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surface charge interactions of the fmn module govern catalysis by nitric-oxide synthase
two conserved residues govern the salt and ph dependencies of the binding reaction of a pdz domain
random mutagenesis of the complement factor 5a (c5a) receptor n terminus provides a structural constraint for c5a docking
the 2‘-phosphate of nadp is responsible for proper orientation of the nicotinamide ring in the oxidative decarboxylation reaction catalyzed by sheep liver 6-phosph..
protein kinase c-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 mapk
structure of the escherichia coli o157:h7 heme oxygenase chus in complex with heme and enzymatic inactivation by mutation of the heme coordinating residue his-193
involvement of p38 mitogen-activated protein kinase in lung metastasis of tumor cells
photon flux density-dependent gene expression in synechocystis sp. pcc 6803 is regulated by a small, redox-responsive, luxr-type regulator
npc2, the protein deficient in niemann-pick c2 disease, consists of multiple glycoforms that bind a variety of sterols
the deubiquitinating enzyme ubp2 modulates rsp5-dependent lys63-linked polyubiquitin conjugates in saccharomyces cerevisiae
activation of platelet iib3 by an exogenous peptide corresponding to the transmembrane domain of iib
identification and characterization of a1,3-glucosyltransferase that synthesizes the glc-1,3-fuc disaccharide on thrombospondin type 1 repeats
protein kinase ck2 is inhibited by human nucleolar phosphoprotein p140 in an inositol hexakisphosphate-dependent manner
novel iso-branched ether lipids as specific markers of developmental sporulation in the myxobacterium myxococcus xanthus
purification of a nifen protein complex that contains bound molybdenum and a femo-co precursor from an azotobacter vinelandii nifhdk strain
structure/function relationships of ccr8 agonists and antagonists
regulation of amp-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular camp
molecular and functional characterization of a soluble form of oncostatin m/interleukin-31 shared receptor
loss of socs3 gene expression converts stat3 function from anti-apoptotic to pro-apoptotic
the transcriptional response of the yeast na+-atpase ena1 gene to alkaline stress involves three main signaling pathways
critical role for cryopyrin/nalp3 in activation of caspase-1 in response to viral infection and double-stranded rna
mitochondrial matrix copper complex used in metallation of cytochrome oxidase and superoxide dismutase
protein serine/threonine phosphatase ppm1a dephosphorylates smad1 in the bone morphogenetic protein signaling pathway
a bifunctional 12,15-desaturase from acanthamoeba castellanii directs the synthesis of highly unusual n-1 series unsaturated fatty acids
phospholipid dependence and liposome reconstitution of purified hyaluronan synthase
uptake and utilization of lyso-phosphatidylethanolamine by saccharomyces cerevisiae
mapping the functional domains of yeast nmd3, the nuclear export adapter for the 60 s ribosomal subunit
a second fatty acid amide hydrolase with variable distribution among placental mammals
modulation of rad26- and rpb9-mediated dna repair by different promoter elements
characterization of gene rearrangements leading to activation of mdr-1
reversed functional organization of mouse and human apobec3 cytidine deaminase domains
changes in c-terminal binding protein 2 (ctbp2) corepressor complex induced by e1a and modulation of e1a transcriptional activity by ctbp2
resistance to nitric oxide-induced necrosis in heme oxygenase-1 overexpressing pulmonary epithelial cells associated with decreased lipid peroxidation
the presence of sarcolipin results in increased heat production by ca2+-atpase
swt1, a novel yeast protein, functions in transcription
l4-33k, an adenovirus-encoded alternative rna splicing factor
the vasp-spred-sprouty domain puzzle
a new flavin radical signal in the na+-pumping nadh:quinone oxidoreductase from vibrio cholerae
flow-activated chloride channels in vascular endothelium
protein phosphatase 6 down-regulates tak1 kinase activation in the il-1 signaling pathway
estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression
calcium-mediated transient phosphorylation of tau and amyloid precursor protein followed by intraneuronal amyloid- accumulation
derlin-1 promotes the efficient degradation of the cystic fibrosis transmembrane conductance regulator (cftr) and cftr folding mutants
negative regulation of osteoclastogenesis by ectodomain shedding of receptor activator of nf-b ligand
activation of muscle-specific receptor tyrosine kinase and binding to dystroglycan are regulated by alternative mrna splicing of agrin
transcriptional regulation by foxp3 is associated with direct promoter occupancy and modulation of histone acetylation
a catalytic mechanism revealed by the crystal structures of the imidazolonepropionase from bacillus subtilis
rna-binding motif protein 15 binds to the rna transport element rte and provides a direct link to the nxf1 export pathway
the structure, location, and function of perlecan, a prominent pericellular proteoglycan of fetal, postnatal, and mature hyaline cartilages
the -phosphoglucomutase of lactococcus lactis is unrelated to the -d-phosphohexomutase superfamily and is encoded by the essential gene pgmh
nitrite reductase activity of sol-gel-encapsulated deoxyhemoglobin
autophagy for cancer therapy through inhibition of pro-apoptotic proteins and mammalian target of rapamycin signaling
