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topography of the prostaglandin endoperoxide h2 synthase-2 in membranes
structure of the subunit binding domain and dynamics of the di-domain region from the core of human branched chain -ketoacid dehydrogenase complex
insights into the mechanism of action of hyaluronate lyase
cprk crystal structures reveal mechanism for transcriptional control of halorespiration
granzyme b proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis
calcium-dependent dimerization of human soluble calcium activated nucleotidase
molecular analysis of the interaction between the hematopoietic master transcription factors gata-1 and pu.1
solution structure and characterization of the lgr8 receptor binding surface of insulin-like peptide 3
rna structural requirements for the association of the spliceosomal hprp31 protein with the u4 and u4atac small nuclear ribonucleoproteins
glutaredoxin modulates platelet-derived growth factor-dependent cell signaling by regulating the redox status of low molecular weight protein-tyrosine phosphatase
glucagon-like peptide 1 activates protein kinase c through ca2+-dependent activation of phospholipase c in insulin-secreting cells
identification and characterization of a novel drosophila 3‘-phosphoadenosine 5‘-phosphosulfate transporter
hereditary hemochromatosis protein, hfe, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing
crystal structures of murine carnitine acetyltransferase in ternary complexes with its substrates
overstimulation of prpc signaling pathways by prion peptide 106-126 causes oxidative injury of bioaminergic neuronal cells
aurothiomalate inhibits transformed growth by targeting the pb1 domain of protein kinase c
ammonia-specific regulation of gln3 localization in saccharomyces cerevisiae by protein kinase npr1
placental thrombosis and spontaneous fetal death in mice deficient in ethanolamine kinase 2
structural basis of robo proline-rich motif recognition by the srgap1 src homology 3 domain in the slit-robo signaling pathway
the caenorhabditis elegans cpi-2a cystatin-like inhibitor has an essential regulatory role during oogenesis and fertilization
structure of the extracellular domain of tie receptor tyrosine kinases and localization of the angiopoietin-binding epitope
the dynamics of the mgatp-driven closure of malk, the energy-transducing subunit of the maltose abc transporter
surface structure and its dynamic rearrangements of the kcsa potassium channel upon gating and tetrabutylammonium blocking
stop-like protein 21 is a novel member of the stop family, revealing a golgi localization of stop proteins
structural and functional analyses of kaposi sarcoma-associated herpesvirus orf57 nuclear localization signals in living cells
transduction of the nitrogen signal activating gln3-mediated transcription is independent of npr1 kinase and rsp5-bul1/2 ubiquitin ligase in saccharomyces cerevisiae
a tyrosine-sulfated peptide derived from the heavy-chain cdr3 region of an hiv-1-neutralizing antibody binds gp120 and inhibits hiv-1 infection
role of conserved surface amino acids in binding of smpb protein to ssra rna
human receptors patched and smoothened partially transduce hedgehog signal when expressed in drosophila cells
binding of p53 to the central domain of mdm2 is regulated by phosphorylation
a synergism between temporins toward gram-negative bacteria overcomes resistance imposed by the lipopolysaccharide protective layer
jagged1-selective notch signaling induces smooth muscle differentiation via a rbp-j-dependent pathway
atr, pml, and chk2 play a role in arsenic trioxide-induced apoptosis
evaluation of approaches to generation of tissue-specific knock-in mice
insulin regulation of cholesterol 7-hydroxylase expression in human hepatocytes
the na+:cl- cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletion
excision of the sinorhizobium meliloti group ii intron rmint1 as circles in vivo
identification and characterization of the cd226 gene promoter
chrebpmlx is the principal mediator of glucose-induced gene expression in the liver
the length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases
inhibition of hiv-1 replication by amphotericin b methyl ester
cytoplasmic cstf-77 protein belongs to a masking complex with cytoplasmic polyadenylation element-binding protein in xenopus oocytes
knock-downs of iron-sulfur cluster assembly proteins iscs and iscu down-regulate the active mitochondrion of procyclic trypanosoma brucei
regulation of mouse inducible costimulator (icos) expression by fyn-nfatc2 and erk signaling in t cells
constitutive gdp/gtp exchange and secretion-dependent gtp hydrolysis activity for rab27 in platelets
the effects of glutaredoxin and copper activation pathways on the disulfide and stability of cu,zn superoxide dismutase
human acf1 alters the remodeling strategy of snf2h
transient kinetic investigation of gtp hydrolysis catalyzed by interferon--induced hgbp1 (human guanylate binding protein 1)
nutrient-dependent multimerization of the mammalian target of rapamycin through the n-terminal heat repeat region
the scaffolding adapter gab2, via shp-2, regulates kit-evoked mast cell proliferation by activating the rac/jnk pathway
estrogen receptor isoform-specific regulation of the retinoblastoma-binding protein 1 (rbbp1) gene
matrix metalloproteinase-7 activation of mouse paneth cell pro--defensins
cfbp is a novel tyrosine-phosphorylated protein that might function as a regulator of cin85/cd2ap
membrane potential-regulated transcription of the resting k+ conductance task-3 via the calcineurin pathway
subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2
auf1 is expressed in the developing brain, binds to at-rich double-stranded dna, and regulates enkephalin gene expression
a novel -ketoglutaric semialdehyde dehydrogenase
inhibition of cyclin-dependent kinase 5 activity protects pancreatic beta cells from glucotoxicity
acetaminophen-induced liver injury is attenuated in male glutamate-cysteine ligase transgenic mice
multifunctional specificity of the protein c/activated protein c gla domain
the polybasic region that follows the plant homeodomain zinc finger 1 of pf1 is necessary and sufficient for specific phosphoinositide binding
mapping conformational changes of a type iib na+/pi cotransporter by voltage clamp fluorometry
n-(3-oxo-acyl)homoserine lactones signal cell activation through a mechanism distinct from the canonical pathogen-associated molecular pattern recognition receptor ..
