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testing the role of gp96 as peptide chaperone in antigen processing
interference with phosphoenzyme isomerization and inhibition of the sarco-endoplasmic reticulum ca2+ atpase by 1,3-dibromo-2,4,6-tris(methylisothiouronium) benzene
characterization of troponin t dilated cardiomyopathy mutations in the fetal troponin isoform
lower inhibitor development in hemophilia a mice following administration of recombinant factor viii-o-phospho-l-serine complex
ceramide 1-phosphate acts as a positive allosteric activator of group iva cytosolic phospholipase a2 and enhances the interaction of the enzyme with phosphatidylcho..
epithelial sodium channel inhibition by amp-activated protein kinase in oocytes and polarized renal epithelial cells
c-myc suppresses p21waf1/cip1 expression during estrogen signaling and antiestrogen resistance in human breast cancer cells
proteomic profiling of hepatic endoplasmic reticulum-associated proteins in an animal model of insulin resistance and metabolic dyslipidemia
switching pyridine nucleotide specificity in p450 bm
quantitative deuterium isotopic profiling at natural abundance indicates mechanistic differences for 12-epoxidase and 12-desaturase in vernonia galamensis
assembly of cytochrome-c oxidase in the absence of assembly protein surf1p leads to loss of the active site heme
identification of a def-type docking domain for extracellular signal-regulated kinases 1/2 that directs phosphorylation and turnover of the bh3-only protein bimel
assembly of human immunodeficiency virus precursor gag proteins
regulatory serine residues mediate phosphorylation-dependent and phosphorylation-independent activation of interferon regulatory factor 7
specific kinetic alterations of human cav2.1 calcium channels produced by mutation s218l causing familial hemiplegic migraine and delayed cerebral edema and coma af..
dimerization of nitric oxide-sensitive guanylyl cyclase requires the 1 n terminus
molecular dissection of the interaction between p27 and kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in g1 phase
mutation of active site residues of insulin-degrading enzyme alters allosteric interactions
independent repression of bile acid synthesis and activation of c-jun n-terminal kinase (jnk) by activated hepatocyte fibroblast growth factor receptor 4 (fgfr4) an..
the role of mitochondrially bound arginase in the regulation of urea synthesis
inhibition of chaperone activity is a shared property of several cu,zn-superoxide dismutase mutants that cause amyotrophic lateral sclerosis
spatial distribution of di- and tri-methyl lysine 36 of histone h3 at active genes
hepatitis c virus core protein acts as a trans-modulating factor on internal translation initiation of the viral rna
analysis of ard1 function in hypoxia response using retroviral rna interference
the global transcriptional response of escherichia coli to induced 32 protein involves 32 regulon activation followed by inactivation and degradation of 32 in vivo
the interaction of lipophilic drugs with intestinal fatty acid-binding protein
the low density lipoprotein receptor-related protein (lrp) is a novel -secretase (bace1) substrate
functional analysis of active site residues of the fosfomycin resistance enzyme fosa from pseudomonas aeruginosa
compounds that bind app and inhibit a processing in vitro suggest a novel approach to alzheimer disease therapeutics
chronic airway infection/inflammation induces a ca2+i-dependent hyperinflammatory response in human cystic fibrosis airway epithelia
assembly of the preb receptor requires a v-like protein encoded by a germline transcript
activation of myosin va function by melanophilin, a specific docking partner of myosin va
molecular and functional characterization of the electroneutral na/hco3 cotransporter nbcn1 in rat hippocampal neurons
comparative agonist/antagonist responses in mutant human c5a receptors define the ligand binding site
the interaction of ledgf/p75 with integrase is lentivirus-specific and promotes dna binding
crystal structure of baculovirus rna triphosphatase complexed with phosphate
exosite modules guide substrate recognition in the zipd/elac protein family
structural and functional characterization of transmembrane segment iv of the nhe1 isoform of the na+/h+ exchanger
the last reaction producing brassinolide is catalyzed by cytochrome p-450s, cyp85a3 in tomato and cyp85a2 in arabidopsis
fluorescence imaging reveals the nuclear behavior of peroxisome proliferator-activated receptor/retinoid x receptor heterodimers in the absence and presence of ligand
a single mms2 “key“ residue insertion into a ubc13 pocket determines the interface specificity of a human lys63 ubiquitin conjugation complex
analysis of glycosylation in cdg-ia fibroblasts by fluorophore-assisted carbohydrate electrophoresis
identification of conserved amino acids n-terminal of the pkcc1b domain crucial for protein kinase c-mediated induction of neurite outgrowth
hyperactive antifreeze protein from winter flounder is a very long rod-like dimer of -helices
bace1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper
adenoviral gene transfer of the nf-b inhibitory protein abin-1 decreases allergic airway inflammation in a murine asthma model
functional characterization of the mental domain
the importance of dynamic effects on the enzyme activity
