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生物物理学杂志2006年第02期封面 购买


stabilization of a stalled replication fork by concerted actions of two helicases
overexpression of apolipoprotein a-iv enhances lipid secretion in ipec-1 cells by increasing chylomicron size
dequalinium-induced protofibril formation of -synuclein
the differential engagement of arrestin surface charges by the various functional forms of the receptor
active site distortion is sufficient for proteinase inhibition by serpins
a novel thioredoxin h is secreted in nicotiana alata and reduces s-rnase in vitro
apolipoprotein e receptor 2 interactions with the n-methyl-d-aspartate receptor
specific recognition of the collagen triple helix by chaperone hsp4
vaccinia virus uracil dna glycosylase interacts with the a20 protein to form a heterodimeric processivity factor for the viral dna polymerase
the st6galnac-i sialyltransferase localizes throughout the golgi and is responsible for the synthesis of the tumor-associated sialyl-tn o-glycan in human breast can..
camp is a ligand for the tandem gaf domain of human phosphodiesterase 10 and cgmp for the tandem gaf domain of phosphodiesterase 11
a conserved motif is prerequisite for the interaction of nac with ribosomal protein l23 and nascent chains
rpe65 is an iron(ii)-dependent isomerohydrolase in the retinoid visual cycle
proteomic analysis of 1-adrenergic receptor interactions with pdz scaffold proteins
dual role of the cdc7-regulatory protein dbf4 during yeast meiosis
iodotyrosine deiodinase is the first mammalian member of the nadh oxidase/flavin reductase superfamily
mouse profilin 2 regulates endocytosis and competes with sh3 ligand binding to dynamin 1
identification of constitutive phosphorylation sites on the epstein-barr virus zebra protein
induction of apoptosis by the ste20-like kinase slk, a germinal center kinase that activates apoptosis signal-regulating kinase and p38
myeloperoxidase generates 5-chlorouracil in human atherosclerotic tissue
hiv-1 tat raises an adjuvant-free humoral immune response controlled by its core region and its ability to form cysteine-mediated oligomers
substrate specificity of human kallikrein
a conserved histidine-aspartate pair is required for exovinyl reduction of biliverdin by a cyanobacterial phycocyanobilin:ferredoxin oxidoreductase
a -arrestin binding determinant common to the second intracellular loops of rhodopsin family g protein-coupled receptors
glucose-stimulated dna synthesis through mammalian target of rapamycin (mtor) is regulated by katp channels
the human anti-apoptotic proteins ciap1 and ciap2 bind but do not inhibit caspases
activation of the rna-dependent protein kinase pkr promoter in the absence of interferon is dependent upon sp proteins
trp channels are inhibited by camp and contribute to pacemaking in neurosecretory insect neurons
protein kinase c negatively regulates akt activity and modifies uvc-induced apoptosis in mouse keratinocytes
divergence in the plasminogen-binding group a streptococcal m protein family
amp deamination delays muscle acidification during heavy exercise and hypoxia
sustained activation of phosphatidylinositol 3-kinase/akt/nuclear factor b signaling mediates g protein-coupled -opioid receptor gene expression
phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian atg8 modifiers, lc3, gabarap, and gate-16
signal-dependent control of gluconeogenic key enzyme genes through coactivator-associated arginine methyltransferase 1
relaxin stimulates leukocyte adhesion and migration through a relaxin receptor lgr7-dependent mechanism
a novel functional interaction between the sp1-like protein klf13 and srebp-sp1 activation complex underlies regulation of low density lipoprotein receptor promoter..
distinct genes encode type ii topoisomerases for the nucleus and mitochondrion in the protozoan parasite trypanosoma brucei
mutations in the amino terminus of the cystic fibrosis transmembrane conductance regulator enhance endocytosis
targeting prostaglandin e2 receptors as an alternative strategy to block cyclooxygenase-2-dependent extracellular matrix-induced matrix metalloproteinase-9 expressi..
