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trapping of an assembly intermediate of photosynthetic lh1 antenna beyond b820 subunit
disease-associated mutations inactivate amp-lysine hydrolase activity of aprataxin
characterization of the functional insulin binding epitopes of the full-length insulin receptor
acute insult of ammonia leads to calcium-dependent glutamate release from cultured astrocytes, an effect of ph
internal translation initiation mediated by the angiogenic factor tie2
gaba induces activity dependent delayed-onset uncoupling of gaba/benzodiazepine site interactions in neocortical neurons
mycobacterium tuberculosis heat shock proteins use diverse toll-like receptor pathways to activate pro-inflammatory signals
phosphoinositide 3-kinase accelerates postoperative tumor growth by inhibiting apoptosis and enhancing resistance to chemotherapy-induced apoptosis
ribosomal rna in alzheimer disease is oxidized by bound redox-active iron
the drosophila acetylcholine receptor subunit d5 is part of an -bungarotoxin binding acetylcholine receptor
activation of p38 has opposing effects on the proliferation and migration of endothelial cells
collagen 1(i) gene (col1a1) is repressed by rfx family
the role of ef-hand domains and c2 domain in regulation of enzymatic activity of phospholipase c
hedgehog signaling induces cardiomyogenesis in p19 cells
thrombin-induced tyrosine phosphorylation of hs1 in human platelets is sequentially catalyzed by syk and lyn tyrosine kinases and associated with the cellular migra..
p38 kinase-mediated transactivation of the epidermal growth factor receptor is required for dedifferentiation of renal epithelial cells after oxidant injury
myocilin mutations causing glaucoma inhibit the intracellular endoproteolytic cleavage of myocilin between amino acids arg226 and ile227
mutation in apolipoprotein b associated with hypobetalipoproteinemia despite decreased binding to the low density lipoprotein receptor
blue light induces mitochondrial dna damage and free radical production in epithelial cells
domain interactions of the mannose 6-phosphate/insulin-like growth factor ii receptor
two discrete promoters regulate the alternatively spliced human interferon regulatory factor-5 isoforms
coactivators and corepressors of nf-b in ib gene promoter
catalysis of thiol/disulfide exchange
functional properties of the p33 and p55 domains of the helicobacter pylori vacuolating cytotoxin
defining a minimal motif required to prevent connexin oligomerization in the endoplasmic reticulum
sir2 and the acetyltransferase, pat, regulate the archaeal chromatin protein, alba
proline-rich tyrosine kinase 2 (pyk2) mediates vascular endothelial-cadherin-based cell-cell adhesion by regulating -catenin tyrosine phosphorylation
concerted auto-regulation in yeast endosomal t-snares
crystal structure of the hydroxyquinol 1,2-dioxygenase from nocardioides simplex 3e, a key enzyme involved in polychlorinated aromatics biodegradation
inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate
essential role of -catenin in postnatal bone acquisition
abnormalities in uridine homeostatic regulation and pyrimidine nucleotide metabolism as a consequence of the deletion of the uridine phosphorylase gene
function of the pex19-binding site of human adrenoleukodystrophy protein as targeting motif in man and yeast
evidence for mr1 antigen presentation to mucosal-associated invariant t cells
acid-triggered membrane insertion of pseudomonas exotoxin a involves an original mechanism based on ph-regulated tryptophan exposure
a phosphoethanolamine transferase specific for the outer 3-deoxy-d-manno-octulosonic acid residue of escherichia coli lipopolysaccharide
reversible inhibition of -synuclein fibrillization by dopaminochrome-mediated conformational alterations
egg case protein-
a novel isoform of sk2 assembles with other sk subunits in mouse brain
clostridium difficile toxin a regulates inducible cyclooxygenase-2 and prostaglandin e2 synthesis in colonocytes via reactive oxygen species and activation of p38 m..
identification of a novel pharmacophore for peptide toxins interacting with k+ channels
phosphorylation of serine 147 of tis21/btg2/pc3 by p-erk1/2 induces pin-1 binding in cytoplasm and cell death
the unfolded protein response modulates toxicity of the expanded glutamine androgen receptor
the kell protein of the common k2 phenotype is a catalytically active metalloprotease, whereas the rare kell k1 antigen is inactive
dynamic transcriptional regulatory complexes, including e2f4, p107, p130, and sp1, control fibroblast growth factor receptor 1 gene expression during myogenesis
interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species
mouse sir2 homolog sirt6 is a nuclear adp-ribosyltransferase
identification of key amino acids responsible for the substantially higher affinities of human type 1 3-hydroxysteroid dehydrogenase/isomerase (3-hsd1) for substrat..