location and mobility of twin arginine translocase subunits in the escherichia coli plasma membrane
functional relevance of amino acid residues involved in interactions with ordered nucleic acid in a spherical virus
expression of constitutively active akt/protein kinase b signals glut4 translocation in the absence of an intact actin cytoskeleton
inactivation of dnmt3b in mouse embryonic fibroblasts results in dna hypomethylation, chromosomal instability, and spontaneous immortalization
identification and characterization of a novel plastidic adenine nucleotide uniporter from solanum tuberosum
a novel, potent dual inhibitor of the leukocyte proteases cathepsin g and chymase
mg2+ and ca2+ differentially regulate dna binding and dimerization of dream
evidence that dystroglycan is associated with dynamin and regulates endocytosis
the macrophage m2 integrin m lectin domain mediates the phagocytosis of chilled platelets
manganese superoxide dismutase protects the proliferative capacity of confluent normal human fibroblasts
increased flexibility as a strategy for cold adaptation
selective uncoupling of g12 from rho-mediated signaling
functional role played by the glycosylphosphatidylinositol anchor glycan of cd48 in interleukin-18-induced interferon- production
structural studies of a stabilized phosphoenzyme intermediate of ca2+-atpase
testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes
roles of 3-phosphoinositide-dependent kinase 1 in the regulation of endothelial nitric-oxide synthase phosphorylation and function by heat shock protein 90
disturbance of sphingolipid biosynthesis abrogates the signaling of mss4, phosphatidylinositol-4-phosphate 5-kinase, in yeast
cdk2-dependent phosphorylation of homeobox transcription factor cdx2 regulates its nuclear translocation and proteasome-mediated degradation in human intestinal epi..
hsp25 inhibits protein kinase c-mediated cell death through direct interaction
p21cip1 and p27kip1 induce distinct cell cycle effects and differentiation programs in myeloid leukemia cells
nuclear localization and chromatin targets of p21-activated kinase 1
glycoprotein tertiary and quaternary structures are monitored by the same quality control mechanism
transient receptor potential vanilloid type 1 activation down-regulates voltage-gated calcium channels through calcium-dependent calcineurin in sensory neurons
conserved interactions in the staphylococcus aureus dna polc chromosome replication machine
genetic- or transforming growth factor-1-induced changes in epidermal peroxisome proliferator-activated receptor / expression dictate wound repair kinetics
a conserved mediator hinge revealed in the structure of the med7·med21 (med7·srb7) heterodimer
novel dimeric acetylcholinesterase inhibitor bis(7)-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking n-methyl-d-aspartate recep..
towards a structure for a tsg-6·hyaluronan complex by modeling and nmr spectroscopy
crystal structures of the rna-dependent rna polymerase genotype 2a of hepatitis c virus reveal two conformations and suggest mechanisms of inhibition by non-nucleos..
cloning and characterization of mouse e2f8, a novel mammalian e2f family member capable of blocking cellular proliferation
crystal structure of human cystatin d, a cysteine peptidase inhibitor with restricted inhibition profile
crystal structure of cc3 (tip30)
constitutively active homo-oligomeric angiotensin ii type 2 receptor induces cell signaling independent of receptor conformation and ligand stimulation
crystal structure of the n-terminal domain of the group b streptococcus alpha c protein
molecular compatibility of the channel gate and the n terminus of s5 segment for voltage-gated channel activity
femtomolar transition state analogue inhibitors of 5‘-methylthioadenosine/s-adenosylhomocysteine nucleosidase from escherichia coli
structural rationale for the affinity of pico- and femtomolar transition state analogues of escherichia coli 5‘-methylthioadenosine/s-adenosylhomocysteine nucleosi..
endothelial nitric-oxide synthase antisense (nos3as) gene encodes an autophagy-related protein (apg9-like2) highly expressed in trophoblast
covalent cross-links between the subunit (fxyd2) and and subunits of na,k-atpase
increased protein stability causes dna methyltransferase 1 dysregulation in breast cancer
exocytic trafficking is required for nicotine-induced up-regulation of 42 nicotinic acetylcholine receptors
from atp as substrate to adp as coenzyme
crystal structure of a nicotinate phosphoribosyltransferase from thermoplasma acidophilum
phospholipid transfer protein deficiency impairs apolipoprotein-b secretion from hepatocytes by stimulating a proteolytic pathway through a relative deficiency of v..
adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner
overexpression of the epithelial na+ channel subunit in collecting duct cells
role of cyclophilin b in activation of interferon regulatory factor-3
mitochondrial malate-aspartate shuttle regulates mouse embryo nutrient consumption
stepping transfer messenger rna through the ribosome
caterpiller 16.2 (clr16.2), a novel nbd/lrr family member that negatively regulates t cell function
failure to assemble the 3 3 subcomplex of the atp synthase leads to accumulation of the and subunits within inclusion bodies and the loss of mitochondrial cristae i..