neuroendocrine protein 7b2 can be inactivated by phosphorylation within the secretory pathway
occupancy of a single anesthetic binding pocket is sufficient to enhance glycine receptor function
release of the soluble transferrin receptor is directly regulated by binding of its ligand ferritransferrin
helicobacter pylori thioredoxin is an arginase chaperone and guardian against oxidative and nitrosative stresses
the expanded octarepeat domain selectively binds prions and disrupts homomeric prion protein interactions
sodium-induced gcn4 expression controls the accumulation of the 5‘ to 3‘ rna degradation inhibitor, 3‘-phosphoadenosine 5‘-phosphate
targeting of miz-1 is essential for myc-mediated apoptosis
kinetic analysis of a mammalian phospholipase d
different residues mediate recognition of 1-o-oleyllysophosphatidic acid and rosiglitazone in the ligand binding domain of peroxisome proliferator-activated receptor
differential use of functional domains by coiled-coil coactivator in its synergistic coactivator function with -catenin or grip1
aminoglycosides decrease glutathione peroxidase-1 activity by interfering with selenocysteine incorporation
the interferon-inducible ubiquitin-protein isopeptide ligase (e3) efp also functions as an isg15 e3 ligase
cyp51 from trypanosoma cruzi
smad6 interacts with runx2 and mediates smad ubiquitin regulatory factor 1-induced runx2 degradation
interaction of huntingtin-associated protein-1 with kinesin light chain
e-cadherin-dependent transcriptional control of apolipoprotein a-iv gene expression in intestinal epithelial cells
high density of octaarginine stimulates macropinocytosis leading to efficient intracellular trafficking for gene expression
nmr structures of the selenoproteins sep15 and selm reveal redox activity of a new thioredoxin-like family
organization of calcium channel 1a subunits in triad junctions in skeletal muscle
structural and biological identification of residues on the surface of ns3 helicase required for optimal replication of the hepatitis c virus
human c4b-binding protein, structural basis for interaction with streptococcal m protein, a major bacterial virulence factor
differential regulation of cardiomyocyte survival and hypertrophy by mdm2, an e3 ubiquitin ligase
involvement of myosin vb in glutamate receptor trafficking
nmr solution structure of the tandem src homology 3 domains of p47phox complexed with a p22phox-derived proline-rich peptide
hepatitis c virus glycoproteins mediate low ph-dependent membrane fusion with liposomes
identification and characterization of rv3281 as a novel subunit of a biotin-dependent acyl-coa carboxylase in mycobacterium tuberculosis h37rv
nucleotide sequence and dna secondary structure, as well as replication protein a, modulate the single-stranded abasic endonuclease activity of ape1
caspase-7 is directly activated by the 700-kda apoptosome complex and is released as a stable xiap-caspase-7 200-kda complex
glycosylphosphatidylinositol-anchored proteins are required for the transport of detergent-resistant microdomain-associated membrane proteins tat2p and fur4p
sumo-3 enhances androgen receptor transcriptional activity through a sumoylation-independent mechanism in prostate cancer cells
characterization of a counterpart to mammalian ornithine decarboxylase antizyme in prokaryotes
activation of toll-like receptor 2 on microglia promotes cell uptake of alzheimer disease-associated amyloid peptide
insulin dynamically regulates calmodulin gene expression by sequential o-glycosylation and phosphorylation of sp1 and its subcellular compartmentalization in liver ..
