互联网 123renren.net
赏析网:首页 > 医药医学 > 《生物物理学杂志》 > 2005年第11期
生物物理学杂志2005年第11期封面 购买


bovine prion protein gene (prnp) promoter polymorphisms modulate prnp expression and may be responsible for differences in bovine spongiform encephalopathy suscepti..
coordinate control and selective expression of the full complement of replication-dependent histone h4 genes in normal and cancer cells
the phosphorylation of ser318 of insulin receptor substrate 1 is not per se inhibitory in skeletal muscle cells but is necessary to trigger the attenuation of the i..
ras oncogene triggers up-regulation of ciap2 and xiap in intestinal epithelial cells
resveratrol promotes clearance of alzheimer‘s disease amyloid- peptides
increased negative superhelical density in vivo enhances the genetic instability of triplet repeat sequences
thermostability of irreversible unfolding -amylases analyzed by unfolding kinetics
increased p85 is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess
hepatitis c virus core protein inhibits mitochondrial electron transport and increases reactive oxygen species (ros) production
role of the cytokine-induced sh2 domain-containing protein cis in growth hormone receptor internalization
structural analysis of mg2+ and ca2+ binding to cabp1, a neuron-specific regulator of calcium channels
ablation of the otcc gene encoding a post-polyketide hydroxylase from the oxytetracyline biosynthetic pathway in streptomyces rimosus results in novel polyketides w..
decrease in ph strongly enhances binding of native, proteolyzed, lipolyzed, and oxidized low density lipoprotein particles to human aortic proteoglycans
phox2b regulates its own expression by a transcriptional auto-regulatory mechanism
stimulatory roles of nitric-oxide synthase 3 and guanylyl cyclase in platelet activation
redox imbalance in cystine/glutamate transporter-deficient mice
identification and molecular cloning of a novel glycoside hydrolase family of core 1 type o-glycan-specific endo--n-acetylgalactosaminidase from bifidobacterium lon..
rin gtpase couples nerve growth factor signaling to p38 and b-raf/erk pathways to promote neuronal differentiation
mass spectrometric evidence that proteolytic processing of rainbow trout egg vitelline envelope proteins takes place on the egg
tdp-43 binds heterogeneous nuclear ribonucleoprotein a/b through its c-terminal tail
heparan sulfate mimicry
identification of a functional phosphatidylinositol 3,4,5-trisphosphate binding site in the epithelial na+ channel
tissue-specific, inducible, and hormonal control of the human udp-glucuronosyltransferase-1 (ugt1) locus
erk1/2-activated de novo mapkapk2 synthesis is essential for osteogenic growth peptide mitogenic signaling in osteoblastic cells
g protein-coupled receptor kinases promote phosphorylation and -arrestin-mediated internalization of ccr5 homo- and hetero-oligomers
rac1 inhibition targets amyloid precursor protein processing by -secretase and decreases a production in vitro and in vivo
a positive feedback loop between glycogen synthase kinase 3 and protein phosphatase 1 after stimulation of nr2b nmda receptors in forebrain neurons
distinct role of calmodulin and calmodulin-dependent protein kinase-ii in lipopolysaccharide and tumor necrosis factor--mediated suppression of apoptosis and antiap..
sox6 attenuates glucose-stimulated insulin secretion by repressing pdx1 transcriptional actvity and is down-regulated in hyperinsulinemic obese mice
cross-talk between wnt and bone morphogenetic protein 2 (bmp-2) signaling in differentiation pathway of c2c12 myoblasts
mapping the region of the -type phospholipase a2 inhibitor responsible for its inhibitory activity
amyloid -protein is degraded by cellular angiotensin-converting enzyme (ace) and elevated by an ace inhibitor
ezrin controls the macromolecular complexes formed between an adapter protein na+/h+ exchanger regulatory factor and the cystic fibrosis transmembrane conductance r..
features of the catalytic domains and c termini of the mapk signal-integrating kinases mnk1 and mnk2 determine their differing activities and regulatory properties
a protein kinase c/ras/erk signaling pathway activates myeloid fibronectin receptors by altering 1 integrin sialylation
discovery of a gene family critical to wyosine base formation in a subset of phenylalanine-specific transfer rnas
different strategies for carboxyl-terminal domain (ctd) recognition by serine 5-specific ctd phosphatases
a novel cysteine-rich domain of sep15 mediates the interaction with udp-glucose:glycoprotein glucosyltransferase
change of the donor substrate specificity of clostridium difficile toxin b by site-directed mutagenesis
cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase b (akt)-mediated phosphorylation of adapter protein aps on serine ..
