxyurea and interleukin-6 synergistically reactivate hiv-1 replication in a latently infected promonocytic cell line via sp1/sp3 transcription factors
the macrophage cell surface glyceraldehyde-3-phosphate dehydrogenase is a novel transferrin receptor
lysyl oxidase interacts with hormone placental lactogen and synergistically promotes breast epithelial cell proliferation and migration
the flexible and clustered lysine residues of human ribonuclease 7 are critical for membrane permeability and antimicrobial activity
the apoptosis inhibitor arc undergoes ubiquitin-proteasomal-mediated degradation in response to death stimuli
identification of a novel mitochondrial complex containing mitofusin 2 and stomatin-like protein 2
the nuclease a-inhibitor complex is characterized by a novel metal ion bridge
glycosylation mediates up-regulation of a potent antiangiogenic and proatherogenic protein, thrombospondin-1, by glucose in vascular smooth muscle cells
individual overexpression of five subunits of human translation initiation factor eif3 promotes malignant transformation of immortal fibroblast cells
characterization of the ph-dependent interaction between the gap junction protein connexin43 carboxyl terminus and cytoplasmic loop domains
lpa4/p2y9/gpr23 mediates rho-dependent morphological changes in a rat neuronal cell line
kallikrein 8 is involved in skin desquamation in cooperation with other kallikreins
regulation of apoptosis and differentiation by p53 in human embryonic stem cells
structural basis for formation and hydrolysis of the calcium messenger cyclic adp-ribose by human cd38
effect of 4-hydroxy-2-nonenal modification on -synuclein aggregation
reticulon 3 binds the 2c protein of enterovirus 71 and is required for viral replication
reversal of agonist selectivity by mutations of conserved amino acids in the binding site of nicotinic acetylcholine receptors
arabidopsis isochorismate synthase functional in pathogen-induced salicylate biosynthesis exhibits properties consistent with a role in diverse stress responses
crystal structure of the tp34 (tp0971) lipoprotein of treponema pallidum
closing the gate to the active site
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