vitamin b6 biosynthesis by the malaria parasite plasmodium falciparum
differential recognition of the type i and ii h antigen acceptors by the human abo(h) blood group a and b glycosyltransferases
the differentiation-dependent desmosomal cadherin desmoglein 1 is a novel caspase-3 target that regulates apoptosis in keratinocytes
parkin ubiquitinates and promotes the degradation of ranbp2
pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1
a novel lipase belonging to the hormone-sensitive lipase family induced under starvation to utilize stored triacylglycerol in mycobacterium tuberculosis
atp induces conformational changes of periplasmic loop regions of the maltose atp-binding cassette transporter
mechanisms for picrotoxin block of 2 homomeric glycine receptors
the involvement of mapk signaling pathways in determining the cellular response to p53 activation
use of synthetic peptides to locate novel integrin 21-binding motifs in human collagen iii
studies on the transcriptional regulation of cholesterol 24-hydroxylase (cyp46a1)
oncogenic ras induces accelerated transition through g2/m and promotes defects in the g2 dna damage and mitotic spindle checkpoints
the novel nucleoside analog r1479 (4‘-azidocytidine) is a potent inhibitor of ns5b-dependent rna synthesis and hepatitis c virus replication in cell culture
lysosomal sialidase (neuraminidase-1) is targeted to the cell surface in a multiprotein complex that facilitates elastic fiber assembly
an evolutionarily conserved function of proliferating cell nuclear antigen for cdt1 degradation by the cul4-ddb1 ubiquitin ligase in response to dna damage
lipid and peptide control of phosphatidylinositol 4-kinase ii activity on golgi-endosomal rafts
the at-hook of the chromatin architectural transcription factor high mobility group a1a is arginine-methylated by protein arginine methyltransferase 6
basic residues in the nucleocapsid domain of gag are required for interaction of hiv-1 gag with abce1 (hp68), a cellular protein important for hiv-1 capsid assembly
golgi localization determinants in arfgap1 and in new tissue-specific arfgap1 isoforms
mutated yeast heat shock transcription factor activates transcription independently of hyperphosphorylation
naturally occurring mutations in human mitochondrial pre-trnaser(ucn) can affect the transfer ribonuclease z cleavage site, processing kinetics, and substrate secon..
the histone acetyltransferase ncoat contains a zinc finger-like motif involved in substrate recognition
combined signaling through erk, pi3k/akt, and rac1/p38 is required for met-triggered cortical neuron migration
hypothyroid phenotype is contributed by mitochondrial complex i inactivation due to translocated neuronal nitric-oxide synthase
the low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity
g inhibits g gtpase-activating proteins by inhibition of g-gtp binding during stimulation by receptor
casein kinase ii phosphorylation of the yeast phospholipid synthesis transcription factor opi1p
identification of p122rhogap (deleted in liver cancer-1) serine 322 as a substrate for protein kinase b and ribosomal s6 kinase in insulin-stimulated cells
endogenous and exogenous ca2+ buffers differentially modulate ca2+-dependent inactivation of cav2.1 ca2+ channels
shielding of the a1 domain by the d‘d3 domains of von willebrand factor modulates its interaction with platelet glycoprotein ib-ix-v
inhibition of reca protein function by the rdgc protein from escherichia coli
her-2/neu represses the metastasis suppressor reck via erk and sp transcription factors to promote cell invasion
expression and characterization of the peptidase domain of streptococcus pneumoniae coma, a bifunctional atp-binding cassette transporter involved in quorum sensing..
formation of the crs2-caf2 group ii intron splicing complex is mediated by a 22-amino acid motif in the cooh-terminal region of caf2
scavenger receptor class b type i (sr-bi) is involved in vitamin e transport across the enterocyte
inhibition of hormone and cytokine-stimulated osteoclastogenesis and bone resorption by interleukin-4 and interleukin-13 is associated with increased osteoprotegeri..
shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells
prostaglandin e2 regulates the nuclear receptor nr4a2 in colorectal cancer
akt kinase phosphorylation of inositol 1,4,5-trisphosphate receptors
the “gyra-box“ is required for the ability of dna gyrase to wrap dna and catalyze the supercoiling reaction
cox24 codes for a mitochondrial protein required for processing of the cox1 transcript
reactivity of apolipoprotein e4 and amyloid peptide
mechanism of proteasomal degradation of inositol trisphosphate receptors in cho-k1 cells
endoplasmic reticulum stress induces apoptosis by an apoptosome-dependent but caspase 12-independent mechanism
arrestin-mediated erk activation by gonadotropin-releasing hormone receptors
dissection of a circumscribed recombination hot spot in hiv-1 after a single infectious cycle
neuron restrictive silencer factor nrsf/rest is a transcriptional repressor of neuropilin-1 and diminishes the ability of semaphorin 3a to inhibit keratinocyte migr..
