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jingzhaotoxin-i, a novel spider neurotoxin preferentially inhibiting cardiac sodium channel inactivation
yeast-like mrna capping apparatus in giardia lamblia
advanced glycation end products enhance expression of pro-apoptotic genes and stimulate fibroblast apoptosis through cytoplasmic and mitochondrial pathways
foxo1 functions as a master switch that regulates gene expression necessary for tumor necrosis factor-induced fibroblast apoptosis
modulation of the heparanase-inhibiting activity of heparin through selective desulfation, graded n-acetylation, and glycol splitting
the role of mitochondria for ca2+ refilling of the endoplasmic reticulum
the deacetylase hdac1 negatively regulates the cardiovascular transcription factor krüppel-like factor 5 through direct interaction
modification of permeability transition pore arginine(s) by phenylglyoxal derivatives in isolated mitochondria and mammalian cells
structure-guided mutational analysis of the nucleotidyltransferase domain of escherichia coli nad+-dependent dna ligase (liga)
src kinase activity is required for integrin v3-mediated activation of nuclear factor-b
pak1 negatively regulates the activity of the rho exchange factor net1
human ran cysteine 112 oxidation by pervanadate regulates its binding to keratins
the mitochondrial type ii peroxiredoxin f is essential for redox homeostasis and root growth of arabidopsis thaliana under stress
chloride conductance is required for the protein kinase a and rac1-dependent phosphorylation of moesin at thr-558 by kcl in pc12 cells
mechanistic differences in rna-dependent dna polymerization and fidelity between murine leukemia virus and hiv-1 reverse transcriptases
structural characterization of netnes, a novel glycoconjugate in trypanosoma cruzi epimastigotes
lipid rafts control signaling of type-1 cannabinoid receptors in neuronal cells
the molecular chaperone, clpa, has a single high affinity peptide binding site per hexamer
the role of the regulatory subunit of fission yeast calcineurin for in vivo activity and its relevance to fk506 sensitivity
interleukin-6 regulation of transforming growth factor (tgf)- receptor compartmentalization and turnover enhances tgf-1 signaling
repression and coactivation of ccaat/enhancer-binding protein by sumoylation and protein inhibitor of activated statx proteins
lipid mixing between lipoplexes and plasma lipoproteins is a major barrier for intravenous transfection mediated by cationic lipids
regulation of the transcriptional activity of the irf7 promoter by a pathway independent of interferon signaling
insights into selective activation of p53 dna binding by c-abl
kinetic analysis of oxidation of coumarins by human cytochrome p450 2a6
the small heat shock protein ibpa of escherichia coli cooperates with ibpb in stabilization of thermally aggregated proteins in a disaggregation competent state
the eb1 homolog mal3 stimulates the atpase of the kinesin tea2 by recruiting it to the microtubule
flow shear stress stimulates gab1 tyrosine phosphorylation to mediate protein kinase b and endothelial nitric-oxide synthase activation in endothelial cells
glucosepane is a major protein cross-link of the senescent human extracellular matrix
rational design of -helical antimicrobial peptides with enhanced activities and specificity/therapeutic index
paired cysteine mutagenesis to establish the pattern of disulfide bonds in the functional intact secretin receptor
activation of p27kip1 expression by e2f
the n-terminal domain of pilb from neisseria meningitidis is a disulfide reductase that can recycle methionine sulfoxide reductases
identification of a novel helicase activity unwinding branched dnas from the hyperthermophilic archaeon, pyrococcus furiosus
hoxa9 activates transcription of the gene encoding gp91phox during myeloid differentiation
recruitment of a foreign quinone into the a1 site of photosystem i
cooperative transition in the conformation of 24-mer tarantula hemocyanin upon oxygen binding
dtl, the drosophila homolog of pimt/tgs1 nuclear receptor coactivator-interacting protein/rna methyltransferase, has an essential role in development
crystal structure of the cysteine-rich secretory protein stecrisp reveals that the cysteine-rich domain has a k+ channel inhibitor-like fold
activation of budding yeast replication origins and suppression of lethal dna damage effects on origin function by ectopic expression of the co-chaperone protein mge1
cloning, expression, and characterization of the human mitochondrial -ketoacyl synthase
centrosomal p4.1-associated protein is a new member of transcriptional coactivators for nuclear factor-b
superoxide anion radical modulates the activity of ras and ras-related gtpases by a radical-based mechanism similar to that of nitric oxide
energetics of proton transfer pathways in reaction centers from rhodobacter sphaeroides
new functions for parts of the krebs cycle in procyclic trypanosoma brucei, a cycle not operating as a cycle
in vivo evidence for the specificity of plasmodium falciparum phosphoethanolamine methyltransferase and its coupling to the kennedy pathway
the interaction of phospholipase c-3 with shank2 regulates mglur-mediated calcium signal
differential role of the 1c subunit tails in regulation of the cav1.2 channel by membrane potential, subunits, and ca2+ ions
bid mediates apoptotic synergy between tumor necrosis factor-related apoptosis-inducing ligand (trail) and dna damage
nogo-a, -b, and -c are found on the cell surface and interact together in many different cell types
elevated 1,4-galactosyltransferase i in highly metastatic human lung cancer cells
the nf2 tumor suppressor merlin and the erm proteins interact with n-wasp and regulate its actin polymerization function
functional overexpression of -secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity
identification of calcium-modulating cyclophilin ligand (caml) as transducer of angiotensin ii-mediated nuclear factor of activated t cells (nfat) activation
the sulfogalactose moiety of sulfoglycosphingolipids serves as a mimic of tyrosine phosphate in many recognition processes
endoproteolytic cleavage of fe65 converts the adaptor protein to a potent suppressor of the sapp pathway in primates
the expression of intact and mutant human apoai/ciii/aiv/av gene cluster in transgenic mice
steric accessibility of the hiv-1 gp41 n-trimer region
nur77 regulates lipolysis in skeletal muscle cells
asymmetric interaction between rod cyclic gmp phosphodiesterase subunits and subunits
co-activation of erk, nf-b, and gadd45 in response to ionizing radiation
role of protein phosphatase 2a in mglur5-regulated mek/erk phosphorylation in neurons
-methylacyl-coa racemase from mycobacterium tuberculosis
signal transducers and activators of transcription 3 augments the transcriptional activity of ccaat/enhancer-binding protein in granulocyte colony-stimulating facto..
structure of the major cytosolic glutathione s-transferase from the parasitic nematode onchocerca volvulus
excretion of putrescine and spermidine by the protein encoded by ykl174c (tpo5) in saccharomyces cerevisiae
novel splicing variant of mouse orc1 is deficient in nuclear translocation and resistant for proteasome-mediated degradation
polo-like kinase 1 phosphorylates heat shock transcription factor 1 and mediates its nuclear translocation during heat stress
monastrol inhibition of the mitotic kinesin eg5
aberrant localization of intracellular organelles, ca2+ signaling, and exocytosis in mist1 null mice
tumor necrosis factor- up-regulates the expression of 1,4-galactosyltransferase i in primary human endothelial cells by mrna stabilization
calcium signal-induced cofilin dephosphorylation is mediated by slingshot via calcineurin
involvement of hu and heterogeneous nuclear ribonucleoprotein k in neuronal differentiation through p21 mrna post-transcriptional regulation
mbd3l2 interacts with mbd3 and components of the nurd complex and can oppose mbd2-mecp1-mediated methylation silencing
inactivation of npc1l1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia
human sperm do not bind to rat zonae pellucidae despite the presence of four homologous glycoproteins
the mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase (dlk) acts as a key regulator of keratinocyte terminal differentiation
transforming growth factor-3 restores fusion in palatal shelves exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin
modulation of the interleukin-6 receptor subunit glycoprotein 130 complex and its signaling by lmo4 interaction
regulation of -catenin signaling and maintenance of chondrocyte differentiation by ubiquitin-independent proteasomal degradation of -catenin
regulatory elements in the immunoglobulin heavy chain gene 3‘-enhancers induce c-myc deregulation and lymphomagenesis in murine b cells
g protein-coupled receptor kinase regulates dopamine d3 receptor signaling by modulating the stability of a receptor-filamin--arrestin complex
impaired gastric acid secretion in mice with a targeted disruption of the nhe4 na+/h+ exchanger
a novel potassium channel in lymphocyte mitochondria
interaction of the mammalian endosomal sorting complex required for transport (escrt) iii protein hsnf7-1 with itself, membranes, and the aaa+ atpase skd1
novel poly-galnac1-4glcnac (lacdinac) and fucosylated poly-lacdinac n-glycans from mammalian cells expressing 1,4-n-acetylgalactosaminyltransferase and 1,3-fucosylt..