sorting nexin 10 induces giant vacuoles in mammalian cells
vp1686, a vibrio type iii secretion protein, induces toll-like receptor-independent apoptosis in macrophage through nf-b inhibition
a membrane-proximal tetracysteine motif contributes to assembly of cd3 and cd3 dimers with the t cell receptor
sequence dependence of renucleation after a gly mutation in model collagen peptides
novel benzene ring biosynthesis from c3 and c4 primary metabolites by two enzymes
the smc5-smc6 dna repair complex
interregulation of proton-gated na+ channel 3 and cystic fibrosis transmembrane conductance regulator
mekk1 is required for mpk4 activation and regulates tissue-specific and temperature-dependent cell death in arabidopsis
identification of tctex2, a novel dynein light chain family member that interacts with different transforming growth factor- receptors
evidence for the formation of a heptameric ion channel complex by the hepatitis c virus p7 protein in vitro
analysis of human phagocyte flavocytochrome b558 by mass spectrometry
antisense targeting of cxxc finger protein 1 inhibits genomic cytosine methylation and primitive hematopoiesis in zebrafish
trim5 accelerates degradation of cytosolic capsid associated with productive hiv-1 entry
expression of expanded polyglutamine proteins suppresses the activation of transcription factor nfb
gemin8 is required for the architecture and function of the survival motor neuron complex
lysophospholipids control integrin-dependent adhesion in splenic b cells through gi and g12/g13 family g-proteins but not through gq/g11
transmembrane segment 12 of the glut1 glucose transporter is an outer helix and is not directly involved in the transport mechanism
a membrane-targeted bid bcl-2 homology 3 peptide is sufficient for high potency activation of bax in vitro
correction of apolipoprotein a-i-mediated lipid efflux and high density lipoprotein particle formation in human niemann-pick type c disease fibroblasts
human t-cell leukemia virus type i p30 nuclear/nucleolar retention is mediated through interactions with rna and a constituent of the 60 s ribosomal subunit
loss of ikk promotes migration and proliferation of mouse embryo fibroblast cells
hop cleavage and function in granzyme b-induced apoptosis
cyclooxygenase-2-derived prostaglandin e2 directs oocyte maturation by differentially influencing multiple signaling pathways
danger, a novel regulatory protein of inositol 1,4,5-trisphosphate-receptor activity
dietary flavonoids attenuate tumor necrosis factor -induced adhesion molecule expression in human aortic endothelial cells
molecular mechanism of membrane docking by the vam7p px domain
mapk-activated protein kinase-2 (mk2)-mediated formation and phosphorylation-regulated dissociation of the signal complex consisting of p38, mk2, akt, and hsp27
observing an induced-fit mechanism during sequence-specific dna methylation
removal of pattern-breaking sequences in microtubule binding repeats produces instantaneous tau aggregation and toxicity
the location of asparagine-linked glycans on west nile virions controls their interactions with cd209 (dendritic cell-specific icam-3 grabbing nonintegrin)
crystal structures of aedes aegypti alanine glyoxylate aminotransferase
biochemical and nmr study on the competition between proteins sc35, srp40, and heterogeneous nuclear ribonucleoprotein a1 at the hiv-1 tat exon 2 splicing site
rtt109 is required for proper h3k56 acetylation
the role of hypothalamic malonyl-coa in energy homeostasis
intracranial microenvironment reveals independent opposing functions of host v3 expression on glioma growth and angiogenesis
overexpression of rat long chain acyl-coa synthetase 1 alters fatty acid metabolism in rat primary hepatocytes
structural basis for calcium-induced inhibition of rhodopsin kinase by recoverin
versatility and differential roles of cysteine residues in human prostacyclin receptor structure and function
molecular mechanism of adaphostin-mediated g1 arrest in prostate cancer (pc-3) cells
association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growth
molecular mechanisms of import of peroxisome-targeting signal type 2 (pts2) proteins by pts2 receptor pex7p and pts1 receptor pex5pl
antiangiogenic antithrombin blocks the heparan sulfate-dependent binding of proangiogenic growth factors to their endothelial cell receptors
human myosin iii is a motor having an extremely high affinity for actin
a tissue-specific variant of the human lysyl oxidase-like protein 3 (loxl3) functions as an amine oxidase with substrate specificity
cloning and initial characterization of a new subunit for mammalian serine-palmitoyltransferase
mitochondrial uncoupling protein-4 regulates calcium homeostasis and sensitivity to store depletion-induced apoptosis in neural cells
murine leukemia virus regulates alternative splicing through sequences upstream of the 5· splice site
phosphatidylinositol 3-kinase-dependent modulation of carnitine palmitoyltransferase 1a expression regulates lipid metabolism during hematopoietic cell growth
mitochondrial creatine kinase activity prevents reactive oxygen species generation
the cold and menthol receptor trpm8 contains a functionally important double cysteine motif
gata-1-mediated transcriptional repression yields persistent transcription factor iib-chromatin complexes
role of scavenger receptor class b type i and sphingosine 1-phosphate receptors in high density lipoprotein-induced inhibition of adhesion molecule expression in en..