ataxin-7 can export from the nucleus via a conserved exportin-dependent signal
a formylated hexapeptide ligand mimics the ability of wnt-5a to impair migration of human breast epithelial cells
n-myc down-regulated gene 1 modulates the response of term human trophoblasts to hypoxic injury
localization of the lipopolysaccharide-binding protein in phospholipid membranes by atomic force microscopy
quantitative proteomic analysis of myc-induced apoptosis
rac1 modulates sphingosine 1-phosphate-mediated activation of phosphoinositide 3-kinase/akt signaling pathways in vascular endothelial cells
diverse effects of pathogenic mutations of parkin that catalyze multiple monoubiquitylation in vitro
sars coronavirus, but not human coronavirus nl63, utilizes cathepsin l to infect ace2-expressing cells
exploration of glycosyl hydrolase family 75, a chitosanase from aspergillus fumigatus
reduced stability of mitogen-activated protein kinase kinase-2 mrna and phosphorylation of poly(a)-binding protein (pabp) in cells overexpressing pabp
tumor necrosis factor--converting enzyme (tace/adam-17) mediates the ectodomain cleavage of intercellular adhesion molecule-1 (icam-1)
effects of restricted feeding on daily fluctuations of hepatic functions including p450 monooxygenase activities in rats
brca1 affects lipid synthesis through its interaction with acetyl-coa carboxylase
dissection of the functional differences between human secretory pathway ca2+/mn2+-atpase (spca) 1 and 2 isoenzymes by steady-state and transient kinetic analyses
characterization of distinct stat5b binding sites that mediate growth hormone-stimulated igf-i gene transcription
exopolysaccharides from burkholderia cenocepacia inhibit neutrophil chemotaxis and scavenge reactive oxygen species
the unique nh2-terminally deleted (n) residues, the pxxp motif, and the ppxy motif are required for the transcriptional activity of the n variant of p63
heterogeneous nuclear ribonucleoprotein h is required for optimal u11 small nuclear ribonucleoprotein binding to a retroviral rna-processing control element
a salvage pathway for phytol metabolism in arabidopsis
arginine/serine-rich protein interaction domain-dependent modulation of a tau exon 10 splicing enhancer
hsf1 down-regulates xaf1 through transcriptional regulation
bcr-abl regulates phosphatidylinositol 3-kinase-p110 transcription and activation and is required for proliferation and drug resistance
deregulation of proteasome function induces abl-mediated cell death by uncoupling p130cas and c-crkii
domain interaction sites of human lens b2-crystallin
cloning, expression, and characterization of bacterial l-arabinose 1-dehydrogenase involved in an alternative pathway of l-arabinose metabolism
dcc-dependent phospholipase c signaling in netrin-1-induced neurite elongation
reactive lipid species from cyclooxygenase-2 inactivate tumor suppressor lkb1/stk1
a novel role of sodium butyrate in the regulation of cancer-associated aromatase promoters i.3 and ii by disrupting a transcriptional complex in breast adipose fibr..
a quantitative approach to catabolite repression in escherichia coli
core fucosylation regulates epidermal growth factor receptor-mediated intracellular signaling
the yeast translation release factors mrf1p and sup45p (erf1) are methylated, respectively, by the methyltransferases mtq1p and mtq2p
binding of manumycin a inhibits ib kinase activity
structure of the n-terminal calcium sensor domain of centrin reveals the biochemical basis for domain-specific function
helicobacter pylori encoding the pathogenicity island activates matrix metalloproteinase 1 in gastric epithelial cells via jnk and erk
identification and functional characterization of three chicken cathelicidins with potent antimicrobial activity
use of probes with fluorescence indicator distributed throughout the pharmacophore to examine the peptide agonist-binding environment of the family b g protein-coup..
rational development of -peptide inhibitors of human cytomegalovirus entry
rip-cre revisited, evidence for impairments of pancreatic -cell function
mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor agonists
g-protein-coupled receptor agonists activate endogenous phospholipase c and phospholipase c3 in a temporally distinct manner
central role of the scaffold protein tumor necrosis factor receptor-associated factor 2 in regulating endoplasmic reticulum stress-induced apoptosis
crystal structure of an archaeal glycogen synthase
platelet-activating factor mediates mmp-2 expression and activation via phosphorylation of camp-response element-binding protein and contributes to melanoma metasta..
