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identification of the preferential ubiquitination site and ubiquitin-dependent degradation signal of rpn4
carmil is a potent capping protein antagonist
structural role of (bacterio)chlorophyll ligated in the energetically unfavorable -position
structural definition of the h-2kd peptide-binding motif
crystal structure of the v domain of human nectin-like molecule-1/syncam3/tsll1/igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule
role of tyrosine kinase csk in g protein-coupled receptor- and receptor tyrosine kinase-induced fibroblast cell migration
actin binding to the central domain of wasp/scar proteins plays a critical role in the activation of the arp2/3 complex
involvement of the ras-ras-activated rab5 guanine nucleotide exchange factor rin2-rab5 pathway in the hepatocyte growth factor-induced endocytosis of e-cadherin
targeted disruption of gb3/cd77 synthase gene resulted in the complete deletion of globo-series glycosphingolipids and loss of sensitivity to verotoxins
thermal stabilization of bacillus subtilis family-11 xylanase by directed evolution
identification of the segments of the mouse transferrin receptor 1 required for mouse mammary tumor virus infection
targeted knockdown of g protein subunits selectively prevents receptor-mediated modulation of effectors and reveals complex changes in non-targeted signaling proteins
neutralization of the aspartic acid residue asp-367, but not asp-454, inhibits binding of na+ to the glutamate-free form and cycling of the glutamate transporter ea..
regulation of foxc1 stability and transcriptional activity by an epidermal growth factor-activated mitogen-activated protein kinase signaling cascade
microfibrillar proteins magp-1 and magp-2 induce notch1 extracellular domain dissociation and receptor activation
a prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4 that regulates the cholesterol 7-hydroxylase gene
the mitochondrial effects of small organic ligands of bcl-
irf-8/interferon (ifn) consensus sequence-binding protein is involved in toll-like receptor (tlr) signaling and contributes to the cross-talk between tlr and ifn- s..
persistent s-nitrosation of complex i and other mitochondrial membrane proteins by s-nitrosothiols but not nitric oxide or peroxynitrite
the saccharomyces cerevisiae proteome of oxidized protein thiols
structures of the carbohydrate recognition domain of ca2+-independent cargo receptors emp46p and emp47p
domain analysis of a groundnut calcium-dependent protein kinase
role of heme iron coordination and protein structure in the dynamics and geminate rebinding of nitric oxide to the h93g myoglobin mutant
molecular cloning and characterization of chick spacrcan
dysfunctions of cellular oxidative metabolism in patients with mutations in the ndufs1 and ndufs4 genes of complex i
c-met expression is regulated by mitf in the melanocyte lineage
ephrin-b1 is critical in t-cell development
green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase
distinct domains in high mobility group n variants modulate specific chromatin modifications
prolonged activation of camp-response element-binding protein and atf-2 needed for nicotine-triggered elevation of tyrosine hydroxylase gene transcription in pc12 c..
functional domains and dynamic assembly of the peroxin pex14p, the entry site of matrix proteins
the urokinase/pai-2 complex
myd88 adapter-like (mal) is phosphorylated by bruton‘s tyrosine kinase during tlr2 and tlr4 signal transduction
nmr study of the electron transfer complex of plant ferredoxin and sulfite reductase
activating transcription factor 3, a stress-inducible gene, suppresses ras-stimulated tumorigenesis
positioned nucleosomes due to sequential remodeling of the yeast u6 small nuclear rna chromatin are essential for its transcriptional activation
fatty acid amide hydrolase determines anandamide-induced cell death in the liver
efficient leukocyte ig-like receptor signaling and crystal structure of disulfide-linked hla-g dimer
transport of the ige receptor -chain is controlled by a multicomponent intracellular retention signal
polo box domain of plk3 functions as a centrosome localization signal, overexpression of which causes mitotic arrest, cytokinesis defects, and apoptosis
activation of the erk8 mitogen-activated protein (map) kinase by ret/ptc3, a constitutively active form of the ret proto-oncogene
genetic analysis of the structure and function of transfer messenger rna pseudoknot 1
the mammalian longevity-associated gene product p66shc regulates mitochondrial metabolism
the properties of the positively charged loop region in psi-g are essential for its “spontaneous“ insertion into thylakoids and rapid assembly into the photosyste..
teds site phosphorylation of the yeast myosins i is required for ligand-induced but not for constitutive endocytosis of the g protein-coupled receptor ste2p
increased ccaat enhancer-binding protein (c/ebp) expression and premature apoptosis in myeloid cells expressing gfi-1 n382s mutant associated with severe congenital..