nuclear targeting of transforming growth factor--activated smad complexes
kcnq-like potassium channels in caenorhabditis elegans
taurine chloramine, an oxidant derived from neutrophils, induces apoptosis in human b lymphoma cells through mitochondrial damage
heparan sulfate targets the hiv-1 envelope glycoprotein gp120 coreceptor binding site
co-dependent activity-controlling mechanism of heme-containing co-sensor protein, neuronal pas domain protein 2
deficiency of the g-protein -subunit gs in osteoblasts leads to differential effects on trabecular and cortical bone
a specific interaction between muskelin and the cyclin-dependent kinase 5 activator p39 promotes peripheral localization of muskelin
cross-interactions of two p38 mitogen-activated protein (map) kinase inhibitors and two cholecystokinin (cck) receptor antagonists with the cck1 receptor and p38 ma..
functional ryanodine receptor expression is required for naadp-mediated local ca2+ signaling in t-lymphocytes
nf-b and not the mapk signaling pathway regulates gadd45 expression during acute inflammation
use of dominant-negative hrpa mutants to dissect hrp pilus assembly and type iii secretion in pseudomonas syringae pv. tomato
age-dependent motor deficits and dopaminergic dysfunction in dj-1 null mice
phosphorylation by the dhipk2 protein kinase modulates the corepressor activity of groucho
phloem-localized, proton-coupled sucrose carrier zmsut1 mediates sucrose efflux under the control of the sucrose gradient and the proton motive force
novel structure of the n terminus in yeast fis1 correlates with a specialized function in mitochondrial fission
regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor activation
chemical rescue of histidine selectivity filter mutants of the m2 ion channel of influenza a virus
glutamate 636 of the escherichia coli pyruvate dehydrogenase-e1 participates in active center communication and behaves as an engineered acetolactate synthase with ..
argbp2 interacts with akt and p21-activated kinase-1 and promotes cell survival
identification of estrogen-responsive genes using a genome-wide analysis of promoter elements for transcription factor binding sites
antagonistic role of h-ns and gadx in the regulation of the glutamate decarboxylase-dependent acid resistance system in escherichia coli
increased very low density lipoprotein secretion and gonadal fat mass in mice overexpressing liver dgat1
unsaturated fatty acids induce cytotoxic aggregate formation of amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutants
proteins in human brain cortex are modified by oxidation, glycoxidation, and lipoxidation
identical hik-rre systems are involved in perception and transduction of salt signals and hyperosmotic signals but regulate the expression of individual genes to di..
cvak104 is a novel poly-l-lysine-stimulated kinase that targets the 2-subunit of ap2
artificial zinc finger fusions targeting sp1-binding sites and the trans-activator-responsive element potently repress transcription and replication of hiv-1
apolipoprotein av accelerates plasma hydrolysis of triglyceriderich lipoproteins by interaction with proteoglycan-bound lipoprotein lipase
bacteriophage t4 helicase loader protein gp59 functions as gatekeeper in origin-dependent replication in vivo
abrogation of transforming growth factor- signaling by smad7 inhibits collagen gel contraction of human dermal fibroblasts
oxysterols inhibit phosphatidylcholine synthesis via erk docking and phosphorylation of ctp:phosphocholine cytidylyltransferase
regulation of n-methyl-d-aspartate receptors by calpain in cortical neurons
local atrial natriuretic peptide signaling prevents hypertensive cardiac hypertrophy in endothelial nitric-oxide synthase-deficient mice
molecular analysis of a store-operated and 2-acetyl-sn-glycerol-sensitive non-selective cation channel
er-ahr-arnt protein-protein interactions mediate estradiol-dependent transrepression of dioxin-inducible gene transcription
apoa-i lipidation in primary mouse hepatocytes
identification of wnk1 as a substrate of akt/protein kinase b and a negative regulator of insulin-stimulated mitogenesis in 3t3-l1 cells
ig-h3 induces keratinocyte differentiation via modulation of involucrin and transglutaminase expression through the integrin 31 and the phosphatidylinositol 3-kinas..
regulation of the dbl proto-oncogene by heat shock cognate protein 70 (hsc70)
compartmentalization of lipid biosynthesis in mycobacteria
wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing
the small g-protein arf6gtp recruits the ap-2 adaptor complex to membranes
phycobilisome linker proteins are phosphorylated in synechocystis sp. pcc 6803
cytokines induce nitric oxide-mediated mtdna damage and apoptosis in oligodendrocytes
actopaxin interacts with tesk1 to regulate cell spreading on fibronectin
hyperacetylated chromatin domains: lessons from heterochromatin
neuroprotective effects of preconditioning ischemia on ischemic brain injury through down-regulating activation of jnk1/2 via n-methyl-d-aspartate receptor-mediated..
are stats arginine-methylated?