prototypical type i e-cadherin and type ii cadherin-7 mediate very distinct adhesiveness through their extracellular domains
enacyloxin iia pinpoints a binding pocket of elongation factor tu for development of novel antibiotics
hma1, a new cu-atpase of the chloro plast envelope, is essential for growth under adverse light conditions
the camp pathway in combination with bmp2 regulates phox2a transcription via camp response element binding sites
crystal structure of a viral flip
camptothecin induces nuclear export of prohibitin preferentially in transformed cells through a crm-1-dependent mechanism
transient ib kinase activity mediates temporal nf-b dynamics in response to a wide range of tumor necrosis factor- doses
crystal structure of the hypoxia-inducible form of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (pfkfb3)
two catalytic domains are required for protein deacetylation
down-regulation of endogenous amyloid precursor protein processing due to cellular aging
ige-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires fyn kinase and contributes to mast cell responses
the rap1 guanine nucleotide exchange factor epac2 couples cyclic amp and ras signals at the plasma membrane
activation of t cell calcium influx by the second messenger adp-ribose
calcium-permeable acid-sensing ion channel is a molecular target of the neurotoxic metal ion lead
chaperoning checkpoint kinase 1 (chk1), an hsp90 client, with purified chaperones
effects of constitutively active and dominant negative mapk kinase (mkk) 3 and mkk6 on the ph-responsive increase in phosphoenolpyruvate carboxykinase mrna
the cln9 protein, a regulator of dihydroceramide synthase
growth phase-dependent activation of nitrogen-related genes by a control network of group 1 and group 2 factors in a cyanobacterium
examining ty3 polypurine tract structure and function by nucleoside analog interference
a novel kcnj11 mutation associated with congenital hyperinsulinism reduces the intrinsic open probability of -cell atp-sensitive potassium channels
cell type-dependent regulation of the hypoxia-responsive plasminogen activator inhibitor-1 gene by upstream stimulatory factor-2
the substrate-induced conformational change of mycobacterium tuberculosis mycothiol synthase
synthesis, processing, and composition of the virion-associated htlv-1 reverse transcriptase
targeted overexpression of sarcolipin in the mouse heart decreases sarcoplasmic reticulum calcium transport and cardiac contractility
mechanism of the long range anti-silencing function of targeted histone acetyltransferases in yeast
activation of the checkpoint kinase rad53 by the phosphatidyl inositol kinase-like kinase mec1
characterization of a muscle-specific enhancer in human musk promoter reveals the essential role of myogenin in controlling activity-dependent gene regulation
bap31 is involved in the retention of cytochrome p450 2c2 in the endoplasmic reticulum
profiles of growth hormone (gh)-regulated genes reveal time-dependent responses and identify a mechanism for regulation of activating transcription factor 3 by gh
stochastic high-speed rotation of escherichia coli atp synthase f1 sector
role of the par1 receptor 8th helix in signaling
prolyl-isomerase pin1 accumulates in lewy bodies of parkinson disease and facilitates formation of -synuclein inclusions
fe65 interacts with p2x2 subunits at excitatory synapses and modulates receptor function
role of the kinesin-2 family protein, kif3, during mitosis
a highly conserved amino-terminal region of sonic hedgehog is required for the formation of its freely diffusible multimeric form
compensatory increase in hepatic lipogenesis in mice with conditional intestine-specific mttp deficiency
mechanisms of pharmacological rescue of trafficking-defective herg mutant channels in human long qt syndrome
three dileucine-like motifs within the interbox1/2 region of the human oncostatin m receptor prevent efficient surface expression in the absence of an associated ja..
excess peroxisomes are degraded by autophagic machinery in mammals
new insights into the evolutionary links relating to the 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase subfamilies
expression of abcg1, but not abca1, correlates with cholesterol release by cerebellar astroglia
nucleotide-binding domains of cystic fibrosis transmembrane conductance regulator, an abc transporter, catalyze adenylate kinase activity but not atp hydrolysis
up-regulation of amp-activated kinase by dysfunctional cystic fibrosis transmembrane conductance regulator in cystic fibrosis airway epithelial cells mitigates exce..