overexpression and mechanistic characterization of blastula protease 10, a metalloprotease involved in sea urchin embryogenesis and development
formins regulate actin filament flexibility through long range allosteric interactions
single variable domain-igg fusion
prion proteins with insertion mutations have altered n-terminal conformation and increased ligand binding activity and are more susceptible to oxidative attack
motexafin gadolinium, a tumor-selective drug targeting thioredoxin reductase and ribonucleotide reductase
proteolytic regulation of nuclear factor of activated t (nfat) c2 cells and nfat activity by caspase-3
human prolyl-4-hydroxylase (i) transcription is mediated by upstream stimulatory factors
differential transcriptional regulation by mouse single-minded 2s
alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-tau is polyubiquitinated through lys-48, lys-11, and lys-6 ubiquitin conjugat..
oxidative damage of dj-1 is linked to sporadic parkinson and alzheimer diseases
structure, function, and mechanism of the phenylacetate pathway hot dog-fold thioesterase paai
phospholipid transfer activity of microsomal triacylglycerol transfer protein is sufficient for the assembly and secretion of apolipoprotein b lipoproteins
a specific mechanomodulatory role for p38 mapk in embryonic joint articular surface cell mek-erk pathway regulation
identification of substrates of human protein-tyrosine phosphatase ptpn22
crystal structure of the sugar binding domain of the archaeal transcriptional regulator trmb
role of p38 mapk and rna-dependent protein kinase (pkr) in hepatitis c virus core-dependent nuclear delocalization of cyclin b1
defective one- or two-electron reduction of the anticancer anthracycline epirubicin in human heart
the comparative roles of suppressor of cytokine signaling-1 and -3 in the inhibition and desensitization of cytokine signaling
structural and functional analyses of the human toll-like receptor
chronic ethanol intake impairs insulin signaling in rats by disrupting akt association with the cell membrane
asymmetric arginine dimethylation of heterogeneous nuclear ribonucleoprotein k by protein-arginine methyltransferase 1 inhibits its interaction with c-src
cholesterol-dependent pore formation of clostridium difficile toxin a
reduced expression of the endothelin receptor type b gene in piebald mice caused by insertion of a retroposon-like element in intron 1
mammalian tolloid-like 1 binds procollagen c-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous prote..
the gene ncgl2918 encodes a novel maleylpyruvate isomerase that needs mycothiol as cofactor and links mycothiol biosynthesis and gentisate assimilation in corynebac..
allosteric modulation bypasses the requirement for atp hydrolysis in regenerating low affinity transition state conformation of human p-glycoprotein
regulating the drought-responsive element (dre)-mediated signaling pathway by synergic functions of trans-active and trans-inactive dre binding factors in brassica ..
purification and atpase activity of human abca1
structure and activity of two metal ion-dependent acetylxylan esterases involved in plant cell wall degradation reveals a close similarity to peptidoglycan deacetyl..
aryl hydrocarbon receptor modulation of tumor necrosis factor--induced apoptosis and lysosomal disruption in a hepatoma model that is caspase-8-independent
molecular cloning and characterization of a novel 3‘-phosphoadenosine 5‘-phosphosulfate transporter, papst2
systematic evaluation of transcellular activities of secretory phospholipases a
dynamics of dna binding of replication initiation proteins during de novo formation of pre-replicative complexes in xenopus egg extracts
expression of cd83 is regulated by hur via a novel cis-active coding region rna element
distinct -arrestin- and g protein-dependent pathways for parathyroid hormone receptor-stimulated erk1/2 activation
specific requirement for bax, not bak, in myc-induced apoptosis and tumor suppression in vivo
the wd40 repeats of fancl are required for fanconi anemia core complex assembly
unique substrate recognition by botulinum neurotoxins serotypes a and e
the farnesoid x receptor modulates adiposity and peripheral insulin sensitivity in mice
tumor necrosis factor- increases circulating osteoclast precursor numbers by promoting their proliferation and differentiation in the bone marrow through up-regulat..
