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diverse biochemical properties of shp2 mutants
familial mutants of -synuclein with increased neurotoxicity have a destabilized conformation
schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin d1
identification of binding sites of evi1 in mammalian cells
disruption of lipid rafts inhibits p2x1 receptor-mediated currents and arterial vasoconstriction
molecular organization of target of rapamycin complex 2
cooperative interactions between activating transcription factor 4 and runx2/cbfa1 stimulate osteoblast-specific osteocalcin gene expression
negative transcriptional modulation and silencing of the bi-exonic rnf35 gene in the preimplantation embryo
nonfixed relationship of the michaelis constant and maximum velocity with their corresponding rate constants
effects of mutagenesis in the switch i region and conserved arginines of escherichia coli mnme protein, a gtpase involved in trna modification
positive regulation of sugar catabolic pathways in the cyanobacterium synechocystis sp. pcc 6803 by the group 2 factor sige
secretase-dependent tyrosine phosphorylation of mdm2 by the erbb-4 intracellular domain fragment
mitochondrial respiration and atp production are significantly impaired in striatal cells expressing mutant huntingtin
bri2 interacts with amyloid precursor protein (app) and regulates amyloid (a) production
long chain coa esters as competitive antagonists of phosphatidylinositol 4,5-bisphosphate activation in kir channels
increasing mitochondrial substrate-level phosphorylation can rescue respiratory growth of an atp synthase-deficient yeast
the human apoptosis-inducing protein amid is an oxidoreductase with a modified flavin cofactor and dna binding activity
arginine methylation of yeast mrna-binding protein npl3 directly affects its function, nuclear export, and intranuclear protein interactions
activation of the bk (slo1) potassium channel by mallotoxin
localized na+/h+ exchanger 1 expression protects ca2+-regulated adenylyl cyclases from changes in intracellular ph
peptidoglycan n-acetylglucosamine deacetylases from bacillus cereus, highly conserved proteins in bacillus anthracis
cooperative interactions between runx2 and homeodomain protein-binding sites are critical for the osteoblast-specific expression of the bone sialoprotein gene
vaccinia virus protein a52r activates p38 mitogen-activated protein kinase and potentiates lipopolysaccharide-induced interleukin-10
identification and characterization of a cyclic di-gmp-specific phosphodiesterase and its allosteric control by gtp
angiotensin ii inhibits btrek-1 k+ channels in adrenocortical cells by separate ca2+- and atp hydrolysis-dependent mechanisms
cysteine-scanning mutagenesis of serotonin transporter intracellular loop 2 suggests an -helical conformation
phenotypic and biochemical analyses of bace1- and bace2-deficient mice
calmodulin and calcium interplay in the modulation of trpc5 channel activity
the groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins msx1 and oct1
s-adenosylmethionine blocks collagen i production by preventing transforming growth factor- induction of the col1a2 promoter
two different zinc transport complexes of cation diffusion facilitator proteins localized in the secretory pathway operate to activate alkaline phosphatases in vert..
multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7
identifying and engineering ion pairs in adenylate kinases
loop 1 of transducer region in mammalian class i myosin, myo1b, modulates actin affinity, atpase activity, and nucleotide access
the synthetic peptide derived from the nh2-terminal extracellular region of an orphan g protein-coupled receptor, gpr1, preferentially inhibits infection of x4 hiv-1
mutations in human cardiac troponin i that are associated with restrictive cardiomyopathy affect basal atpase activity and the calcium sensitivity of force developm..
the n-terminal module of thrombospondin-1 interacts with the link domain of tsg-6 and enhances its covalent association with the heavy chains of inter--trypsin inhi..