the active site his-460 of human acyl-coenzyme a:cholesterol acyltransferase 1 resides in a hitherto undisclosed transmembrane domain
characterization of the role of the rab gtpase-activating protein as160 in insulin-regulated glut4 trafficking
phosphatidylcholine homeostasis and liver failure
-cleavage is dependent on -cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain
inhibition of the calcineurin-nfat interaction by small organic molecules reflects binding at an allosteric site
the distinct binding specificities exhibited by enterobacterial type 1 fimbriae are determined by their fimbrial shafts
interaction with the na,k-atpase and tissue distribution of fxyd5 (related to ion channel)
glucocorticoid-induced tumor necrosis factor receptor is a p21cip1/waf1 transcriptional target conferring resistance of keratinocytes to uv light-induced apoptosis
structural insights into the secretin puld and its trypsin-resistant core
an active enzyme constructed from a 9-amino acid alphabet
structural basis for accommodation of nonsteroidal ligands in the androgen receptor
truncation and activation of calcineurin a by calpain i in alzheimer disease brain
the channel kinases trpm6 and trpm7 are functionally nonredundant
jsap1/jip3 cooperates with focal adhesion kinase to regulate c-jun n-terminal kinase and cell migration
pregnancy-associated plasma protein-a regulates myoblast proliferation and differentiation through an insulin-like growth factor-dependent mechanism
pitx2a binds to human papillomavirus type 18 e6 protein and inhibits e6-mediated p53 degradation in hela cells
erk2 shows a restrictive and locally selective mechanism of recognition by its tyrosine phosphatase inactivators not shared by its activator mek1
molecular basis for zinc potentiation at strychnine-sensitive glycine receptors
molecular determinants for the complex formation between the retinoblastoma protein and lxcxe sequences
interaction of -catenin and tif2/grip1 in transcriptional activation by the androgen receptor
differential requirement for phospholipase d/spo14 and its novel interactor sma1 for regulation of exocytotic vesicle fusion in yeast meiosis
hur stabilizes vacuolar h+-translocating atpase mrna during cellular energy depletion
dna damage regulates chk2 association with chromatin
localization of a disease-associated mutation site in the three-dimensional structure of the cardiac muscle ryanodine receptor
selective seca association with signal sequences in ribosome-bound nascent chains
pyruvate kinase revisited
delineating a ca2+ binding pocket within the venus flytrap module of the human calcium-sensing receptor
functional characterization of evolutionarily conserved dna regions in forkhead box f1 gene locus
local change in phospholipid composition at the cleavage furrow is essential for completion of cytokinesis
changes in structural and functional properties of oxygen-evolving complex induced by replacement of d1-glutamate 189 with glutamine in photosystem ii
cytotoxicity of an anti-cancer lysophospholipid through selective modification of lipid raft composition
fli-1 functionally interacts with piasx, a member of the pias e3 sumo ligase family
regulation of oxidative stress by the anti-aging hormone klotho
camp differentially regulates axonal and dendritic development of dentate granule cells
functional analysis of rna binding by the hepatitis c virus rna-dependent rna polymerase
dynamics of human protein arginine methyltransferase 1(prmt1) in vivo
endoplasmic reticulum retention and associated degradation of a gabaa receptor epilepsy mutation that inserts an aspartate in the m3 transmembrane segment of the 1 ..
the coiled-coil domain is required for hs1 to bind to f-actin and activate arp2/3 complex
epidermal growth factor induces tyrosine phosphorylation, membrane insertion, and activation of transient receptor potential channel 4
biochemical coupling of the two nucleotide binding domains of clpb
the identification of a succinyl-coa thioesterase suggests a novel pathway for succinate production in peroxisomes
glutamatergic regulation of the p70s6 kinase in primary mouse neurons
the dexh protein product of the dhx36 gene is the major source of tetramolecular quadruplex g4-dna resolving activity in hela cell lysates
molecular mechanism of the blockade of plasma cholesteryl ester transfer protein by its physiological inhibitor apolipoprotein ci
suppression of hypoxia-inducible factor 1 (hif-1) transcriptional activity by the hif prolyl hydroxylase egln1
in vitro murein (peptidoglycan) synthesis by dimers of the bifunctional transglycosylase-transpeptidase pbp1b from escherichia coli
hp1 binds specifically to lys26-methylated histone h1.4, whereas simultaneous ser27 phosphorylation blocks hp1 binding
crystal structure of lipoate-protein ligase a bound with the activated intermediate
heterotrimeric g-protein -subunit adopts a “preactivated“ conformation when associated with -subunits
synthesis of anticoagulantly active heparan sulfate proteoglycans by glomerular epithelial cells involves multiple 3-o-sulfotransferase isoforms and a limiting prec..