control of calcium signal propagation to the mitochondria by inositol 1,4,5-trisphosphate-binding proteins
transduction of the scorpion toxin maurocalcine into cells
hiv-1 nef disrupts antigen presentation early in the secretory pathway
the novel drosophila lysosomal enzyme receptor protein mediates lysosomal sorting in mammalian cells and binds mammalian and drosophila gga adaptors
monooxygenation of an aromatic ring by f43w/h64d/v68i myoglobin mutant and hydrogen peroxide
role of krüppel-like factor 15 (klf15) in transcriptional regulation of adipogenesis
maturation of bacteriophage t4 lagging strand fragments depends on interaction of t4 rnase h with t4 32 protein rather than the t4 gene 45 clamp
the fatty acid-binding protein, ap2, coordinates macrophage cholesterol trafficking and inflammatory activity
interferon induces neurite outgrowth by up-regulation of p35 neuron-specific cyclin-dependent kinase 5 activator via activation of erk1/2 pathway
iii-tubulin induces paclitaxel resistance in association with reduced effects on microtubule dynamic instability
apical localization of a functional trpc3/trpc6-ca2+-signaling complex in polarized epithelial cells
crystal structures of apo-form and binary/ternary complexes of podophyllum secoisolariciresinol dehydrogenase, an enzyme involved in formation of health-protecting ..
dna lesion-specific co-localization of the mre11/rad50/nbs1 (mrn) complex and replication protein a (rpa) to repair foci
integrative genomics revealed rai3 is a cell growth-promoting gene and a novel p53 transcriptional target
phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis
tal1/scl binding to pericentromeric dna represses transcription
aph-1 contributes to the stabilization and trafficking of the -secretase complex through mechanisms involving intermolecular and intramolecular interactions
cell cycle and developmental regulations of replication factors in mouse embryonic stem cells
epidermal growth factor-induced proliferation requires down-regulation of pax6 in corneal epithelial cells
the sec-independent function of escherichia coli yidc is evolutionary-conserved and essential
evolution of mitochondrial oxa proteins from bacterial yidc
hyaluronan biosynthesis by class i streptococcal hyaluronan synthases occurs at the reducing end
regulation of the versican promoter by the -catenin-t-cell factor complex in vascular smooth muscle cells
functional relevance of the conserved dna-binding domain of stat2
snon is a cell type-specific mediator of transforming growth factor- responses
activation, proteolytic processing, and peptide specificity of recombinant cardosin a
the role of the novel fem protein vank in vancomycin resistance in streptomyces coelicolor
a second human dbf4/ask-related protein, drf1/askl1, is required for efficient progression of s and m phases
the c-myc dna-unwinding element-binding protein modulates the assembly of dna replication complexes in vitro
cdc24 regulates nuclear shuttling and recruitment of the ste5 scaffold to a heterotrimeric g protein in saccharomyces cerevisiae
the transcriptional activity of estrogen receptor- is dependent on ca2+/calmodulin
a complex mechanism determines polarity of dna replication fork arrest by the replication terminator complex of bacillus subtilis
repression of an interleukin-4-responsive promoter requires cooperative bcl-6 function
par1 cleavage and signaling in response to activated protein c and thrombin
sh2-containing 5‘-inositol phosphatase, ship2, regulates cytoskeleton organization and ligand-dependent down-regulation of the epidermal growth factor receptor
ohanin, a novel protein from king cobra venom, induces hypolocomotion and hyperalgesia in mice
heat shock protein 90 stabilization of erbb2 expression is disrupted by atp depletion in myocytes
mrna guanylation catalyzed by the s-adenosylmethionine-dependent guanylyltransferase of bamboo mosaic virus
gata transcription factors inhibit cytokine-dependent growth and survival of a hematopoietic cell line through the inhibition of stat3 activity
regulation of -fibrinogen chain expression by heterogeneous nuclear ribonucleoprotein a1
preheating accelerates mitogen-activated protein (map) kinase inactivation post-heat shock via a heat shock protein 70-mediated increase in phosphorylated map kinas..
14-3-3 proteins modulate the expression of epithelial na+ channels by phosphorylation-dependent interaction with nedd4-2 ubiquitin ligase
cdx binding determines the timing of enhancer activation in postnatal duodenum
proinsulin disulfide maturation and misfolding in the endoplasmic reticulum
differential regulation of mdr1 transcription by the p53 family members
probing the structure of the infectious amyloid form of the prion-forming domain of het-s using high resolution hydrogen/deuterium exchange monitored by mass spectr..
antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrate inositol-1,4,5-trisphosphate 3-kinases and inositol polyphosphate multikin..
cellular fate of truncated slow skeletal muscle troponin t produced by glu180 nonsense mutation in amish nemaline myopathy
novel avidin-like protein from a root nodule symbiotic bacterium, bradyrhizobium japonicum
structural and mechanistic studies of escherichia coli nitroreductase with the antibiotic nitrofurazone
regulation of 17,20 lyase activity by cytochrome b5 and by serine phosphorylation of p450c17
importin / mediates nuclear transport of a mammalian circadian clock component, mcry2, together with mper2, through a bipartite nuclear localization signal
substrate enhances the sensitivity of type i protein kinase a to camp
oleate promotes the proliferation of breast cancer cells via the g protein-coupled receptor gpr40
catalytic cooperativity among subunits of escherichia coli transcription termination factor rho
active site occupancy required for catalytic cooperativity by escherichia coli transcription termination factor rho
functional characterization of human rsk4, a new 90-kda ribosomal s6 kinase, reveals constitutive activation in most cell types
dimeric trigger factor stably binds folding-competent intermediates and cooperates with the dnak-dnaj-grpe chaperone system to allow refolding
yeh2/ylr020c encodes a novel steryl ester hydrolase of the yeast saccharomyces cerevisiae
identification and characterization of the protein-associated splicing factor as a negative co-regulator of the progesterone receptor
mechanism of stimulation of catalytic activity of dnmt3a and dnmt3b dna-(cytosine-c5)-methyltransferases by dnmt3l
hypoxic modulation of ca2+ signaling in human venous endothelial cells
methylation of the imidazole side chains of the alzheimer disease amyloid- peptide results in abolition of superoxide dismutase-like structures and inhibition of ne..
