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免疫学杂志2004年第02期封面 购买


cutting edge: distinct tcr- and cd28-derived signals regulate cd95l, bcl-x l, and the survival of primary t cells
induction of tumor regression by administration of b7-ig fusion proteins: mediation by type 2 cd8 + t cells and dependence on il-4 production
mechanistic insights into impaired dendritic cell function by rapamycin: inhibition of jak2/stat4 signaling pathway
tolerance induction by intrathymic expression of p0
cellular maturation defects in brutons tyrosine kinase-deficient immature b cells are amplified by premature b cell receptor expression and reduced by receptor edit..
tc1 and tc2 effector cell therapy elicit long-term tumor immunity by contrasting mechanisms that result in complementary endogenous type 1 antitumor responses
il-11 protects human microvascular endothelium from alloinjury in vivo by induction of survivin expression
mature human thymocytes migrate on laminin-5 with activation of metalloproteinase-14 and cleavage of cd44
ccl17 and il-10 as effectors that enable alternatively activated macrophages to inhibit the generation of classically activated macrophages
independent control of ly49g alleles: implications for nk cell repertoire selection and tumor cell killing
estrogen preferentially promotes the differentiation of cd11c + cd11b intermediate dendritic cells from bone marrow precursors
lck is required for activation-induced t cell death after tcr ligation with partial agonists
chimeric donor cells play an active role in both induction and maintenance phases of transplantation tolerance induced by mixed chimerism
importance of il-10 for ctla-4-mediated inhibition of tumor-eradicating immunity
the abundant nk cells in human secondary lymphoid tissues require activation to express killer cell ig-like receptors and become cytolytic
production of donor t cells is critical for induction of donor-specific tolerance and maintenance of chimerism
-associated protein of 70 kda (zap-70), but not syk, tyrosine kinase can mediate apoptosis of t cells through the fas/fas ligand, caspase-8 and caspase-3 pathways
zwitterionic polysaccharides stimulate t cells with no preferential v usage and promote anergy, resulting in protection against experimental abscess formation
effect of chronic viral infection on epitope selection, cytokine production, and surface phenotype of cd8 t cells and the role of ifn- receptor in immune regulation
cpg-dna aided cross-priming by cross-presenting b cells
tumor-infiltrating lymphocyte secretion of il-6 antagonizes tumor-derived tgf- 1 and restores the lymphokine-activated killing activity
expression of dual tcr on do11.10 t cells allows for ovalbumin-induced oral tolerance to prevent t cell-mediated colitis directed against unrelated enteric bacteria..
early adenoviral gene expression mediates immunosuppression by transduced dendritic cell (dc): implications for immunotherapy using genetically modified dc
cd4 + and cd8 + regulatory t cells generated ex vivo with il-2 and tgf- suppress a stimulatory graft-versus-host disease with a lupus-like syndrome
il-21 induces tumor rejection by specific ctl and ifn- -dependent cxc chemokines in syngeneic mice
deceptive multilineage reconstitution analysis of mice transplanted with hemopoietic stem cells, and implications for assessment of stem cell numbers and lineage po..
autoreactive b cells in lupus-prone new zealand black mice exhibit aberrant survival and proliferation in the presence of self-antigen in vivo
phosphatidylinositol 3-kinase is a determinant of responsiveness to b cell antigen receptor-mediated epstein-barr virus activation
intraocular tumor antigen drains specifically to submandibular lymph nodes, resulting in an abortive cytotoxic t cell reaction
e-selectin, thymus- and activation-regulated chemokine/ccl17, and intercellular adhesion molecule-1 are constitutively coexpressed in dermal microvessels: a foundat..
intravenous injection of a lentiviral vector encoding ny-eso-1 induces an effective ctl response
ifn- promotes fas ligand- and perforin-mediated liver cell destruction by cytotoxic cd8 t cells
escherichia coli expressing recombinant antigen and listeriolysin o stimulate class i-restricted cd8 + t cells following uptake by human apc
characterization of defective cd4 - cd8 - t cells in murine tumors generated independent of antigen specificity
regulation of c-jun n-terminal kinase by mekk-2 and mitogen-activated protein kinase kinase kinases in rheumatoid arthritis
the role of tnf-related activation-induced cytokine-receptor activating nf- b interaction in acute allograft rejection and cd40l-independent chronic allograft rejec..