hypoxic augmentation of ca2+ channel currents requires a functional electron transport chain
hepatitis b virus dna-negative dane particles lack core protein but contain a 22-kda precore protein without c-terminal arginine-rich domain
pypaf3, a pyrin-containing apaf-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1 secretion
insights into hydrophobicity and the chaperone-like function of a- and b-crystallins
novel role for cyclin-dependent kinase 2 in neuregulin-induced acetylcholine receptor subunit expression in differentiated myotubes
dual effect of tamoxifen on arterial kca channels does not depend on the presence of the 1 subunit
wave3-mediated cell migration and lamellipodia formation are regulated downstream of phosphatidylinositol 3-kinase
the pro33 isoform of integrin 3 enhances outside-in signaling in human platelets by regulating the activation of serine/threonine phosphatases
free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor- and interleukin-
binding of adamts13 to von willebrand factor
mechanism of transcription factor recruitment by acidic activators
a systematic mutagenesis study of ile-282 in transmembrane segment m4 of the plasma membrane h+-atpase
main chain hydrogen bond interactions in the binding of proline-rich gluten peptides to the celiac disease-associated hla-dq2 molecule
the balance between acetylation and deacetylation controls smad7 stability
function of mammalian lkb1 and ca2+/calmodulin-dependent protein kinase kinase as snf1-activating kinases in yeast
distinct amino acid residues may be involved in coactivator and ligand interactions in hepatocyte nuclear factor-4
heme oxygenase-1 gene activation by the nad(p)h oxidase inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride via a protein kinase b, p38-dependent signaling pathway ..
bioenergetics in glutaryl-coenzyme a dehydrogenase deficiency
single cell analysis and temporal profiling of agonist-mediated inositol 1,4,5-trisphosphate, ca2+, diacylglycerol, and protein kinase c signaling using fluorescent..
high-throughput screening for potent and selective inhibitors of plasmodium falciparum dihydroorotate dehydrogenase
an amino-terminal motif functions as a second nuclear export sequence in brca1
smad7 abrogates transforming growth factor-1-mediated growth inhibition in colo-357 cells through functional inactivation of the retinoblastoma protein
detoxification and transcriptome response in arabidopsis seedlings exposed to the allelochemical benzoxazolin-2(3h)-one
specific interference of urokinase-type plasminogen activator receptor and matrix metalloproteinase-9 gene expression induced by double-stranded rna results in decr..
a family of k+ channel ancillary subunits regulate taste sensitivity in caenorhabditis elegans
the molecular architecture of galactose mutarotase/udp-galactose 4-epimerase from saccharomyces cerevisiae
the serine-rich domain from crk-associated substrate (p130cas) is a four-helix bundle
p400 is required for e1a to promote apoptosis
calcium-dependent changes in the flexibility of the regulatory domain of troponin c in the troponin complex
regulation of phospholipase c-1 through direct interactions with the small gtpase ral and calmodulin
sumoylation of the polyglutamine repeat protein, ataxin-1, is dependent on a functional nuclear localization signal
dynamic regulation of tec kinase localization in membrane-proximal vesicles of a t cell clone revealed by total internal reflection fluorescence and confocal micros..
nectin-like protein 2 defines a subset of t-cell zone dendritic cells and is a ligand for class-i-restricted t-cell-associated molecule
structure of human cyclophilin a in complex with the novel immunosuppressant sanglifehrin a at 1.6 å resolution
coupled translation of the respiratory syncytial virus m2 open reading frames requires upstream sequences
crystal structure of dynein light chain tctex-1
peptides derived from the reverse transcriptase of human immunodeficiency virus type 1 as novel inhibitors of the viral integrase
lipopolysaccharide improves cardiomyocyte survival and function after serum deprivation
crystal structure of a fragment of mouse ubiquitin-activating enzyme
identification and characterization of giv, a novel gi/s -interacting protein found on copi, endoplasmic reticulum-golgi transport vesicles
phosphorylation of arfaptin 2 at ser260 by akt inhibits polyq-huntingtin-induced toxicity by rescuing proteasome impairment
substrate specificity of tyrosyl-dna phosphodiesterase i (tdp1)
a new renal mitochondrial carrier, kmcp1, is up-regulated during tubular cell regeneration and induction of antioxidant enzymes
membrane depolarization induces the undulating phosphorylation/dephosphorylation of glycogen synthase kinase 3, and this dephosphorylation involves protein phosphat..
differential localization of alternatively spliced hypoxanthine-xanthine-guanine phosphoribosyltransferase isoforms in toxoplasma gondii
nuclear translocation of phospholipase c-1 is linked to the cell cycle and nuclear phosphatidylinositol 4,5-bisphosphate
the calpain system is involved in the constitutive regulation of -catenin signaling functions
developmental regulation of the direct interaction between the intracellular loop of connexin 45.6 and the c terminus of major intrinsic protein (aquaporin-0)
in situ photoactivation of a caged phosphotyrosine peptide derived from focal adhesion kinase temporarily halts lamellar extension of single migrating tumor cells
crystal structures of the ferrous dioxygen complex of wild-type cytochrome p450eryf and its mutants, a245s and a245t
a novel dimeric structure of the riml n-acetyltransferase from salmonella typhimurium
degradation of the tumor suppressor smad4 by ww and hect domain ubiquitin ligases
the glucagon-like peptide-2 receptor c terminus modulates -arrestin-2 association but is dispensable for ligand-induced desensitization, endocytosis, and g-protein-..