the natural inverse agonist agouti-related protein induces arrestin-mediated endocytosis of melanocortin-3 and -4 receptors
molecular adaptation and allostery in plant pantothenate synthetases
the functional effects of physical interactions among toll-like receptors 7, 8, and 9
mitochondrial production of reactive oxygen species mediate dicumarol-induced cytotoxicity in cancer cells
protease domain glycans affect oligomerization, disulfide bond formation, and stability of the meprin a metalloprotease homo-oligomer
evolutionary and functional conservation of the dna non-homologous end-joining protein, xlf/cernunnos
unique and overlapping transcriptional roles of arylhydrocarbon receptor nuclear translocator (arnt) and arnt2 in xenobiotic and hypoxic responses
voltage gating of vdac is regulated by nonlamellar lipids of mitochondrial membranes
the basic domain of trf2 directs binding to dna junctions irrespective of the presence of ttaggg repeats
hd1, a thrombin-directed aptamer, binds exosite 1 on prothrombin with high affinity and inhibits its activation by prothrombinase
binding of the universal minicircle sequence binding protein at the kinetoplast dna replication origin
membrane type 1 matrix metalloproteinase (mt1-mmp/mmp-14) cleaves and releases a 22-kda extracellular matrix metalloproteinase inducer (emmprin) fragment from tumor..
polycystin-2 cation channel function is under the control of microtubular structures in primary cilia of renal epithelial cells
bacterial bioreactors for high yield production of recombinant protein
calcium-dependent spontaneously reversible remodeling of brain mitochondria
the arabidopsis protein kinase pti1-2 is activated by convergent phosphatidic acid and oxidative stress signaling pathways downstream of pdk1 and oxi1
ack1 mediates cdc42-dependent cell migration and signaling to p130cas
chemokine cxcl12 induces binding of ferritin heavy chain to the chemokine receptor cxcr4, alters cxcr4 signaling, and induces phosphorylation and nuclear translocat..
aberrant hepatic expression of ppar2 stimulates hepatic lipogenesis in a mouse model of obesity, insulin resistance, dyslipidemia, and hepatic steatosis
tuning of a neuronal calcium sensor
discovery of a new prokaryotic type i gtp cyclohydrolase family
a pentatricopeptide repeat protein is a site recognition factor in chloroplast rna editing
interactions between the rna interference effector protein ago1 and 14-3-3 proteins
a r2r3 type myb transcription factor is involved in the cold regulation of cbf genes and in acquired freezing tolerance
topology of the virb4 c terminus in the agrobacterium tumefaciens virb/d4 type iv secretion system
gastrointestinal hormones cause rapid c-met receptor down-regulation by a novel mechanism involving clathrin-mediated endocytosis and a lysosome-dependent mechanism
retinol dehydrogenase (rdh12) protects photoreceptors from light-induced degeneration in mice
the “linker“ region (amino acids 38-47) of the disintegrin elegantin is a novel inhibitory domain of integrin 51-dependent cell adhesion on fibronectin
association of kv1.5 and kv1.3 contributes to the major voltage-dependent k+ channel in macrophages
an allosteric activator of glucokinase impairs the interaction of glucokinase and glucokinase regulatory protein and regulates glucose metabolism
regulation of the platelet-derived growth factor receptor- by g protein-coupled receptor kinase-5 in vascular smooth muscle cells involves the phosphatase shp2
the interaction of a carbohydrate-binding module from a clostridium perfringens n-acetyl--hexosaminidase with its carbohydrate receptor
mammalian lin-7 stabilizes polarity protein complexes
autocrine and juxtacrine effects of amphiregulin on the proliferative, invasive, and migratory properties of normal and neoplastic human mammary epithelial cells
pre-steady state electrogenic events of ca2+/h+ exchange and transport by the ca2+-atpase
side chain-dependent stacking modulates tau filament structure
structural characterization of a blue chromoprotein and its yellow mutant from the sea anemone cnidopus japonicus
structural determinants in the group iii truncated hemoglobin from campylobacter jejuni
maximal 3-adrenergic regulation of lipolysis involves src and epidermal growth factor receptor-dependent erk1/2 activation
kinetic and mechanistic basis of the nonprocessive kinesin-3 motor nckin3
x-ray crystal structures of the estrogen-related receptor- ligand binding domain in three functional states reveal the molecular basis of small molecule regulation
pgam5, a bcl-xl-interacting protein, is a novel substrate for the redox-regulated keap1-dependent ubiquitin ligase complex
post-meiotic shifts in hspa2/hsp70.2 chaperone activity during mouse spermatogenesis
detection and purification of tyrosine-sulfated proteins using a novel anti-sulfotyrosine monoclonal antibody
a new class of signal transducer in his-asp phosphorelay systems
cross-linking between helices within subunit a of escherichia coli atp synthase defines the transmembrane packing of a four-helix bundle
enhanced amyloidogenic metabolism of the amyloid -protein precursor in the x11l-deficient mouse brain
low molecular weight fucoidan increases vegf165-induced endothelial cell migration by enhancing vegf165 binding to vegfr-2 and nrp1
ckap4/p63 is a receptor for the frizzled-8 protein-related antiproliferative factor from interstitial cystitis patients
adenomatous polyposis coli control of c-terminal binding protein-1 stability regulates expression of intestinal retinol dehydrogenases
slc26a3 (dra)-deficient mice display chloride-losing diarrhea, enhanced colonic proliferation, and distinct up-regulation of ion transporters in the colon
the sl1-sl2 (stem-loop) domain is the primary determinant for stability of the gamma retroviral genomic rna dimer
structure of fitab from neisseria gonorrhoeae bound to dna reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs
structural snapshots of escherichia coli histidinol phosphate phosphatase along the reaction pathway
cd4 and ccr5 constitutively interact at the plasma membrane of living cells
oncostatin m inhibits adipogenesis through the ras/erk and stat5 signaling pathways
a small molecule agonist of an integrin, l2
physical and functional interaction of the p14arf tumor suppressor with ribosomes
fragmented hyaluronan induces transcriptional up-regulation of the multidrug resistance-1 gene in cd4+ t cells
amino-terminal dimerization, nrdp1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (usp8)
a three-dimensional model of human organic anion transporter
regulation of catalysis by the smallpox virus topoisomerase
secretory granule biogenesis in sympathoadrenal cells
identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor
structural insights into the design of nonpeptidic isothiazolidinone-containing inhibitors of protein-tyrosine phosphatase 1b
src tail phosphorylation is limited by structural changes in the regulatory tyrosine kinase csk
structural characterization of spo0e-like protein-aspartic acid phosphatases that regulate sporulation in bacilli
saccharomyces cerevisiae sit4 phosphatase is active irrespective of the nitrogen source provided, and gln3 phosphorylation levels become nitrogen source-responsive ..