ruvabc is required to resolve holliday junctions that accumulate following replication on damaged templates in escherichia coli
osmotic stress activates the tak1-jnk pathway while blocking tak1-mediated nf-b activation
yaf2 inhibits caspase 8-mediated apoptosis and regulates cell survival during zebrafish embryogenesis
bone marrow-derived cells require a functional glucose 6-phosphate transporter for normal myeloid functions
structural requirements for heparin/heparan sulfate binding to type v collagen
denmotoxin, a three-finger toxin from the colubrid snake boiga dendrophila (mangrove catsnake) with bird-specific activity
the inhibitor of apoptosis protein fusion c-iap2·malt1 stimulates nf-b activation independently of traf1 and traf2
global translational responses to oxidative stress impact upon multiple levels of protein synthesis
argos mutants define an affinity threshold for spitz inhibition in vivo
voltage-gated sodium channels confer excitability to human odontoblasts
structural characterization of a k-antigen capsular polysaccharide essential for normal symbiotic infection in rhizobium sp. ngr23
pdzk1 is required for maintaining hepatic scavenger receptor, class b, type i (sr-bi) steady state levels but not its surface localization or function
an act-like domain participates in the dimerization of several plant basic-helix-loop-helix transcription factors
the structural context of disease-causing mutations in gap junctions
gadd45a interacts with aurora-a and inhibits its kinase activity
acidic residues at the active sites of cd38 and adp-ribosyl cyclase determine nicotinic acid adenine dinucleotide phosphate (naadp) synthesis and hydrolysis activit..
insights into allosteric control of vinculin function from its large scale conformational dynamics
a subfamily of dr adhesins of escherichia coli bind independently to decay-accelerating factor and the n-domain of carcinoembryonic antigen
proteomic analysis of salmonella enterica serovar typhimurium isolated from raw 264.7 macrophages
degradation of the amyloid -protein by the novel mitochondrial peptidasome, prep
the anti-hiv-1 editing enzyme apobec3g binds hiv-1 rna and messenger rnas that shuttle between polysomes and stress granules
induction of krox-24 by endogenous cannabinoid type 1 receptors in neuro2a cells is mediated by the mek-erk mapk pathway and is suppressed by the phosphatidylinosit..
polycomb complexes and the propagation of the methylation mark at the drosophila ubx gene
transgenic mice expressing dominant-negative activin receptor ib in forebrain neurons reveal novel functions of activin at glutamatergic synapses
regulation of neuronal morphology by toca-1, an f-bar/efc protein that induces plasma membrane invagination
differential release and distribution of nod1 and nod2 immunostimulatory molecules among bacterial species and environments
nucleosome depletion activates poised rna polymerase iii at unconventional transcription sites in saccharomyces cerevisiae
solution structure and intermolecular interactions of the third metal-binding domain of atp7a, the menkes disease protein
signal peptide peptidase cleavage of gb virus b core protein is required for productive infection in vivo
aspirin induces apoptosis through the inhibition of proteasome function
identification of the cadaverine recognition site on the cadaverine-lysine antiporter cadb
a functional interaction between sprouty proteins and caveolin-1
laminin 5 regulates polycystic kidney cell proliferation and cyst formation
dual roles of tight junction-associated protein, zonula occludens-1, in sphingosine 1-phosphate-mediated endothelial chemotaxis and barrier integrity
a role for 14-3-3 in insulin-stimulated glut4 translocation through its interaction with the rabgap as160
heme displacement mechanism of cooa activation
understanding the biological rationale for the diversity of cellulose-directed carbohydrate-binding modules in prokaryotic enzymes
crystal structure and binding properties of the cd2 and cd244 (2b4)-binding protein, cd48
2-adaptin, a novel ubiquitin-interacting adaptor, and nedd4 ubiquitin ligase control hepatitis b virus maturation
structure of a membrane-binding domain from a non-enveloped animal virus
atomic structure of plant glutamine synthetase
neuroserpin binds a and is a neuroprotective component of amyloid plaques in alzheimer disease
substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding
evidence that the satin hair mutant gene foxq1 is among multiple and functionally diverse regulatory targets for hoxc13 during hair follicle differentiation
new insights from the structure-function analysis of the catalytic region of human platelet phosphodiesterase 3a
deletion of the transmembrane transporter abcg1 results in progressive pulmonary lipidosis
neurotrophic factors stabilize microtubules and protect against rotenone toxicity on dopaminergic neurons
determinants of rbp1p localization in specific cytoplasmic mrna-processing foci, p-bodies
modulation of acid-sensing ion channel currents, acid-induced increase of intracellular ca2+, and acidosis-mediated neuronal injury by intracellular ph
caspase-3-dependent activation of calcium-independent phospholipase a2 enhances cell migration in non-apoptotic ovarian cancer cells
bmp4 activation and secretion are negatively regulated by an intracellular gremlin-bmp4 interaction
the galactose switch in kluyveromyces lactis depends on nuclear competition between gal4 and gal1 for gal80 binding
destruction of pancreatic -cells by transgenic induction of prostaglandin e2 in the islets
membrane mucin muc4 induces density-dependent changes in erk activation in mammary epithelial and tumor cells
native trpc7 channel activation by an inositol trisphosphate receptor-dependent mechanism
fli1 and ets1 have distinct roles in connective tissue growth factor/ccn2 gene regulation and induction of the profibrotic gene program
an rna-binding respiratory component mediates import of type ii trnas into leishmania mitochondria
increased sensitivity of oxidized large isoform of ribulose-1,5-bisphosphate carboxylase/oxygenase (rubisco) activase to adp inhibition is due to an interaction bet..