ftdp-17 mutations compromise the ability of tau to regulate microtubule dynamics in cells
glyoxalase i is critical for human retinal capillary pericyte survival under hyperglycemic conditions
raft-mediated src homology 2 domain-containing proteintyrosine phosphatase 2 (shp-2) regulation in microglia
chymotrypsin c (caldecrin) stimulates autoactivation of human cationic trypsinogen
identification and characterization of murine scara5, a novel class a scavenger receptor that is expressed by populations of epithelial cells
regulation of surface localization of the small conductance ca2+-activated potassium channel, sk2, through direct phosphorylation by camp-dependent protein kinase
internalization and recycling of the human prostacyclin receptor is modulated through its isoprenylation-dependent interaction with the subunit of cgmp phosphodiest..
a gating mutation in the internal pore of asic1a
cyclooxygenase-2 induction and prostacyclin release by protease-activated receptors in endothelial cells require cooperation between mitogen-activated protein kinas..
dual specificity of the interfacial inhibitor brefeldin a for arf proteins and sec7 domains
similar protein phosphatases control starch metabolism in plants and glycogen metabolism in mammals
-tocopheryl succinate induces apoptosis in prostate cancer cells in part through inhibition of bcl-xl/bcl-2 function
the actin-depolymerizing factor homology and charged/helical domains of drebrin and mabp1 direct membrane binding and localization via distinct interactions with ac..
suppression of wnt signaling by the green tea compound (-)-epigallocatechin 3-gallate (egcg) in invasive breast cancer cells
transition from rolling to firm adhesion can be mimicked by extension of integrin l2 in an intermediate affinity state
insulin-like growth factor-binding protein-5 activates plasminogen by interaction with tissue plasminogen activator, independently of its ability to bind to plasmin..
pragmin, a novel effector of rnd2 gtpase, stimulates rhoa activity
acetylcholinesterase dynamics at the neuromuscular junction of live animals
individual timp deficiencies differentially impact pro-mmp-2 activation
tumor necrosis factor-like weak inducer of apoptosis inhibits skeletal myogenesis through sustained activation of nuclear factor-b and degradation of myod protein
saccharomyces cerevisiae lacking btn1p modulate vacuolar atpase activity to regulate ph imbalance in the vacuole
identification of mcm2 phosphorylation sites by s-phase-regulating kinases
characterization of human dhrs6, an orphan short chain dehydrogenase/reductase enzyme
the anti-angiogenic his/pro-rich fragment of histidine-rich glycoprotein binds to endothelial cell heparan sulfate in a zn2+-dependent manner
a chlorophyll a/b-binding protein homolog that is induced by iron deficiency is associated with enlarged photosystem i units in the eucaryotic alga dunaliella salina
persistent interleukin-1 signaling causes long term activation of nfb in a promoter-specific manner in human glial cells
ccn2 is necessary for adhesive responses to transforming growth factor-1 in embryonic fibroblasts
distinct requirements for translocation of the n-tail and c-tail of the escherichia coli inner membrane protein cyoa
role of histone deacetylase in the expression of ctp:phosphocholine cytidylyltransferase
salt tolerance of archaeal extremely halophilic lipid membranes
endogenous lipid hydroperoxide-mediated dna-adduct formation in min mice
transient down-regulation of dnmt1 methyltransferase leads to activation and stable hypomethylation of mage-a1 in melanoma cells
foxo1 regulates multiple metabolic pathways in the liver
defining the role of the escherichia coli chaperone secb using comparative proteomics
functional coupling between trpc3 and ryr1 regulates the expressions of key triadic proteins
mechanistic basis for the action of new cephalosporin antibiotics effective against methicillin- and vancomycin-resistant staphylococcus aureus
mara-mediated transcriptional repression of the rob promoter
tamoxifen and estradiol interact with the flavin mononucleotide site of complex i leading to mitochondrial failure
effect of arachidonic acid reacylation on leukotriene biosynthesis in human neutrophils stimulated with granulocyte-macrophage colony-stimulating factor and formyl-..
a phosphatidylinositol 3-kinase-regulated akt-independent signaling promotes cigarette smoke-induced fra-1 expression
the vp2/vp3 minor capsid protein of simian virus 40 promotes the in vitro assembly of the major capsid protein vp1 into particles
interrelated roles for mcl-1 and bim in regulation of trail-mediated mitochondrial apoptosis
real-time enzyme dynamics illustrated with fluorescence spectroscopy of p-hydroxybenzoate hydroxylase
a regulatory role for 1-acylglycerol-3-phosphate-o-acyltransferase 2 in adipocyte differentiation
probing the adhesive footprints of mytilus californianus byssus
enhancement of the recycling and activation of -adrenergic receptor by rab4 gtpase in cardiac myocytes
g13 interacts with pdz domain-containing proteins
interactions of gtp with the atp-grasp domain of gtp-specific succinyl-coa synthetase
prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor
trpm7 regulates cell adhesion by controlling the calcium-dependent protease calpain
helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic proteins bax and bak, leading to cytochrome c release and cell death, independent o..