proteolytic processing of opa1 links mitochondrial dysfunction to alterations in mitochondrial morphology
vav1 acidic region tyrosine 174 is required for the formation of t cell receptor-induced microclusters and is essential in t cell development and activation
translesion synthesis across o6-alkylguanine dna adducts by recombinant human dna polymerases
dentin sialophosphoprotein is processed by mmp-2 and mmp-20 in vitro and in vivo
trypanosoma seryl-trna synthetase is a metazoan-like enzyme with high affinity for trnasec
plasmacytic transcription factor blimp-1 is repressed by bach2 in b cells
decorin modulates fibrin assembly and structure
cpg-b oligodeoxynucleotide promotes cell survival via up-regulation of hsp70 to increase bcl-xl and to decrease apoptosis-inducing factor translocation
proline-rich motifs in the parathyroid hormone (pth)/pth-related protein receptor c terminus mediate scaffolding of c-src with -arrestin2 for erk1/2 activation
tort, a member of a new periplasmic binding protein family, triggers induction of the tor respiratory system upon trimethylamine n-oxide electron-acceptor binding i..
mammalian transcription in support of hybrid mrna and protein synthesis in testis and lung
a chinese hamster ovarian cell line imports cholesterol by high density lipoprotein degradation
biochemical and genetic analysis of methylenetetrahydrofolate reductase in leishmania metabolism and virulence
phosphatidylinositol 4-phosphate is required for translation initiation in saccharomyces cerevisiae
critical role of serine 465 in isoflurane-induced increase of cell-surface redistribution and activity of glutamate transporter type 3
nanostructures of apobec3g support a hierarchical assembly model of high molecular mass ribonucleoprotein particles from dimeric subunits
post-transcriptional destabilization of p21cip1 by protein kinase c in fibroblasts
molecular recognition in the assembly of collagens: terminal noncollagenous domains are key recognition modules in the formation of triple helical protomers
crystal structure of inositol phosphate multikinase 2 and implications for substrate specificity
nucleocytoplasmic shuttling of the retinoblastoma tumor suppressor protein via cdk phosphorylation-dependent nuclear export
amyloid--(1-42) increases ryanodine receptor-3 expression and function in neurons of tgcrnd8 mice
novel functions of small conductance ca2+-activated k+ channel in enhanced cell proliferation by atp in brain endothelial cells
inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (mst3) involves paxillin and protein-tyrosine phosphatase-pest
lipid phosphate phosphatase-1 regulates lysophosphatidate-induced fibroblast migration by controlling phospholipase d2-dependent phosphatidate generation
trafficking and assembly of the cold-sensitive trpm8 channel
the pdx1 homeodomain transcription factor negatively regulates the pancreatic ductal cell-specific keratin 19 promoter
small c-terminal domain phosphatases dephosphorylate the regulatory linker regions of smad2 and smad3 to enhance transforming growth factor- signaling
apoptotic cells, through transforming growth factor-, coordinately induce anti-inflammatory and suppress pro-inflammatory eicosanoid and no synthesis in murine macr..
ethanolamine phosphate linked to the first mannose residue of glycosylphosphatidylinositol (gpi) lipids is a major feature of the gpi structure that is recognized b..