the canonical intrinsic mitochondrial death pathway has a non-apoptotic role in signaling lens cell differentiation
laminin 3 chain binds to nidogen and is located in murine basement membranes
3-hydroxykynurenine-mediated modification of human lens proteins
probing the 2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists
thrombin modulates the expression of a set of genes including thrombospondin-1 in human microvascular endothelial cells
post-transcriptional regulation of the yeast high affinity iron transport system
psak2 subunit in photosystem i is involved in state transition under high light condition in the cyanobacterium synechocystis sp. pcc 6803
evidence that interspecies polymorphism in the human and rat cholecystokinin receptor-2 affects structure of the binding site for the endogenous agonist cholecystok..
tumor suppression by the von hippel-lindau protein requires phosphorylation of the acidic domain
regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-coa reductase inhibition
commd proteins, a novel family of structural and functional homologs of murr1
cloning and functional study of porcine parotid hormone, a novel proline-rich protein
analysis of the interaction between the saccharomyces cerevisiae msh2-msh6 and mlh1-pms1 complexes with dna using a reversible dna end-blocking system
the x-ray structure of a hemipteran ecdysone receptor ligand-binding domain
modeling and experimental validation of the binary complex of the plectin actin-binding domain and the first pair of fibronectin type iii (fniii) domains of the 4 i..
the forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature
suppression of calcium release from inositol 1,4,5-trisphosphate-sensitive stores mediates the anti-apoptotic function of nuclear factor-b
glucose-dependent insulinotropic polypeptide (gip) stimulation of pancreatic -cell survival is dependent upon phosphatidylinositol 3-kinase (pi3k)/protein kinase b ..
caveolin-1 enhances tissue factor pathway inhibitor exposure and function on the cell surface
identification of a subversive substrate of trichomonas vaginalis purine nucleoside phosphorylase and the crystal structure of the enzyme-substrate complex
the t loop structure is dispensable for substrate recognition by trnase zl
mind bomb-2 is an e3 ligase for notch ligand
dna polymerase is specifically required for recovery from the benzopyrene-dihydrodiol epoxide (bpde)-induced s-phase checkpoint
the high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the g-helix
dissection of synapse induction by neuroligins
further characterization of human dna polymerase interacting protein 38
graded levels of gata-1 expression modulate survival, proliferation, and differentiation of erythroid progenitors
isolation and characterization of novel cyclotides from viola hederaceae
a hairpin-like structure within an au-rich mrna-destabilizing element regulates trans-factor binding selectivity and mrna decay kinetics
expression of bovine f1-atpase with functional complementation in yeast saccharomyces cerevisiae
surface calreticulin mediates muramyl dipeptide-induced apoptosis in rk13 cells
down-regulation of human dab2ip gene expression mediated by polycomb ezh2 complex and histone deacetylase in prostate cancer
effects of protein and gene transfer of the angiopoietin-1 fibrinogen-like receptor-binding domain on endothelial and vessel organization
characterization of heparin affin regulatory peptide signaling in human endothelial cells
presenilin-1 d257a and d385a mutants fail to cleave notch in their endoproteolyzed forms, but only presenilin-1 d385a mutant can restore its -secretase activity wit..
epidermal growth factor and hypoxia-induced expression of cxc chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-ki..
down-regulation of brca2 expression by collagen type i promotes prostate cancer cell proliferation
helicobacter pylori-induced macrophage apoptosis requires activation of ornithine decarboxylase by c-myc
a novel protein kinase c (pkc) is required for fmet-leu-phe-induced activation of nf-b in human peripheral blood monocytes
cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by ric-3
functional analyses of oxygenases in jadomycin biosynthesis and identification of jadh as a bifunctional oxygenase/dehydrase
synthesis of sphingolipids with very long chain fatty acids but not ergosterol is required for routing of newly synthesized plasma membrane atpase to the cell surfa..
pten, but not ship2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/akt pathway in 3t3-l1 adipocytes
overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced parkinson disease phenotype
alternative splicing switches the divalent cation selectivity of trpm3 channels
rapid in vitro assembly dynamics and subunit turnover of ftsz demonstrated by fluorescence resonance energy transfer
a vertebrate-type ferredoxin domain in the na+-translocating nadh dehydrogenase from vibrio cholerae
galanin receptor 1 has anti-proliferative effects in oral squamous cell carcinoma
dissecting the structural determinants of the stability of cholesterol oxidase containing covalently bound flavin
nmr analysis of synthetic human serum albumin -helix 28 identifies structural distortion upon amadori modification
chrr, a soluble quinone reductase of pseudomonas putida that defends against h2o2
endo180 binds to the c-terminal region of type i collagen
characterization of a novel positive transcription regulatory element that differentially regulates the insulin-like growth factor binding protein-3 (igfbp-3) gene ..