differential stat5 signaling by ligand-dependent and constitutively active cytokine receptors
the role of p70s6k in hepatic stellate cell collagen gene expression and cell proliferation
regulators of g-protein signaling form a quaternary complex with the agonist, receptor, and g-protein
amp-activated protein kinase subunit tethers and subunits via its c-terminal sequence (186-270)
the mrna nuclear export factor hpr1 is regulated by rsp5-mediated ubiquitylation
effects of adsorption to aluminum salt adjuvants on the structure and stability of model protein antigens
phosphorylation of maskin by aurora-a participates in the control of sequential protein synthesis during xenopus laevis oocyte maturation
regulation of ca2+-dependent desensitization in the vanilloid receptor trpv1 by calcineurin and camp-dependent protein kinase
subunit stoichiometry of the kir1.1 channel in proton-dependent gating
distinct turnover of alternatively spliced isoforms of the ret kinase receptor mediated by differential recruitment of the cbl ubiquitin ligase
identification of the geometric requirements for allosteric communication between the - and -subunits of tryptophan synthase
interactions of multiple heparin binding growth factors with neuropilin-1 and potentiation of the activity of fibroblast growth factor-2
evidence for the involvement of cytosolic 5‘-nucleotidase (cn-ii) in the synthesis of guanine nucleotides from xanthosine
catalysis of creatine kinase refolding by protein disulfide isomerase involves disulfide cross-link and dimer to tetramer switch
dimerization through the catalytic domain is essential for mekk2 activation
dissociation of insulin receptor expression and signaling from caveolin-1 expression
identification of the type i collagen-binding domain of bone sialoprotein and characterization of the mechanism of interaction
mediators of galactose sensitivity in udp-galactose 4‘-epimerase-impaired mammalian cells
simvastatin attenuates expression of cytokine-inducible nitric-oxide synthase in embryonic cardiac myoblasts
inhibition of host and viral translation during vesicular stomatitis virus infection
three- and four-repeat tau regulate the dynamic instability of two distinct microtubule subpopulations in qualitatively different manners
biophysical characterization of erp2
the pro-inflammatory mediator leukotriene d4 induces phosphatidylinositol 3-kinase and rac-dependent migration of intestinal epithelial cells
phosphorylation of ser28 in histone h3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase
resistance to a protein farnesyltransferase inhibitor in plasmodium falciparum
sirt3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes
site-directed mutagenesis, proteolytic cleavage, and activation of human proheparanase
crystal structure of vinorine synthase, the first representative of the bahd superfamily
pals1 specifies the localization of ezrin to the apical membrane of gastric parietal cells
the 1.4 å crystal structure of the human oxidized low density lipoprotein receptor lox-1
the nuclear receptor corepressors ncor and smrt decrease peroxisome proliferator-activated receptor transcriptional activity and repress 3t3-l1 adipogenesis
chromatin immunoprecipitation (chip) on chip experiments uncover a widespread distribution of nf-y binding ccaat sites outside of core promoters
interaction between lrp5 and frat1 mediates the activation of the wnt canonical pathway
calmodulin is required for vasopressin-stimulated increase in cyclic amp production in inner medullary collecting duct
gating-enhanced accessibility of hydrophobic sites within the transmembrane region of the nicotinic acetylcholine receptor‘s -subunit
lipocalin 2 diminishes invasiveness and metastasis of ras-transformed cells
granulin and granulin repeats interact with the tat·p-tefb complex and inhibit tat transactivation
structural basis for metal ion coordination and the catalytic mechanism of sphingomyelinases d
the mammalian yl1 protein is a shared subunit of the trrap/tip60 histone acetyltransferase and srcap complexes
low resolution structural study of two human hsp40 chaperones in solution
oxidative activation of protein kinase c through the c1 domain
an arginine residue in the pore region is a key determinant of chloride dependence in cardiac pacemaker channels
triticum durum metallothionein
how an enzyme binds the c1 carrier tetrahydromethanopterin
negative regulation of rankl-induced osteoclastic differentiation in raw264.7 cells by estrogen and phytoestrogens
pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by ly294002
latent s49p neuroserpin forms polymers in the dementia familial encephalopathy with neuroserpin inclusion bodies
a novel role of lactosylceramide in the regulation of tumor necrosis factor -mediated proliferation of rat primary astrocytes
effects of p47phox c terminus phosphorylations on binding interactions with p40phox and p67phox
protein kinase d1 phosphorylates hdac7 and induces its nuclear export after t-cell receptor activation
the role of the hinge loop in domain swapping
crystal structure of the virulence gene activator apha from vibrio cholerae reveals it is a novel member of the winged helix transcription factor superfamily
critical and distinct roles of amino- and carboxyl-terminal sequences in regulation of the biological activity of the chp atypical rho gtpase
design of a novel class of peptide inhibitors of cyclin-dependent kinase/cyclin activation
neurotrophin receptor interacting factor (nrif) is an essential mediator of apoptotic signaling by the p75 neurotrophin receptor
compensatory roles of foxa1 and foxa2 during lung morphogenesis
suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with stat5 or stat3 and attenuating their nuclear translo..
par-4 is involved in regulation of -secretase cleavage of the alzheimer amyloid precursor protein
soluble tyrosinase is an endoplasmic reticulum (er)-associated degradation substrate retained in the er by calreticulin and bip/grp78 and not calnexin
solution structure of af-6 pdz domain and its interaction with the c-terminal peptides from neurexin and bcr
a streptococcal collagen-like protein interacts with the 21 integrin and induces intracellular signaling
chicken ovalbumin upstream promoter-transcription factor members repress retinoic acid-induced cdx1 expression
direct binding of nuclear membrane protein man1 to emerin in vitro and two modes of binding to barrier-to-autointegration factor
iqgap1 promotes neurite outgrowth in a phosphorylation-dependent manner
opposing effects of protein kinase c and protein kinase c on collagen expression by human lung fibroblasts are mediated via mek/erk and caveolin-1 signaling
proliferating cell nuclear antigen (pcna) may function as a double homotrimer complex in the mammalian cell
intersubunit and domain interactions of the meprin b metalloproteinase
microsomal triglyceride transfer protein promotes the secretion of xenopus laevis vitellogenin a1
aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis
the amyloid precursor protein (app) of alzheimer disease and its paralog, aplp2, modulate the cu/zn-nitric oxide-catalyzed degradation of glypican-1 heparan sulfate..
dna binding by the substrate specificity (wedge) domain of recg helicase suggests a role in processivity
transcriptional repression and heterochromatin formation by mbd1 and mcaf/am family proteins
malignant transformation of human cells by constitutive expression of platelet-derived growth factor-bb
the 1.1-å structure of the spindle checkpoint protein bub3p reveals functional regions
identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation
a new type of peroxisomal acyl-coenzyme a synthetase from arabidopsis thaliana has the catalytic capacity to activate biosynthetic precursors of jasmonic acid
mitosin/cenp-f as a negative regulator of activating transcription factor-4
the crystal structure of rv1347c, a putative antibiotic resistance protein from mycobacterium tuberculosis, reveals a gcn5-related fold and suggests an alternative ..
comparative analysis of the human and chicken prion protein copper binding regions at ph 6.5
molecular motions of human cyclin-dependent kinase 2
mart-1 is required for the function of the melanosomal matrix protein pmel17/gp100 and the maturation of melanosomes
characterization of the intronic splicing silencers flanking fgfr2 exon iiib
group vib ca2+-independent phospholipase a2 promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospho..
a novel caspase-1/toll-like receptor 4-independent pathway of cell death induced by cytosolic shigella in infected macrophages
the trap-like relaxin-binding site of the leucine-rich g-protein-coupled receptor 7
gene expression profiling in conjunction with physiological rescues of ikk-null cells with wild type or mutant ikk reveals distinct classes of ikk/nf-b-dependent ge..