blockade of lymphotoxin signaling inhibits the clinical expression of murine graft-versus-host skin disease
ontogeny of t cells in humans
ifn- induced adenosine production on the endothelium: a mechanism mediated by cd73 (ecto-5‘-nucleotidase) up-regulation
nuclear pro-il-16 regulation of t cell proliferation: p27 kip1 -dependent g 0 /g 1 arrest mediated by inhibition of skp2 transcription
the nonclassical mhc class i molecule qa-1 forms unstable peptide complexes
the c4a and c4b isotypic forms of human complement fragment c4b have the same intrinsic affinity for complement receptor 1 (cr1/cd35)
hypoxia selectively inhibits monocyte chemoattractant protein-1 production by macrophages
critical role of ox40 in cd28 and cd154-independent rejection
ifn- sensitizes human umbilical vein endothelial cells to apoptosis induced by double-stranded rna
impaired production of proinflammatory cytokines and host resistance to acute infection with trypanosoma cruzi in mice lacking functional myeloid differentiation fa..
hla class ii polymorphisms determine responses to bacterial superantigens
dendritic cells pulsed with live and dead legionella pneumophila elicit distinct immune responses
human t cell lymphotropic virus type i (htlv-i)-specific cd4 + t cells: immunodominance hierarchy and preferential infection with htlv-i
pervasive influence of hepatitis c virus on the phenotype of antiviral cd8 + t cells
distinct modulatory effects of lps and cpg on il-18-dependent ifn- synthesis
selective killing of vaccinia virus by ll-37: implications for eczema vaccinatum
chlamydia pneumoniae multiply in neutrophil granulocytes and delay their spontaneous apoptosis
nonmethylated cg motifs packaged into virus-like particles induce protective cytotoxic t cell responses in the absence of systemic side effects
overproduction of tnf- by cd8 + type 1 cells and down-regulation of ifn- production by cd4 + th1 cells contribute to toxic shock-like syndrome in an animal model of..
p47 phox deficiency impairs nf- b activation and host defense in pseudomonas pneumonia
leptin indirectly activates human neutrophils via induction of tnf-
transcript signatures in experimental asthma: identification of stat6-dependent and -independent pathways
macrophage-stimulating protein, the ligand for the stem cell-derived tyrosine kinase/ron receptor tyrosine kinase, inhibits il-12 production by primary peritoneal m..
cysteinyl leukotrienes regulate dendritic cell functions in a murine model of asthma
kinin b 1 receptor up-regulation after lipopolysaccharide administration: role of proinflammatory cytokines and neutrophil influx
the essential involvement of cross-talk between ifn- and tgf- in the skin wound-healing process
a molecular defect in intracellular lipid signaling in human neutrophils in localized aggressive periodontal tissue damage
expression of cd154 (cd40 ligand) by human lung fibroblasts: differential regulation by ifn- and il-13, and implications for fibrosis
the c10/ccl6 chemokine and ccr1 play critical roles in the pathogenesis of il-13-induced inflammation and remodeling
immune complexes bind preferentially to fc riia (cd32) on apoptotic neutrophils, leading to augmented phagocytosis by macrophages and release of proinflammatory cyt..
induction of c chemokine xcl1 (lymphotactin/single c motif-1 /activation-induced, t cell-derived and chemokine-related cytokine) expression by hiv-1 tat protein
chemotaxis and calcium responses of phagocytes to formyl peptide receptor ligands is differentially regulated by cyclic adp ribose
tnf- -induced apoptosis of macrophages following inhibition of nf- b: a central role for disruption of mitochondria
lymphoid hyperplasia resulting in immune dysregulation is caused by porcine reproductive and respiratory syndrome virus infection in neonatal pigs
metal-protein complex-mediated transport and delivery of ni 2+ to tcr/mhc contact sites in nickel-specific human t cell activation
nucleotide sequencing of psoriatic arthritis tissue before and during methotrexate administration reveals a complex inflammatory t cell infiltrate with very few clo..
ets-1 regulates tnf- -induced matrix metalloproteinase-9 and tenascin expression in primary bronchial fibroblasts
mycobacterium tuberculosis recall antigens suppress hiv-1 replication in anergic donor cells via cd8 + t cell expansion and increased il-10 levels
molecular analysis of tcr clonotypes in lgl: a clonal model for polyclonal responses
cutting edge: in vitro-generated tolerogenic apc induce cd8 + t regulatory cells that can suppress ongoing experimental autoimmune encephalomyelitis
cutting edge: conventional cd8 + dendritic cells are generally involved in priming ctl immunity to viruses
cutting edge: toll-like receptor signaling in macrophages induces ligands for the nkg2d receptor
cutting edge: il-26 signals through a novel receptor complex composed of il-20 receptor 1 and il-10 receptor 2
cutting edge: t cells trigger cd40-dependent platelet activation and granular rantes release: a novel pathway for immune response amplification
cutting edge: dendritic cells copulsed with microbial and helminth antigens undergo modified maturation, segregate the antigens to distinct intracellular compartmen..