traf6 regulates cell fate decisions by inducing caspase 8-dependent apoptosis and the activation of nf-b
tocopherol cyclase (vte1) localization and vitamin e accumulation in chloroplast plastoglobule lipoprotein particles
stomach-specific calpain, ncl-2, localizes in mucus cells and proteolyzes the -subunit of coatomer complex, -cop
complex role of the vitamin d receptor and its ligand in adipogenesis in 3t3-l1 cells
sr-bi-mediated high density lipoprotein (hdl) endocytosis leads to hdl resecretion facilitating cholesterol efflux
the group b streptococcal sialic acid o-acetyltransferase is encoded by neud, a conserved component of bacterial sialic acid biosynthetic gene clusters
specific recognition of the collagen triple helix by chaperone hsp4
development of selective inhibitors and substrate of matrix metalloproteinase-12
structure of the atp binding domain from the archaeoglobus fulgidus cu+-atpase
gata factor translation is the final downstream step in the amino acid/target-of-rapamycin-mediated vitellogenin gene expression in the anautogenous mosquito aedes ..
fumarate reductase and succinate oxidase activity of escherichia coli complex ii homologs are perturbed differently by mutation of the flavin binding domain
robo4 signaling in endothelial cells implies attraction guidance mechanisms
inhibition of heme oxygenase-1 interferes with the transforming activity of the kaposi sarcoma herpesvirusencoded g protein-coupled receptor
the structure of cody, a gtp- and isoleucine-responsive regulator of stationary phase and virulence in gram-positive bacteria
autophagy controls salmonella infection in response to damage to the salmonella-containing vacuole
endosome sorting and autophagy are essential for differentiation and virulence of leishmania major
hypoxia regulates cross-talk between syk and lck leading to breast cancer progression and angiogenesis
cysteine string protein monitors late steps in cystic fibrosis transmembrane conductance regulator biogenesis
intrinsic inhibition of the hsp90 atpase activity
evidence for displacements of the c-helix by co ligation and dna binding to cooa revealed by uv resonance raman spectroscopy
functional genomic responses to cystic fibrosis transmembrane conductance regulator (cftr) and cftr508 in the lung
molecular properties of adult mouse gastric and intestinal epithelial progenitors in their niches
fgf-1 and fgf-2 require the cytosolic chaperone hsp90 for translocation into the cytosol and the cell nucleus
glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury
identification of a sialate o-acetyltransferase from campylobacter jejuni
multiple active site conformers in the carbon monoxide complexes of trematode hemoglobins
the ectodomain of the viral receptor yueb forms a fiber that triggers ejection of bacteriophage spp1 dna
postreplicative mismatch repair factors are recruited to epstein-barr virus replication compartments
essential roles of 3‘-phosphoadenosine 5‘-phoshosulfate synthase in embryonic and larval development of the nematode caenorhabditis elegans
trophoblast stem cells rescue placental defect in socs3-deficient mice
hormonal control of reversible translocation of perilipin b to the plasma membrane in primary human adipocytes
effects of mutations and truncations on the kinetic behavior of iiaglc, a phosphocarrier and regulatory protein of the phosphoenolpyruvate phosphotransferase system..
steady-state kinetics and inhibitory action of antitubercular phenothiazines on mycobacterium tuberculosis type-ii nadh-menaquinone oxidoreductase (ndh-2)
fat10 plays a role in the regulation of chromosomal stability
functional isk/kvlqt1 potassium channel in a new corticosteroid-sensitive cell line derived from the inner ear
apoptosis signal-regulating kinase 1 is a direct target of e2f1 and contributes to histone deacetylase inhibitorinduced apoptosis through positive feedback regulati..
the nucleocapsid protein of severe acute respiratory syndrome-coronavirus inhibits the activity of cyclin-cyclin-dependent kinase complex and blocks s phase progres..