the association of the antenna system to photosystem i in higher plants
crystal structure of a novel fad-, fmn-, and atp-containing l-proline dehydrogenase complex from pyrococcus horikoshii
the platelet-derived growth factor receptor- phosphorylates and activates g protein-coupled receptor kinase-
motion of carboxyl terminus of g is restricted upon g protein activation
role of phospholipase c- domains in ca2+-dependent phosphatidylinositol 4,5-bisphosphate hydrolysis and cytoplasmic ca2+ oscillations
mechanism of redox-mediated guanine nucleotide exchange on redox-active rho gtpases
regulation of p21-activated kinase-independent rac1 signal transduction by nischarin
involvement of intracellular ca2+ levels in nonsteroidal anti-inflammatory drug-induced apoptosis
arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (hif)-1 and is not induced by hypoxia or hif
the reaction between nitrite and deoxyhemoglobin
focal adhesion kinase plays a pivotal role in herpes simplex virus entry
atypical protein kinase c plays a critical role in human lung cancer cell growth and tumorigenicity
the farnesyl transferase inhibitor (fti) sch66336 (lonafarnib) inhibits rheb farnesylation and mtor signaling
protein phosphatase 2a regulates apoptosis in intestinal epithelial cells
peptide blockers of the inhibition of neuronal nicotinic acetylcholine receptors by amyloid
differential effects of lipoprotein lipase on tumor necrosis factor- and interferon--mediated gene expression in human endothelial cells
the rise and fall of the chemoattractant receptor gpr33
crystal structure of pyridoxal kinase in complex with roscovitine and derivatives
roscovitine targets, protein kinases and pyridoxal kinase
preponderance of free mediator in the yeast saccharomyces cerevisiae
the prp19-associated complex is required for specifying interactions of u5 and u6 with pre-mrna during spliceosome activation
radiation-induced epidermal growth factor receptor nuclear import is linked to activation of dna-dependent protein kinase
transforming growth factor-1-induced expression of smooth muscle marker genes involves activation of pkn and p38 mapk
structural and functional studies of interaction between plasmodium falciparum knob-associated histidine-rich protein (kahrp) and erythrocyte spectrin
multiple signals induce endoplasmic reticulum stress in both primary and immortalized chondrocytes resulting in loss of differentiation, impaired cell growth, and a..
crystal structure of the yersinia enterocolitica type iii secretion chaperone syct
p53-dependent caspase-2 activation in mitochondrial release of apoptosis-inducing factor and its role in renal tubular epithelial cell injury
mechanism of the maturation process of sars-cov 3cl protease
crystal structure of the actinomadura r39 dd-peptidase reveals new domains in penicillin-binding proteins
nuclear dna helicase ii (rna helicase a) interacts with werner syndrome helicase and stimulates its exonuclease activity
interplay of ca2+ and camp signaling in the insulin-secreting min6 -cell line
a ligand-mediated hydrogen bond network required for the activation of the mineralocorticoid receptor
bmp-2 and insulin-like growth factor-i mediate osterix (osx) expression in human mesenchymal stem cells via the mapk and protein kinase d signaling pathways
phosphorylation of the a-kinase-anchoring protein yotiao contributes to protein kinase a regulation of a heart potassium channel
the common a467t mutation in the human mitochondrial dna polymerase (polg) compromises catalytic efficiency and interaction with the accessory subunit
reduced n-acetylaspartate levels in mice lacking aralar, a brain- and muscle-type mitochondrial aspartate-glutamate carrier
apoplastic calmodulin receptor-like binding proteins in suspension-cultured cells of arabidopsis thaliana
15(s)-lipoxygenase-2 mediates arachidonic acid-stimulated adhesion of human breast carcinoma cells through the activation of tak1, mkk6, and p38 mapk
conversion of acetaminophen to the bioactive n-acylphenolamine am404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system
atrip oligomerization is required for atr-dependent checkpoint signaling
xcpx controls biogenesis of the pseudomonas aeruginosa xcpt-containing pseudopilus
evidence that phosphorylation of the rna polymerase ii carboxyl-terminal repeats is similar in yeast and humans
structural requirements for signal-induced target binding of fadd determined by functional reconstitution of fadd deficiency
suppression of urokinase expression and invasion by a soybean kunitz trypsin inhibitor are mediated through inhibition of src-dependent signaling pathways
presenilins mediate phosphatidylinositol 3-kinase/akt and erk activation via select signaling receptors
interferon induces nf-b-inducing kinase/tumor necrosis factor receptor-associated factor-dependent nf-b activation to promote cell survival
phosphorylation of ftdp-17 mutant tau by cyclin-dependent kinase 5 complexed with p35, p25, or p39
socs1 deficiency enhances hepatic insulin signaling
heparin regulates vascular endothelial growth factor165-dependent mitogenic activity, tube formation, and its receptor phosphorylation of human endothelial cells