a novel role for proline- and acid-rich basic region leucine zipper (par bzip) proteins in the transcriptional regulation of a bh3-only proapoptotic gene
deletion of core fucosylation on 31 integrin down-regulates its functions
dynamics of myosin heavy chain gene regulation in slow skeletal muscle
toll-like receptor 4 region glu24-lys47 is a site for md-2 binding
translation initiation of cyanobacterial rbcs mrnas requires the 38-kda ribosomal protein s1 but not the shine-dalgarno sequence
the roles of substrate thermal stability and p2 and p1‘ subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity
solution structure of human von willebrand factor studied using small angle neutron scattering
lrp5 mutations linked to high bone mass diseases cause reduced lrp5 binding and inhibition by sost
potassium as an intrinsic uncoupler of the plasma membrane h+-atpase
phosphorylation of maskin by aurora-a is regulated by rangtp and importin
reconstitution in vitro of v1 complex of thermus thermophilus v-atpase revealed that atp binding to the a subunit is crucial for v1 formation
hydrophobic interface between two regulators of k+ conductance domains critical for calcium-dependent activation of large conductance ca2+-activated k+ channels
flap endonuclease disengages dna2 helicase/nuclease from okazaki fragment flaps
single strand annealing and atp-independent strand exchange activities of yeast and human dna
regulation of anterograde transport of 2-adrenergic receptors by the n termini at multiple intracellular compartments
small organic compounds enhance antigen loading of class ii major histocompatibility complex proteins by targeting the polymorphic p1 pocket
rac1 gtpase regulates cell genomic stability and senescence
tec kinase itk forms membrane clusters specifically in the vicinity of recruiting receptors
the nh2-terminal propeptide of type i procollagen acts intracellularly to modulate cell function
calcineurin increases cardiac transient outward k+ currents via transcriptional up-regulation of kv4.2 channel subunits
involvement of gsk-3 and dyrk1b in differentiation-inducing factor-3-induced phosphorylation of cyclin d1 in hela cells
charged extracellular residues, conserved throughout a g-protein-coupled receptor family, are required for ligand binding, receptor activation, and cell-surface exp..
structure of the escherichia coli dna polymerase iii -hot proofreading complex
the tandem brct domain of 53bp1 is not required for its repair function
insights to substrate binding and processing by west nile virus ns3 protease through combined modeling, protease mutagenesis, and kinetic studies
similar transition states mediate the q-cycle and superoxide production by the cytochrome bc1 complex
myeloid leukemia factor 1 associates with a novel heterogeneous nuclear ribonucleoprotein u-like molecule
the n-terminal lobes of both regulatory light chains interact with the tail domain in the 10 s-inhibited conformation of smooth muscle myosin
cytokine response modifier a inhibition of initiator caspases results in covalent complex formation and dissociation of the caspase tetramer
sulfur mobilization in cyanobacteria
molecular level probing of preferential hydration and its modulation by osmolytes through the use of pyranine complexed to hemoglobin
intracellular coiled-coil domain engaged in subunit interaction and assembly of melastatin-related transient receptor potential channel 2
requirement of the trpc1 cation channel in the generation of transient ca2+ oscillations by the calcium-sensing receptor
the ubiquitin ligase itch is auto-ubiquitylated in vivo and in vitro but is protected from degradation by interacting with the deubiquitylating enzyme fam/usp9x
telomestatin-induced telomere uncapping is modulated by pot1 through g-overhang extension in ht1080 human tumor cells
allosteric regulation of hsp70 chaperones involves a conserved interdomain linker
monocyte differentiation, activation, and mycobacterial killing are linked to transsulfuration-dependent redox metabolism
a mitogen-activated protein kinase kinase kinase mediates reactive oxygen species homeostasis in arabidopsis
single molecule force spectroscopy of salt-dependent bacteriophage t7 gene 2.5 protein binding to single-stranded dna
induction of the heat shock pathway during hypoxia requires regulation of heat shock factor by hypoxia-inducible factor-1
hemoglobin-degrading plasmepsin ii is active as a monomer
hierarchical network between the components of the multi-trna synthetase complex
chondroitin 4-o-sulfotransferase-1 regulates e disaccharide expression of chondroitin sulfate required for herpes simplex virus infectivity
cyclic gmp-dependent protein kinase i attenuates necrosis and apoptosis following ischemia/reoxygenation in adult cardiomyocyte
investigation of the dimer interface and substrate specificity of prolyl dipeptidase dpp8
actin filaments are required for fibripositor-mediated collagen fibril alignment in tendon
identification of a novel phosphorylation site in protein phosphatase inhibitor-1 as a negative regulator of cardiac function
rala-exocyst-dependent recycling endosome trafficking is required for the completion of cytokinesis
nf-b2 is required for the control of autoimmunity by regulating the development of medullary thymic epithelial cells
crystal structure of protoporphyrinogen oxidase from myxococcus xanthus and its complex with the inhibitor acifluorfen
synergistic effects of the sapk/jnk and the proteasome pathway on glial fibrillary acidic protein (gfap) accumulation in alexander disease
the membrane-proximal region of the thrombopoietin receptor confers its high surface expression by jak2-dependent and -independent mechanisms
crystal structure of the human aaa+ protein ruvbl1
s100a16, a novel calcium-binding protein of the ef-hand superfamily
stage-specific effects of camp signaling during distal lung epithelial development
protein-protein interactions mediate mitochondrial cholesterol transport and steroid biosynthesis
on the processing of proghrelin to ghrelin
spontaneous mobility of gabaa receptor m2 extracellular half relative to noncompetitive antagonist action
atypical polyproline recognition by the cms n-terminal src homology 3 domain
dectin-2 is a pattern recognition receptor for fungi that couples with the fc receptor chain to induce innate immune responses
mapping erk2-mkp3 binding interfaces by hydrogen/deuterium exchange mass spectrometry
snare status regulates tether recruitment and function in homotypic copii vesicle fusion
orexin-1 receptor-cannabinoid cb1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and..