pten deletion leads to up-regulation of a secreted growth factor pleiotrophin
lysosomal trafficking and cysteine protease metabolism confer target-specific cytotoxicity by peptide-linked anti-cd30-auristatin conjugates
identification of the amino acid residues essential for proteolytic activity in an archaeal signal peptide peptidase
conformational stabilities of the structural repeats of erythroid spectrin and their functional implications
vitamin d receptor agonists specifically modulate the volume of the ligand-binding pocket
nucleotide excision repair and template-independent addition by hiv-1 reverse transcriptase in the presence of nucleocapsid protein
determinants of the ubiquitin-mediated degradation of the met4 transcription factor
integrin-induced tyrosine phosphorylation of protein-tyrosine phosphatase- is required for cytoskeletal reorganization and cell migration
transcriptional tradeoff between metabolic and stress-response programs in pseudomonas putida kt2440 cells exposed to toluene
t-bet binding to newly identified target gene promoters is cell type-independent but results in variable context-dependent functional effects
co-expression and functional interaction of silicatein with galectin
genetic analysis of the first and third extracellular loops of the c5a receptor reveals an essential wxfg motif in the first loop
molecular properties of oep21, an atp-regulated anion-selective solute channel from the outer chloroplast membrane
ing3 promotes uv-induced apoptosis via fas/caspase-8 pathway in melanoma cells
a mutation in aminopeptidase n (cd13) isolated from a patient suffering from leukemia leads to an arrest in the endoplasmic reticulum
the phosphorylation of serine 492 of perilipin a directs lipid droplet fragmentation and dispersion
activity-dependent synaptic wnt release regulates hippocampal long term potentiation
functional and structural characterization of rhodopsin oligomers
ps-341 (bortezomib) induces lysosomal cathepsin b release and a caspase-2-dependent mitochondrial permeabilization and apoptosis in human pancreatic cancer cells
the cytosolic loop of the -secretase component presenilin enhancer 2 protects zebrafish embryos from apoptosis
the upstream-activating sequences of the 54 promoter pu of pseudomonas putida filter transcription readthrough from upstream genes
cytokine secretion via cholesterol-rich lipid raft-associated snares at the phagocytic cup
mutational analysis of membrane and soluble forms of human md-2
solution structure of the severe acute respiratory syndrome-coronavirus heptad repeat 2 domain in the prefusion state
mutation of two intramembrane polar residues conserved within the hyaluronan synthase family alters hyaluronan product size
structural requirements for efficient processing and activation of recombinant human udp-n-acetylglucosamine:lysosomal-enzyme-n-acetylglucosamine-1-phosphotransferase
regulation of integrin activity by mia
nfb negatively regulates interferon-induced gene expression and anti-influenza activity
reconstitution of the yeast rna polymerase iii transcription system with all recombinant factors
the calmodulin-binding site of sphingosine kinase and its role in agonist-dependent translocation of sphingosine kinase 1 to the plasma membrane
use of substrate analogs and mutagenesis to study substrate binding and catalysis in the sir2 family of nad-dependent protein deacetylases
dissociation of regulated trafficking of trpc3 channels to the plasma membrane from their activation by phospholipase c
ss-lrpb from sulfolobus solfataricus condenses about 100 base pairs of its own operator dna into globular nucleoprotein complexes
the peroxisomal acyl-coa thioesterase pte1p from saccharomyces cerevisiae is required for efficient degradation of short straight chain and branched chain fatty acids
ptp-pest couples membrane protrusion and tail retraction via vav2 and p190rhogap
nucleotide-binding oligomerization domain-1 and epidermal growth factor receptor
recombination mediator and rad51 targeting activities of a human brca2 polypeptide
synaptic mitochondria are more susceptible to ca2+overload than nonsynaptic mitochondria
inhibition of s/g2 phase cdk4 reduces mitotic fidelity
dystrophin and utrophin bind actin through distinct modes of contact
characterization of p87pikap, a novel regulatory subunit of phosphoinositide 3-kinase that is highly expressed in heart and interacts with pde3b
identification of functional domains within the septation initiation network kinase, cdc7
strict pairing of var promoters and introns is required for var gene silencing in the malaria parasite plasmodium falciparum
a weak fe-o bond in the oxygenated complex of the nitric-oxide synthase of staphylococcus aureus
a novel hematopoietic granulin induces proliferation of goldfish (carassius auratus l.) macrophages
phosphorylation of -catenin by cyclic amp-dependent protein kinase
a model for c74 addition by cca-adding enzymes
nonvisual arrestin oligomerization and cellular localization are regulated by inositol hexakisphosphate binding
6-hydroxydopamine but not 1-methyl-4-phenylpyridinium abolishes -synuclein anti-apoptotic phenotype by inhibiting its proteasomal degradation and by promoting its a..
estrogen receptor- binds p53 tumor suppressor protein directly and represses its function
a low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (tshr) and luteinizing hormone/chorionic gonad..