light-induced oxidation of photoreceptor outer segment phospholipids generates ligands for cd36-mediated phagocytosis by retinal pigment epithelium
regulation of de novo purine biosynthesis by methenyltetrahydrofolate synthetase in neuroblastoma
analyses of variant acid -glucosidases
crystal structure of the c2 domain of class ii phosphatidylinositide 3-kinase c2
crystal structure of a metal ion-bound is200 transposase
interaction between sap97 and psd-95, two maguk proteins involved in synaptic trafficking of ampa receptors
purinergic receptors mediate two distinct glutamate release pathways in hippocampal astrocytes
chronic wasting disease of elk and deer and creutzfeldt-jakob disease
the hydrogen peroxide reactivity of peptidylglycine monooxygenase supports a cu(ii)-superoxo catalytic intermediate
acetylation by p300 regulates nuclear localization and function of the transcriptional corepressor ctbp2
structural and kinetic analysis of two covalent sialosyl-enzyme intermediates on trypanosoma rangeli sialidase
the cysteine-rich secretory protein domain of tpx-1 is related to ion channel toxins and regulates ryanodine receptor ca2+ signaling
beads-on-a-string, characterization of ets-1 sumoylated within its flexible n-terminal sequence
identification of amino acids in hiv-1 and avian sarcoma virus integrase subsites required for specific recognition of the long terminal repeat ends
differential inhibition of arabidopsis methionine adenosyltransferases by protein s-nitrosylation
characterization of the bifunctional -glutamate-cysteine ligase/glutathione synthetase (gshf) of pasteurella multocida
structural and mutagenesis studies on the cytochrome c peroxidase from rhodobacter capsulatus provide new insights into structure-function relationships of bacteria..
molecular structure of a 9-mda icosahedral pyruvate dehydrogenase subcomplex containing the e2 and e3 enzymes using cryoelectron microscopy
ezrin directly interacts with the 1b-adrenergic receptor and plays a role in receptor recycling
characterization of the dna binding and structural properties of the brct region of human replication factor c p140 subunit
ph-dependent equilibrium between long lived near-uv intermediates of photoactive yellow protein
tumor necrosis factor promotes runx2 degradation through up-regulation of smurf1 and smurf2 in osteoblasts
herc5, an interferon-induced hect e3 enzyme, is required for conjugation of isg15 in human cells
p53 mediates the accelerated onset of senescence of endothelial progenitor cells in diabetes
high density lipoprotein endocytosis by scavenger receptor sr-bii is clathrin-dependent and requires a carboxyl-terminal dileucine motif
the basic region of the diaphanous-autoregulatory domain (dad) is required for autoregulatory interactions with the diaphanous-related formin inhibitory domain
targeting amyloid- peptide (a) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in a precursor prote..
roles of the hydrophobic cavity and lid of lola in the lipoprotein transfer reaction in escherichia coli
protein-tyrosine kinase and gtpase signals cooperate to phosphorylate and activate wiskott-aldrich syndrome protein (wasp)/neuronal wasp
apical transport and folding of prostate-specific membrane antigen occurs independent of glycan processing
collagen xxviii, a novel von willebrand factor a domain-containing protein with many imperfections in the collagenous domain
cell death in pancreatitis
effects of inhibitors on luminal opening of ca2+ binding sites in an e2p-like complex of sarcoplasmic reticulum ca22+-atpase with be22+-fluoride
mitochondrial reactive oxygen species in mice lacking superoxide dismutase
modulation of neural carbohydrate epitope expression in drosophila melanogaster cells
membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase doa10 and comparison with its human ortholog teb4 (march-vi)
3-o-sulfated oligosaccharide structures are recognized by anti-heparan sulfate antibody hs4c3
apoptotic cells, at all stages of the death process, trigger characteristic signaling events that are divergent from and dominant over those triggered by necrotic c..