differential requirement for rhoa gtpase depending on the cellular localization of protein kinase d
regulation of glutamine and glutamate metabolism by glnr and glna in streptococcus pneumoniae
broad substrate stereospecificity of the mycobacterium tuberculosis 7-keto-8-aminopelargonic acid synthase
cysteine biosynthesis in trichomonas vaginalis involves cysteine synthase utilizing o-phosphoserine
insig-dependent ubiquitination and degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase stimulated by - and -tocotrienols
the role of src kinase in insulin-like growth factor-dependent mitogenic signaling in vascular smooth muscle cells
mutations in the fad binding domain cause stress-induced misoxidation of the endoplasmic reticulum oxidoreductase ero1
nucleotide misincorporation, 3‘-mismatch extension, and responses to abasic sites and dna adducts by the polymerase component of bacterial dna ligase d
the death domain kinase rip has an important role in dna damage-induced, p53-independent cell death
structure of the n-terminal ankyrin repeat domain of the trpv2 ion channel
endoglin structure and function
rapid atp-dependent deadenylation of nanos mrna in a cell-free system from drosophila embryos
identification of cell cycle regulatory genes as principal targets of p53-mediated transcriptional repression
pime is a polyprenol-phosphate-mannose-dependent mannosyltransferase that transfers the fifth mannose of phosphatidylinositol mannoside in mycobacteria
assembly of the major light-harvesting chlorophyll-a/b complex
the forkhead box m1 protein regulates the transcription of the estrogen receptor in breast cancer cells
cyanovirin-n inhibits hepatitis c virus entry by binding to envelope protein glycans
ccl5-ccr5-mediated apoptosis in t cells
domain structure and dna binding regions of protein from bacteriophage
p38 map kinase mediates apoptosis through phosphorylation of bimel at ser-65
phosphorylation-dependent regulation of unique nuclear and nucleolar localization signals of lim kinase 2 in endothelial cells
crystal structure of staphylococcal enterotoxin i (sei) in complex with a human major histocompatibility complex class ii molecule
differences in crystal and solution structures of the cytolethal distending toxin b subunit
erbb-4 s80 intracellular domain abrogates eto2-dependent transcriptional repression
stepwise two-photon excited fluorescence from higher excited states of chlorophylls in photosynthetic antenna complexes
microtubule binding and clustering of human tau-4r and tau-p301l proteins isolated from yeast deficient in orthologues of glycogen synthase kinase-3 or cdk5
rna silencing of mitochondrial m-nfs1 reduces fe-s enzyme activity both in mitochondria and cytosol of mammalian cells
topoisomerase action on short dna duplexes reveals requirements for gate and transfer dna segments
tonebp/orebp is a regulator of nucleus pulposus cell function and survival in the intervertebral disc
the transcriptional ets2 repressor factor associates with active and inactive erks through distinct fxf motifs
transforming growth factor suppresses human telomerase reverse transcriptase (htert) by smad3 interactions with c-myc and the htert gene
characterization of the 2 glutamate receptor-binding protein delphilin
importance in catalysis of the 6-phosphate-binding site of 6-phosphogluconate in sheep liver 6-phosphogluconate dehydrogenase
calmodulin kinase ii is involved in voltage-dependent facilitation of the l-type cav1.2 calcium channel
similarities and differences between cyclobutane pyrimidine dimer photolyase and (6-4) photolyase as revealed by resonance raman spectroscopy
the heme transfer from the soluble hasa hemophore to its membrane-bound receptor hasr is driven by protein-protein interaction from a high to a lower affinity bindi..
atireg2 encodes a tonoplast transport protein involved in iron-dependent nickel detoxification in arabidopsis thaliana roots
the histone variant macro-h2a preferentially forms “hybrid nucleosomes“
systemically administered bone morphogenetic protein-6 restores bone in aged ovariectomized rats by increasing bone formation and suppressing bone resorption
elevated testosterone induces apoptosis in neuronal cells
the pub domain functions as a p97 binding module in human peptide n-glycanase
untranslated regions of fbrbcs1 mrna mediate bundle sheath cell-specific gene expression in leaves of a c4 plant
the c terminus of the immunophilin pasticcino1 is required for plant development and for interaction with a nac-like transcription factor
stepped changes of monovalent ligand-binding force during ligand-induced clustering of integrin iib3
the roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation
rheb inhibits c-raf activity and b-raf/c-raf heterodimerization
heterodimerization of ccr2 chemokines and regulation by glycosaminoglycan binding
structural and functional characterization of falcipain-2, a hemoglobinase from the malarial parasite plasmodium falciparum
arrestin serves as a molecular switch, linking endogenous 2-adrenergic receptor to src-dependent, but not src-independent, erk activation
in vivo targeting of the yeast pop2 deadenylase subunit to reporter transcripts induces their rapid degradation and generates new decay intermediates
interplay between chromatin and trans-acting factors regulating the hoxd4 promoter during neural differentiation
matrix metalloproteinase-2 expression by vascular smooth muscle cells is mediated by both stimulatory and inhibitory signals in response to growth factors
cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1 signal pathways increases resistance to apoptosis by up-regulating survivin gene ..