the carotenase atccd1 from arabidopsis thaliana is a dioxygenase
pctaire1 phosphorylates n-ethylmaleimide-sensitive fusion protein
stimulation of the epithelial sodium channel (enac) by camp involves putative erk phosphorylation sites in the c termini of the channel‘s - and -subunit
fez1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region
stereochemical analysis of the functional significance of the conserved inverted ccaat and tata elements in the rat bone sialoprotein gene promoter
gap1 family members constitute bifunctional ras and rap gtpase-activating proteins
cpg sites preferentially methylated by dnmt3a in vivo
pyruvate formate-lyase and a novel route of eukaryotic atp synthesis in chlamydomonas mitochondria
small ubiquitin-like modifier (sumo) modification of natively unfolded proteins tau and -synuclein
cys-113 and cys-422 form a high affinity metalloid binding site in the arsa atpase
visual arrestin binding to microtubules involves a distinct conformational change
agonist-stimulated -adrenergic receptor internalization requires dynamic cytoskeletal actin turnover
the rack1 homologue from trypanosoma brucei is required for the onset and progression of cytokinesis
functional and trafficking defects in atp binding cassette a3 mutants associated with respiratory distress syndrome
biosynthesis of dermatan sulfate
xenopus cdc7/drf1 complex is required for the initiation of dna replication
drosophila dna polymerase interacts with recombination repair protein 1, the drosophila homologue of human abasic endonuclease 1
aslfm, the d-aspartate ligase responsible for the addition of d-aspartic acid onto the peptidoglycan precursor of enterococcus faecium
removal or maintenance of inositol-linked acyl chain in glycosylphosphatidylinositol is critical in trypanosome life cycle
phosphorylation of frizzled-3
calcium-sensing receptor ubiquitination and degradation mediated by the e3 ubiquitin ligase dorfin
quaternary structure and cleavage specificity of a poxvirus holliday junction resolvase
parp-2 interacts with ttf-1 and regulates expression of surfactant protein-b
fulvestrant (ici 182,780)-dependent interacting proteins mediate immobilization and degradation of estrogen receptor-
triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death
structure and reactivity of a thermostable prokaryotic nitric-oxide synthase that forms a long-lived oxy-heme complex
a non-cleavable umud variant that acts as a umud‘ mimic
the holo-form of the nucleotide binding domain of the kdpfabc complex from escherichia coli reveals a new binding mode
edem3, a soluble edem homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming
the structural basis of signal transduction for the response regulator prra from mycobacterium tuberculosis
a mutation linked with autism reveals a common mechanism of endoplasmic reticulum retention for the,-hydrolase fold protein family
an aurora kinase homologue is involved in regulating both mitosis and cytokinesis in trypanosoma brucei
nmr dynamic studies suggest that allosteric activation regulates ligand binding in chicken liver bile acid-binding protein
atm activation by ionizing radiation requires brca1-associated baat1
extracellular matrix metalloproteinase inducer (cd147) confers resistance of breast cancer cells to anoikis through inhibition of bim
suppression of apoptosis in the protein kinase c null mouse in vivo
laboratory-evolved vanadium chloroperoxidase exhibits 100-fold higher halogenating activity at alkaline ph
calpain is required for normal osteoclast function and is down-regulated by calcitonin
contribution of the histone h3 and h4 amino termini to gcn4p- and gcn5p-mediated transcription in yeast
characterization of testis-specific isoenzyme of human pyruvate dehydrogenase
functional genomic analysis of caf-1 mutants in arabidopsis thaliana
20s proteasomes have the potential to keep substrates in store for continual degradation
up-regulation of the wnt, estrogen receptor, insulin-like growth factor-i, and bone morphogenetic protein pathways in c57bl/6j osteoblasts as opposed to c3h/hej ost..
leucine 135 of tropomodulin-1 regulates its association with tropomyosin, its cellular localization, and the integrity of sarcomeres
cytokines promote wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3t3-l1 preadipocytes
a tryptophan neutral radical in the oxidized state of versatile peroxidase from pleurotus eryngii
enhancement of +1 frameshift by polyamines during translation of polypeptide release factor 2 in escherichia coli
recombinant expression and biochemical characterization of the unique elongating -ketoacyl-acyl carrier protein synthase involved in fatty acid biosynthesis of plas..