visualizing the site and dynamics of igg salvage by the mhc class i-related receptor, fcrn
visualization of antigen presentation by actin-mediated targeting of glycolipid-enriched membrane domains to the immune synapse of b cell apcs
inhibitory effect of toll-like receptor 4 on fusion between phagosomes and endosomes/lysosomes in macrophages
il-21 induces the functional maturation of murine nk cells
il-4 induces differentiation and expansion of th2 cytokine-producing eosinophils
nf- b-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner
mechanisms governing b cell developmental defects in invariant chain-deficient mice
b cell receptor-mediated apoptosis of human lymphocytes is associated with a new regulatory pathway of bim isoform expression
transgenic expression of a human polyreactive ig expressed in chronic lymphocytic leukemia generates memory-type b cells that respond to nonspecific immune activation
severely impaired b lymphocyte proliferation, survival, and induction of the c-myc:cullin 1 ubiquitin ligase pathway resulting from cd22 deficiency on the c57bl/6 g..
distinct expression profiles of the peripheral cannabinoid receptor in lymphoid tissues depending on receptor activation status
complete loss of fas ligand gene causes massive lymphoproliferation and early death, indicating a residual activity of gld allele
exosomes as potent cell-free peptide-based vaccine. i. dendritic cell-derived exosomes transfer functional mhc class i/peptide complexes to dendritic cells
exosomes as potent cell-free peptide-based vaccine. ii. exosomes in cpg adjuvants efficiently prime naive tc1 lymphocytes leading to tumor rejection
novel regulatory mechanisms of cd40-induced prostanoid synthesis by il-4 and il-10 in human monocytes
reduced ig class switch in aged mice correlates with decreased e47 and activation-induced cytidine deaminase
dependency of direct pathway cd4 + t cells on cd40-cd154 costimulation is determined by nature and microenvironment of primary contact with alloantigen
disparate in vitro and in vivo requirements for il-2 during antigen-independent cd8 t cell expansion
a novel role for an insect apolipoprotein (apolipophorin iii) in -1,3-glucan pattern recognition and cellular encapsulation reactions
extremely rapid and intense induction of apoptosis in human eosinophils by anti-cd30 antibody treatment in vitro
resistance of short term activated t cells to cd95-mediated apoptosis correlates with de novo protein synthesis of c-flip short
il-10-conditioned dendritic cells, decommissioned for recruitment of adaptive immunity, elicit innate inflammatory gene products in response to danger signals
the cytoplasmic domain of ig is necessary and sufficient to support efficient early b cell development
hiv-infected langerhans cells preferentially transmit virus to proliferating autologous cd4 + memory t cells located within langerhans cell-t cell clusters
wsx-1 and glycoprotein 130 constitute a signal-transducing receptor for il-2
identification of new antigenic peptide presented by hla-cw7 and encoded by several mage genes using dendritic cells transduced with lentiviruses
antigen nonspecific suppression of t cell responses by activated stimulation-refractory cd4 + t cells
the impact of thymic antigen diversity on the size of the selected t cell repertoire
human cytomegalovirus proteins pp65 and immediate early protein 1 are common targets for cd8 + t cell responses in children with congenital or postnatal human cytom..
nf- b controls cell fate specification, survival, and molecular differentiation of immunoregulatory natural t lymphocytes
adjuvant costimulation during secondary antigen challenge directs qualitative aspects of oral tolerance induction, particularly during the neonatal period
cd4 + t cells regulate cd8 + t cell-mediated cutaneous immune responses by restricting effector t cell development through a fas ligand-dependent mechanism
reduced thymocyte development in sonic hedgehog knockout embryos
dendritic cell maturation requires stat1 and is under feedback regulation by suppressors of cytokine signaling
caspase-3 is a component of fas death-inducing signaling complex in lipid rafts and its activity is required for complete caspase-8 activation during fas-mediated c..
the impact of self-tolerance on the polyclonal cd8 + t cell repertoire
activation of discoidin domain receptor 1 isoform b with collagen up-regulates chemokine production in human macrophages: role of p38 mitogen-activated protein kina..