substrate binding to the molecular chaperone hsp104 and its regulation by nucleotides
superoxide-dependent oxidation of melatonin by myeloperoxidase
pias1 interaction and sumoylation of metabotropic glutamate receptor 8
a novel peptidoglycan cross-linking enzyme for a -lactam-resistant transpeptidation pathway
recognition of double-stranded rna by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic ph
a nmr study of the interaction of a three-domain construct of atp7a with copper(i) and copper(i)-hah
progesterone down-regulates the open probability of the amiloride-sensitive epithelial sodium channel via a nedd4-2-dependent mechanism
kruppel-like factor 4 is a mediator of proinflammatory signaling in macrophages
the carboxyl-terminal segment of the adaptor protein alx directs its nuclear export during t cell activation
t cells gene-engineered with dap12 mediate effector function in an nkg2d-dependent and major histocompatibility complex-independent manner
rhythmic expression of adenylyl cyclase vi contributes to the differential regulation of serotonin n-acetyltransferase by bradykinin in rat pineal glands
escherichia coli rna polymerase contacts outside the -10 promoter element are not essential for promoter melting
identification of the interface between cgmp-dependent protein kinase i and its interaction partners tfii-i and irag reveals a common interaction motif
regulation of the pancreatic duodenal homeobox-1 protein by dna-dependent protein kinase
specific role for yeast homologs of the diamond blackfan anemia-associated rps19 protein in ribosome synthesis
loss of editing activity during the evolution of mitochondrial phenylalanyl-trna synthetase
an energy-dependent maturation step is required for release of the cystic fibrosis transmembrane conductance regulator from early endoplasmic reticulum biosynthetic..
-arrestin mediates desensitization and internalization but does not affect dephosphorylation of the thyrotropin-releasing hormone receptor
an fmn hydrolase is fused to a riboflavin kinase homolog in plants
expression of human ctp synthetase in saccharomyces cerevisiae reveals phosphorylation by protein kinase a
distinct mechanisms of glucose lowering by specific agonists for peroxisomal proliferator activated receptor and retinoic acid x receptors
degree of polymerization (dp) of polysialic acid (polysia) on neural cell adhesion molecules (n-cams)
differential expression of cd45 isoforms is controlled by the combined activity of basal and inducible splicing-regulatory elements in each of the variable exons
glycerophosphocholine catabolism as a new route for choline formation for phosphatidylcholine synthesis by the kennedy pathway
essential roles of the bcl-2 family of proteins in caspase-2-induced apoptosis
coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase a/camp-response element-binding protein (creb) and epac1-rap1 sig..
interactions between areas i and ii direct pdx-1 expression specifically to islet cell types of the mature and developing pancreas
a urokinase-type plasminogen activator-inhibiting cyclic peptide with an unusual p2 residue and an extended protease binding surface demonstrates new modalities for..
adaptor protein arh is recruited to the plasma membrane by low density lipoprotein (ldl) binding and modulates endocytosis of the ldl/ldl receptor complex in hepato..
cholecystokinin levels in prohormone convertase 2 knock-out mouse brain regions reveal a complex phenotype of region-specific alterations
glucose 6-phosphate release of wild-type and mutant human brain hexokinases from mitochondria
functional interaction of phospholipid hydroperoxide glutathione peroxidase with sperm mitochondrion-associated cysteine-rich protein discloses the adjacent cystein..
biochemical and functional characterization of membrane blebs purified from neisseria meningitidis serogroup b
the c terminus of hiv-1 tat modulates the extent of cd178-mediated apoptosis of t cells
phosphorylation of chk1 by atm- and rad3-related (atr) in xenopus egg extracts requires binding of atrip to atr but not the stable dna-binding or coiled-coil domain..
recruitment of nuclear factor y to the inverted ccaat element (ice) by c-jun and e1a stimulates basal transcription of the bone sialoprotein gene in osteosarcoma ce..