a novel inhibitor that suspends the induced fit mechanism of udp-n-acetylglucosamine enolpyruvyl transferase (mura)
ca2+-dependent interface formation in fibrillin-1
the 14-3-3 proteins of trypanosoma brucei function in motility, cytokinesis, and cell cycle
a highly conserved binding site in vesicle-associated membrane protein-associated protein (vap) for the ffat motif of lipid-binding proteins
insights into the structure and regulation of glucokinase from a novel mutation (v62m), which causes maturity-onset diabetes of the young
strong in vivo maturation compensates for structurally restricted h3 loops in antibody repertoires
dragon, a bone morphogenetic protein co-receptor
nongenotropic, anti-apoptotic signaling of 1,25(oh)2-vitamin d3 and analogs through the ligand binding domain of the vitamin d receptor in osteoblasts and osteocytes
crystal structure of the trna 3‘ processing endoribonuclease trnase z from thermotoga maritima
,-unsaturated ketone is a core moiety of natural ligands for covalent binding to peroxisome proliferator-activated receptor
a formyltransferase required for polymyxin resistance in escherichia coli and the modification of lipid a with 4-amino-4-deoxy-l-arabinose
systematic evaluation of anti-apoptotic growth factor signaling in vascular smooth muscle cells
calcium-sensing receptor gene transcription is up-regulated by the proinflammatory cytokine, interleukin-
phosphorylation of the -subunit of the eukaryotic initiation factor-2 (eif2) reduces protein synthesis and enhances apoptosis in response to proteasome inhibition
inducible nitric-oxide synthase and no donor induce insulin receptor substrate-1 degradation in skeletal muscle cells
delayed activation of insulin-like growth factor-1 receptor/src/mapk/egr-1 signaling regulates clusterin expression, a pro-survival factor
foxo1 stimulates fatty acid uptake and oxidation in muscle cells through cd36-dependent and -independent mechanisms
tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a srp30c·srp55 complex that either recruits ..
activity of hypoxia-inducible factor 2 is regulated by association with the nf-b essential modulator
novel symmetric and asymmetric dna scission determinants for streptococcus pneumoniae topoisomerase iv and gyrase are clustered at the dna breakage site
direct effects of polymyxin b on human dendritic cells maturation
the intercellular signaling activity of the mycobacterium tuberculosis chaperonin 60.1 protein resides in the equatorial domain
bacillolysin ma, a novel bacterial metalloproteinase that produces angiostatin-like fragments from plasminogen and activates protease zymogens in the coagulation an..
a loss-of-function mutation in natriuretic peptide receptor 2 (npr2) gene is responsible for disproportionate dwarfism in cn/cn mouse
polyunsaturated fatty acids block dendritic cell activation and function independently of nf-b activation
molecular and genetic studies imply akt-mediated signaling promotes protein kinase cii alternative splicing via phosphorylation of serine/arginine-rich splicing fac..
identification of human aminopeptidase o, a novel metalloprotease with structural similarity to aminopeptidase b and leukotriene a4 hydrolase
expression of cd45 lacking the catalytic protein tyrosine phosphatase domain modulates lck phosphorylation and t cell activation
c-myc promoter-binding protein 1 (mbp-1) regulates prostate cancer cell growth by inhibiting mapk pathway
camp-response element-binding protein contributes to suppression of the a2a adenosine receptor promoter by mutant huntingtin with expanded polyglutamine residues
manduca sexta serpin-6 regulates immune serine proteinases pap-3 and hp
the role of checkpoint kinase 1 in sensitivity to topoisomerase i poisons
yeast glutamine-fructose-6-phosphate aminotransferase (gfa1) requires methionine aminopeptidase activity for proper function
crystal structure of n-acetylornithine transcarbamylase from xanthomonas campestris
regulation of biological activity and matrix assembly of laminin-5 by cooh-terminal, lg4-5 domain of 3 chain
na+/ca2+ exchanger activity modulates connective tissue growth factor mrna expression in transforming growth factor 1- and des-arg10-kallidin-stimulated myofibrobla..
substrate specificity, localization, and essential role of the glutathione peroxidase-type tryparedoxin peroxidases in trypanosoma brucei
the importance of having thermosensor control in the dnak chaperone system
cysteines in ch1 underlie retention of unassembled ig heavy chains
hemimethylation and non-cpg methylation levels in a promoter region of human line-1 (l1) repeated elements
peptidase activity of the escherichia coli hsp31 chaperone
support vector machine-based method for subcellular localization of human proteins using amino acid compositions, their order, and similarity search
prostaglandin e2 induces interleukin-8 gene transcription by activating c/ebp homologous protein in human t lymphocytes
acceptor rna cleavage profile supports an invasion mechanism for hiv-1 minus strand transfer
inhibition of protein-tyrosine phosphatases by mild oxidative stresses is dependent on s-nitrosylation
evidence for a role of adam17 (tace) in the regulation of platelet glycoprotein v
the regulatory effects of tropomyosin and troponin-i on the interaction of myosin loop regions with f-actin
tsg-6 protein binding to glycosaminoglycans
subunit exchange of polydisperse proteins
differential regulation of c-jun-dependent transcription by sumo-specific proteases
role of tom5 in maintaining the structural stability of the tom complex of mitochondria
c-flipr, a new regulator of death receptor-induced apoptosis
a novel quinone-forming monooxygenase family involved in modification of aromatic polyketides
the otsab pathway is essential for trehalose biosynthesis in mycobacterium tuberculosis
disappearance of nucleosome positioning in mitotic chromatin in vivo
insulin receptor substrate 2 plays diverse cell-specific roles in the regulation of glucose transport
a novel mechanism of thyroid hormone-dependent negative regulation by thyroid hormone receptor, nuclear receptor corepressor (ncor), and gaga-binding factor on the ..
tyrosine phosphorylation of 3 integrin provides a binding site for pyk2
cleavage of p75 neurotrophin receptor by -secretase and -secretase requires specific receptor domains
exoribonuclease r interacts with endoribonuclease e and an rna helicase in the psychrotrophic bacterium pseudomonas syringae lz4w
protein o-glcnac modulates motility-associated signaling intermediates in neutrophils
lgr8 signal activation by the relaxin-like factor
analysis of the role of phosphorylation in fission yeast cdc13p/cyclinb function
requirement of tyr-992 and tyr-1173 in phosphorylation of the epidermal growth factor receptor by ionizing radiation and modulation by shp2
examination of lipid-bound conformation of apolipoprotein e4 by pyrene excimer fluorescence
role of a conserved glutamate residue in the escherichia coli seca atpase mechanism
a salmonella typhimurium effector protein sifa is modified by host cell prenylation and s-acylation machinery
biochemical and enzymatic characterization of human kallikrein 5 (hk5), a novel serine protease potentially involved in cancer progression
the human hyaluronan synthase 2 gene is a primary retinoic acid and epidermal growth factor responding gene
the skp1 prolyl hydroxylase from dictyostelium is related to the hypoxia-inducible factor- class of animal prolyl 4-hydroxylases
lysophosphatidic acid inhibits adipocyte differentiation via lysophosphatidic acid 1 receptor-dependent down-regulation of peroxisome proliferator-activated recepto..