recognition of saccharides by the opca, opad, and opab outer membrane proteins from neisseria meningitidis
mechanisms of socs3 phosphorylation upon interleukin-6 stimulation
ezh2 and histone 3 trimethyl lysine 27 associated with il4 and il13 gene silencing in th1 cells
regulatory mechanism of histidine-tagged homocitrate synthase from saccharomyces cerevisiae
dna polymerase protects mouse fibroblasts against oxidative dna damage and is recruited to sites of dna damage/repair
o-glycosylation of the tail domain of neurofilament protein m in human neurons and in spinal cord tissue of a rat model of amyotrophic lateral sclerosis (als)
crystallographic study on the dioxygen complex of wild-type and mutant cytochrome p450cam
a combinatorial code for the interaction of -synuclein with membranes
the plastid division protein atmind1 is a ca2+-atpase stimulated by atmine1
mouse and human resistins impair glucose transport in primary mouse cardiomyocytes, and oligomerization is required for this biological action
hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the nadph-cytochrome p450 reductase gene
the phosphoinositide-3-phosphatase mtmr2 associates with mtmr13, a membrane-associated pseudophosphatase also mutated in type 4b charcot-marie-tooth disease
a role for gz in pancreatic islet -cell biology
ser-557-phosphorylated mcry2 is degraded upon synergistic phosphorylation by glycogen synthase kinase-3
multiple gtf2i-like repeats of general transcription factor 3 exhibit dna binding properties
ubiquitin manipulation by an e2 conjugating enzyme using a novel covalent intermediate
microtubule-independent and protein kinase a-mediated function of kinesin kif17b controls the intracellular transport of activator of crem in testis (act)
-amyloid-induced dynamin 1 depletion in hippocampal neurons
a novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen
p300/cbp-associated factor drives dek into interchromatin granule clusters
specific patterns of electrophile adduction trigger keap1 ubiquitination and nrf2 activation
an electron-sharing network involved in the catalytic mechanism is functionally conserved in different glutathione transferase classes
depletion of anaphase-promoting complex or cyclosome (apc/c) subunit homolog apc1 or cdc27 of trypanosoma brucei arrests the procyclic form in metaphase but the blo..
reactivities of quinone-free dsbb from escherichia coli
ra-rhogap, rap-activated rho gtpase-activating protein implicated in neurite outgrowth through rho
intermolecular contact between globular n-terminal fold and c-terminal domain of apoa-i stabilizes its lipid-bound conformation
glycogen synthase kinase-3 interacts with and phosphorylates estrogen receptor and is involved in the regulation of receptor activity
the utrophin a 5‘-untranslated region confers internal ribosome entry site-mediated translational control during regeneration of skeletal muscle fibers
dimerization of doublesex is mediated by a cryptic ubiquitin-associated domain fold
a novel platinum compound inhibits constitutive stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells
oligosaccharide binding to barley -amylase 1
high -secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid- levels
differential membrane localization of eras and rheb, two ras-related proteins involved in the phosphatidylinositol 3-kinase/mtor pathway
modulation of replication protein a function by its hyperphosphorylation-induced conformational change involving dna binding domain b
the molecular architecture of human n-acetylgalactosamine kinase
a synthetic glycosaminoglycan mimetic binds vascular endothelial growth factor and modulates angiogenesis
human telomerase rna template sequence is a determinant of telomere repeat extension rate
glycosylation influences the lectin activities of the macrophage mannose receptor
redox-induced protein structural changes in cytochrome bo revealed by fourier transform infrared spectroscopy and [13c]tyr labeling
mechanistic insights into the isochorismate pyruvate lyase activity of the catalytically promiscuous pchb from combinatorial mutagenesis and selection
expression of an uncleavable n-terminal rasgap fragment in insulin-secreting cells increases their resistance toward apoptotic stimuli without affecting their gluco..
ultrasonication-induced amyloid fibril formation of 2-microglobulin
exploring the binding domain of emre, the smallest multidrug transporter
phosphoinositide 3-kinase signaling to akt promotes keratinocyte differentiation versus death
a novel mechanism of g protein-dependent phosphorylation of vasodilator-stimulated phosphoprotein
reactive site mutations in tissue inhibitor of metalloproteinase-3 disrupt inhibition of matrix metalloproteinases but not tumor necrosis factor--converting enzyme
alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis
prmt8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family
uteroglobin inhibits prostaglandin f2 receptor-mediated expression of genes critical for the production of pro-inflammatory lipid mediators
contribution of nuclear factor of activated t cells c1 to the transcriptional control of immunoreceptor osteoclast-associated receptor but not triggering receptor e..