a general model for preferential hetero-oligomerization of lin-2/7 domains
membrane-bound conformation of m13 major coat protein
novel glycosidic linkage in aedes aegypti chorion peroxidase
ca2+ dysregulation induces mitochondrial depolarization and apoptosis
bacterial cell killing mediated by topoisomerase i dna cleavage activity
endogenous unsaturated c18 n-acylethanolamines are vanilloid receptor (trpv1) agonists
structural determinants of l-type channel activation in segment iis6 revealed by a retinal disorder
a role for the distal carboxyl tails in generating the novel pharmacology and g protein activation profile of µ and opioid receptor hetero-oligomers
the glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase, triose-phosphate isomerase, and pyruvate kinase are components of the katp channel macromolecular ..
higher plant plastids and cyanobacteria have folate carriers related to those of trypanosomatids
conjugated linoleic acid promotes human adipocyte insulin resistance through nfb-dependent cytokine production
the saccharomyces cerevisiae sae2 protein promotes resection and bridging of double strand break ends
nherf2/sip-1 interacts with mouse sry via a different mechanism than human sry
why is quinidine an inhibitor of cytochrome p450 2d6?
amyloid fibril formation of -synuclein is accelerated by preformed amyloid seeds of other proteins
x-linked inhibitor of apoptosis (xiap) inhibits c-jun n-terminal kinase 1 (jnk1) activation by transforming growth factor 1 (tgf-1) through ubiquitin-mediated prote..
the elongated first fibronectin type iii domain of collagen xiv is an inducer of quiescence and differentiation in fibroblasts and preadipocytes
a novel role for gadd45 as a mediator of mmp-13 gene expression during chondrocyte terminal differentiation
phenylalanine side chain behavior of the intestinal fatty acid-binding protein
structural basis of cellulosome efficiency explored by small angle x-ray scattering
evolution of constrained gonadotropin-releasing hormone ligand conformation and receptor selectivity
specific sequences in the n and c termini of apolipoprotein a-iv modulate its conformation and lipid association
a novel galectin-like domain from toxoplasma gondii micronemal protein 1 assists the folding, assembly, and transport of a cell adhesion complex
carboxyl ester lipase expression in macrophages increases cholesteryl ester accumulation and promotes atherosclerosis
identification of the critical residues involved in peptidoglycan detection by nod1
tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression
toll-like receptor 4 signaling regulates cytosolic phospholipase a2 activation and lipid generation in lipopolysaccharide-stimulated macrophages
kinetic mechanism of myosin ixb and the contributions of two class ix-specific regions
binding of the global response regulator protein covr to the sag promoter of streptococcus pyogenes reveals a new mode of covr-dna interaction
methyltransferase erm(37) slips on rrna to confer atypical resistance in mycobacterium tuberculosis
molecular cloning and characterization of the human akt1 promoter uncovers its up-regulation by the src/stat3 pathway
isozyme-specific stimulation of phospholipase c-2 by rac gtpases
activation of a methylated promoter mediated by a sequence-specific dna-binding protein, rfx
interaction between the androgen receptor and rnase l mediates a cross-talk between the interferon and androgen signaling pathways
peptide mapping of bacterial fimbrial epitopes interacting with pattern recognition receptors
histone acetylation-independent effect of histone deacetylase inhibitors on akt through the reshuffling of protein phosphatase 1 complexes
a three-dimensional working model of the multienzyme complex of aminoacyl-trna synthetases based on electron microscopic placements of trna and proteins
nucleocytoplasmic shuttling of the splicing factor sipp1
disease-related prion protein forms aggresomes in neuronal cells leading to caspase activation and apoptosis
construction and characterization of genetically modified synechocystis sp. pcc 6803 photosystem ii core complexes containing carotenoids with shorter -conjugation ..
the 9-1-1 checkpoint clamp physically interacts with pol and is partially required for spontaneous pol-dependent mutagenesis in saccharomyces cerevisiae
annexin ii light chain p11 promotes functional expression of acid-sensing ion channel asic1a
regulation of the cytoplasmic quality control protein degradation pathway by bag2
recognition and ubiquitination of salmonella type iii effector sopa by a ubiquitin e3 ligase, hsrma1
metabolic response of mice to a postnatal ablation of ccaat/enhancer-binding protein
transcriptional repression of peroxisome proliferator-activated receptor / in murine keratinocytes by ccaat/enhancer-binding proteins
the cgl2612 protein from corynebacterium glutamicum is a drug resistance-related transcriptional repressor
acute glutathione depletion restricts mitochondrial atp export in cerebellar granule neurons
hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing bax translocation
the position 68(e11) side chain in myoglobin regulates ligand capture, bond formation with heme iron, and internal movement into the xenon cavities
on the relationships of substrate orientation, hydrogen abstraction, and product stereochemistry in single and double dioxygenations by soybean lipoxygenase-1 and i..