photochromicity of anabaena sensory rhodopsin, an atypical microbial receptor with a cis-retinal light-adapted form
a comparison of staphostatin b with standard mechanism serine protease inhibitors
h-ras-specific activation of rac-mkk3/6-p38 pathway
identification of a novel prothoracicostatic hormone and its receptor in the silkworm bombyx mori
two arabidopsis metacaspases atmcp1b and atmcp2b are arginine/lysine-specific cysteine proteases and activate apoptosis-like cell death in yeast
blockade of nuclear factor of activated t cells activation signaling suppresses balloon injury-induced neointima formation in a rat carotid artery model
cell cycle dependence of dna-dependent protein kinase phosphorylation in response to dna double strand breaks
phosphorylation of ser-446 determines stability of mkp-7
grif-1 and oip106, members of a novel gene family of coiled-coil domain proteins
heat shock protein 70 inhibits -synuclein fibril formation via preferential binding to prefibrillar species
use of the h,k-atpase subunit to identify multiple sorting pathways for plasma membrane delivery in polarized cells
identification of two novel human acyl-coa wax alcohol acyltransferases
transcriptional regulation of the 4-amino-4-deoxy-l-arabinose biosynthetic genes in yersinia pestis
2-methoxyestradiol-induced apoptosis in prostate cancer cells requires smad7
activation of the lict transcriptional antiterminator involves a domain swing/lock mechanism provoking massive structural changes
telomerase mediates vascular endothelial growth factor-dependent responsiveness in a rat model of hind limb ischemia
substrate-assisted leaving group activation in enzyme-catalyzed n-glycosidic bond cleavage
two anti-radial spoke monoclonal antibodies inhibit chlamydomonas axonemal motility by different mechanisms
regulation of urokinase receptor proteolytic function by the tetraspanin cd82
bmp09, a “long chain“ scorpion peptide blocker of bk channels
differential contribution of two peroxisomal protein receptors to the maintenance of peroxisomal functions in arabidopsis
structural and biochemical characterization of a quinol binding site of escherichia coli nitrate reductase a
structural requirements of the extracellular to transmembrane domain junction for erythropoietin receptor function
mutational analysis of target enzyme recognition of the -trefoil fold barley -amylase/subtilisin inhibitor
structural mechanism governing the quaternary organization of monocot mannose-binding lectin revealed by the novel monomeric structure of an orchid lectin
fanconi anemia complementation group d2 (fancd2) functions independently of brca2- and rad51-associated homologous recombination in response to dna damage
d-3-phosphoglycerate dehydrogenase from mycobacterium tuberculosis is a link between the escherichia coli and mammalian enzymes
crystal structure of mycobacterium tuberculosis d-3-phosphoglycerate dehydrogenase
molecular characterization of the human c-formylglycine-generating enzyme
crystal structures of hiv-1 tat-derived nonapeptides tat-(1-9) and trp2-tat-(1-9) bound to the active site of dipeptidyl-peptidase iv (cd26)
cholesteryl ester transfer protein variants have differential stability but uniform inhibition by torcetrapib
manduca sexta serpin-4 and serpin-5 inhibit the prophenol oxidase activation pathway
identification of plasma proteases inhibited by manduca sexta serpin-4 and serpin-5 and their association with components of the prophenol oxidase activation pathway
smad6s regulates plasminogen activator inhibitor-1 through a protein kinase c--dependent up-regulation of transforming growth factor-
two functional but noncomplementing drosophila tyrosine decarboxylase genes
weakening of the t7 promoter-polymerase interaction facilitates promoter release
crucial role of two potential cytosolic regions of nox2, 191tsstktirrs200 and 484desqanhfavhhdeekd500, on nadph oxidase activation
biophysical comparison of bmp-2, probmp-2, and the free pro-peptide reveals stabilization of the pro-peptide by the mature growth factor
inhibition of rick/nuclear factor-b and p38 signaling attenuates the inflammatory response in a murine model of crohn disease
the transcriptional co-activator protein p100 recruits histone acetyltransferase activity to stat6 and mediates interaction between the creb-binding protein and stat6
nucleotide-dependent formation of catalytically competent dimers from engineered monomeric ribonucleotide reductase protein r1
external gtp-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification
a phosphorylation state-specific antibody recognizes hsp27, a novel substrate of protein kinase d
expression of interferon-inducible rna adenosine deaminase adar1 during pathogen infection and mouse embryo development involves tissue-selective promoter utilizati..
molecular identification and characterization of xenopus egg uroplakin iii, an egg raft-associated transmembrane protein that is tyrosine-phosphorylated upon fertil..
liver-specific protein-tyrosine phosphatase 1b (ptp1b) re-expression alters glucose homeostasis of ptp1b-/-mice
a crucial role of mafa as a novel therapeutic target for diabetes
two regions in the n-terminal domain of ionotropic glutamate receptor 3 form the subunit oligomerization interfaces that control subtype-specific receptor assembly
tumor necrosis factor -induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating ..
mechanism of action of myosin x, a membrane-associated molecular motor
global gene expression profiling in escherichia coli k1
functional consequences of polyamine synthesis inhibition by l--difluoromethylornithine (dfmo)
glutamine rich and basic region/leucine zipper (bzip) domains stabilize camp-response element-binding protein (creb) binding to chromatin
leuo protein delimits the transcriptionally active and repressive domains on the bacterial chromosome
asc-mediated nf-b activation leading to interleukin-8 production requires caspase-8 and is inhibited by clarp
structures of escherichia coli nad synthetase with substrates and products reveal mechanistic rearrangements
modulation of dna fragmentation factor 40 nuclease activity by poly(adp-ribose) polymerase-1
the tumor-specific hyperactive forms of cyclin e are resistant to inhibition by p21 and p27
dna damage-induced association of atm with its target proteins requires a protein interaction domain in the n terminus of atm
a secretory-type protein, containing a pentraxin domain, interacts with an a-type k+ channel
expression, localization, structural, and functional characterization of pfge, the paralog of the c-formylglycine-generating enzyme
crystal structure of human pfge, the paralog of the c-formylglycine-generating enzyme
identification and characterization of a polyamine permease from the protozoan parasite leishmania major
a random peptide library fused to ccr5 for selection of mimetopes expressed on the mammalian cell surface via retroviral vectors
crystal structure of human sco
the human trex2 3‘ 5‘-exonuclease structure suggests a mechanism for efficient nonprocessive dna catalysis
effect of nicotine on lung s-adenosylmethionine and development of pneumocystis pneumonia
distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors
lactisole interacts with the transmembrane domains of human t1r3 to inhibit sweet taste
analysis of rat insulin ii promoter-ghrelin transgenic mice and rat glucagon promoter-ghrelin transgenic mice
zhangfei is a potent and specific inhibitor of the host cell factor-binding transcription factor luman
a role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense
role of arginine 220 in the oxygen sensor fixl from bradyrhizobium japonicum
membrane localization and function of vav3 in t cells depend on its association with the adapter slp-76
cellular uptake of unconjugated tat peptide involves clathrin-dependent endocytosis and heparan sulfate receptors
the crystal structure of the outer membrane protein vcec from the bacterial pathogen vibrio cholerae at 1.8 å resolution
receptor-specific ubiquitination of -arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes
the euryarchaeota, nature‘s medium for engineering of single-stranded dna-binding proteins
protein kinase ck1 regulates mrna binding by heterogeneous nuclear ribonucleoprotein c in response to physiologic levels of hydrogen peroxide
atp-independent control of vac8 palmitoylation by a snare subcomplex on yeast vacuoles
31p nmr and genetic analysis establish hint as the only escherchia coli purine nucleoside phosphoramidase and as essential for growth under high salt conditions
physicochemical characterization of casein phosphopeptide-amorphous calcium phosphate nanocomplexes
search for apoptotic nucleases in yeast
ca2+ signaling in hek-293 and skeletal muscle cells expressing recombinant ryanodine receptors harboring malignant hyperthermia and central core disease mutations
the sialic acid binding saba adhesin of helicobacter pylori is essential for nonopsonic activation of human neutrophils
role of cd44 in epithelial wound repair
leucine zipper-mediated homo-oligomerization regulates the rho-gef activity of akap-lbc
rna interference-mediated silencing of x11 and x11 attenuates amyloid -protein levels via differential effects on -amyloid precursor protein processing
3 tyrosine phosphorylation and v3-mediated adhesion are required for vav1 association and rho activation in leukocytes
importance of temporal flow gradients and integrin iib3 mechanotransduction for shear activation of platelets
gonadotropins regulate n-cadherin-mediated human ovarian surface epithelial cell survival at both post-translational and transcriptional levels through a cyclic amp..