vacuolar processing enzyme is essential for mycotoxin-induced cell death in arabidopsis thaliana
reconstruction of the conserved -bulge in mammalian defensins using d-amino acids
regulation of actin ring formation by rho gtpases in osteoclasts
perturbations in o-linked -n-acetylglucosamine protein modification cause severe defects in mitotic progression and cytokinesis
possible role of direct rac1-rab7 interaction in ruffled border formation of osteoclasts
protein kinase c-dependent protein kinase d activation modulates erk signal pathway and endothelial cell proliferation by vascular endothelial growth factor
structural organization and zn2+-dependent subdomain interactions involving autoantigenic epitopes in the ring-b-box-coiled-coil (rbcc) region of ro52
activation of peroxisome proliferator-activated receptor / (ppar/) increases the expression of prostaglandin e2 receptor subtype ep
streptococcus pyogenes collagen type i-binding cpa surface protein
lithium chloride increases the production of amyloid- peptide independently from its inhibition of glycogen synthase kinase 3
the absb gene encodes a double strand-specific endoribonuclease that cleaves the read-through transcript of the rpso-pnp operon in streptomyces coelicolor
chemical rescue of i-site cleavage in living cells and in vitro discriminates between the cytomegalovirus protease, assemblin, and its precursor, pul80a
af6 negatively regulates rap1-induced cell adhesion
adhesion and rac1-dependent regulation of biglycan gene expression by transforming growth factor-
brca1 interaction with human papillomavirus oncoproteins
-oxidation of 20-hydroxyeicosatetraenoic acid (20-hete) in cerebral microvascular smooth muscle and endothelium by alcohol dehydrogenase 4
reactive oxygen species induce tyrosine phosphorylation of and src kinase recruitment to no-sensitive guanylyl cyclase
deletion of cg-emb in corynebacterianeae leads to a novel truncated cell wall arabinogalactan, whereas inactivation of cg-ubia results in an arabinan-deficient muta..
structural characterization of calcineurin b homologous protein 1
t-oligo treatment decreases constitutive and uvb-induced cox-2 levels through p53- and nfb-dependent repression of the cox-2 promoter
a new type of bacteriophytochrome acts in tandem with a classical bacteriophytochrome to control the antennae synthesis in rhodopseudomonas palustris
a helical hairpin region of soluble annexin b12 refolds and forms a continuous transmembrane helix at mildly acidic ph
investigating the receptor-independent neuroprotective mechanisms of nicotine in mitochondria
palmitate inhibits insulin gene expression by altering pdx-1 nuclear localization and reducing mafa expression in isolated rat islets of langerhans
interactions with pdz domain proteins pist/gopc and pdzk1 regulate intracellular sorting of the somatostatin receptor subtype 5
ca2+ and calmodulin regulate the binding of filamin a to actin filaments
identification of dicarboxylate carrier slc25a10 as malate transporter in de novo fatty acid synthesis
identification of determinants of ligand binding affinity and selectivity in the prostaglandin d2 receptor crth2
cytoplasmic atp-sensing domains regulate gating of skeletal muscle clc-1 chloride channels
“host tissue damage“ signal atp promotes non-directional migration and negatively regulates toll-like receptor signaling in human monocytes
decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis
free energy contributions to direct readout of a dna sequence
nrf2 controls constitutive and inducible expression of are-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by keap1
structure and biosynthesis of staphyloxanthin from staphylococcus aureus
bace is degraded via the lysosomal pathway
overexpression of nbs1 contributes to transformation through the activation of phosphatidylinositol 3-kinase/akt
a novel binding site in collagen type iii for integrins 11 and 21
dominant negative mechanism underlies autosomal dominant stargardt-like macular dystrophy linked to mutations in elovl4
conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets
probing the mechanism of the mycobacterium tuberculosis -ketoacyl-acyl carrier protein synthase iii mtfabh
temporal-spatial expression and transcriptional regulation of 7 nicotinic acetylcholine receptor by thyroid transcription factor-1 and early growth response factor-..