structural analysis of a hamp domain
a new type of sulfite reductase, a novel coenzyme f420-dependent enzyme, from the methanarchaeon methanocaldococcus jannaschii
distinct regulatory elements mediate similar expression patterns in the excretory cell of caenorhabditis elegans
structural details on mdm2-p53 interaction
molecular basis of cysteine biosynthesis in plants
histone h4-lysine 20 monomethylation is increased in promoter and coding regions of active genes and correlates with hyperacetylation
crystal structure of the first kh domain of human poly(c)-binding protein-2 in complex with a c-rich strand of human telomeric dna at 1.7 å
crystal structure of glucooligosaccharide oxidase from acremonium strictum
human topoisomerase ii rapidly relaxes positively supercoiled dna
mapping chemical gradients within and along a fibrous structural tissue, mussel byssal threads
critical role of protein kinase c ii in activation of mast cells by monomeric ige
phorbol ester-induced apoptosis in prostate cancer cells via autocrine activation of the extrinsic apoptotic cascade
knockdown of glutamate-cysteine ligase by small hairpin rna reveals that both catalytic and modulatory subunits are essential for the survival of primary neurons
accumulation of mutant 1-antitrypsin z in the endoplasmic reticulum activates caspases-4 and -12, nfb, and bap31 but not the unfolded protein response
gata-1 and oct-1 are required for expression of the human -hemoglobin-stabilizing protein gene
nitric oxide scavenging by red blood cells as a function of hematocrit and oxygenation
amp-activated protein kinase 2 activity is not essential for contraction- and hyperosmolarity-induced glucose transport in skeletal muscle
radixin stimulates rac1 and ca2+/calmodulin-dependent kinase, camkii
the p2y2 nucleotide receptor interacts with v integrins to activate go and induce cell migration
tyrosine 740 phosphorylation of discoidin domain receptor 2 by src stimulates intramolecular autophosphorylation and shc signaling complex formation
atg19p ubiquitination and the cytoplasm to vacuole trafficking pathway in yeast
a dual function for seca in the assembly of single spanning membrane proteins in escherichia coli
the integrase of the long terminal repeat-retrotransposon tf1 has a chromodomain that modulates integrase activities
long-patch base excision dna repair of 2-deoxyribonolactone prevents the formation of dna-protein cross-links with dna polymerase
truncation of the lipopolysaccharide outer core affects susceptibility to antimicrobial peptides and virulence of actinobacillus pleuropneumoniae serotype 1
recognition of sulfation pattern of chondroitin sulfate by uronosyl 2-o-sulfotransferase
functional comparison between secretory pathway ca2+/mn2+-atpase (spca) 1 and sarcoplasmic reticulum ca2+-atpase (serca) 1 isoforms by steady-state and transient ki..
sap1p binds to ter1 at the ribosomal dna of schizosaccharomyces pombe and causes polar replication fork arrest
domain unfolding plays a role in superfibronectin formation
family members p53 and p73 act together in chromatin modification and direct repression of -fetoprotein transcription
regulation of epithelial na+ channel activity by conserved serine/threonine switches within sorting signals
isoforms of cyclic nucleotide phosphodiesterase pde3 and their contribution to camp hydrolytic activity in subcellular fractions of human myocardium
slp4-a/granuphilin-a interacts with syntaxin-2/3 in a munc18-2-dependent manner
phosphatidylinositol 4,5-bisphosphate rescues trpm4 channels from desensitization
a mode of assembly of p0, p1, and p2 proteins at the gtpase-associated center in animal ribosome
mj0917 in archaeon methanococcus jannaschii is a novel nadp phosphatase/nad kinase
c-terminal tail residue arg1400 enables nadph to regulate electron transfer in neuronal nitric-oxide synthase
the ras/raf-1/mek1/erk signaling pathway coupled to integrin expression mediates cholinergic regulation of keratinocyte directional migration
a dual upstream open reading frame-based autoregulatory circuit controlling polyamine-responsive translation
glycine metabolism in intact leaves by in vivo 13c and 15n labeling
depletion of chk1 leads to premature activation of cdc2-cyclin b and mitotic catastrophe
the c2b domain of rabphilin directly interacts with snap-25 and regulates the docking step of dense core vesicle exocytosis in pc12 cells
binding site characterization and resistance to a class of non-nucleoside inhibitors of the hepatitis c virus ns5b polymerase
saitohin, which is nested in the tau locus and confers allele-specific susceptibility to several neurodegenerative diseases, interacts with peroxiredoxin 6
erythropoietin promotes mcf-7 breast cancer cell migration by an erk/mitogen-activated protein kinase-dependent pathway and is primarily responsible for the increas..