mutational analysis of the stator subunit e of the yeast v-atpase
regulation of sphingosine-1-phosphate lyase gene expression by members of the gata family of transcription factors
inhibition of p90 ribosomal s6 kinase-mediated ccaat/enhancer-binding protein activation and cyclooxygenase-2 expression by salicylate
direct interaction of rnd1 with frs2 regulates rnd1-induced down-regulation of rhoa activity and is involved in fibroblast growth factor-induced neurite outgrowth i..
upstream stimulatory factors (usf-1/usf-2) regulate human cgmp-dependent protein kinase i gene expression in vascular smooth muscle cells
g12/13- and reactive oxygen species-dependent activation of c-jun nh2-terminal kinase and p38 mitogen-activated protein kinase by angiotensin receptor stimulation i..
reconstitution of nup157 and nup145n into the nup84 complex
protein kinase c activates human lipocalin-type prostaglandin d synthase gene expression through de-repression of notch-hes signaling and enhancement of ap-2 functi..
a novel eukaryotic selenoprotein in the haptophyte alga emiliania huxleyi
dna polymerase mediates a back-up base excision repair activity in extracts of mouse embryonic fibroblasts
exosite-interactive regions in the a1 and a2 domains of factor viii facilitate thrombin-catalyzed cleavage of heavy chain
evidence for the involvement of the cannabinoid cb2 receptor and its endogenous ligand 2-arachidonoylglycerol in 12-o-tetradecanoylphorbol-13-acetate-induced acute ..
asparagine deamidation perturbs antigen presentation on class ii major histocompatibility complex molecules
low density lipoprotein receptor-related protein 1 (lrp1) controls endocytosis and c-cbl-mediated ubiquitination of the platelet-derived growth factor receptor (pdg..
leader peptide-mediated transcriptional attenuation of lysine biosynthetic gene cluster in thermus thermophilus
the rna-binding protein imp-3 is a translational activator of insulin-like growth factor ii leader-3 mrna during proliferation of human k562 leukemia cells
a novel protein kinase b (pkb)/akt-binding protein enhances pkb kinase activity and regulates dna synthesis
manganese superoxide dismutase protects against 6-hydroxydopamine injury in mouse brains
insulin stimulates postsynaptic density-95 protein translation via the phosphoinositide 3-kinase-akt-mammalian target of rapamycin signaling pathway
properties of the permeability transition pore in mitochondria devoid of cyclophilin d
serum amyloid a protein binds to outer membrane protein a of gram-negative bacteria
complex formation between glutamyl-trna reductase and glutamate-1-semialdehyde 2,1-aminomutase in escherichia coli during the initial reactions of porphyrin biosynt..
ubiquitination of apobec3g by an hiv-1 vif-cullin5-elongin b-elongin c complex is essential for vif function
interleukin-1 decreases expression of the epithelial sodium channel -subunit in alveolar epithelial cells via a p38 mapk-dependent signaling pathway
thermal destabilization of non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from streptococcus mutans upon phosphate binding in the active site
instability of the mitofusin fzo1 regulates mitochondrial morphology during the mating response of the yeast saccharomyces cerevisiae
a gtp:amp phosphotransferase, adk2p, in saccharomyces cerevisiae
translation of eukaryotic translation initiation factor 4gi (eif4gi) proceeds from multiple mrnas containing a novel cap-dependent internal ribosome entry site (ire..
localization of the n-terminal domain in light-harvesting chlorophyll a/b protein by epr measurements
fluorescence resonance energy transfer analysis of the antagonist- and partial agonist-occupied states of the cholecystokinin receptor
protein kinase c-dependent regulation of nag-1/placental bone morphogenic protein/mic-1 expression in lncap prostate carcinoma cells
identification of a dna methylation-dependent activator sequence in the pseudoxanthoma elasticum gene, abcc6
tissue-specific positive feedback requirements for production of type i interferon following virus infection
developmental changes of bile acid composition and conjugation in l- and d-bifunctional protein single and double knockout mice
peroxisome proliferator-activated receptor interacts with high affinity and is conformationally responsive to endogenous ligands
cleavage of the apoptosis inhibitor diap1 by the apical caspase dronc in both normal and apoptotic drosophila cells
identification of multiple genes encoding membrane proteins with undecaprenyl pyrophosphate phosphatase (uppp) activity in escherichia coli
p2y2 nucleotide receptors enhance -secretase-dependent amyloid precursor protein processing
trafficking of the plasma membrane -aminobutyric acid transporter gat
mint represses transactivation of the type ii collagen gene enhancer through interaction with a-crystallin-binding protein 1
the tuberous sclerosis protein tsc2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses
conformationally sensitive residues in extracellular loop 5 of the na+/dicarboxylate co-transporter
thr-774 (transmembrane segment m5), val-920 (m8), and glu-954 (m9) are involved in na+ transport, and gln-923 (m8) is essential for na,k-atpase activity
the average conformation at micromolar [ca2+] of ca2+-atpase with bound nucleotide differs from that adopted with the transition state analog adp·alfx or with ampp..