reconstitution and mechanism of the stimulation of de novo methylation by human dnmt3l
the inner interhelix loop 4-5 of the melibiose permease from escherichia coli takes part in conformational changes after sugar binding
hybrid receptors formed by insulin receptor (ir) and insulin-like growth factor i receptor (igf-ir) have low insulin and high igf-1 affinity irrespective of the ir ..
isoform-specific effects of the 2 subunit on voltage-gated sodium channel gating
the interaction of piasy with trim32, an e3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2h, promotes piasy degradation and regulates uvb-induced..
the c-terminal residues of bacteriophage t7 gene 4 helicase-primase coordinate helicase and dna polymerase activities
autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid
essential residues in the c terminus of the bacteriophage t7 gene 2.5 single-stranded dna-binding protein
kinetic dependence to hiv-1 entry inhibition
hypertonic saline therapy in cystic fibrosis
human mitochondrial dna nucleoids are linked to protein folding machinery and metabolic enzymes at the mitochondrial inner membrane
solution structure and antiestrogenic activity of the unique c-terminal, nr-box motif-containing region of mta1s
evolution and function of leukocyte rnase a ribonucleases of the avian species, gallus gallus
mechanistic coupling of bacteriophage t4 dna packaging to components of the replication-dependent late transcription machinery
cyclin d3 expression in melanoma cells is regulated by adhesion-dependent phosphatidylinositol 3-kinase signaling and contributes to g1-s progression
toxoplasma gondii purine nucleoside phosphorylase biochemical characterization, inhibitor profiles, and comparison with the plasmodium falciparum ortholog
identification of an n-terminal transactivation domain of runx1 that separates molecular function from global differentiation function
identification of the sialic acid structures recognized by minute virus of mice and the role of binding affinity in virulence adaptation
specificity profiling of seven human tissue kallikreins reveals individual subsite preferences
system-wide genomic and biochemical comparisons of sialic acid biology among primates and rodents
hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development
differential susceptibility of hiv-1 reverse transcriptase to inhibition by rna aptamers in enzymatic reactions monitoring specific steps during genome replication
size matters for the tripeptidylpeptidase ii complex from drosophila
engineering and characterization of a stabilized 1/2 module of the class i major histocompatibility complex product ld
collagen xvi harbors an integrin 11 recognition site in its c-terminal domains
crucial mitochondrial impairment upon cdc48 mutation in apoptotic yeast
lamins a and c but not lamin b1 regulate nuclear mechanics
decapentaplegic-responsive silencers contain overlapping mad-binding sites
essential role of g protein-gated inwardly rectifying potassium channels in gonadotropin-induced regulation of gnrh neuronal firing and pulsatile neurosecretion
phosphorylation and ubiquitination of the transcription factor sterol regulatory element-binding protein-1 in response to dna binding
ribonucleotide reductase modularity
biochemical basis of genotoxicity of heterocyclic arylamine food mutagens
bone morphogenetic protein-4, a novel modulator of melanogenesis
caliciviruses differ in their functional requirements for eif4f components
zinc metalloregulation of the zinc finger pair domain
mammalian tak1 activates snf1 protein kinase in yeast and phosphorylates amp-activated protein kinase in vitro
heterogeneous nuclear ribonucleoprotein k modulates angiotensinogen gene expression in kidney cells
evidence that clustered phosphocholine head groups serve as sites for binding and assembly of an oligomeric protein pore
homotetrameric form of cin8p, a saccharomyces cerevisiae kinesin-5 motor, is essential for its in vivo function
characterization of an active spore photoproduct lyase, a dna repair enzyme in the radical s-adenosylmethionine superfamily
superoxide fluxes limit nitric oxide-induced signaling
allosteric effectors influence the tetramer stability of both r- and t-states of hemoglobin a
the maintenance of high affinity plasminogen binding by group a streptococcal plasminogen-binding m-like protein is mediated by arginine and histidine residues with..
5-aminoimidazole-4-carboxamide-1--d-ribofuranoside-induced amp-activated protein kinase phosphorylation inhibits basal and insulin-stimulated glucose uptake, lipid ..
linking adhesive and structural proteins in the attachment plaque of mytilus californianus
two glucose-sensing pathways converge on rgt1 to regulate expression of glucose transporter genes in saccharomyces cerevisiae
the mode of interaction of the relaxin-like factor (rlf) with the leucine-rich repeat g protein-activated receptor 8
sequential proteolytic processing of the capsular caf1 antigen of yersinia pestis for major histocompatibility complex class ii-restricted presentation to t lymphoc..