identification of the minimal domain structure of bone morphogenetic protein-1 (bmp-1) for chordinase activity
activation of the lipid droplet controls the rate of lipolysis of triglycerides in the insect fat body
leptin receptor activation depends on critical cysteine residues in its fibronectin type iii subdomains
heterogeneous nuclear ribonucleoprotein f/h proteins modulate the alternative splicing of the apoptotic mediator bcl-x
the met-tyr-trp cross-link in mycobacterium tuberculosis catalase-peroxidase (katg)
functional analysis of the domains in cox11
a precipitating role for truncated -synuclein and the proteasome in -synuclein aggregation
the sphingoid long chain base phytosphingosine activates agc-type protein kinases in saccharomyces cerevisiae including ypk1, ypk2, and sch9
hypoxia inhibition of adipocytogenesis in human bone marrow stromal cells requires transforming growth factor-/smad3 signaling
calibration of the channel that determines the -hydroxylation regiospecificity of cytochrome p4504a
reactive carbonyls and polyunsaturated fatty acids produce a hydroxyl radical-like species
manganese activation of superoxide dismutase 2 in the mitochondria of saccharomyces cerevisiae
identification of amino acids required for the functional up-regulation of human dihydrofolate reductase protein in response to antifolate treatment
rapid electron transfer between monomers when the cytochrome bc1 complex dimer is reduced through center n
critical assessment of important regions in the subunit association and catalytic action of the severe acute respiratory syndrome coronavirus main protease
evidence for a triplex dna conformation at the bcl-2 major breakpoint region of the t(14;18) translocation
the c-terminal (331-376) sequence of escherichia coli dnaj is essential for dimerization and chaperone activity
disease-associated mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins ii-b and ii-c
human telomerase reverse transcriptase immortalizes bovine lens epithelial cells and suppresses differentiation through regulation of the erk signaling pathway
identification of an acquired jak2 mutation in polycythemia vera
ligand-receptor and receptor-receptor interactions act in concert to activate signaling in the drosophila toll pathway
the secretory pathway ca2+/mn2+-atpase 2 is a golgi-localized pump with high affinity for ca2+ ions
modulation of prion-dependent polyglutamine aggregation and toxicity by chaperone proteins in the yeast model
enhanced proliferation of cultured human vascular smooth muscle cells linked to increased function of rna-binding protein hur
differential kinetics of cell surface loss of von willebrand factor and its propolypeptide after secretion from weibel-palade bodies in living human endothelial cells
the n-acetyl-d-glucosaminylphosphatidylinositol de-n-acetylase of glycosylphosphatidylinositol biosynthesis is a zinc metalloenzyme
artificially lipid-anchored proteins can elicit clustering-induced intracellular signaling events in jurkat t-lymphocytes independent of lipid raft association
hydralysins, a new category of -pore-forming toxins in cnidaria
transformation by oncogenic ras sensitizes human colon cells to trail-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a mek-depende..
small gtpase proteins rin and rit bind to par6 gtp-dependently and regulate cell transformation
amino acid-stimulated ca2+ oscillations produced by the ca2+-sensing receptor are mediated by a phospholipase c/inositol 1,4,5-trisphosphate-independent pathway tha..
cdc42 and ras cooperate to mediate cellular transformation by intersectin-l
role of the gyvg pore motif of hslu atpase in protein unfolding and translocation for degradation by hslv peptidase
the selectivity filter of the cation channel trpm4
prostaglandin e2 stimulates fibronectin expression through ep1 receptor, phospholipase c, protein kinase c, and c-src pathway in primary cultured rat osteoblasts
subunits of the translocon interact with components of the oligosaccharyl transferase complex
induction of the nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo
structure and mode of action of the membrane-permeabilizing antimicrobial peptide pheromone plantaricin a
receptor epitope usage by an interleukin-5 mimetic peptide
crystal structure of human vacuolar protein sorting protein 29 reveals a phosphodiesterase/nuclease-like fold and two protein-protein interaction sites
differential trafficking of glur7 kainate receptor subunit splice variants
drosophila lysyl oxidases dmloxl-1 and dmloxl-2 are differentially expressed and the active dmloxl-1 influences gene expression and development
portal fibroblasts regulate the proliferation of bile duct epithelia via expression of ntpdase2
selective binding of the scavenger receptor c-type lectin to lewisx trisaccharide and related glycan ligands
structure and function of both domains of arna, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-l-arabinose biosynthesis
subunits of voltage-gated sodium channels are novel substrates of -site amyloid precursor protein-cleaving enzyme (bace1) and -secretase
identification of spectrin-like repeats required for high affinity utrophin-actin interaction
lxr is required for adipocyte growth, glucose homeostasis, and cell function
monoclonal antibody epitope mapping describes tailspike -helix folding and aggregation intermediates
g12/13-mediated production of reactive oxygen species is critical for angiotensin receptor-induced nfat activation in cardiac fibroblasts
convergence of cell cycle regulation and growth factor signals on grasp65
histone h1 proteins act as receptors for the 987p fimbriae of enterotoxigenic escherichia coli
rho gtpase-dependent signaling is required for macrophage migration inhibitory factor-mediated expression of cyclin d1
functional analysis of the plant disease resistance gene pto using dna shuffling
biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodi..