statins cause intracellular accumulation of amyloid precursor protein, -secretase-cleaved fragments, and amyloid -peptide via an isoprenoid-dependent mechanism
mdm2 binds to nbs1 at sites of dna damage and regulates double strand break repair
structure and function of carbonic anhydrases from mycobacterium tuberculosis
tumor necrosis factor stimulation of rac1 activity
role of t-loop phosphorylation in pdk1 activation, stability, and substrate binding
borrelia burgdorferi binds fibronectin through a tandem -zipper, a common mechanism of fibronectin binding in staphylococci, streptococci, and spirochetes
cullins 3a and 3b assemble with members of the broad complex/tramtrack/bric-a-brac (btb) protein family to form essential ubiquitin-protein ligases (e3s) in arabido..
role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo
structure of the intermolecular complex between plastocyanin and cytochrome f from spinach
phosphorylation of c-fos by members of the p38 mapk family
dpp10 modulates kv4-mediated a-type potassium channels
structure of hnrnp d complexed with single-stranded telomere dna and unfolding of the quadruplex by heterogeneous nuclear ribonucleoprotein d
fibronectin regulates latent transforming growth factor- (tgf) by controlling matrix assembly of latent tgf-binding protein-1
the cytosolic phospholipase a2 pathway, a safeguard of 2-adrenergic cardiac effects in rat
a structural basis for 14-3-3 functional specificity
synthesis of the blood circulating c-terminal fragment of insulin-like growth factor (igf)-binding protein-4 in its native conformation
structure of the complex between plastocyanin and cytochrome f from the cyanobacterium nostoc sp. pcc 7119 as determined by paramagnetic nmr
escherichia coli folc structure reveals an unexpected dihydrofolate binding site providing an attractive target for anti-microbial therapy
interaction with type iv pili induces structural changes in the bacterial outer membrane secretin pilq
palmitoylation and intracellular domain interactions both contribute to raft targeting of linker for activation of t cells
structural characterization of a novel cbl phosphotyrosine recognition motif in the aps family of adapter proteins
roles of phosphorylation-dependent and -independent mechanisms in the regulation of m1 muscarinic acetylcholine receptors by g protein-coupled receptor kinase 2 in ..
decreased stability and translation of t cell receptor mrna with an alternatively spliced 3‘-untranslated region contribute to chain down-regulation in patients wi..
mechanisms involved in enhancement of osteoclast formation and function by low molecular weight hyaluronic acid
pathway-specific profiling identifies the nf-b-dependent tumor necrosis factor -regulated genes in epidermal keratinocytes
nf90 regulates cell cycle exit and terminal myogenic differentiation by direct binding to the 3‘-untranslated region of myod and p21waf1/cip1 mrnas
n-myristoyltransferase 1 is essential in early mouse development
functional characterization of xendou, the endoribonuclease involved in small nucleolar rna biosynthesis
na,k-atpase from mice lacking the subunit (fxyd2) exhibits altered na+ affinity and decreased thermal stability
novel role for amphiregulin in protection from liver injury
grim-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells
integrin 5/1 expression mediates her-2 down-regulation in colon cancer cells
protein kinase d specifically mediates apoptosis signal-regulating kinase 1-jnk signaling induced by h2o2 but not tumor necrosis factor
1.6-å crystal structure of enta-im
bax-dependent regulation of bak by voltage-dependent anion channel 2
persistent nuclear factor-b activation in ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production
random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid -peptides
the benzophenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1
a novel ligand-independent apoptotic pathway induced by scavenger receptor class b, type i and suppressed by endothelial nitric-oxide synthase and high density lipo..
molecular determinants of cardiac katp channel activation by epoxyeicosatrienoic acids
cyclin-dependent kinase inhibitors and jnk act as molecular switches, regulating the choice between growth arrest and apoptosis induced by galectin-8
identification of direct serum-response factor gene targets during me2so-induced p19 cardiac cell differentiation
tetrameric architecture of the circadian clock protein kaib
determination of aberrant o-glycosylation in the iga1 hinge region by electron capture dissociation fourier transform-ion cyclotron resonance mass spectrometry
s3-12, adipophilin, and tip47 package lipid in adipocytes
developmental regulation of gonadotropin-releasing hormone gene expression by the msx and dlx homeodomain protein families
transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria
substrate binding stoichiometry and kinetics of the norepinephrine transporter
developmental regulation of wnt/-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification
uv-c light induces raft-associated acid sphingomyelinase and jnk activation and translocation independently on a nuclear signal
structural insight into the binding diversity between the tyr-phosphorylated human ephrinbs and nck2 sh2 domain
the shwachman-bodian-diamond syndrome protein family is involved in rna metabolism
structural and mutational analysis of the sbds protein family
involvement of the nf-b/matrix metalloproteinase pathway in cardiac fibrosis of mice lacking guanylyl cyclase/natriuretic peptide receptor a
palmitoylated cysteine 192 is required for rhob tumor-suppressive and apoptotic activities
structural basis for the cell-specific activities of the ngfi-b and the nurr1 ligand-binding domain
mutations near amino end of 1(i) collagen cause combined osteogenesis imperfecta/ehlers-danlos syndrome by interference with n-propeptide processing
functional dissection of an ap-2 2 appendage-binding sequence within the autosomal recessive hypercholesterolemia protein
transient homodimer interactions studied using the electron self-exchange reaction
fatty acid transduction of nitric oxide signaling
complete inhibition of anisomycin and uv radiation but not cytokine induced jnk and p38 activation by an aryl-substituted dihydropyrrolopyrazole quinoline and mixed..