suppression of nf-b activation by entamoeba histolytica in intestinal epithelial cells is mediated by heat shock protein 27
effects of human a3 and a4 mutations that result in osteopetrosis and distal renal tubular acidosis on yeast v-atpase expression and activity
translational control of collagen prolyl 4-hydroxylase-(i) gene expression under hypoxia
cyclic phosphatidic acid is produced by autotaxin in blood
cd47 is necessary for inhibition of nitric oxide-stimulated vascular cell responses by thrombospondin-1
reconstituted okazaki fragment processing indicates two pathways of primer removal
raising the active site of factor viia above the membrane surface reduces its procoagulant activity but not factor vii autoactivation
nf-b1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages
the irak-1-bcl10-malt1-traf6-tak1 cascade mediates signaling to nf-b from toll-like receptor 4
the involvement of arg265 of mouse ribonucleotide reductase r2 protein in proton transfer and catalysis
amp-activated kinase inhibits the epithelial na+ channel through functional regulation of the ubiquitin ligase nedd4-2
subunits of the snf1 kinase heterotrimer show interdependence for association and activity
lysine residues lys-19 and lys-49 of -catenin regulate its levels and function in t cell factor transcriptional activation and neoplastic transformation
toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by prdi-binding factor-1/blimp1
rack1 binds to smad3 to modulate transforming growth factor-1-stimulated 2(i) collagen transcription in renal tubular epithelial cells
tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events
identification of human stat5-dependent gene regulatory elements based on interspecies homology
multiple activation mechanisms of p38 mitogen-activated protein kinase
defining the requirements for hsp40 and hsp70 in the hsp90 chaperone pathway
nrf2-mediated induction of cytoprotective enzymes by 15-deoxy-12,14-prostaglandin j2 is attenuated by alkenal/one oxidoreductase
regulatory protein phosphorylation in mycoplasma pneumoniae
the psbq protein is required in arabidopsis for photosystem ii assembly/stability and photoautotrophy under low light conditions
yeast recombination factor rdh54 functionally interacts with the rad51 recombinase and catalyzes rad51 removal from dna
atgrxcp, an arabidopsis chloroplastic glutaredoxin, is critical for protection against protein oxidative damage
the structural basis for substrate anchoring, active site selectivity, and product formation by p450 pikc from streptomyces venezuelae
antiinflammatory and immunosuppressive activity of sialostatin l, a salivary cystatin from the tick ixodes scapularis
dynamics of bacteriophage t4 presynaptic filament assembly from extrinsic fluorescence measurements of gp32-single-stranded dna interactions
leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (vegf) and its receptor type two (vegf-r2)
the polycystin 1-c-terminal fragment stimulates erk-dependent spreading of renal epithelial cells
role of angiotensin ii type 1a receptor phosphorylation, phospholipase d, and extracellular calcium in isoform-specific protein kinase c membrane translocation resp..
cytocidal actions of parasporin-2, an anti-tumor crystal toxin from bacillus thuringiensis
a transverse tubule nadph oxidase activity stimulates calcium release from isolated triads via ryanodine receptor type 1 s -glutathionylation
endocannabinoid biosynthesis proceeding through glycerophospho-n-acyl ethanolamine and a role for /-hydrolase 4 in this pathway
the interaction between calcium- and integrin-binding protein 1 and the iib integrin cytoplasmic domain involves a novel c-terminal displacement mechanism
inhibitory activity of the drosophila melanogaster serpin necrotic is dependent on lysine residues in the d-helix
state-dependent conformations of the translocation pathway in the tyrosine transporter tyt1, a novel neurotransmitter:sodium symporter from fusobacterium nucleatum
expression cloning identifies transgelin (sm22) as a novel repressor of 92-kda type iv collagenase (mmp-9) expression
leucine-rich repeats 2-4 (leu60-glu128) of platelet glycoprotein ib regulate shear-dependent cell adhesion to von willebrand factor
decorin protein core inhibits in vivo cancer growth and metabolism by hindering epidermal growth factor receptor function and triggering apoptosis via caspase-3 act..
interaction between presenilin 1 and ubiquilin 1 as detected by fluorescence lifetime imaging microscopy and a high-throughput fluorescent plate reader
microtubules and actin microfilaments regulate lipid raft/caveolae localization of adenylyl cyclase signaling components
transcriptional activation of dehalorespiration
the c-terminal zinc finger of uvra does not bind dna directly but regulates damage-specific dna binding
anti-hemostatic effects of a serpin from the saliva of the tick ixodes ricinus
nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2 signaling and cell survival to endoplasmic retic..
extracellular calpains increase tubular epithelial cell mobility
human artificial chromosomes constructed using the bottom-up strategy are stably maintained in mitosis and efficiently transmissible to progeny mice
overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance
the pto kinase of tomato, which regulates plant immunity, is repressed by its myristoylated n terminus
brca1 suppresses osteopontin-mediated breast cancer
presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway
pcaf modulates pten activity
the structural and functional units of heteromeric amino acid transporters
regulation of constitutive androstane receptor and its target genes by fasting, camp, hepatocyte nuclear factor, and the coactivator peroxisome proliferator-activat..
timp independence of matrix metalloproteinase (mmp)-2 activation by membrane type 2 (mt2)-mmp is determined by contributions of both the mt2-mmp catalytic and hemop..