immunosuppressive activity of endovanilloids: n -arachidonoyl-dopamine inhibits activation of the nf- b, nfat, and activator protein 1 signaling pathways
molecular characterization of human 4ig-b7-h3, a member of the b7 family with four ig-like domains
biases in ig light chain rearrangements in human intestinal plasma cells
conformation and glycosylation of a megalin fragment correlate with nephritogenicity in heymann nephritis
fc ri -itam is differentially required for mast cell function in vivo
the crystal structure of human cd1b with a bound bacterial glycolipid 1,
activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins
antibody-dependent cellular cytotoxicity via humoral immune epitope of nef protein expressed on cell surface
macrophages, cd4 + or cd8 + cells are each sufficient for protection against chlamydia pneumoniae infection through their ability to secrete ifn-
calcium and its role in the nuclear translocation and activation of cytosolic phospholipase a 2 in cells rendered sensitive to tnf-induced apoptosis by cycloheximide
peripheral cd4 t cells rapidly accumulate at the host:parasite interface during an inflammatory th2 memory response
haemophilus influenzae type b-outer membrane protein complex glycoconjugate vaccine induces cytokine production by engaging human toll-like receptor 2 (tlr2) and re..
parasite antigen-driven basophils are a major source of il-4 in human filarial infections
the zinc finger mutation c417r of i- b kinase impairs lipopolysaccharide- and tnf-mediated nf- b activation through inhibiting phosphorylation of the i- b kinase ac..
recognition of homo- and heterosubtypic variants of influenza a viruses by human cd8 + t lymphocytes
protective immunization against group b meningococci using anti-idiotypic mimics of the capsular polysaccharide
cyclooxygenase-2-mediated prostaglandin e 2 production in mesenteric lymph nodes and in cultured macrophages and dendritic cells after infection with salmonella
hiv-1-specific memory cd4 + t cells are phenotypically less mature than cytomegalovirus-specific memory cd4 + t cells
protective t cell immunity against malaria liver stage after vaccination with live sporozoites under chloroquine treatment
liver dendritic cells present bacterial antigens and produce cytokines upon salmonella encounter
suppression of osteoprotegerin expression by prostaglandin e 2 is crucially involved in lipopolysaccharide-induced osteoclast formation
tnf receptor signaling contributes to chemokine secretion, inflammation, and respiratory deficits during pneumocystis pneumonia
involvement of reactive oxygen species in toll-like receptor 4-dependent activation of nf- b
b7-dc regulates asthmatic response by an ifn- -dependent mechanism
role of bradykinin b 2 and b 1 receptors in the local, remote, and systemic inflammatory responses that follow intestinal ischemia and reperfusion injury
contribution of antigen-primed cd8 + t cells to the development of airway hyperresponsiveness and inflammation is associated with il-13
microtubule-associated serine/threonine kinase-205 kda and fc receptor control il-12 p40 synthesis and nf- b activation 1,
inhibition of c-jun nh 2 -terminal kinase activity improves ischemia/reperfusion injury in rat lungs
peptide-mediated inhibition of neutrophil transmigration by blocking cd47 interactions with signal regulatory protein
matrix metalloproteinase-9 deficiency results in enhanced allergen-induced airway inflammation
inflammatory gene profiles in gastric mucosa during helicobacter pylori infection in humans
key roles of cd4 + t cells and ifn- in the development of abdominal aortic aneurysms in a murine model
inhibition of il-10 receptor function in alveolar macrophages by toll-like receptor agonists
construction of hevein (hev b 6.02) with reduced allergenicity for immunotherapy of latex allergy by comutation of six amino acid residues on the conformational ige..
role of toll-like receptor 4 in endotoxin-induced acute renal failure
respective roles of decay-accelerating factor and cd59 in circumventing glomerular injury in acute nephrotoxic serum nephritis
tnf- coupled to membrane of apoptotic cells favors the cross-priming to melanoma antigens
a spontaneous model for autoimmune myocarditis using the human mhc molecule hla-dq8
in vivo evidence that peptide vaccination can induce hla-dr-restricted cd4 + t cells reactive to a class i tumor peptide
pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation through il-1 -induced il-6 expression
cd40 ligand dysregulation in hiv infection: hiv glycoprotein 120 inhibits signaling cascades upstream of cd40 ligand transcription
hiv-1 does not provoke alteration of cytokine gene expression in lymphoid tissue after acute infection ex vivo
breakdown of tolerance to a self-peptide of acetylcholine receptor -subunit induces experimental myasthenia gravis in rats
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