molecular requirements for rna-induced silencing complex assembly in the drosophila rna interference pathway
a multifunctional shuttling protein nucleolin is a macrophage receptor for apoptotic cells
negative regulation of monocyte adhesion to arterial elastic laminae by signal regulatory protein and src homology 2 domain-containing protein-tyrosine phosphatase-1
triadin (trisk 95) overexpression blocks excitation-contraction coupling in rat skeletal myotubes
thrombomodulin-independent activation of protein c and specificity of hemostatically active snake venom serine proteinases
differential modulation of ca2+/calmodulin-dependent protein kinase ii activity by regulated interactions with n-methyl-d-aspartate receptor nr2b subunits and -acti..
self-association of transmembrane -helices in model membranes
5-aminoimidazole-4-carboxamide-1--d-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via amp-activated protein kinase
cysteine-scanning mutagenesis and substituted cysteine accessibility analysis of transmembrane segment 4 of the glut1 glucose transporter
catalytic activation of the plant mapk phosphatase ntmkp1 by its physiological substrate salicylic acid-induced protein kinase but not by calmodulins
attenuating lymphocyte activity
insights from the x-ray crystal structure of coral 8r-lipoxygenase
focal adhesion kinase signaling regulates cardiogenesis of embryonic stem cells
the neurofibromatosis type 1 gene product neurofibromin enhances cell motility by regulating actin filament dynamics via the rho-rock-limk2-cofilin pathway
differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues sppl2b and sppl3
redox regulation of the nutrient-sensitive raptor-mtor pathway and complex
elucidation of the substrate specificity of the c1s protease of the classical complement pathway
a highly conserved arginine in gp120 governs hiv-1 binding to both syndecans and ccr5 via sulfated motifs
mitochondrial manganese-superoxide dismutase expression in ovarian cancer
a novel arabidopsis gene causes bax-like lethality in saccharomyces cerevisiae
rac1 is essential for platelet lamellipodia formation and aggregate stability under flow
fas-, caspase 8-, and caspase 3-dependent signaling regulates the activity of the aminophospholipid translocase and phosphatidylserine externalization in human eryt..
repair of methylation damage in dna and rna by mammalian alkb homologues
microspherule protein 1, mi-2, and ret finger protein associate in the nucleolus and up-regulate ribosomal gene transcription
novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (trpm8) in the activation of store-operated channels in lncap human pr..
whole-cell voltage clamp measurements of anthrax toxin pore current
biologically active novel conformational state of botulinum, the most poisonous poison
angiotensin-converting enzyme 2 (ace2), but not ace, is preferentially localized to the apical surface of polarized kidney cells
kinetic and physical characterization of the inducible udp-n-acetylglucosamine pyrophosphorylase from giardia intestinalis
activation of wild type p53 function by its mortalin-binding, cytoplasmically localizing carboxyl terminus peptides
lipid peroxidation induces cholesterol domain formation in model membranes
phosphatase and tensin homolog regulation of islet growth and glucose homeostasis
catalytic degradation of vitamin d up-regulated protein 1 mrna enhances cardiomyocyte survival and prevents left ventricular remodeling after myocardial ischemia
nitric oxide induces timp-1 expression by activating the transforming growth factor -smad signaling pathway
vertebrate myosin viib is a high duty ratio motor adapted for generating and maintaining tension
purification of atp-binding cassette transporter a1 and associated binding proteins reveals the importance of 1-syntrophin in cholesterol efflux
x-ray crystallographic analysis of 6-aminohexanoate-dimer hydrolase
functional analysis of conserved polar residues in vc-nhad, na+/h+ antiporter of vibrio cholerae
modulation of werner syndrome protein function by a single mutation in the conserved recq domain
nox4 nad(p)h oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney
wfs1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic -cells
importin kpna2 is required for proper nuclear localization and multiple functions of nbs1
solution structures and backbone dynamics of arsenate reductase from bacillus subtilis
polo-like kinase 1-mediated phosphorylation stabilizes pin1 by inhibiting its ubiquitination in human cells
stabilization of hypoxia-inducible factor-1 by prostacyclin under prolonged hypoxia via reducing reactive oxygen species level in endothelial cells
rip1 mediates the trif-dependent toll-like receptor 3- and 4-induced nf-b activation but does not contribute to interferon regulatory factor 3 activation
proprotein covertases are responsible for proteolysis and inactivation of endothelial lipase
regulation of fish gill na+-k+-atpase by selective sulfatide-enriched raft partitioning during seawater adaptation
iso-1 binding to the tautomerase active site of mif inhibits its pro-inflammatory activity and increases survival in severe sepsis
the incorporation of glucosamine into enterobacterial core lipopolysaccharide
-globin gene expression in chemical inducer of dimerization (cid)-dependent multipotential cells established from human -globin locus yeast artificial chromosome (-..