protein kinase a regulates caspase-9 activation by apaf-1 downstream of cytochrome c
the zip7 gene (slc39a7) encodes a zinc transporter involved in zinc homeostasis of the golgi apparatus
rapid endocytosis of the low density lipoprotein receptor-related protein modulates cell surface distribution and processing of the -amyloid precursor protein
the affinity of protein c for the thrombin·thrombomodulin complex is determined in a primary way by active site-dependent interactions
phosphoinositide binding regulates -actinin dynamics
structural clues to rab gtpase functional diversity
mad1 function in cell proliferation and transcriptional repression is antagonized by cyclin e/cdk2
progressive adipocyte hypertrophy in aquaporin-7-deficient mice
phosphorylated retinoblastoma protein complexes with pp32 and inhibits pp32-mediated apoptosis
cyclooxygenase-2 regulation in colon cancer cells
vanishingly low levels of ess1 prolyl-isomerase activity are sufficient for growth in saccharomyces cerevisiae
homocysteine down-regulates cellular glutathione peroxidase (gpx1) by decreasing translation
a novel metabolic pathway for degradation of 4-nonylphenol environmental contaminants by sphingomonas xenophaga bayram
identification of a functioning mitochondrial uncoupling protein 1 in thymus
misfolding of collagen x chains harboring schmid metaphyseal chondrodysplasia mutations results in aberrant disulfide bond formation, intracellular retention, and a..
efficient refolding of aggregation-prone citrate synthase by polyol osmolytes
involvement of noxa in cellular apoptotic responses to interferon, double-stranded rna, and virus infection
equilibrium unfolding of neuronal calcium sensor-
mitochondria permeabilization by a novel polycation peptide btm-p1
dopamine-derived dopaminochrome promotes h2o2 release at mitochondrial complex i
a partially zipped snare complex stabilized by the membrane
novel characteristics of the biological properties of the yeast saccharomyces cerevisiae eukaryotic initiation factor 2a
probucol protects against hypochlorite-induced endothelial dysfunction
haloperidol-associated stealth liposomes
temperature-dependent modification and activation of b-myb
nfb-dependent down-regulation of tumor necrosis factor receptor-associated proteins contributes to interleukin-1-mediated enhancement of ultraviolet b-induced apopt..
tord, an essential chaperone for tora molybdoenzyme maturation at high temperature
p38 mapk activation elevates serotonin transport activity via a trafficking-independent, protein phosphatase 2a-dependent process
mitochondrial initiation factor 2 of trypanosoma brucei binds imported formylated elongator-type trnamet
chondroitin synthase 1 is a key molecule in myeloma cell-osteoclast interactions
the stat3 transcription factor is a target for the myc and riboblastoma proteins on the cdc25a promoter
regulation of vascular smooth muscle proliferation by heparin
association states of nucleosome assembly protein 1 and its complexes with histones
regulation and function of the sonic hedgehog signal transduction pathway in isolated gastric parietal cells
tumor necrosis factor-related apoptosis-inducing ligand (trail) induces rheumatoid arthritis synovial fibroblast proliferation through mitogen-activated protein kin..
differential regulation of angiotensin ii-induced expression of connective tissue growth factor by protein kinase c isoforms in the myocardium
proteasome inhibition alters glucose-stimulated (pro)insulin secretion and turnover in pancreatic -cells
calorimetric studies of melanotransferrin (p97) and its interaction with iron
distinct substrate specificities of bacterial heparinases against n-unsubstituted glucosamine residues in heparan sulfate
analysis of regulatory regions of emilin1 gene and their combinatorial contribution to tissue-specific transcription
demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase b by specific reversible inhibitors
decorin, a novel player in the insulin-like growth factor system
poly(adp-ribose) polymerase activity prevents signaling pathways for cell cycle arrest after dna methylating agent exposure
substrate-induced interconversion of protein quaternary structure isoforms
stable golgi-mitochondria complexes and formation of golgi ca2+ gradients in pancreatic acinar cells
crystal structure of n-succinylarginine dihydrolase astb, bound to substrate and product, an enzyme from the arginine catabolic pathway of escherichia coli
peptide-mediated interference of tir domain dimerization in myd88 inhibits interleukin-1-dependent activation of nf-b
humanin binds and nullifies bid activity by blocking its activation of bax and bak
cytoprotective peptide humanin binds and inhibits proapoptotic bcl-2/bax family protein bimel
id2 reverses cell cycle arrest induced by -irradiation in human hacat keratinocytes
critical regulation of bone morphogenetic protein-induced osteoblastic differentiation by delta1/jagged1-activated notch1 signaling
the crystal structure of archaeal nascent polypeptide-associated complex (nac) reveals a unique fold and the presence of a ubiquitin-associated domain
a transmembrane form of the prion protein is localized in the golgi apparatus of neurons
p97 is in a complex with cholera toxin and influences the transport of cholera toxin and related toxins to the cytoplasm
nkx3.2-mediated repression of runx2 promotes chondrogenic differentiation
functional characterization of novel human and mouse equilibrative nucleoside transporters (hent3 and ment3) located in intracellular membranes
-protocadherins, presenilin-mediated release of c-terminal fragment promotes locus expression
ca2+-induced ca2+ release in sensory neurons
importance of a surface hydrophobic pocket on protein phosphatase-1 catalytic subunit in recognizing cellular regulators
cardiac type 2 inositol 1,4,5-trisphosphate receptor
global transcriptional programs reveal a carbon source foraging strategy by escherichia coli
biphasic currents evoked by chemical or thermal activation of the heat-gated ion channel, trpv3
nf-b is transported into the nucleus by importin 3 and importin 4
a minimal structural analogue of cyclic adp-ribose
crystal structure of a phou protein homologue
total conversion of tissue inhibitor of metalloproteinase (timp) for specific metalloproteinase targeting
structural and functional analysis of the c-terminal stas (sulfate transporter and anti-sigma antagonist) domain of the arabidopsis thaliana sulfate transporter sul..
crystal structure of a peptidoglycan synthesis regulatory factor (pbp3) from streptococcus pneumoniae
the integral inner nuclear membrane protein man1 physically interacts with the r-smad proteins to repress signaling by the transforming growth factor- superfamily o..
crystal structure of trna adenosine deaminase (tada) from aquifex aeolicus
solution structure of synthetic penaeidin-4 with structural and functional comparisons with penaeidin-3
tumor suppressor smar1 activates and stabilizes p53 through its arginine-serine-rich motif
structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations
nuclear and mitochondrial localization signals overlap within bovine herpesvirus 1 tegument protein vp22
survival function of protein kinase c as a novel nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-activated bad kinase
activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type ii transforming growth factor- receptor (triik)
reconstitution of two recombinant lsm protein complexes reveals aspects of their architecture, assembly, and function
c-cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2
retinoblastoma and the related pocket protein p107 act as coactivators of neurod1 to enhance gene transcription
positively charged ceramide is a potent inducer of mitochondrial permeabilization
ph-dependent substrate preference of pig heart lipoamide dehydrogenase varies with oligomeric state
is there a dynamic dna-protein interface in the transcription factor iiia-5 s rrna gene complex?
the stomatin/prohibitin/flotillin/hflk/c domain of flotillin-1 contains distinct sequences that direct plasma membrane localization and protein interactions in 3t3-..
the putidaredoxin reductase-putidaredoxin electron transfer complex
parathymosin affects the binding of linker histone h1 to nucleosomes and remodels chromatin structure
the crucial role of conserved intermolecular h-bonds inaccessible to the solvent in formation and stabilization of the tl5·5 srrna complex
metal ion-dependent effects of clioquinol on the fibril growth of an amyloid peptide
mcp-1 is induced by receptor activator of nuclear factor-b ligand, promotes human osteoclast fusion, and rescues granulocyte macrophage colony-stimulating factor su..
the manganese-stabilizing protein is required for photosystem ii assembly/stability and photoautotrophy in higher plants
calpain mediates excitotoxic dna fragmentation via mitochondrial pathways in adult brains
the clpp double ring tetradecameric protease exhibits plastic ring-ring interactions, and the n termini of its subunits form flexible loops that are essential for c..