uncoupled redox systems in the lumen of the endoplasmic reticulum
the binding of chondroitin sulfate to pleiotrophin/heparin-binding growth-associated molecule is regulated by chain length and oversulfated structures
the receptor protein-tyrosine phosphatase ptpµ interacts with iqgap1
conserved role of the linker -helix of the bacterial disulfide isomerase dsbc in the avoidance of misoxidation by dsbb
a novel principle for partial agonism of liver x receptor ligands
maintenance of olfactory neurogenesis requires hsf1, a major heat shock transcription factor in mice
a rostrocaudal muscular dystrophy caused by a defect in choline kinase beta, the first enzyme in phosphatidylcholine biosynthesis
oligomeric structure of the carnitine transporter cait from escherichia coli
a reassessment of the fnr regulon and transcriptomic analysis of the effects of nitrate, nitrite, narxl, and narqp as escherichia coli k12 adapts from aerobic to an..
the tumor suppressor pten is necessary for human sprouty 2-mediated inhibition of cell proliferation
a molecular determinant of nickel inhibition in cav3.2 t-type calcium channels
immunogenicity and protective efficacy of bacillus anthracis poly--d-glutamic acid capsule covalently coupled to a protein carrier using a novel triazine-based conj..
mucin granule intraluminal organization in living mucous/goblet cells
promoter organization of the interferon-a genes differentially affects virus-induced expression and responsiveness to tbk1 and ikk
the drosophila fused lobes gene encodes an n-acetylglucosaminidase involved in n-glycan processing
a carboxyl-terminal determinant of the neuronal glutamate transporter, eaac1, is required for platelet-derived growth factor-dependent trafficking
identification of in vivo phosphorylation sites on human deoxycytidine kinase
a novel receptor activator of nf-b (rank) cytoplasmic motif plays an essential role in osteoclastogenesis by committing macrophages to the osteoclast lineage
rapid loss of structural motifs in the manganese complex of oxygenic photosynthesis by x-ray irradiation at 10-300 k
guide molecule-driven stereospecific degradation of -methylpolyamines by polyamine oxidase
mutational analysis of the ras converting enzyme reveals a requirement for glutamate and histidine residues
dna reshaping by mukb right-handed knotting, left-handed supercoiling
release of free f2-isoprostanes from esterified phospholipids is catalyzed by intracellular and plasma platelet-activating factor acetylhydrolases
the 2‘,5‘-oligoadenylate synthetase 1b is a potent inhibitor of west nile virus replication inside infected cells
a downshift in temperature activates the high osmolarity glycerol (hog) pathway, which determines freeze tolerance in saccharomyces cerevisiae
regulation of nuclear translocation of hdac3 by ib is required for tumor necrosis factor inhibition of peroxisome proliferator-activated receptor function
the role of ribosomal protein l11 in class i release factor-mediated translation termination and translational accuracy
the rassf1a tumor suppressor activates bax via moap-1
expression of cyclooxygenase-2 is regulated by glycogen synthase kinase-3 in gastric cancer cells
epithelial growth factor-induced phosphorylation of caveolin 1 at tyrosine 14 stimulates caveolae formation in epithelial cells
intracellular inclusions containing mutant 1-antitrypsin z are propagated in the absence of autophagic activity
huntingtin and mutant sod1 form aggregate structures with distinct molecular properties in human cells
mutator phenotypes caused by substitution at a conserved motif a residue in eukaryotic dna polymerase
involvement of a novel q-snare, d12, in quality control of the endomembrane system
functional asymmetry of nucleotide-binding domains in abcg5 and abcg8
inhibition of mrna deadenylation by the nuclear cap binding complex (cbc)
snf1p-dependent spt-ada-gcn5-acetyltransferase (saga) recruitment and chromatin remodeling activities on the hxt2 and hxt4 promoters
mouse sphingosine kinase isoforms sphk1a and sphk1b differ in enzymatic traits including stability, localization, modification, and oligomerization
oaz regulates bone morphogenetic protein signaling through smad6 activation
regulation of the assembly and adhesion activity of e-cadherin by nectin and afadin for the formation of adherens junctions in madin-darby canine kidney cells
notch, epidermal growth factor receptor, and 1-integrin pathways are coordinated in neural stem cells
the regulatory domain of srk2e/ost1/snrk2.6 interacts with abi1 and integrates abscisic acid (aba) and osmotic stress signals controlling stomatal closure in arabid..