sequence determinants for the reaction specificity of murine (12r)-lipoxygenase
an activin-a/c chimera exhibits activin and myostatin antagonistic properties
domain exchange between human toll-like receptors 1 and 6 reveals a region required for lipopeptide discrimination
role of group a p21-activated kinases in activation of extracellular-regulated kinase by growth factors
diabetes alters the occupancy of the hepatic 3-hydroxy-3-methylglutaryl-coa reductase promoter
inducible dimerization of ret reveals a specific akt deregulation in oncogenic signaling
involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu
the tagb protein in bacillus subtilis 168 is an intracellular peripheral membrane protein that can incorporate glycerol phosphate onto a membrane-bound acceptor in ..
two conserved histidine residues are critical to the function of the tagf-like family of enzymes
regulation of the sphingoid long-chain base kinase lcb4p by ergosterol and heme
role of p73 in regulating human caspase-1 gene transcription induced by interferon- and cisplatin
binding of escherichia coli hemolysin and activation of the target cells is not receptor-dependent
evidence for the regulatory role of the n-terminal helix of secretory phospholipase a2 from studies on native and chimeric proteins
the short apical membrane half-life of rescued f508-cystic fibrosis transmembrane conductance regulator (cftr) results from accelerated endocytosis of f508-cftr in ..
thermoglobin, oxygen-avid hemoglobin in a bacterial hyperthermophile
functional characterization of the c-terminal domain of the cytochrome c maturation protein ccme
the essential role of mekk3 signaling in angiotensin ii-induced calcineurin/nuclear factor of activated t-cells activation
the binding site in 2-glycoprotein i for apoer2‘ on platelets is located in domain v
reconstitution and characterization of aminopyrrolnitrin oxygenase, a rieske n-oxygenase that catalyzes unusual arylamine oxidation
nod1 participates in the innate immune response to pseudomonas aeruginosa
pasteurella multocida toxin-induced activation of rhoa is mediated via two families of g proteins, gq and g12/13
the glycolytic metabolite methylglyoxal activates pap1 and sty1 stress responses in schizosaccharomyces pombe
molecular structure of saccharomyces cerevisiae gal1p, a bifunctional galactokinase and transcriptional inducer
a -secretase-independent mechanism of signal transduction by the amyloid precursor protein
familial danish dementia
two functional active conformations of the integrin 21, depending on activation condition and cell type
sphingosine kinase 2 is required for modulation of lymphocyte traffic by fty720
the q-loop disengages from the first intracellular loop during the catalytic cycle of the multidrug abc transporter bmra
a single aromatic amino acid at the carboxyl terminus of helicobacter pylori 1,3/4 fucosyltransferase determines substrate specificity
a malaria parasite-encoded vacuolar h+-atpase is targeted to the host erythrocyte
o2- and h2o2-dependent verdoheme degradation by heme oxygenase
in vitro studies of cross-resistance mutations against two hepatitis c virus serine protease inhibitors, vx-950 and biln 2061
anthocyanins induce cholesterol efflux from mouse peritoneal macrophages
structural and genetic analyses reveal a key role in prophage excision for the tori response regulator inhibitor
high pressure enhances hexacoordination in neuroglobin and other globins
lipids as modulators of proteolytic activity of bace
dopamine d2-like receptors are expressed in pancreatic beta cells and mediate inhibition of insulin secretion
macromolecular translocation inhibitor ii (zn2+-binding protein, parathymosin) interacts with the glucocorticoid receptor and enhances transcription in vivo
structural and functional separation of the n- and c-terminal domains of the yeast v-atpase subunit h
recycling of cell surface pro-transforming growth factor- regulates epidermal growth factor receptor activation
gtp cyclohydrolase ii structure and mechanism
analysis of u1 small nuclear rna interaction with cyclin h
identification of intra- and intermolecular disulfide bridges in the multidrug resistance transporter abcg2
interaction of the epstein-barr virus mrna export factor eb2 with human spen proteins sharp, ott1, and a novel member of the family, ott3, links spen proteins with ..