amino acid transporter ata2 is stored at the trans-golgi network and released by insulin stimulus in adipocytes
roles of asp75, asp78, and glu83 of gtp-dependent phosphoenolpyruvate carboxykinase from mycobacterium smegmatis
phosphorylation of mcm4 by cdc7 kinase facilitates its interaction with cdc45 on the chromatin
indirect recognition in sequence-specific dna binding by escherichia coli integration host factor
the human sef-a isoform utilizes different mechanisms to regulate receptor tyrosine kinase signaling pathways and subsequent cell fate
the enzymatic function of tafazzin
a control switch for prothrombinase
ceacam1 (cd66a) promotes human monocyte survival via a phosphatidylinositol 3-kinase- and akt-dependent pathway
orphan nuclear receptor small heterodimer partner inhibits transforming growth factor- signaling by repressing smad3 transactivation
the repression of human differentiation-related gene ndrg2 expression by myc via miz-1-dependent interaction with the ndrg2 core promoter
alix facilitates the interaction between c-cbl and platelet-derived growth factor -receptor and thereby modulates receptor down-regulation
structural and functional properties of two human fxyd3 (mat-8) isoforms
the drosophila heterogeneous nuclear ribonucleoprotein m protein, hrp59, regulates alternative splicing and controls the production of its own mrna
expression of claudin7 is tightly associated with epithelial structures in synovial sarcomas and regulated by an ets family transcription factor, elf3
mouse disabled1 (dab1) is a nucleocytoplasmic shuttling protein
brg1 chromatin remodeling activity is required for efficient chromatin binding by repressor element 1-silencing transcription factor (rest) and facilitates rest-med..
specific adduction of plant lipid transfer protein by an allene oxide generated by 9-lipoxygenase and allene oxide synthase
determinants of ring-e2 fidelity for hrd1p, a membrane-anchored ubiquitin ligase
identification and stage-specific association with the translational apparatus of tbzfp3, a ccch protein that promotes trypanosome life-cycle development
identification of nuclear import mechanisms for the neuronal cdk5 activator
nickel compounds render anti-apoptotic effect to human bronchial epithelial beas-2b cells by induction of cyclooxygenase-2 through an ikk/p65-dependent and ikk- and..
control of death-associated protein kinase (dapk) activity by phosphorylation and proteasomal degradation
mitochondrial aberrations in mucolipidosis type iv
down syndrome candidate region 1 increases the stability of the ib protein
characterization of the amino acids from neisseria meningitidis msra involved in the chemical catalysis of the methionine sulfoxide reduction step
dephosphorylation by default, a potential mechanism for regulation of insulin receptor substrate-1/2, akt, and erk1/2
cyclophilin a protects peg3 from hypermethylation and inactive histone modification
ligand specificity of the anaphylatoxin c5l2 receptor and its regulation on myeloid and epithelial cell lines
inhibition of bone morphogenetic protein 1 by native and altered forms of 2-macroglobulin
disruption of an sp2/klf6 repression complex by shp is required for farnesoid x receptor-induced endothelial cell migration
functional characterization of heterogeneous nuclear ribonuclear protein c1/c2 in vitamin d resistance
glucose and insulin synergistically activate phosphatidylinositol 3-kinase to trigger oscillations of phosphatidylinositol 3,4,5-trisphosphate in -cells
dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of redd1
structure of acyl carrier protein bound to fabi, the fasii enoyl reductase from escherichia coli
lipid-induced extension of apolipoprotein e helix 4 correlates with low density lipoprotein receptor binding ability
molecular determinants for g protein modulation of ionotropic glycine receptors
sterol-regulated degradation of insig-1 mediated by the membrane-bound ubiquitin ligase gp78
a multienzyme network functions in intestinal protein digestion by a platyhelminth parasite
lipid rafts facilitate the interaction of pecam-1 with the glycoprotein vi-fcr -chain complex in human platelets
a solanesyl-diphosphate synthase localizes in glycosomes of trypanosoma cruzi
close packing of helices 3 and 12 of 16 s rrna is required for the normal ribosome function
foxo1 is required for the regulation of preproglucagon gene expression by insulin in pancreatic tc1-9 cells
myomaxin is a novel transcriptional target of mef2a that encodes a xin-related -actinin-interacting protein
calcium stiffens archaeal rad51 recombinase from methanococcus voltae for homologous recombination
a toll receptor and a cytokine, toll5a and spz1c, are involved in toll antifungal immune signaling in the mosquito aedes aegypti
structural and membrane binding analysis of the phox homology domain of phosphoinositide 3-kinase-c2
lexa represses ctx transcription by blocking access of the c-terminal domain of rna polymerase to promoter dna
reduction of soluble a and tau, but not soluble a alone, ameliorates cognitive decline in transgenic mice with plaques and tangles
the role of the gx9gx3g motif in the gating of high voltage-activated ca2+ channels
vesicular glutamate transporter contains two independent transport machineries
an unusual twin-his arrangement in the pore of ammonia channels is essential for substrate conductance