spatiotemporal switch from np73 to tap73 isoforms during nephrogenesis
collagen phagocytosis by fibroblasts is regulated by decorin
amidation and structure relaxation abolish the neurotoxicity of the prion peptide prp106-126 in vivo and in vitro
involvement of gadd153 and cardiac ankyrin repeat protein in hypoxia-induced apoptosis of h9c2 cells
epiya motif is a membrane-targeting signal of helicobacter pylori virulence factor caga in mammalian cells
design, expression, and immunogenicity of a soluble hiv trimeric envelope fragment adopting a prefusion gp41 configuration
kinetics of src homology 3 domain association with the proline-rich domain of dynamins
cooperative mechanism of rna packaging motor
phosphorylation-dependent translocation of glycogen synthase to a novel structure during glycogen resynthesis
phosphorylation of ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by mouse pelle-like kinase/interleukin-1 receptor-associated kinase
a functional dermatan sulfate epitope containing iduronate(2-o-sulfate)1-3galnac(6-o-sulfate) disaccharide in the mouse brain
fluoride induces endoplasmic reticulum stress in ameloblasts responsible for dental enamel formation
neuronal expression and neuritogenic action of group x secreted phospholipase a2
involvement of actin in agonist-induced endocytosis of the g protein-coupled receptor for thromboxane a
engineering soluble monomeric streptavidin with reversible biotin binding capability
vitamin d receptor-dependent regulation of colon multidrug resistance-associated protein 3 gene expression by bile acids
repression of interleukin-5 transcription by the glucocorticoid receptor targets gata3 signaling and involves histone deacetylase recruitment
presenilin/-secretase-mediated cleavage of the voltage-gated sodium channel 2-subunit regulates cell adhesion and migration
down-regulation of atm protein sensitizes human prostate cancer cells to radiation-induced apoptosis
mutation of cys105 inhibits dimerization of p12cdk2-ap1 and its growth suppressor effect
recombinant severe acute respiratory syndrome (sars) coronavirus nucleocapsid protein forms a dimer through its c-terminal domain
isolation and characterization of a microsomal acid retinyl ester hydrolase
role of chloride ions in modulation of the interaction between von willebrand factor and adamts-13
differential activities of plant polyphenols on the binding and internalization of cholera toxin in vero cells
a role for the protease-sensitive loop region of shiga-like toxin 1 in the retrotranslocation of its a1 domain from the endoplasmic reticulum lumen
oxidation of a eukaryotic 2-cys peroxiredoxin is a molecular switch controlling the transcriptional response to increasing levels of hydrogen peroxide
the nadph oxidase nox3 constitutively produces superoxide in a p22phox-dependent manner
targeted deletion of the chicken -globin regulatory elements reveals a cooperative gene silencing activity
exosome-dependent trafficking of hsp7
stearoyl-coa desaturase 1 deficiency increases ctp:choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver
ras-mediated loss of the pro-apoptotic response protein par-4 is mediated by dna hypermethylation through raf-independent and raf-dependent signaling cascades in ep..
induction of klf2 by fluid shear stress requires a novel promoter element activated by a phosphatidylinositol 3-kinase-dependent chromatin-remodeling pathway
the adapter protein crkii regulates neuronal wiskott-aldrich syndrome protein, actin polymerization, and tension development during contractile stimulation of smoot..