dynamic membrane topology of the escherichia coli -glucoside transporter bglf
interaction between argr and ahrc controls regulation of arginine metabolism in lactococcus lactis
growth hormone receptor is a target for presenilin-dependent -secretase cleavage
prediction of collagen stability from amino acid sequence
folding efficiency is rate-limiting in dopamine d4 receptor biogenesis
physical and functional interactions of the lysophosphatidic acid receptors with pdz domain-containing rho guanine nucleotide exchange factors (rhogefs)
identification and functional characterization of a novel low affinity aromatic-preferring amino acid transporter (arpat)
identification of transcriptional targets of hoxa5
jnk1 differentially regulates osteopontin-induced nuclear factorinducing kinase/mekk1-dependent activating protein-1-mediated promatrix metalloproteinase-9 activation
mxa, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of trpc
selective knockdown of the long variant of cellular flice inhibitory protein augments death receptor-mediated caspase-8 activation and apoptosis
differential gene regulation of stard4 and stard5 cholesterol transfer proteins
degradation of trafficking-defective long qt syndrome type ii mutant channels by the ubiquitin-proteasome pathway
differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in l6 myotubes
light-induced electron transfer in arabidopsis cryptochrome-1 correlates with in vivo function
structural and kinetic analysis of the substrate specificity of human fibroblast activation protein
structure of s6 kinase 1 determines whether raptor-mtor or rictor-mtor phosphorylates its hydrophobic motif site
lipid raft association of snare proteins regulates exocytosis in pc12 cells
physical and functional interaction between elongator and the chromatin-associated kti12 protein
human tumorous imaginal disc 1 (tid1) associates with trk receptor tyrosine kinases and regulates neurite outgrowth in nnr5-trka cells
birb796 inhibits all p38 mapk isoforms in vitro and in vivo
a conserved n-capping motif contributes significantly to the stabilization and dynamics of the c-terminal region of class alpha glutathione s-transferases
reduction of unusual iron-sulfur clusters in the h2-sensing regulatory ni-fe hydrogenase from ralstonia eutropha h16
cytochrome p450 3a4-catalyzed testosterone 6-hydroxylation stereochemistry, kinetic deuterium isotope effects, and rate-limiting steps
free fatty acids inhibit serum deprivation-induced apoptosis through gpr120 in a murine enteroendocrine cell line stc-1
a3 adenosine receptor activation inhibits cell proliferation via phosphatidylinositol 3-kinase/akt-dependent inhibition of the extracellular signal-regulated kinase..
phosphorylation of rat liver mitochondrial glycerol-3-phosphate acyltransferase by casein kinase 2
biosynthesis of udp-n-acetyl-l-fucosamine, a precursor to the biosynthesis of lipopolysaccharide in pseudomonas aeruginosa serotype o11
nectin-4, a new serological breast cancer marker, is a substrate for tumor necrosis factor--converting enzyme (tace)/adam-17
sequence context effects on oligo(dt) termination signal recognition by saccharomyces cerevisiae rna polymerase iii
chemical synthesis of (s)-4,5-dihydroxy-2,3-pentanedione, a bacterial signal molecule precursor, and validation of its activity in salmonella typhimurium
directed evolution of mammalian cytochrome p450 2b
neuronal differentiation of p19 embryonal carcinoma cells modulates kinin b2 receptor gene expression and function
exercise stimulates pgc-1 transcription in skeletal muscle through activation of the p38 mapk pathway
vertebrate nonmuscle myosin ii isoforms rescue small interfering rna-induced defects in cos-7 cell cytokinesis
eap45 in mammalian escrt-ii binds ubiquitin via a phosphoinositide-interacting glue domain
identification by site-directed mutagenesis and chemical modification of three vicinal cysteine residues in rat mitochondrial carnitine/acylcarnitine transporter
interdomain and membrane interactions of ctp:phosphocholine cytidylyltransferase revealed via limited proteolysis and mass spectrometry
restoration of wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell dif..
the atm/p53/p21 pathway influences cell fate decision between apoptosis and senescence in reoxygenated hematopoietic progenitor cells
purified recombinant hypothetical protein coded by open reading frame rv1885c of mycobacterium tuberculosis exhibits a monofunctional aroq class of periplasmic chor..