cannabinoid receptor agonist-induced apoptosis of human prostate cancer cells lncap proceeds through sustained activation of erk1/2 leading to g1 cell cycle arrest
regulation of sox9 mrna in human articular chondrocytes involving p38 mapk activation and mrna stabilization
crystal structure of the mycobacterium tuberculosis p450 cyp121-fluconazole complex reveals new azole drug-p450 binding mode
dimeric eg5 maintains processivity through alternating-site catalysis with rate-limiting atp hydrolysis
paxillin regulates steroid-triggered meiotic resumption in oocytes by enhancing an all-or-none positive feedback kinase loop
inhibition of escherichia coli heat-labile enterotoxin b subunit pentamer (etxb5) assembly in vitro using monoclonal antibodies
a molecular mechanism for the heparan sulfate dependence of slit-robo signaling
zhx proteins regulate podocyte gene expression during the development of nephrotic syndrome
a mouse model for monitoring calpain activity under physiological and pathological conditions
human mitochondrial branched chain aminotransferase isozyme
importin-mediated nuclear translocation of galectin-3
recognition and blocking of hiv-1 gp41 pre-transmembrane sequence by monoclonal 4e10 antibody in a raft-like membrane environment
rgd-dependent binding of procathepsin x to integrin v3 mediates cell-adhesive properties
isoform-specific heparan sulfate binding within the amino-terminal noncollagenous domain of collagen 1(xi)
rpa2 is a direct downstream target for atr to regulate the s-phase checkpoint
ipaa targets 1 integrins and rho to promote actin cytoskeleton rearrangements necessary for shigella entry
the g13-rho signaling axis is required for sdf-1-induced migration through cxcr4
p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition
p2x5 subunit assembly requires scaffolding by the second transmembrane domain and a conserved aspartate
the role of the 1 subunit of the na,k-atpase and its glycosylation in cell-cell adhesion
identification of a mutation in slc30a2 (znt-2) in women with low milk zinc concentration that results in transient neonatal zinc deficiency
the cysteine-rich domain of snake venom metalloproteinases is a ligand for von willebrand factor a domains
prelamin a farnesylation and progeroid syndromes
the vaccinia virus protein f1l interacts with bim and inhibits activation of the pro-apoptotic protein bax
microtubule network is required for insulin signaling through activation of akt/protein kinase b
influence of agonists and antagonists on the segmental motion of residues near the agonist binding pocket of the acetylcholine-binding protein
modeling the reactions of superoxide and myeloperoxidase in the neutrophil phagosome
human erythrocyte membranes contain a cytochrome b561 that may be involved in extracellular ascorbate recycling
catalytic site modifications of tap1 and tap2 and their functional consequences
farnesoid x receptor agonist reduces serum asymmetric dimethylarginine levels through hepatic dimethylarginine dimethylaminohydrolase-1 gene regulation
overexpression of the notch1 intracellular domain inhibits cell proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells
the role of mapks in b cell receptor-induced down-regulation of egr-1 in immature b lymphoma cells
g protein-coupled receptor (gpcr) kinase 2 regulates agonist-independent gq/11 signaling from the mouse cytomegalovirus gpcr m33
signaling alkaline ph stress in the yeast saccharomyces cerevisiae through the wsc1 cell surface sensor and the slt2 mapk pathway
p53 suppresses the nrf2-dependent transcription of antioxidant response genes
impaired proteolysis of collagen i inhibits proliferation of hepatic stellate cells
reactive oxygen and targeted antioxidant administration in endothelial cell mitochondria
a genome scale location analysis of human staf/znf143-binding sites suggests a widespread role for human staf/znf143 in mammalian promoters
the n-terminal arm of small heat shock proteins is important for both chaperone activity and substrate specificity
expression of a novel marine viral single-chain serine palmitoyltransferase and construction of yeast and mammalian single-chain chimera
need for tripeptidyl-peptidase ii in major histocompatibility complex class i viral antigen processing when proteasomes are detrimental
sirt1 regulates adiponectin gene expression through foxo1-c/enhancer-binding protein transcriptional complex
the dna binding activities of smad2 and smad3 are regulated by coactivator-mediated acetylation
cysteine-scanning analysis of the nucleobase-ascorbate transporter signature motif in ygfo permease of escherichia coli
identification of a bifunctional lipopolysaccharide sialyltransferase in haemophilus influenzae
kcne1 subunits require co-assembly with k+ channels for efficient trafficking and cell surface expression
mechanical unfolding pathways of the enhanced yellow fluorescent protein revealed by single molecule force spectroscopy
the dna binding preference of rad52 and rad59 proteins
edd mediates dna damage-induced activation of chk2
deletion of the gene encoding the ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein (ugrp)/glucose-6-phosphatase catalytic subunit- res..
sequential modifications in class ii transactivator isoform 1 induced by lipopolysaccharide stimulate major histocompatibility complex class ii transcription in mac..