molecular mechanisms of cation transport by the renal na+-k+-cl- cotransporter
histone deacetylase inhibitors suppress the induction of c-jun and its target genes including cox-2
human high density lipoproteins are platforms for the assembly of multi-component innate immune complexes
interaction of a small heat shock protein of the fission yeast, schizosaccharomyces pombe, with a denatured protein at elevated temperature
feedback regulation of murine pantothenate kinase 3 by coenzyme a and coenzyme a thioesters
genetic inhibition or activation of jnk1/2 protects the myocardium from ischemia-reperfusion-induced cell death in vivo
myelin basic protein-primed t cells of female but not male mice induce nitric-oxide synthase and proinflammatory cytokines in microglia
allelic expression imbalance of human mu opioid receptor (oprm1) caused by variant a118g
glucose uptake via glucose transporter 3 by human platelets is regulated by protein kinase b
maintenance of the keratocyte phenotype during cell proliferation stimulated by insulin
regulation of cdc2p and cdc13p is required for cell cycle arrest induced by defective rna splicing in fission yeast
substituted cysteine accessibility of the third transmembrane domain of the creatine transporter
cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins
a b12-responsive internal ribosome entry site (ires) element in human methionine synthase
interaction between constitutively expressed heat shock protein, hsc 70, and cysteine string protein is important for cortical granule exocytosis in xenopus oocytes
differentiation-dependent up-regulation of intestinal thiamin uptake
cyclic gmp-dependent protein kinase regulates ccaat enhancer-binding protein functions through inhibition of glycogen synthase kinase-3
shp2 is required for protein kinase c-dependent phosphorylation of serine 307 in insulin receptor substrate-1
alternative splicing of type ii procollagen exon 2 is regulated by the combination of a weak 5‘ splice site and an adjacent intronic stem-loop cis element
differential regulation of cdp/cux p110 by cyclin a/cdk2 and cyclin a/cdk1
identification of factor xa residues critical for interaction with protein z-dependent protease inhibitor
subunit architecture of the conserved oligomeric golgi complex
genetic analysis of the subunit organization and function of the conserved oligomeric golgi (cog) complex
group v secretory phospholipase a2-modified low density lipoprotein promotes foam cell formation by a sr-a- and cd36-independent process that involves cellular prot..
the conformation of a signal peptide bound by escherichia coli preprotein translocase seca
how family 26 glycoside hydrolases orchestrate catalysis on different polysaccharides
rack1 binds to a signal transfer region of g and inhibits phospholipase c 2 activation
characterization of symmetric complexes of nerve growth factor and the ectodomain of the pan-neurotrophin receptor, p75ntr
sequence-dependent cleavage site selection by rnase z from the cyanobacterium synechocystis sp. pcc 6803
uncoupling proteins 2 and 3 function in concert to augment tolerance to cardiac ischemia
leukotriene a4 hydrolase, insights into the molecular evolution by homology modeling and mutational analysis of enzyme from saccharomyces cerevisiae
glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic -cells
polypeptide substrate recognition by calnexin requires specific conformations of the calnexin protein
structural insights into sulfite oxidase deficiency
anillin is a substrate of anaphase-promoting complex/cyclosome (apc/c) that controls spatial contractility of myosin during late cytokinesis
the hepatitis b virus x protein sensitizes hepg2 cells to uv light-induced dna damage
insulin and angiotensin ii induce the translocation of scavenger receptor class b, type i from intracellular sites to the plasma membrane of adipocytes
cyclic amp-mediated regulation of transcription factor lot1 expression in cerebellar granule cells
salt-dependent intra- and internucleosomal interactions of the h3 tail domain in a model oligonucleosomal array
induction of androgen receptor expression by phosphatidylinositol 3-kinase/akt downstream substrate, foxo3a, and their roles in apoptosis of lncap prostate cancer c..
subtype-selective interaction with the transcription factor ccaat/enhancer-binding protein (c/ebp) homologous protein (chop) regulates cell surface expression of ga..
fate of a larch unedited trna precursor expressed in potato mitochondria
rpgr-orf15, which is mutated in retinitis pigmentosa, associates with smc1, smc3, and microtubule transport proteins
peroxisome proliferator-activated receptor- co-activator 1-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mi..