solution structure and dna-binding mode of the matrix attachment region-binding domain of the transcription factor satb1 that regulates the t-cell maturation
allosteric threonine synthase
a conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasites
a major cell wall lipopeptide of mycobacterium avium subspecies paratuberculosis
crystal structure of nbla from anabaena sp. pcc 7120, a small protein playing a key role in phycobilisome degradation
crystal structure of the cytomegalovirus dna polymerase subunit ul44 in complex with the c terminus from the catalytic subunit
targeting and trafficking of the human thiamine transporter-2 in epithelial cells
hepatocyte nuclear factor-4 is essential for glucose-stimulated insulin secretion by pancreatic -cells
residues distant from the active site influence protein-tyrosine phosphatase 1b inhibitor binding
runx3 cooperates with foxo3a to induce apoptosis in gastric cancer cells
the giardia duodenalis 14-3-3 protein is post-translationally modified by phosphorylation and polyglycylation of the c-terminal tail
the nuclear import of protein kinase d3 requires its catalytic activity
forskolin-induced cell shrinkage and apical translocation of functional enhanced green fluorescent protein-human enac in h441 lung epithelial cell monolayers
structural and functional insights into the interaction of echoviruses and decay-accelerating factor
targeting perlecan in human keratinocytes reveals novel roles for perlecan in epidermal formation
amino acid changes in drosophila ps2ps integrins that affect ligand affinity
human alveolar macrophages are deficient in pten
the btb-kelch protein lztr-1 is a novel golgi protein that is degraded upon induction of apoptosis
decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in oat1 knock-out mice
biochemical characterization of the diaphanous autoregulatory interaction in the formin homology protein fhod1
degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class i is independent of mammalian escrtii
target selectivity of vertebrate notch proteins
stanniocalcin 1 acts as a paracrine regulator of growth plate chondrogenesis
overexpression of cyp2e1 in mitochondria sensitizes hepg2 cells to the toxicity caused by depletion of glutathione
hepatocyte growth factor-regulated tyrosine kinase substrate (hrs) interacts with pelp1 and activates mapk
glutamine binding opens the ammonia channel and activates glucosamine-6p synthase
small weak acids reactivate proton transfer in reaction centers from rhodobacter sphaeroides mutated at aspl210 and aspm17
control of mef2 transcriptional activity by coordinated phosphorylation and sumoylation
further insight into s-adenosylmethionine-dependent methyltransferases
the saccharomyces cerevisiae eht1 and eeb1 genes encode novel enzymes with medium-chain fatty acid ethyl ester synthesis and hydrolysis capacity
protein kinase c promotes nicotine-induced migration and invasion of cancer cells via phosphorylation of µ- and m-calpains
rational design of intercellular adhesion molecule-1 (icam-1) variants for antagonizing integrin lymphocyte function-associated antigen-1-dependent adhesion
sensing of lysophospholipids by trpc5 calcium channel
a comparative study of uracil-dna glycosylases from human and herpes simplex virus type 1
structural mechanics of the ph-dependent activity of -carbonic anhydrase from mycobacterium tuberculosis
dominant role of thyrotropin-releasing hormone in the hypothalamic-pituitary-thyroid axis
laminin 5 is required for dental epithelium growth and polarity and the development of tooth bud and shape
a new type of non-ca2+-buffering apo(a)-based fluorescent indicator for intraluminal ca2+ in the endoplasmic reticulum
solution structure of the human ubiquitin-specific protease 15 dusp domain
the carbohydrate at fcriiia asn-16
formation of tau inclusions in knock-in mice with familial alzheimer disease (fad) mutation of presenilin 1 (ps1)
a unique atp hydrolysis mechanism of single-headed processive myosin, myosin ix
elovl3 is an important component for early onset of lipid recruitment in brown adipose tissue
substrate specificity and domain functions of extracellular heparan sulfate 6-o-endosulfatases, qsulf1 and qsulf2
a dominant role for fe65 (apbb1) in nuclear signaling
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