inhibition of platelet-derived growth factor-bb-induced receptor activation and fibroblast migration by hyaluronan activation of cd44
rapid translocation and insertion of the epithelial na+ channel in response to rhoa signaling
exploiting reaction intermediates of the atpase reaction to elucidate the mechanism of transport by p-glycoprotein (abcb1)
mechanism of inhibition of rho-dependent transcription termination by bacteriophage p4 protein psu
differential mapping of the amino acids mediating agonist and antagonist coordination with the human thromboxane a2 receptor protein
antitumorigenic effect of wnt 7a and fzd 9 in non-small cell lung cancer cells is mediated through erk-5-dependent activation of peroxisome proliferator-activated r..
microrna-9 controls the expression of granuphilin/slp4 and the secretory response of insulin-producing cells
dinucleotide spore photoproduct, a minimal substrate of the dna repair spore photoproduct lyase enzyme from bacillus subtilis
the replicative helicases of bacteria, archaea, and eukarya can unwind rna-dna hybrid substrates
akt-independent phosphorylation of tsc2 and activation of mtor and ribosomal protein s6 kinase signaling by prostaglandin f2
mechanism of dna recognition at a viral replication origin
heparan sulfate-related oligosaccharides in ternary complex formation with fibroblast growth factors 1 and 2 and their receptors
uv induces p21 rapid turnover independently of ubiquitin and skp2
toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes
lectin from the manila clam ruditapes philippinarum is induced upon infection with the protozoan parasite perkinsus olseni
the first catalytic step of the light-driven enzyme protochlorophyllide oxidoreductase proceeds via a charge transfer complex
fumarate is an essential intermediary metabolite produced by the procyclic trypanosoma brucei
conformational transitions as determinants of specificity for the dna methyltransferase ecori
escherichia coli cora periplasmic domain functions as a homotetramer to bind substrate
negative regulation of the rela/p65 transactivation function by the product of the dek proto-oncogene
serglycin is the major secreted proteoglycan in macrophages and has a role in the regulation of macrophage tumor necrosis factor- secretion in response to lipopolys..
growth yield homeostasis in respiring yeast is due to a strict mitochondrial content adjustment
biochemical characterization of vlml, a seryl-trna synthetase encoded by the valanimycin biosynthetic gene cluster
promyelocytic leukemia activates chk2 by mediating chk2 autophosphorylation
differences in protonation of ubiquinone and menaquinone in fumarate reductase from escherichia coli
par4, but not par1, signals human platelet aggregation via ca2+ mobilization and synergistic p2y12 receptor activation
molecular determinants of specificity for synthetic nucleoside analogs in the concentrative nucleoside transporter, cnt2
estrogen-induced proliferation of uterine epithelial cells is independent of estrogen receptor binding to classical estrogen response elements
x-ray crystal structure of leukocyte type core 2 1,6-n-acetylglucosaminyltransferase
glyoxalase ii, a detoxifying enzyme of glycolysis byproduct methylglyoxal and a target of p63 and p73, is a pro-survival factor of the p53 family
chip protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation
cdmp1/gdf5 has specific processing requirements that restrict its action to joint surfaces
probing active site chemistry in shv -lactamase variants at ambler position 24
structural and computational characterization of the shv-1 -lactamase--lactamase inhibitor protein interface
inf2 is a wasp homology 2 motif-containing formin that severs actin filaments and accelerates both polymerization and depolymerization
c/ebp null mouse as a model for the double knock-out of slc5a8 and slc5a12 in kidney
binding of the cooh-terminal lysine residue of streptokinase to plasmin(ogen) kringles enhances formation of the streptokinase·plasmin(ogen) catalytic complexes
roles for udp-glcnac 2-epimerase/mannac 6-kinase outside of sialic acid biosynthesis
membrane association of the cycling peroxisome import receptor pex5p
measurement of nitric oxide levels in the red cell
in vitro synthesis of cross-linked murein and its attachment to sacculi by pbp1a from escherichia coli
ikk-i/ikk controls constitutive, cancer cell-associated nf-b activity via regulation of ser-536 p65/rela phosphorylation
analysis of properties of small heat shock protein hsp25 in mapk-activated protein kinase 2 (mk2)-deficient cells
hiv-1 nef selectively activates src family kinases hck, lyn, and c-src through direct sh3 domain interaction
pfmdr2 confers heavy metal resistance to plasmodium falciparum
retention of core catalytic functions by a conserved minimal ribonuclease e peptide that lacks the domain required for tetramer formation
structural determinants for cross-talk between pyruvate dehydrogenase kinase 3 and lipoyl domain 2 of the human pyruvate dehydrogenase complex
mast cell costimulation by cd226/cd112 (dnam-1/nectin-2)
n-glycosylation of fibroblast growth factor receptor 1 regulates ligand and heparan sulfate co-receptor binding
inhibition of gluconeogenesis through transcriptional activation of egr1 and dusp4 by amp-activated kinase
bem1p is a positive regulator of the homotypic fusion of yeast vacuoles
mubs, a family of ubiquitin-fold proteins that are plasma membrane-anchored by prenylation
c-terminal domain of kv4.2 and associated kchip2 interactions regulate functional expression and gating of kv4.2
pfpkb, a protein kinase b-like enzyme from plasmodium falciparum
the involvement of ataxia-telangiectasia mutated protein activation in nucleotide excision repair-facilitated cell survival with cisplatin treatment
serotonin 5-ht2c receptor homodimer biogenesis in the endoplasmic reticulum
direct phosphorylation and activation of a nim1-related kinase gin4 by elm1 in budding yeast
nsa2 is an unstable, conserved factor required for the maturation of 27 sb pre-rrnas
insights into phycoerythrobilin biosynthesis point toward metabolic channeling
fluorescent indicators distributed throughout the pharmacophore of cholecystokinin provide insights into distinct modes of binding and activation of type a and b ch..