mechanism of class 1 (glycosylhydrolase family 47) -mannosidases involved in n-glycan processing and endoplasmic reticulum quality control
oxygen-sensitive -opioid receptor-regulated survival and death signals
modulation of n-ethylmaleimide-sensitive factor activity upon amino acid deprivation
effect of ganglioside and tetraspanins in microdomains on interaction of integrins with fibroblast growth factor receptor
a lipid-modified phosphoinositide-specific phospholipase c (tcpi-plc) is involved in differentiation of trypomastigotes to amastigotes of trypanosoma cruzi
b-raf and raf-1 are regulated by distinct autoregulatory mechanisms
a novel chloride channel in drosophila melanogaster is inhibited by protons
anchor structure of staphylococcal surface proteins
the 14-3-3 protein translates the na+,k+-atpase 1-subunit phosphorylation signal into binding and activation of phosphoinositide 3-kinase during endocytosis
participation of rip2 in lipopolysaccharide signaling is independent of its kinase activity
stage-specific expression of myelin basic protein in oligodendrocytes involves nkx2.2-mediated repression that is relieved by the sp1 transcription factor
protein nitration in a mouse model of familial amyotrophic lateral sclerosis
potent glycan inhibitors of myelin-associated glycoprotein enhance axon outgrowth in vitro
the oxytocin receptor antagonist atosiban inhibits cell growth via a “biased agonist“ mechanism
implication of phospholipase d2 in oxidant-induced phosphoinositide 3-kinase signaling via pyk2 activation in pc12 cells
action of designer cellulosomes on homogeneous versus complex substrates
n-terminal region of the large subunit of leishmania donovani bisubunit topoisomerase i is involved in dna relaxation and interaction with the smaller subunit
selective disruption of phosphatidylcholine metabolism of the intracellular parasite toxoplasma gondii arrests its growth
c/ebp and its binding element are required for nfb-induced cox2 expression following hypertonic stress
hexim2, a hexim1-related protein, regulates positive transcription elongation factor b through association with 7sk
compensatory contributions of hexim1 and hexim2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control o..
intracellular ca2+ release triggers translocation of membrane marker fm1-43 from the extracellular leaflet of plasma membrane into endoplasmic reticulum in t lympho..
disruption of mcl-1·bim complex in granzyme b-mediated mitochondrial apoptosis
the spry domain-containing socs box protein 1 (ssb-1) interacts with met and enhances the hepatocyte growth factor-induced erk-elk-1-serum response element pathway
endoplasmic reticulum localization of gaa1 and pig-t, subunits of the glycosylphosphatidylinositol transamidase complex
membrane topology mapping of vitamin k epoxide reductase by in vitro translation/cotranslocation
estrogen, insulin, and dietary signals cooperatively regulate longevity signals to enhance resistance to oxidative stress in mice
the regulation of hepatic protein synthesis during fasting in the rat
beyond the xi
identification and functional analysis of 20 box h/aca small nucleolar rnas (snornas) from schizosaccharomyces pombe
sirt1 functionally interacts with the metabolic regulator and transcriptional coactivator pgc-1
essential role for mitogen-activated protein (map) kinase phosphatase-1 in stress-responsive map kinase and cell survival signaling
role of histone deacetylation in cell-specific expression of endothelial nitric-oxide synthase
the c-terminal region of tim17 links the outer and inner mitochondrial membranes in arabidopsis and is essential for protein import
differences in gene expression between wild type and hoxa1 knockout embryonic stem cells after retinoic acid treatment or leukemia inhibitory factor (lif) removal
rel1, a homologue of drosophila dorsal, regulates toll antifungal immune pathway in the female mosquito aedes aegypti
induction of endoplasmic reticulum-induced stress genes in panc-1 pancreatic cancer cells is dependent on sp proteins
polyribosome binding by gcn1 is required for full activation of eukaryotic translation initiation factor 2 kinase gcn2 during amino acid starvation
a central kinase domain of type i phosphatidylinositol phosphate kinases is sufficient to prime exocytosis
the rnase z homologue encoded by escherichia coli elac gene is rnase bn
integrin activation and matrix binding mediate cellular responses to mechanical stretch
iso-coenzyme a
a mitochondrial nadh-dependent fumarate reductase involved in the production of succinate excreted by procyclic trypanosoma brucei
two proteins mediate class ii ribonucleotide reductase activity in pseudomonas aeruginosa
redirection of eicosanoid metabolism in mpges-1-deficient macrophages
identification and characterization of the unique n-linked glycan common to the flagellins and s-layer glycoprotein of methanococcus voltae
xanthine oxidase catalyzes anaerobic transformation of organic nitrates to nitric oxide and nitrosothiols
catechol oxidase-like oxidation chemistry of the 1-20 and 1-16 fragments of alzheimer‘s disease-related -amyloid peptide
purification of na+,k+-atpase expressed in pichia pastoris reveals an essential role of phospholipid-protein interactions
-synuclein and parkin contribute to the assembly of ubiquitin lysine 63-linked multiubiquitin chains
transcriptional co-activators creb-binding protein/p300 increase chondrocyte cd-rap gene expression by multiple mechanisms including sequestration of the repressor ..
depletion of human micro-rna mir-125b reveals that it is critical for the proliferation of differentiated cells but not for the down-regulation of putative targets ..
cgmp inhibition of na+/h+ antiporter 3 (nhe3) requires pdz domain adapter nherf2, a broad specificity protein kinase g-anchoring protein
mek-erk signaling controls hdm2 oncoprotein expression by regulating hdm2 mrna export to the cytoplasm
a yeast polyamine acetyltransferase
identification of protein kinase a catalytic subunit as a novel binding partner of p73 and regulation of p73 function
the lh gene of several mammals embeds a carboxyl-terminal peptide-like sequence revealing a critical role for mucin oligosaccharides in the evolution of lutropin to..
g-dependent and g-independent basal activity of g protein-activated k+ channels
identification of the putative staphylococcal agrb catalytic residues involving the proteolytic cleavage of agrd to generate autoinducing peptide
regulation of neuroprotective activity of myocyte-enhancer factor 2 by camp-protein kinase a signaling pathway in neuronal survival
role of regulatory f-domain in hepatocyte nuclear factor-4 ligand specificity
cyclin a is a c-jun target gene and is necessary for c-jun-induced anchorage-independent growth in rat1a cells
distinct poly(i-c) and virus-activated signaling pathways leading to interferon- production in hepatocytes
genetically engineered production of 1-desmethylcobyrinic acid, 1-desmethylcobyrinic acid a,c-diamide, and cobyrinic acid a,c-diamide in escherichia coli implies a ..
ion regulation of homotypic vacuole fusion in saccharomyces cerevisiae
a hepatocyte nuclear factor-3 site in the fibrinogen promoter is important for interleukin 6-induced expression, and its activity is influenced by the adjacent -148..
cell signaling through the protein kinases camp-dependent protein kinase, protein kinase c, and raf-1 regulates amphotropic murine leukemia virus envelope protein-i..
a direct signaling role for phosphatidylinositol 4,5-bisphosphate (pip2) in the visual excitation process of microvillar receptors
functional properties of endogenous receptor- and store-operated calcium influx channels in hek293 cells
mechanism of insulin gene regulation by the pancreatic transcription factor pdx-
disulfide linkage controls the affinity and stoichiometry of ige fc3-4 binding to fcri
drosophila mitochondrial transcription factor b1 modulates mitochondrial translation but not transcription or dna copy number in schneider cells
transcriptional regulation of the grp78 promoter by endoplasmic reticulum stress
comparative biochemical studies of the murine fatty acid transport proteins (fatp) expressed in yeast
non-canonical wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells
function of polo-like kinase 3 in nf-b-mediated proapoptotic response
a novel pineal-specific product of the oligopeptide transporter pept1 gene
plasmodial surface anion channel-independent phloridzin resistance in plasmodium falciparum
ph-dependent intraluminal organization of mucin granules in live human mucous/goblet cells
the intermediate filament protein vimentin is a new target for epigallocatechin gallate
bach1 competes with nrf2 leading to negative regulation of the antioxidant response element (are)-mediated nad(p)h:quinone oxidoreductase 1 gene expression and indu..