cathepsin d, a lysosomal protease, regulates abca1-mediated lipid efflux
pat1a modulates intracellular transport and processing of amyloid precursor protein (app), aplp1, and aplp2
gtpase activity of mycobacterial ftsz is impaired due to its transphosphorylation by the eukaryotic-type ser/thr kinase, pkna
rap55, a cytoplasmic mrnp component, represses translation in xenopus oocytes
ligand-induced structural changes of the cd44 hyaluronan-binding domain revealed by nmr
mechanistic and structural studies of apoform, binary, and ternary complexes of the arabidopsis alkenal double bond reductase at5g16970
negative constraints underlie the erbb specificity of epidermal growth factor-like ligands
analysis of growth of lactobacillus plantarum wcfs1 on a complex medium using a genome-scale metabolic model
rapid kinetics of na+ binding to thrombin
arg-158 is critical in both binding the substrate and stabilizing the transition-state oxyanion for the enzymatic reaction of malonamidase e2
stress-induced inactivation of the c-myb transcription factor through conjugation of sumo-2/3 proteins
right-handed dna supercoiling by an octameric form of histone-like protein hu
identification of human scfvs targeting atherosclerotic lesions
structural reorganization and the cooperative binding of single-stranded telomere dna in sterkiella nova
adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism
kinetic analysis of interaction of eukaryotic release factor 3 with guanine nucleotides
a protein kinase family in arabidopsis phosphorylates chloroplast precursor proteins
specificity of dna binding and dimerization by cspe from escherichia coli
biochemical basis of glucokinase activation and the regulation by glucokinase regulatory protein in naturally occurring mutations
smooth muscle -actin deficiency in myofibroblasts leads to enhanced renal tissue fibrosis
epidermal growth factor receptor (egfr) antibody down-regulates mutant receptors and inhibits tumors expressing egfr mutations
ca2+-independent phospholipase a2-dependent gating of trpm8 by lysophospholipids
bile acids induce ca2+ release from both the endoplasmic reticulum and acidic intracellular calcium stores through activation of inositol trisphosphate receptors an..
actinfilin is a cul3 substrate adaptor, linking glur6 kainate receptor subunits to the ubiquitin-proteasome pathway
structure of fbp11 ww1-pl ligand complex reveals the mechanism of proline-rich ligand recognition by group ii/iii ww domains
the proto-oncogene set interacts with muscarinic receptors and attenuates receptor signaling
sustained activity of calcium release-activated calcium channels requires translocation of mitochondria to the plasma membrane
kinetic and mass spectrometric analysis of p300 histone acetyltransferase domain autoacetylation
combined leptin actions on adipose tissue and hypothalamus are required to deplete adipocyte fat in lean rats
membrane topology and identification of key functional amino acid residues of murine acyl-coa:diacylglycerol acyltransferase-2
atomic level insight into the oxidative half-reaction of aromatic amine dehydrogenase
interaction of foxo1 and tsc2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 s6k pathway
isolation of intracellular proteinase inhibitors derived from designed ankyrin repeat proteins by genetic screening
disruption of rhogdi and rhoa regulation by a rac1 specificity switch mutant
an n-linked glycan modulates the interaction between the cd1d heavy chain and 2-microglobulin
identification of cysteines involved in s-nitrosylation, s-glutathionylation, and oxidation to disulfides in ryanodine receptor type 1
depletion of camp-response element-binding protein/atf1 inhibits adipogenic conversion of 3t3-l1 cells ectopically expressing ccaat/enhancer-binding protein (c/ebp)..
deficiency of the zinc finger protein zpr1 causes defects in transcription and cell cycle progression
bcl-2 localized at the nuclear compartment induces apoptosis after transient overexpression
menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells
molecular architecture of the glucose 1-phosphate site in adp-glucose pyrophosphorylases
deficiency in phylloquinone (vitamin k1) methylation affects prenyl quinone distribution, photosystem i abundance, and anthocyanin accumulation in the arabidopsis a..
integrin regulation by vascular endothelial growth factor in human brain microvascular endothelial cells
yb-1 is important for an early stage embryonic development
down-regulation of manganese-superoxide dismutase through phosphorylation of foxo3a by akt in explanted vascular smooth muscle cells from old rats
cryoelectron microscopy and epr analysis of engineered symmetric and polydisperse hsp16.5 assemblies reveals determinants of polydispersity and substrate binding
dephosphorylation of the linker regions of smad1 and smad2/3 by small c-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transf..
coincidence of actin filaments and talin is required to activate vinculin
the crh family coding for cell wall glycosylphosphatidylinositol proteins with a predicted transglycosidase domain affects cell wall organization and virulence of c..
telomerase-independent regulation of atr by human telomerase rna
bmp2 commitment to the osteogenic lineage involves activation of runx2 by dlx3 and a homeodomain transcriptional network
loss of nidogen-1 and -2 results in syndactyly and changes in limb development
crystal structures of salmonella typhimurium biodegradative threonine deaminase and its complex with cmp provide structural insights into ligand-induced oligomeriza..
seeing the process of histidine phosphorylation in human bisphosphoglycerate mutase
human daxx-mediated repression of human cytomegalovirus gene expression correlates with a repressive chromatin structure around the major immediate early promoter
the insulin-like growth factor-binding protein 1 gene is a primary target of peroxisome proliferator-activated receptors
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