translocation efficiency of apolipoprotein b is determined by the presence of -sheet domains, not pause transfer sequences
analysis of strains with mutations in six genes encoding subunits of the v-atpase
titin as a giant scaffold for integrating stress and src homology domain 3-mediated signaling pathways
monocyte differentiation up-regulates the expression of the lysosomal sialidase, neu1, and triggers its targeting to the plasma membrane via major histocompatibilit..
mouse homologue of skin-specific retroviral-like aspartic protease involved in wrinkle formation
conserved features in the extracellular domain of human toll-like receptor 8 are essential for ph-dependent signaling
structural insights into hypb, a gtp-binding protein that regulates metal binding
overexpression of bone morphogenetic protein 10 in myocardium disrupts cardiac postnatal hypertrophic growth
collagen xii interacts with avian tenascin-x through its nc3 domain
engineering atpase activity in the isolated abc cassette of human tap1
ribonucleases and angiogenins from fish
an extended rna binding site for the yeast branch point-binding protein and the role of its zinc knuckle domains in rna binding
loss of n-linked glycosylation reduces urea transporter ut-a1 response to vasopressin
the transcriptional activity of cited1 is regulated by phosphorylation in a cell cycle-dependent manner
identification of hydrogen bonds to the rieske cluster through the weakly coupled nitrogens detected by electron spin echo envelope modulation spectroscopy
defining the cd59-c9 binding interaction
calcium-regulated phosphorylation of soybean serine acetyltransferase in response to oxidative stress
transcriptional specificity of rpon1 and rpon2 involves differential recognition of the promoter sequences and specific interaction with the cognate activator prote..
mapping the grif-1 binding domain of the kinesin, kif5c, substantiates a role for grif-1 as an adaptor protein in the anterograde trafficking of cargoes
pro-inflammatory cytokine tumor necrosis factor- induces bone morphogenetic protein-2 in chondrocytes via mrna stabilization and transcriptional up-regulation
set-mediated promoter hypoacetylation is a prerequisite for coactivation of the estrogen-responsive ps2 gene by prmt1
nrf2 possesses a redox-sensitive nuclear exporting signal in the neh5 transactivation domain
molecular and enzymatic characterizations of novel bifunctional 3-hydroxysteroid dehydrogenases/c-4 decarboxylases from arabidopsis thaliana
screening-based discovery and structural dissection of a novel family 18 chitinase inhibitor
the properties of steric gate mutants reveal different constraints within the active sites of y-family and a-family dna polymerases
intracellular retention, degradation, and signaling of glycosylation-deficient fgfr2 and craniosynostosis syndrome-associated fgfr2c278f
the n-terminal domains of neuregulin 1 confer signal attenuation
cell migration and signaling specificity is determined by the phosphatidylserine recognition motif of rac1
retinoic acid regulates the expression of photoreceptor transcription factor nrl
the isoflavone equol mediates rapid vascular relaxation
widespread, but non-identical, association of proteasomal 19 and 20 s proteins with yeast chromatin
the histidine triad protein hint1 triggers apoptosis independent of its enzymatic activity
epidermal growth factor protects prostate cancer cells from apoptosis by inducing bad phosphorylation via redundant signaling pathways
identification of the missing links in prokaryotic pentose oxidation pathways
oxidative inhibition of receptor-type protein-tyrosine phosphatase by ultraviolet irradiation activates epidermal growth factor receptor in human keratinocytes
structural basis for the redox control of plant glutamate cysteine ligase
the crystal structure of a collagen-like polypeptide with 3(s)-hydroxyproline residues in the xaa position forms a standard 7/2 collagen triple helix
identification in archaea of a novel d-tyr-trnatyr deacylase
structural variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/microtubule affinity regulating kinase (mark) 1 and mark2
tbvps34, the trypanosome orthologue of vps34, is required for golgi complex segregation
predictions of ccr1 chemokine receptor structure and bx 471 antagonist binding followed by experimental validation
matricellular hevin regulates decorin production and collagen assembly
contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the -secretase complex
the mammalian target of rapamycin (mtor) pathway regulates mitochondrial oxygen consumption and oxidative capacity
apoptotic neutrophils release macrophage migration inhibitory factor upon stimulation with tumor necrosis factor-
the iron-sulfur clusters in escherichia coli succinate dehydrogenase direct electron flow
hiv-1 tar rna subverts rna interference in transfected cells through sequestration of tar rna-binding protein, trbp
signal peptide peptidase-catalyzed cleavage of hepatitis c virus core protein is dispensable for virus budding but destabilizes the viral capsid
dynamic and functional assembly of the aaa peroxins, pex1p and pex6p, and their membrane receptor pex26p
enzymatically active mammalian ribonucleotide reductase exists primarily as an 62 octamer
neisseria gonorrhoeae type iv pili undergo multisite, hierarchical modifications with phosphoethanolamine and phosphocholine requiring an enzyme structurally relate..