functionally diverse complement of large conductance calcium- and voltage-activated potassium channel (bk) -subunits generated from a single site of splicing
a new functional role of the fibrinogen rgd motif as the molecular switch that selectively triggers integrin iib3-dependent rhoa activation during cell spreading
lmp1 protein from the epstein-barr virus is a structural cd40 decoy in b lymphocytes for binding to traf3
structure of plant photosystem i revealed by theoretical modeling
the anti-apoptotic protein mcl-1 inhibits mitochondrial ca2+ signals
crystal structure of lipoate-protein ligase a from escherichia coli
ultrafast and low barrier motions in the photoreactions of the green fluorescent protein
the elicitation of plant innate immunity by lipooligosaccharide of xanthomonas campestris
trs85 (gsg1), a component of the trapp complexes, is required for the organization of the preautophagosomal structure during selective autophagy via the cvt pathway
stn8 protein kinase in arabidopsis thaliana is specific in phosphorylation of photosystem ii core proteins
dephosphorylation of ser-226 facilitates plasma membrane retention of ntcp
amisyn regulates exocytosis and fusion pore stability by both syntaxin-dependent and syntaxin-independent mechanisms
the import motor of the yeast mitochondrial tim23 preprotein translocase contains two different j proteins, tim14 and mdj2
increased production of functional recombinant human clotting factor ix by baby hamster kidney cells engineered to overexpress vkorc1, the vitamin k 2,3-epoxide-red..
photosystem ii assembly in cp47 mutant of synechocystis sp. pcc 6803 is dependent on the level of chlorophyll precursors regulated by ferrochelatase
cl- interference with the epithelial na+ channel enac
autophagy is required for maintenance of amino acid levels and protein synthesis under nitrogen starvation
tumor necrosis factor receptor 2 (tnfr2) signaling is negatively regulated by a novel, carboxyl-terminal tnfr-associated factor 2 (traf2)-binding site
physical and functional association of c-src and adhesion and degranulation promoting adaptor protein (adap) in osteoclastogenesis in vitro
involvement of transforming growth factor-1 signaling in hypoxia-induced tolerance to glucose starvation
hepatocyte growth factor induces redistribution of p21cip1 and p27kip1 through erk-dependent p16ink4a up-regulation, leading to cell cycle arrest at g1 in hepg2 hep..
identification of n10-substituted phenoxazines as potent and specific inhibitors of akt signaling
tyrosine phosphorylation of ve-cadherin prevents binding of p120- and -catenin and maintains the cellular mesenchymal state
heterotrimeric g protein-independent signaling of a g protein-coupled receptor
plasma membrane residence of hyaluronan synthase is coupled to its enzymatic activity
alteration in location of a conserved gtpase-associated center of the ribosome induced by mutagenesis influences the structure of peptidyltransferase center and act..
akt-mediated valosin-containing protein 97 phosphorylation regulates its association with ubiquitinated proteins
point mutations in the proline-rich region of p22phox are dominant inhibitors of nox1- and nox2-dependent reactive oxygen generation
-crystallin is a target gene of the farnesoid x-activated receptor in human livers
in vivo regulation of acetylcholinesterase insertion at the neuromuscular junction
fibromodulin gene transcription is induced by ultraviolet irradiation, and its regulation is impaired in senescent human fibroblasts
evolutionary trace-based peptides identify a novel asymmetric interaction that mediates oligomerization in nuclear receptors
jak/stat3 pathway is involved in survival of neurons in response to insulin-like growth factor and negatively regulated by suppressor of cytokine signaling-3
angiopoietin-1 attenuates h2o2-induced sek1/jnk phosphorylation through the phosphatidylinositol 3-kinase/akt pathway in vascular endothelial cells
mutations of the pc2 substrate binding pocket alter enzyme specificity
structures of tryptophanyl-trna synthetase ii from deinococcus radiodurans bound to atp and tryptophan
a nima-related protein kinase is essential for completion of the sexual cycle of malaria parasites
heparin-binding sites in granulocyte-macrophage colony-stimulating factor
long range allosteric control of cytoplasmic dynein atpase activity by the stalk and c-terminal domains
transforming activity of the rho family gtpase, wrch-1, a wnt-regulated cdc42 homolog, is dependent on a novel carboxyl-terminal palmitoylation motif
tissue-specific expression and dimerization of the endoplasmic reticulum oxidoreductase ero1
hvps34 is a nutrient-regulated lipid kinase required for activation of p70 s6 kinase
myosin phosphatase and cofilin mediate camp/camp-dependent protein kinase-induced decline in endothelial cell isometric tension and myosin ii regulatory light chain..