fenofibrate induces a novel degradation pathway for scavenger receptor b-i independent of pdzk1
recq family members combine strand pairing and unwinding activities to catalyze strand exchange
candida albicans pmr1p, a secretory pathway p-type ca2+/mn2+-atpase, is required for glycosylation and virulence
degradation of cdt1 during s phase is skp2-independent and is required for efficient progression of mammalian cells through s phase
internal ribosome entry sites in cellular mrnas: mystery of their existence
n-acylphosphatidylethanolamine-hydrolyzing phospholipase d is an important determinant of uterine anandamide levels during implantation
rheb binding to mammalian target of rapamycin (mtor) is regulated by amino acid sufficiency
role of tim21 in mitochondrial translocation contact sites
two-step mechanism that determines the donor binding specificity of human udp-n-acetylhexosaminyltransferase
proliferating cell nuclear antigen promotes translesion synthesis by dna polymerase
interleukin-1 differentially regulates 2 adrenoreceptor and prostaglandin e2-mediated camp accumulation and chloride efflux from calu-3 bronchial epithelial cells
different structural requirements for the constitutive and the agonist-induced activities of the 2-adrenergic receptor
cooperation of the metalloprotease, disintegrin, and cysteine-rich domains of adam12 during inhibition of myogenic differentiation
dual mechanisms whereby a broken rna end assists the catalysis of its repair by t4 rna ligase 2
reversibility of caspase activation and its role during glycochenodeoxycholate-induced hepatocyte apoptosis
bruton‘s tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during nfb activation by lipopolysaccharide
comparative functional study of the viral telomerase rna based on natural mutations
p130cas but not paxillin is essential for caco-2 intestinal epithelial cell spreading and migration on collagen iv
exosite-mediated substrate recognition of factor ix by factor xia
ubiquitin-dependent degradation of interferon regulatory factor-8 mediated by cbl down-regulates interleukin-12 expression
the periplasmic chaperone sura exploits two features characteristic of integral outer membrane proteins for selective substrate recognition
extracellular matrix remodeling by human granzyme b via cleavage of vitronectin, fibronectin, and laminin
role of 1 2.3 subunit i-ii linker sites in the enhancement of cav 2.3 current by phorbol 12-myristate 13-acetate and acetyl--methylcholine
defects in sumo (small ubiquitin-related modifier) conjugation and deconjugation alter cell sensitivity to dna topoisomerase i-induced dna damage
deficiency of adap/fyb/slap-130 destabilizes skap55 in jurkat t cells
annexin a2-s100a10 heterotetramer, a novel substrate of thioredoxin
direct dna binding activity of the fanconi anemia d2 protein
delineation of positron emission tomography imaging agent binding sites on -amyloid peptide fibrils
application of the “codon-shuffling“ method
n-linked keratan sulfate in the aggrecan interglobular domain potentiates aggrecanase activity
activating cystic fibrosis transmembrane conductance regulator channels with pore blocker analogs
selective and atp-dependent translocation of peptides by the homodimeric atp binding cassette transporter tap-like (abcb9)
solution x-ray scattering evidence for agonist- and antagonist-induced modulation of cleft closure in a glutamate receptor ligand-binding domain
roles of tyrosine phosphorylation and cleavage of protein kinase c in its protective effect against tumor necrosis factor-related apoptosis inducing ligand-induced ..
sulfonylurea agents exhibit peroxisome proliferator-activated receptor agonistic activity
the role of specs, small cdc42-binding proteins, in f-actin accumulation at the immunological synapse
cyclophilin a binds to linear peptide motifs containing a consensus that is present in many human proteins
identification of a novel recognition sequence for fibronectin within the nh2-terminal -sandwich domain of tissue transglutaminase
cehmt-1, a putative phytochelatin transporter, is required for cadmium tolerance in caenorhabditis elegans
neuronal differentiation of bone marrow-derived stromal stem cells involves suppression of discordant phenotypes through gene silencing
dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (dc-sign)-mediated enhancement of dengue virus infection is independent of dc-sign i..
cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by rna interference-mediated depletion of telomerase rna
probing the mechanism of ligand recognition in family 29 carbohydrate-binding modules
the co-chaperone carboxyl terminus of hsp70-interacting protein (chip) mediates -synuclein degradation decisions between proteasomal and lysosomal pathways
nuclear localization of flavonoid enzymes in arabidopsis
myosin ii regulatory light chain is required for trafficking of bile salt export protein to the apical membrane in madin-darby canine kidney cells
tpl2/cot signals activate erk, jnk, and nf-b in a cell-type and stimulus-specific manner
bcl-2 rescues ceramide- and etoposide-induced mitochondrial apoptosis through blockage of caspase-2 activation
conkunitzin-s1 is the first member of a new kunitz-type neurotoxin family
backbone-methylated analogues of the principle receptor binding region of human parathyroid hormone
desmosome signaling
substrate specificity and ionic regulation of glnpq from lactococcus lactis
oxygen tolerance of the h2-sensing hydrogenase from ralstonia eutropha h16 is based on limited access of oxygen to the active site
atp-dependent rotation of mutant atp synthases defective in proton transport
proteomic and functional analyses reveal a mitochondrial dysfunction in p301l tau transgenic mice
x-ray structure of human acid--glucosidase covalently bound to conduritol-b-epoxide
cd8+ cytotoxic t lymphocyte activation by soluble major histocompatibility complex-peptide dimers
bh3-only bik regulates bax,bak-dependent release of ca2+ from endoplasmic reticulum stores and mitochondrial apoptosis during stress-induced cell death
x-ray structure of plasmepsin ii complexed with a potent achiral inhibitor
adamts1 proteinase is up-regulated in wounded skin and regulates migration of fibroblasts and endothelial cells
identification of trichomonas vaginalis cysteine proteases that induce apoptosis in human vaginal epithelial cells
disassembling protein aggregates in the yeast cytosol
a chaperone pathway in protein disaggregation
a non-sulfated form of the hnk-1 carbohydrate is expressed in mouse kidney
phosphatidylinositol phosphate kinase type i directly associates with and regulates shp-1 tyrosine phosphatase
requirements for catalysis in mammalian glycogenin
high resolution structures of highly bulged viral epitopes bound to major histocompatibility complex class i
essential role of p38 in k-ras transformation independent of phosphorylation
inactivation of src family tyrosine kinases by reactive oxygen species in vivo
receptor activity-modifying protein (ramp) isoform-specific regulation of adrenomedullin receptor trafficking by nherf-1
g protein 2 subunit-derived peptides for inhibition and induction of g protein pathways
the affinity of the dynein microtubule-binding domain is modulated by the conformation of its coiled-coil stalk
amino acid-dependent transfer rna affinity in a class i aminoacyl-trna synthetase
trna-dependent aminoacyl-adenylate hydrolysis by a nonediting class i aminoacyl-trna synthetase
gene expression profiling to identify oncogenic determinants of autocrine human growth hormone in human mammary carcinoma
wnt signaling inhibits adipogenesis through -catenin-dependent and -independent mechanisms
somatostatin receptor type 5 modulates somatostatin receptor type 2 regulation of adrenocorticotropin secretion
ipgb1 is a novel shigella effector protein involved in bacterial invasion of host cells
prostaglandin e2 receptors ep2 and ep4 are down-regulated during differentiation of mouse osteoclasts from their precursors
a structural model for the membrane-bound form of the juxtamembrane domain of the epidermal growth factor receptor
cyclooxygenase-2-derived prostaglandin e2 promotes human cholangiocarcinoma cell growth and invasion through ep1 receptor-mediated activation of the epidermal growt..
gating deficiency in a familial hemiplegic migraine type 1 mutant p/q-type calcium channel
spatial and functional heterogeneity of sphingolipid-rich membrane domains
the adipocyte as an important target cell for trypanosoma cruzi infection
regulation of e-cadherin endocytosis by nectin through afadin, rap1, and p120ctn
molecular conversion of nad kinase to nadh kinase through single amino acid residue substitution
synthesis and characterization of a triphenylphosphonium-conjugated peroxidase mimetic
the ib kinase is a key factor in triggering influenza a virus-induced inflammatory cytokine production in airway epithelial cells
role of p90 ribosomal s6 kinase (p90rsk) in reactive oxygen species and protein kinase c (pkc-)-mediated cardiac troponin i phosphorylation
promoter rearrangements cause species-specific hepatic regulation of the glyoxylate reductase/hydroxypyruvate reductase gene by the peroxisome proliferator-activate..
proteolytic cleavage of the p65-rela subunit of nf-b during poliovirus infection
identification and characterization of a novel, psoriasis susceptibility-related noncoding rna gene, prins
acceleration of yeast actin polymerization by yeast arp2/3 complex does not require an arp2/3-activating protein
erbb4/her4 potentiates stat5a transcriptional activity by regulating novel stat5a serine phosphorylation events
differentiation of epithelial na+ channel function
substrate-specific modulation of a multisubstrate proteinase
hyaluronan fragments induce endothelial cell differentiation in a cd44- and cxcl1/gro1-dependent mannerboxs
cnk1 is a scaffold protein that regulates src-mediated raf-1 activation
g protein-coupled receptor activation rapidly stimulates focal adhesion kinase phosphorylation at ser-84
nuclear phospholipase c 1 (plc1) affects cd24 expression in murine erythroleukemia cells
repression of bone morphogenetic protein and activin-inducible transcription by evi-1
activation of hif-prolyl hydroxylases by r59949, an inhibitor of the diacylglycerol kinase
the codon 47 polymorphism in p53 is functionally significant
regulation of endothelial argininosuccinate synthase expression and no production by an upstream open reading frame
proteomic analysis of protein nitration in aging skeletal muscle and identification of nitrotyrosine-containing sequences in vivo by nanoelectrospray ionization tan..
agp2 encodes the major permease for high affinity polyamine import in saccharomyces cerevisiae
distinct transcriptional control mechanisms of killer immunoglobulin-like receptors in natural killer (nk) and in t cells
cellular retinol-binding protein type iii is needed for retinoid incorporation into milk
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