structure and kinetics of a monomeric glucosamine 6-phosphate deaminase
ap2 clathrin adaptor complex, but not ap1, controls the access of the major histocompatibility complex (mhc) class ii to endosomes
a fully human recombinant igg-like bispecific antibody to both the epidermal growth factor receptor and the insulin-like growth factor receptor for enhanced antitum..
molecular cloning and characterization of a human aif-like gene with ability to induce apoptosis
acetylation of gata-4 is involved in the differentiation of embryonic stem cells into cardiac myocytes
caenorhabditis elegans geminin homologue participates in cell cycle regulation and germ line development
novel binding epitope for helicobacter pylori found in neolacto carbohydrate chains
estrogen induces vascular wall dilation
the -amino-3-hydroxyl-5-methyl-4-isoxazolepropionate receptor trafficking regulator “stargazin“ is related to the claudin family of proteins by its ability to med..
human mitochondrial mrnas are stabilized with polyadenylation regulated by mitochondria-specific poly(a) polymerase and polynucleotide phosphorylase
the suppression of galactose metabolism in procylic form trypanosoma brucei causes cessation of cell growth and alters procyclin glycoprotein structure and copy num..
r-state amp complex reveals initial steps of the quaternary transition of fructose-1,6-bisphosphatase
rb enhances p160/src coactivator-dependent activity of nuclear receptors and hormone responsiveness
cooperation of amphiregulin and insulin-like growth factor-1 inhibits bax- and bad-mediated apoptosis via a protein kinase c-dependent pathway in non-small cell lun..
paired activation of two components within muscarinic m3 receptor dimers is required for recruitment of -arrestin-1 to the plasma membrane
presenilin-dependent -secretase processing regulates multiple erbb4/her4 activities
diacylglycerol-induced membrane targeting and activation of protein kinase c
frataxin and mitochondrial carrier proteins, mrs3p and mrs4p, cooperate in providing iron for heme synthesis
protease-activated receptor-1 signaling by activated protein c in cytokine-perturbed endothelial cells is distinct from thrombin signaling
a more complex isoleucine aptamer with a cognate triplet
mitochondrial myopathy and sideroblastic anemia (mlasa)
ubiquitin binding site of the ubiquitin e2 variant (uev) protein mms2 is required for dna damage tolerance in the yeast rad6 pathway
caspase-10 triggers bid cleavage and caspase cascade activation in fasl-induced apoptosis
siglec-5 (cd170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation
the fusion activity of hiv-1 gp41 depends on interhelical interactions
recycling of the membrane-anchored chemokine, cx3cl1
novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1
identification of an endogenous inhibitor of the cardiac na+/ca2+ exchanger, phospholemman
sclerostin binds to lrp5/6 and antagonizes canonical wnt signaling
receptor-regulated dynamic s-nitrosylation of endothelial nitric-oxide synthase in vascular endothelial cells
up-regulation of human myo-inositol oxygenase by hyperosmotic stress in renal proximal tubular epithelial cells
thiazide-sensitive nacl-cotransporter in the intestine
sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species
connexin43 associated with an n-cadherin-containing multiprotein complex is required for gap junction formation in nih3t3 cells
the mammalian target of rapamycin-p70 ribosomal s6 kinase but not phosphatidylinositol 3-kinase-akt signaling is responsible for fibroblast growth factor-9-induced ..
ofloxacin-like antibiotics inhibit pneumococcal cell wall-degrading virulence factors
histone octamer instability under single molecule experiment conditions
patterns of gene expression differentially regulated by platelet-derived growth factor and hypertrophic stimuli in vascular smooth muscle cells
a novel myc-target gene, mimitin, that is involved in cell proliferation of esophageal squamous cell carcinoma
transgenic mice expressing dominant-negative osmotic-response element-binding protein (orebp) in lens exhibit fiber cell elongation defect associated with increased..
jnk1 and jnk2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix
nrip, a novel nuclear receptor interaction protein, enhances the transcriptional activity of nuclear receptors
an insulin-response element-binding protein that ameliorates hyperglycemia in diabetes
roles of the n-terminal domain on the function and quaternary structure of the ionotropic glutamate receptor
biochemical and biophysical characterization of photosystem i from phytoene desaturase and -carotene desaturase deletion mutants of synechocystis sp. pcc 680
phosducin-like protein regulates g-protein folding by interaction with tailless complex polypeptide-
biochemical properties of saccharomyces cerevisiae dna polymerase iv
curcumin selectively induces apoptosis in deregulated cyclin d1-expressed cells at g2 phase of cell cycle in a p53-dependent manner
pokeweed antiviral protein inhibits brome mosaic virus replication in plant cells
exploring cellular activity of locked nucleic acid-modified triplex-forming oligonucleotides and defining its molecular basis
crd-bp/imp1 expression characterizes cord blood cd34+ stem cells and affects c-myc and igf-ii expression in mcf-7 cancer cells
intestinal glucose-dependent expression of glucose-6-phosphatase
identification of stereoselective transporters for s-nitroso-l-cysteine
the c-terminal sterile motif and the extreme c terminus regulate the transcriptional activity of the isoform of p73
attribution of the various inhibitory actions of the streptococcal inhibitor of complement (sic) to regions within the molecule
oligomerization and multimerization are critical for angiopoietin-1 to bind and phosphorylate tie2
role of the novel metallopeptidase mop112 and saccharolysin for the complete degradation of proteins residing in different subcompartments of mitochondria
sequences from the low density lipoprotein receptor-related protein (lrp) cytoplasmic domain enhance amyloid protein production via the -secretase pathway without a..
acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling
investigating hiv-1 polypurine tract geometry via targeted insertion of abasic lesions in the (-)-dna template and (+)-rna primer
fluid shear stress synergizes with insulin-like growth factor-i (igf-i) on osteoblast proliferation through integrin-dependent activation of igf-i mitogenic signali..
dynamic cpg and non-cpg methylation of the peg1/mest gene in the mouse oocyte and preimplantation embryo
mycobacterium tuberculosis strains possess functional cellulases
characterization of a new pantothenate kinase isoform from helicobacter pylori
recombinant porcine zona pellucida glycoproteins expressed in sf9 cells bind to bovine sperm but not to porcine sperm
synaptotagmin vi and viii and syntaxin 2 are essential for the mouse sperm acrosome reaction
identification, evolution, and regulation of expression of guinea pig trappin with an unusually long transglutaminase substrate domain
base pair opening in three dna-unwinding elements
binding of iron-free siderophore, a common feature of siderophore outer membrane transporters of escherichia coli and pseudomonas aeruginosa
coq3 and coq4 define a polypeptide complex in yeast mitochondria for the biosynthesis of coenzyme q
the interaction of trimethylamine dehydrogenase and electron-transferring flavoprotein
the mre11-rad50-xrs2 complex, in addition to other non-homologous end-joining factors, is required for v(d)j joining in yeast
molecular characterization of a purified 5-ht4 receptor
membrane topology of the stt3 subunit of the oligosaccharyl transferase complex
expression of four glutamine synthetase genes in the early stages of development of rainbow trout (oncorhynchus mykiss) in relationship to nitrogen excretion
the bone-specific expression of runx2 oscillates during the cell cycle to support a g1-related antiproliferative function in osteoblasts
2-haloacrylate reductase, a novel enzyme of the medium chain dehydrogenase/reductase superfamily that catalyzes the reduction of a carbon-carbon double bond of unsa..
n-acetylmuramic acid as capping element of -d-fucose-containing s-layer glycoprotein glycans from geobacillus tepidamans gs5-97t
reaction of ferric cytochrome p450cam with peracids
regulation of mdr1 expression and drug resistance by a positive feedback loop involving hyaluronan, phosphoinositide 3-kinase, and erbb2
transporter-associated currents in the -aminobutyric acid transporter gat-1 are conditionally impaired by mutations of a conserved glycine residue
endogenous calcitonin gene-related peptide protects human alveolar epithelial cells through protein kinase c and heat shock protein
the oxidative stressor arsenite activates vascular endothelial growth factor mrna transcription by an atf4-dependent mechanism
transcriptional regulation of nf-e2 p45-related factor (nrf2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway
the extracellular matrix protein magp-2 interacts with jagged1 and induces its shedding from the cell surface
the critical role of exo84p in the organization and polarized localization of the exocyst complex
lys6-modified ubiquitin inhibits ubiquitin-dependent protein degradation
silibinin up-regulates dna-protein kinase-dependent p53 activation to enhance uvb-induced apoptosis in mouse epithelial jb6 cells
wallerian degeneration involves rho/rho-kinase signaling
glucose suppresses superoxide generation in metabolically responsive pancreatic cells
the crystal structure of the collagen-like polypeptide (glycyl-4(r)-hydroxyprolyl-4(r)-hydroxyprolyl)9 at 1.55 å resolution shows up-puckering of the proline ring ..
encephalitozoon cuniculi mrna cap (guanine n-7) methyltransferase
functional characterization of mouse rdh11 as a retinol dehydrogenase involved in dark adaptation in vivo
endogenous coactivator ara70 interacts with estrogen receptor (er) and modulates the functional er/androgen receptor interplay in mcf-7 cells
n-terminal processing of lhca3 is a key step in remodeling of the photosystem i-light-harvesting complex under iron deficiency in chlamydomonas reinhardtii
tpl2 (tumor progression locus 2) phosphorylation at thr290 is induced by lipopolysaccharide via an i-b kinase--dependent pathway and is required for tpl2 activation..