the v-snare vti1a regulates insulin-stimulated glucose transport and acrp30 secretion in 3t3-l1 adipocytes
phosphatidylinositol 3-kinase is required for rhinovirus-induced airway epithelial cell interleukin-8 expression
the residue mass of l-pyrrolysine in three distinct methylamine methyltransferases
inactivation of organellar glutamyl- and seryl-trna synthetases leads to developmental arrest of chloroplasts and mitochondria in higher plants
converting a -glycosidase into a -transglycosidase by directed evolution
translocation by the recb motor is an absolute requirement for -recognition and reca protein loading by recbcd enzyme
bipolar dna translocation contributes to highly processive dna unwinding by recbcd enzyme
kinetic effects of kinesin switch i and switch ii mutations
alternating site atpase pathway of rat conventional kinesin
nucleotide-dependent domain movement in the atpase domain of a human type iia dna topoisomerase
recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stres..
interleukin-8-induced priming of neutrophil oxidative burst requires sequential recruitment of nadph oxidase components into lipid rafts
calindol, a positive allosteric modulator of the human ca2+ receptor, activates an extracellular ligand-binding domain-deleted rhodopsin-like seven-transmembrane st..
ryanodine receptor type 1 (ryr1) mutations c4958s and c4961s reveal excitation-coupled calcium entry (ecce) is independent of sarcoplasmic reticulum store depletion
selective recognition of synthetic lysine and meso-diaminopimelic acid-type peptidoglycan fragments by human peptidoglycan recognition proteins i and s
irradiation-induced translocation of p53 to mitochondria in the absence of apoptosis
the mechanism of copper uptake mediated by human ctr
structure of the prion ure2p in protein fibrils assembled in vitro
nuclear import of b-crystallin is phosphorylation-dependent and hampered by hyperphosphorylation of the myopathy-related mutant r120g
cholesterol-dependent syntaxin-4 and snap-23 clustering regulates caveolar fusion with the endothelial plasma membrane
sphk1 and sphk2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism
tlr3 and tlr7 are targeted to the same intracellular compartments by distinct regulatory elements
dissection of merozoite surface protein 3, a representative of a family of plasmodium falciparum surface proteins, reveals an oligomeric and highly elongated molecule
dopamine receptor oligomerization visualized in living cells
mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod
characterization of a human core-specific lysosomal 1,6-mannosidase involved in n-glycan catabolism
inhibitory interaction of the 14-3-3 protein with isoform 4 of the plasma membrane ca2+-atpase pump
sugar-binding properties of vip36, an intracellular animal lectin operating as a cargo receptor
f110i and r278c troponin t mutations that cause familial hypertrophic cardiomyopathy affect muscle contraction in transgenic mice and reconstituted human cardiac fi..
properties of synaptic vesicle pools in mature central nerve terminals
galectin-1 interacts with the 51 fibronectin receptor to restrict carcinoma cell growth via induction of p21 and p27
role of an s4-s5 linker lysine in the trafficking of the ca2+-activated k+ channels ik1 and sk3
structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin
dc-sign mediates binding of dendritic cells to authentic pseudo-lewisy glycolipids of schistosoma mansoni cercariae, the first parasite-specific ligand of dc-sign
superoxide generation from mitochondrial nadh dehydrogenase induces self-inactivation with specific protein radical formation
overexpression of glutamate-cysteine ligase extends life span in drosophila melanogaster
characterization of the condensin component cnap1 and protein kinase melk as novel e2f target genes down-regulated by 1,25-dihydroxyvitamin d3
murine -herpesvirus 68 latency protein m2 binds to vav signaling proteins and inhibits b-cell receptor-induced cell cycle arrest and apoptosis in wehi-231 b cells
tgl4p and tgl5p, two triacylglycerol lipases of the yeast saccharomyces cerevisiae are localized to lipid particles
a family portrait of the rio kinases
phosphodiesterase activity of alkaline phosphatase in atp-initiated ca2+ and phosphate deposition in isolated chicken matrix vesicles
购买 收藏 投稿
关于我们 | 网站声明 | 刊社管理 | 网站地图 | 联系方式 | 中图分类法 | RSS 2.0订阅 | IP查询
全刊赏析网 2018