heat shock response modulators as therapeutic tools for diseases of protein conformation
calmodulin-dependent protein kinase iv regulates hematopoietic stem cell maintenance
phosphorylation of phosphophoryn is crucial for its function as a mediator of biomineralization
the non-gastric h,k-atpase is oligomycin-sensitive and can function as an h+,nh4+-atpase
pu.1 regulates the tissue-specific expression of dendritic cell-specific intercellular adhesion molecule (icam)-3-grabbing nonintegrin
reconstruction of the complete ouabain-binding pocket of na,k-atpase in gastric h,k-atpase by substitution of only seven amino acids
a mechanism for death receptor discrimination by death adaptors
nuclear export factor family protein participates in cytoplasmic mrna trafficking
dentin sialoprotein and dentin phosphoprotein overexpression during amelogenesis
ligand-assisted aggregation of proteins
mammalian target of rapamycin (mtor) signaling is required for a late-stage fusion process during skeletal myotube maturation
cyclin-dependent kinase inhibitors uncouple cell cycle progression from mitochondrial apoptotic functions in dna-damaged cancer cells
defining the role of ubiquitin-interacting motifs in the polyglutamine disease protein, ataxin-3
activation of m1 muscarinic acetylcholine receptors stimulates the formation of a multiprotein complex centered on trpc6 channels
leukotriene b4 receptor and the function of its helix 8
structure of the brct repeat domain of mdc1 and its specificity for the free cooh-terminal end of the -h2ax histone tail
a peptide core motif for binding to heterotrimeric g protein subunits
myosin viib from drosophila is a high duty ratio motor
pot1 stimulates recq helicases wrn and blm to unwind telomeric dna substrates
akt activates the mammalian target of rapamycin by regulating cellular atp level and ampk activity
different roles of n-terminal and c-terminal halves of hira in transcription regulation of cell cycle-related genes that contribute to control of vertebrate cell gr..
giardia lamblia rna cap guanine-n2 methyltransferase (tgs2)
protein kinase c stimulates apoptosis by initiating g1 phase cell cycle progression and s phase arrest
coenzyme binding during catalysis is beneficial for the stability of 4-hydroxyacetophenone monooxygenase
identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses
highly conserved o-fucose sites have distinct effects on notch1 function
dna-induced secondary structure of the carboxyl-terminal domain of histone h1
unexpected functional diversity among fadr fatty acid transcriptional regulatory proteins
-arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts
golgi and endoplasmic reticulum functions take place in different subcellular compartments of entamoeba histolytica
low energy cd of rna hairpin unveils a loop conformation required for n antitermination activity
inhibition of nucleotide excision repair by high mobility group protein hmga1
chondroitin sulfate characterized by the e-disaccharide unit is a potent inhibitor of herpes simplex virus infectivity and provides the virus binding sites on gro2c..
chemokine-glycosaminoglycan binding
cross-talk between bone morphogenetic protein and transforming growth factor- signaling is essential for exendin-4-induced insulin-positive differentiation of ar42j..
heteroduplex joint formation by a stoichiometric complex of rad51 and rad52 of saccharomyces cerevisiae
trpc4 knockdown suppresses epidermal growth factor-induced store-operated channel activation and growth in human corneal epithelial cells
identical phenotypes of catsper1 and catsper2 null sperm
discovery, structural determination, and putative processing of the precursor protein that produces the cyclic trypsin inhibitor sunflower trypsin inhibitor 1
a bacterial glutathione transporter (escherichia coli cyddc) exports reductant to the periplasm
functional coupling of cleavage and polyadenylation with transcription of mrna
mef2-dependent recruitment of the hand1 transcription factor results in synergistic activation of target promoters
identification of a gene involved in polysaccharide export as a transcription target of frua, an essential factor for myxococcus xanthus development
human organic anion transporter hoat1 forms homooligomers
on the two components of pyridoxal 5‘-phosphate synthase from bacillus subtilis
the extracellular matrix and inflammation
human acyl-coa dehydrogenase-9 plays a novel role in the mitochondrial -oxidation of unsaturated fatty acids
diet-induced obesity in c57bl/6j mice causes increased renal lipid accumulation and glomerulosclerosis via a sterol regulatory element-binding protein-1c-dependent ..