switching human telomerase on and off with hpot1 protein in vitro
identification and characterization of heparin/heparan sulfate binding domains of the endoglycosidase heparanase
nucleotide- and stoichiometry-dependent dna supercoiling by reverse gyrase
locating an antagonist in the 5-ht3 receptor binding site using modeling and radioligand binding
molecular determinants of trif proteolysis mediated by the hepatitis c virus ns3/4a protease
pharmacological inhibition of amp-activated protein kinase provides neuroprotection in stroke
neurochondrin negatively regulates camkii phosphorylation, and nervous system-specific gene disruption results in epileptic seizure
fibroblast growth factor (fgf) 18 signals through fgf receptor 3 to promote chondrogenesis
novel heparan sulfate structures revealed by monoclonal antibodies
an immunologically cryptic epitope of plasmodium falciparum circumsporozoite protein facilitates liver cell recognition and induces protective antibodies that block..
the autonomous activity of calcium/calmodulin-dependent protein kinase iv is required for its role in transcription
molecular determinants for the complex binding specificity of the pdz domain in pick1
rna cug-binding protein 1 increases translation of 20-kda isoform of ccaat/enhancer-binding protein by interacting with the and subunits of eukaryotic initiation tr..
the solution structure of the fatc domain of the protein kinase target of rapamycin suggests a role for redox-dependent structural and cellular stability
target of rapamycin-dependent activation of s6 kinase is a central step in the transduction of nutritional signals during egg development in a mosquito
in vitro synthesized small interfering rnas elicit rna interference in african trypanosomes
roles of the hif-1 hypoxia-inducible factor during hypoxia response in caenorhabditis elegans
nuclear trapping of the forkhead transcription factor foxo1 via sirt-dependent deacetylation promotes expression of glucogenetic genes
the nature of the stimulus and of the fumarate binding site of the fumarate sensor dcus of escherichia coli
alternative splicing of vitamin d-24-hydroxylase
pigment-pigment interactions in lhca4 antenna complex of higher plants photosystem i
toll-like receptor signaling stimulates cell cycle entry and progression in fibroblasts
mechanistic studies on a novel, highly potent gold-phosphole inhibitor of human glutathione reductase
aspartyl-trna synthetase requires a conserved proline in the anticodon-binding loop for trnaasn recognition in vivo
sp4 is expressed in retinal neurons, activates transcription of photoreceptor-specific genes, and synergizes with crx
cdk5 activator-binding protein c53 regulates apoptosis induced by genotoxic stress via modulating the g2/m dna damage checkpoint
divergent distribution in vascular and avascular mammalian retinae links neuroglobin to cellular respiration
phea (rv3838c) of mycobacterium tuberculosis encodes an allosterically regulated monofunctional prephenate dehydratase that requires both catalytic and regulatory d..
cyanobacterial non-mevalonate pathway
dentin matrix protein 1 gene cis-regulation
extracellular acid block and acid-enhanced inactivation of the ca2+-activated cation channel trpm5 involve residues in the s3-s4 and s5-s6 extracellular domains
src-mediated tyrosine phosphorylation of p47phox in hyperoxia-induced activation of nadph oxidase and generation of reactive oxygen species in lung endothelial cells
crystal structure of himalayan mistletoe ribosome-inactivating protein reveals the presence of a natural inhibitor and a new functionally active sugar-binding site
essential roles of atg5 and fadd in autophagic cell death
structure of the functional domain of 29 replication organizer
pyrrolysine and selenocysteine use dissimilar decoding strategies
a novel mechanism for protein delivery
crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate
solution nmr structure of the 48-kda iiamannose-hpr complex of the escherichia coli mannose phosphotransferase system
solution structure of the c-terminal domain of tfiih p44 subunit reveals a novel type of c4c4 ring domain involved in protein-protein interactions
channel function is dissociated from the intrinsic kinase activity and autophosphorylation of trpm7/chak1
acid sphingomyelinase is indispensable for uv light-induced bax conformational change at the mitochondrial membrane
the foxo3a transcription factor regulates cardiac myocyte size downstream of akt signaling
probing the role of asp-120(81) of metallo--lactamase (imp-1) by site-directed mutagenesis, kinetic studies, and x-ray crystallography
metastasis-associated protein s100a4 induces angiogenesis through interaction with annexin ii and accelerated plasmin formation
chip controls the sensitivity of transforming growth factor- signaling by modulating the basal level of smad3 through ubiquitin-mediated degradation
mouse large can modify complex n- and mucin o-glycans on -dystroglycan to induce laminin binding
activation of the rat renin promoter by hoxd10·pbx1b·prep1, ets-1, and the intracellular domain of notch
c-jun n-terminal kinase (jnk) positively regulates nfatc2 transactivation through phosphorylation within the n-terminal regulatory domain
the keratan sulfate disaccharide gal(6s03) 1,4-glcnac(6s03) modulates interleukin 12 production by macrophages in murine thy-1 type autoimmune disease
the multidrug efflux regulator ttgv recognizes a wide range of structurally different effectors in solution and complexed with target dna
comprehensive proteomic analysis of saccharomyces cerevisiae cell walls
biochemical characterization of the campylobacter jejuni cj1294, a novel udp-4-keto-6-deoxy-glcnac aminotransferase that generates udp-4-amino-4,6-dideoxy-galnac
visualization of single escherichia coli ftsz filament dynamics with atomic force microscopy
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