clotrimazole inhibits the ca2+-atpase (serca) by interfering with ca2+ binding and favoring the e2 conformation
identification of a novel region of the cytoplasmic dynein intermediate chain important for dimerization in the absence of the light chains
conversion efficiency of bank vole prion protein in vitro is determined by residues 155 and 170, but does not correlate with the high susceptibility of bank voles t..
two distinct pathways for o-fucosylation of epidermal growth factor-like or thrombospondin type 1 repeats
protein o-fucosyltransferase 2 adds o-fucose to thrombospondin type 1 repeats
formation, structure, and dissociation of the ribonuclease s three-dimensional domain-swapped dimer.
dynamics of arrestin-rhodopsin interactions
adam12 is a four-leafed clover
targeted disruption of tyrosylprotein sulfotransferase-2, an enzyme that catalyzes post-translational protein tyrosine o-sulfation, causes male infertility
consequences of n-acylation on structure and membrane binding properties of dermaseptin derivative k4-s4-(1-13)
the catalytic activity of the eukaryotic initiation factor-2 kinase pkr is required to negatively regulate stat1 and stat3 via activation of the t-cell protein-tyro..
urokinase-type plasminogen activator receptor regulates a novel pathway of fibronectin matrix assembly requiring src-dependent transactivation of epidermal growth f..
intracellular zinc release and erk phosphorylation are required upstream of 12-lipoxygenase activation in peroxynitrite toxicity to mature rat oligodendrocytes
asparagine 706 and glutamate 183 at the catalytic site of sarcoplasmic reticulum ca2+-atpase play critical but distinct roles in e2 states
1,4-galactosyltransferase v functions as a positive growth regulator in glioma
identification and functional characterization of a presqualene diphosphate phosphatase
modulation of nav1.5 channel function by an alternatively spliced sequence in the dii/diii linker region
extracellular signal-regulated kinase-dependent proliferation is mediated through the protein kinase a/b-raf pathway in human uveal melanoma cells
binding of -synuclein affects the lipid packing in bilayers of small vesicles
regulatory factor for x-box family proteins differentially interact with histone deacetylases to repress collagen 2(i) gene (col1a2) expression
interaction of -1,3-glucan with its recognition protein activates hemolymph proteinase 14, an initiation enzyme of the prophenoloxidase activation system in manduca..
heterogeneous nuclear ribonucleoprotein-a2/b1 modulate collagen prolyl 4-hydroxylase, (i) mrna stability
modifications of h3 and h4 during chromatin replication, nucleosome assembly, and histone exchange
lipid phosphate phosphatase-2 activity regulates s-phase entry of the cell cycle in rat2 fibroblasts
regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose
characterization of a monoclonal antibody b1 that recognizes phosphorylated ser-158 in the activation peptide region of human coagulation factor ix
expression cloning and periplasmic orientation of the francisella novicida lipid a 4‘-phosphatase lpxf
unveiling a hidden folding intermediate in c-type cytochromes by protein engineering
active metabolite of atorvastatin inhibits membrane cholesterol domain formation by an antioxidant mechanism
rapid activation of atr by ionizing radiation requires atm and mre11
serial analysis of gene expression in mouse uterus at the implantation site
the zn2+-transporting pathways in pancreatic -cells
atutr1, a udp-glucose/udp-galactose transporter from arabidopsis thaliana, is located in the endoplasmic reticulum and up-regulated by the unfolded protein response
myocyte enhancer factors 2a and 2c induce dilated cardiomyopathy in transgenic mice
the latent membrane protein 1 of epstein-barr virus (ebv) primes ebv latency cells for type i interferon production
binding of active matrilysin to cell surface cholesterol sulfate is essential for its membrane-associated proteolytic action and induction of homotypic cell adhesion
genetic and biochemical properties of streptococcal nad-glycohydrolase inhibitor
mechanisms of cystic fibrosis transmembrane conductance regulator activation by s-nitrosoglutathione
significant redox insensitivity of the functions of the sars-cov spike glycoprotein
the role of drosophila ninag oxidoreductase in visual pigment chromophore biogenesis
the saccharomyces cerevisiae lipin homolog is a mg2+-dependent phosphatidate phosphatase enzyme
new insights into the role of conserved, essential residues in the gtp binding/gtp hydrolytic cycle of large g proteins
the interleukin-1 gene is transcribed from a poised promoter architecture in monocytes
methylglyoxal as a signal initiator for activation of the stress-activated protein kinase cascade in the fission yeast schizosaccharomyces pombe
effects of polycyclic aromatic hydrocarbons (pahs) on vascular endothelial growth factor induction through phosphatidylinositol 3-kinase/ap-1-dependent, hif-1-indep..