disabled1 regulates the intracellular trafficking of reelin receptors
p2y6 nucleotide receptors activate nf-b and increase survival of osteoclasts
mitochondrial h2o2 regulates the angiogenic phenotype via pten oxidation
heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and m..
cyclin d1 inhibits peroxisome proliferator-activated receptor -mediated adipogenesis through histone deacetylase recruitment
rapid apoptosis induction by igfbp-3 involves an insulin-like growth factor-independent nucleomitochondrial translocation of rxr/nur77
cytoplasmic and nuclear retained dmpk mrnas are targets for rna interference in myotonic dystrophy cells
structural origin of endotoxin neutralization and antimicrobial activity of a lactoferrin-based peptide
role for a kinase-anchoring proteins (akaps) in glutamate receptor trafficking and long term synaptic depression
udp-3-o-((r)-3-hydroxymyristoyl)-n-acetylglucosamine deacetylase functions through a general acid-base catalyst pair mechanism
expression and function of cgmp-dependent protein kinase type i during medaka fish embryogenesis
phosphorylation of grb10 regulates its interaction with 14-3-3
proteome analysis of human metaphase chromosomes
the interferon regulatory factor, irf5, is a central mediator of toll-like receptor 7 signaling
regulation of cd147 cell surface expression
nicastrin is critical for stability and trafficking but not association of other presenilin/-secretase components
vinexin interacts with the non-phosphorylated af-1 domain of retinoid receptor (rar) and represses rar-mediated transcription
substrate-specific activation of sirtuins by resveratrol
ligand specificity of human surfactant protein d
prpsc incorporation to cells requires endogenous glycosaminoglycan expression
heparan sulfate is a cellular receptor for purified infectious prions
distinct conformation-mediated functions of an active site loop in the catalytic reactions of nad-dependent d-lactate dehydrogenase and formate dehydrogenase
regulation of poly(adp-ribose) polymerase-1 by dna structure-specific binding
small interference rna-mediated gene silencing of human biliverdin reductase, but not that of heme oxygenase-1, attenuates arsenite-mediated induction of the oxygen..
structural basis for the unique biological function of small gtpase rheb
crystal structure of a novel shikimate dehydrogenase from haemophilus influenzae
two distinct head-tail interfaces cooperate to suppress activation of vinculin by talin
a dominant negative peroxisome proliferator-activated receptor- knock-in mouse exhibits features of the metabolic syndrome
myocyte enhancer factor-2 and serum response factor binding elements regulate fast myosin heavy chain transcription in vivo
an activation switch in the rhodopsin family of g protein-coupled receptors
cytochrome b mutations that modify the ubiquinol-binding pocket of the cytochrome bc1 complex and confer anti-malarial drug resistance in saccharomyces cerevisiae
the inner mitochondrial membrane has aquaporin-8 water channels and is highly permeable to water
parkin stabilizes microtubules through strong binding mediated by three independent domains
regulation of brca2 gene expression by the slug repressor protein in human breast cells
secretion of cartilage oligomeric matrix protein is affected by the signal peptide
structural basis for the specificity of the reducing end xylose-releasing exo-oligoxylanase from bacillus halodurans c-125
mechanism of human sirt1 activation by resveratrol
tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin b-dependent mechanism
evodiamine abolishes constitutive and inducible nf-b activation by inhibiting ib kinase activation, thereby suppressing nf-b-regulated antiapoptotic and metastatic ..
atp binding regulates oligomerization and endosome association of rme-1 family proteins
casein kinase 2- and protein kinase a-regulated adenomatous polyposis coli and -catenin cellular localization is dependent on p38 mapk
nuclear poly(adp-ribose) polymerase-1 rapidly triggers mitochondrial dysfunction
binding of htm4 to cyclin-dependent kinase (cdk)-associated phosphatase (kap)·cdk2·cyclin a complex enhances the phosphatase activity of kap, dissociates cyclin a..
the crystal structures of eap domains from staphylococcus aureus reveal an unexpected homology to bacterial superantigens
structural analysis of the laetiporus sulphureus hemolytic pore-forming lectin in complex with sugars
exercise capacity of mice genetically lacking muscle glycogen synthase
amyotrophic lateral sclerosis mutations have the greatest destabilizing effect on the apo- and reduced form of sod1, leading to unfolding and oxidative aggregation
a role of stat3 in rho gtpase-regulated cell migration and proliferation
activated protein c mediates novel lung endothelial barrier enhancement
calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers
ephb receptor-binding peptides identified by phage display enable design of an antagonist with ephrin-like affinity
neuroligins mediate excitatory and inhibitory synapse formation
sphingosine 1-phosphate-induced mobilization of intracellular ca2+ mediates rac activation and adherens junction assembly in endothelial cells
relief of p53-mediated telomerase suppression by p73
crystal structure of hemoglobin protease, a heme binding autotransporter protein from pathogenic escherichia coli
the activation of exocytotic sites by the formation of phosphatidylinositol 4,5-bisphosphate microdomains at syntaxin clusters
secretion of the human t cell leukemia virus type i transactivator protein tax
structural investigation of borrelia burgdorferi ospb, a bactericidalfab target
regulation of monocyte apoptosis by the protein kinase c-dependent phosphorylation of caspase-3
structural basis for the function of stringent starvation protein a as a transcription factor
active site aspartate residues are critical for tryptophan tryptophylquinone biogenesis in methylamine dehydrogenase
energetics of structural transitions of the addiction antitoxin maze
cxcl12 signaling is independent of jak2 and jak3
proteolysis of macrophage inflammatory protein-1 isoforms ld78 and ld78 by neutrophil-derived serine proteases
mechanistic differences in promoter dna melting by thermus aquaticus and escherichia coli rna polymerases
mammalian prion protein suppresses bax-induced cell death in yeast
identification of direct genomic targets downstream of the nuclear factor-b transcription factor mediating tumor necrosis factor signaling
dynamic assembly of the urokinase-type plasminogen activator signaling receptor complex determines the mitogenic activity of urokinase-type plasminogen activator
autoantibodies to redox-modified oligomeric a are attenuated in the plasma of alzheimer‘s disease patients
nuclear factor-b activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy
dentin glycoprotein
a novel antiestrogenic mechanism in progesterone receptor-transfected breast cancer cells
a hiv-1 minimal gag protein is superior to nucleocapsid at in vitro annealing and exhibits multimerization-induced inhibition of reverse transcription
reactive oxygen species stimulates receptor activator of nf-b ligand expression in osteoblast
syndecan-4 is required for thrombin-induced migration and proliferation in human vascular smooth muscle cells
identification of four adenosine kinase isoforms in tobacco by-2 cells and their putative role in the cell cycle-regulated cytokinin metabolism
paradoxical inhibition of protein aggregation and precipitation by transglutaminase-catalyzed intermolecular cross-linking
light-independent phosphorylation of white collar-1 regulates its function in the neurospora circadian negative feedback loop
two purified domains of telomerase reverse transcriptase reconstitute sequence-specific interactions with rna
disabled-2 (dab2) is required for transforming growth factor -induced epithelial to mesenchymal transition (emt)
a serine/threonine-rich motif is one of three nuclear localization signals that determine unidirectional transport of the mineralocorticoid receptor to the nucleus
transforming growth factor (tgf)--activated kinase 1 mimics and mediates tgf--induced stimulation of type ii collagen synthesis in chondrocytes independent of col2a..
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