differential effects of ca2+ and camp on transcription mediated by mef2d and camp-response element-binding protein in hippocampal neurons
cj1121c, a novel udp-4-keto-6-deoxy-glcnac c-4 aminotransferase essential for protein glycosylation and virulence in campylobacter jejuni
selective excision of chain-terminating nucleotides by hiv-1 reverse transcriptase with phosphonoformate as substrate
identification of nerve growth factor-responsive element of the tcl1 promoter as a novel negative regulatory element
cloning of a cholesterol--glucosyltransferase from helicobacter pylori
ubiquitin-dependent down-regulation of the neurokinin-1 receptor
interplay between ku, artemis, and the dna-dependent protein kinase catalytic subunit at dna ends
the role of x/y linker region and n-terminal ef-hand domain in nuclear translocation and ca2+ oscillation-inducing activities of phospholipase c, a mammalian egg-ac..
escherichia coli transcriptome dynamics during the transition from anaerobic to aerobic conditions
sterol intermediates from cholesterol biosynthetic pathway as liver x receptor ligands
paired bacillus anthracis dps (mini-ferritin) have different reactivities with peroxide
ligand selectivity of soluble guanylyl cyclase
transforming growth factor activation of c-abl is independent of receptor internalization and regulated by phosphatidylinositol 3-kinase and pak2 in mesenchymal cul..
replication protein a directs loading of the dna damage checkpoint clamp to 5‘-dna junctions
pre-transfer editing by class ii prolyl-trna synthetase
examining interactions of hiv-1 reverse transcriptase with single-stranded template nucleotides by nucleoside analog interference
ligand-independent androgen receptor activity is activation function-2-independent and resistant to antiandrogens in androgen refractory prostate cancer cells
sterol transfer by abcg5 and abcg
multiple consequences of mutating two conserved -bridge forming residues in the translocation cycle of a neuronal glutamate transporter
acceleration of amyloid -peptide aggregation by physiological concentrations of calcium
gcp60 preferentially interacts with a caspase-generated golgin-160 fragment
the structure of the major cell wall polysaccharide of bacillus anthracis is species-specific
airway surface liquid volume regulates enac by altering the serine protease-protease inhibitor balance
(cag)·(ctg) repeats associated with neurodegenerative diseases are stable in the escherichia coli chromosome
interplay of isca and iscu in biogenesis of iron-sulfur clusters
molecular identification and physiological roles of parotid acinar cell maxi-k channels
sumo-binding motifs mediate the rad60-dependent response to replicative stress and self-association
insulin-stimulated interaction between insulin receptor substrate 1 and p85 and activation of protein kinase b/akt require rab5
dual role of peroxiredoxin i in macrophage-derived foam cells
interaction of genome-linked protein (vpg) of turnip mosaic virus with wheat germ translation initiation factors eifiso4e and eifiso4f
c-src control of chloride channel support for osteoclast hcl transport and bone resorption
identification of a novel binding motif in pyrococcus furiosus dna ligase for the functional interaction with proliferating cell nuclear antigen
trigger factor binding to ribosomes with nascent peptide chains of varying lengths and sequences
maintenance of nitric oxide and redox homeostasis by the salmonella flavohemoglobin hmp
cyclin i protects podocytes from apoptosis
atp regulation in adult rat cardiomyocytes
structural and functional characterization of the conserved salt bridge in mammalian paneth cell -defensins
-amyloid-induced dynamin 1 degradation is mediated by n-methyl-d-aspartate receptors in hippocampal neurons
cd8 has two distinct binding modes of interaction with peptide-major histocompatibility complex class i
two proteases defining a melanization cascade in the immune system of drosophila
functional domains of human tryptophan hydroxylase 2 (htph2)
ets-1-dependent expression of vascular endothelial growth factor receptors is activated by latency-associated nuclear antigen of kaposi‘s sarcoma-associated herpes..
n-terminally truncated wt1 protein with oncogenic properties overexpressed in leukemia
the folding nucleus of the insulin superfamily
characterization of peripheral human cannabinoid receptor (hcb2) expression and pharmacology using a novel radioligand, [35s]sch225336
ligand-induced conformational changes in the capping subdomain of a bacterial old yellow enzyme homologue and conserved sequence fingerprints provide new insights i..
assembly of synthetic locked chromophores with agrobacterium phytochromes agp1 and agp2
snap-25/syntaxin 1a complex functionally modulates neurotransmitter -aminobutyric acid reuptake
structural and biophysical characterization of the ephb4·ephrinb2 protein-protein interaction and receptor specificity
a deletion in the golgi -mannosidase ii gene of caenorhabditis elegans results in unexpected non-wild-type n-glycan structures
biological functions of mammalian nit1, the counterpart of the invertebrate nitfhit rosetta stone protein, a possible tumor suppressor
interaction of stim1 with endogenously expressed human canonical trp1 upon depletion of intracellular ca2+ stores
structure-function analysis of the coxsackievirus protein 3a
r7bp augments the function of rgs7·g5 complexes by a plasma membrane-targeting mechanism
the protozoan inositol phosphorylceramide synthase
characterization of the transport mechanism and permeant binding profile of the uridine permease fui1p of saccharomyces cerevisiae
v-src-dependent down-regulation of the ste20-like kinase slk by casein kinase ii
formation of soluble oligomers and amyloid fibrils with physical properties of the scrapie isoform of the prion protein from the c-terminal domain of recombinant mu..
a role for the g12 family of heterotrimeric g proteins in prostate cancer invasion
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