nitric oxide-dependent negative feedback of parp-1 trans-activation of the inducible nitric-oxide synthase gene
regulation of epithelial na+ channels (enac) by methylation
rho family guanine nucleotide exchange factor brx couples extracellular signals to the glucocorticoid signaling system
kinetics and thermodynamics of ligand binding by cytochrome p450 3a4
rna aptamers targeting the cell death inhibitor ced-9 induce cell killing in caenorhabditis elegans
the plasma membrane lactate transporter mct4, but not mct1, is up-regulated by hypoxia through a hif-1-dependent mechanism
an unusual signal peptide extension inhibits the binding of bacterial presecretory proteins to the signal recognition particle, trigger factor, and the secyeg complex
tlr1- and tlr6-independent recognition of bacterial lipopeptides
polyvinylpyrrolidone 40 assists the refolding of bovine carbonic anhydrase b by accelerating the refolding of the first molten globule intermediate
anandamide uptake is consistent with rate-limited diffusion and is regulated by the degree of its hydrolysis by fatty acid amide hydrolase
regulation of the transient receptor potential channel trpm2 by the ca2+ sensor calmodulin
dna methylation-dependent epigenetic regulation of dimethylarginine dimethylaminohydrolase 2 gene in trophoblast cell lineage
ligand-induced conformational changes in the acetylcholine-binding protein analyzed by hydrogen-deuterium exchange mass spectrometry
a role for adp-ribosylation factor 6 in the processing of g-protein-coupled receptors
vascular endothelial growth factor (vegf)/vegf-c mosaic molecules reveal specificity determinants and feature novel receptor binding patterns
myeloperoxidase impairs abca1-dependent cholesterol efflux through methionine oxidation and site-specific tyrosine chlorination of apolipoprotein a-i
structurally altered peptides reveal an important role for n-terminal heptad repeat binding and stability in the inhibitory action of hiv-1 peptide dp178
identification of a novel protein with a role in lipoarabinomannan biosynthesis in mycobacteria
members of the arabidopsis fae1-like 3-ketoacyl-coa synthase gene family substitute for the elop proteins of saccharomyces cerevisiae
cgmp-dependent protein kinase phosphorylates p21-activated kinase (pak) 1, inhibiting pak/nck binding and stimulating pak/vasodilator-stimulated phosphoprotein asso..
in prostate cancer cells the interaction of c/ebp with ku70, ku80, and poly(adp-ribose) polymerase-1 increases sensitivity to dna damage
cellular heparan sulfate negatively modulates transforming growth factor-1 (tgf-1) responsiveness in epithelial cells
caspase-3-derived c-terminal product of synphilin-1 displays antiapoptotic function via modulation of the p53-dependent cell death pathway
pir proteins of saccharomyces cerevisiae are attached to -1,3-glucan by a new protein-carbohydrate linkage
probing of hiv-1 integrase/dna interactions using novel analogs of viral dna
role of the ccaat/enhancer-binding protein nfatc2 transcription factor cascade in the induction of secretory phospholipase a2
the lipoprotein lipase inhibitor angptl3 is negatively regulated by thyroid hormone
akt1 provides an essential survival signal required for differentiation and stratification of primary human keratinocytes
structural characterization of the split pleckstrin homology domain in phospholipase c-1 and its interaction with trpc3
endocytic function of von hippel-lindau tumor suppressor protein regulates surface localization of fibroblast growth factor receptor 1 and cell motility
the lipoprotein receptor-related protein-1 (lrp) adapter protein gulp mediates trafficking of the lrp ligand prosaposin, leading to sphingolipid and free cholestero..
free fatty acids induce jnk-dependent hepatocyte lipoapoptosis
independence of protein kinase c- activity from activation loop phosphorylation
recycling of muc1 is dependent on its palmitoylation
versican v0 and v1 guide migratory neural crest cells
phosphorylation of tyrosine 568 controls nuclear export of nrf2
membrane electrical activity elicits inositol 1,4,5-trisphosphate-dependent slow ca2+ signals through a g/phosphatidylinositol 3-kinase pathway in skeletal myotubes
interaction of pdzrhogef with microtubule-associated protein 1 light chains
importin- mediates cdc7 nuclear import by binding to the kinase insert ii domain, which can be antagonized by importin-
evidence for distinct mechanisms of starch granule breakdown in plants
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