structure of the chromo barrel domain from the mof acetyltransferase
isolation and functional characterization of a novel organic solute carrier protein, hoscp1
specific amino acids in the first fibronectin type iii repeat of the neural cell adhesion molecule play a role in its recognition and polysialylation by the polysia..
dodecameric structure of the small heat shock protein acr1 from mycobacterium tuberculosis
fragile x mental retardation protein (fmrp) binds specifically to the brain cytoplasmic rnas bc1/bc200 via a novel rna-binding motif
serglycin-deficient cytotoxic t lymphocytes display defective secretory granule maturation and granzyme b storage
novel interaction partners of the cd2bp2-gyf domain
srs2 helicase of saccharomyces cerevisiae selectively unwinds triplet repeat dna
identification of the minimal lysosomal enzyme recognition domain in cathepsin d
the eal domain protein viea is a cyclic diguanylate phosphodiesterase
electron transfer within complex ii
both rotor and stator subunits are necessary for efficient binding of f1 to f0 in functionally assembled escherichia coli atp synthase
redefining the role of the endogenous xap2 and c-terminal hsp70-interacting protein on the endogenous ah receptors expressed in mouse and rat cell lines
cellular p32 recruits cytomegalovirus kinase pul97 to redistribute the nuclear lamina
src regulates constitutive internalization and rapid resensitization of a cholecystokinin 2 receptor splice variant
the muc1 sea module is a self-cleaving domain
x-ray snapshots of peptide processing in mutants of tricorn-interacting factor f1 from thermoplasma acidophilum
interaction of calmodulin with the serotonin 5-hydroxytryptamine2a receptor
kinetic analysis of steps in the repair of damaged dna by human o6-alkylguanine-dna alkyltransferase
jumonji regulates cardiomyocyte proliferation via interaction with retinoblastoma protein
g-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes
dhhc9 and gcp16 constitute a human protein fatty acyltransferase with specificity for h- and n-ras
involvement of inflammation, degradation, and apoptosis in a mouse model of glaucoma
crystal structure of m-ras reveals a gtp-bound “off“ state conformation of ras family small gtpases
icln159 folds into a pleckstrin homology domain-like structure
both high mobility group (hmg)-boxes and the acidic tail of hmgb1 regulate recombination-activating gene (rag)-mediated recombination signal synapsis and cleavage i..
consequences of disease-causing mutations on lubricin protein synthesis, secretion, and post-translational processing
coq9, a new gene required for the biosynthesis of coenzyme q in saccharomyces cerevisiae
interactions among yeast protein-disulfide isomerase proteins and endoplasmic reticulum chaperone proteins influence their activities
modulation of dna end joining by nuclear proteins
ethanol alters trafficking and functional n-methyl-d-aspartate receptor nr2 subunit ratio via h-ras
the protozoan parasite cryptosporidium parvum possesses two functionally and evolutionarily divergent replication protein a large subunits
modulation of apoptosis in hacat keratinocytes via differential regulation of erk signaling pathway by flavonoids
mast cell tryptase controls paracellular permeability of the intestine
increased expression of mcl-1 is required for protection against serum starvation in phosphatase and tensin homologue on chromosome 10 null mouse embryonic fibrobla..
a feedback-resistant mutant of bacillus subtilis glutamine synthetase with pleiotropic defects in nitrogen-regulated gene expression
proteolytic activity of htpx, a membrane-bound and stress-controlled protease from escherichia coli
a true autoactivating enzyme
phosphorylation of coronin 1b by protein kinase c regulates interaction with arp2/3 and cell motility
canonical wnt signaling promotes osteogenesis by directly stimulating runx2 gene expression
cellular uptake of mammalian heparanase precursor involves low density lipoprotein receptor-related proteins, mannose 6-phosphate receptors, and heparan sulfate pro..
a single pdz domain protein interacts with the menkes copper atpase, atp7a
microautophagic vacuole invagination requires calmodulin in a ca2+-independent function
the go/i-coupled cannabinoid receptor-mediated neurite outgrowth involves rap regulation of src and stat3
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