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核酸研究医学期刊2008年第05期封面 购买


combined in silico and experimental identification of the pyrococcus abyssi h/aca srnas and their target sites in ribosomal rnas
step-wise formation of eukaryotic double-row polyribosomes and circular translation of polysomal mrna
two conserved modules of schizosaccharomyces pombe mediator regulate distinct cellular pathways
single-molecule manipulation reveals supercoiling-dependent modulation of lac repressor-mediated dna looping
evolution of acceptor stem trna recognition by class ii prolyl-trna synthetase
molecular dissection of penelope transposable element regulatory machinery
bioinformatic and functional analysis of rna secondary structure elements among different genera of human and animal caliciviruses
a systematic characterization of factors that regulate drosophila segmentation via a bacterial one-hybrid system
distinct roles of xrcc4 and ku80 in non-homologous end-joining of endonuclease- and ionizing radiation-induced dna double-strand breaks
the small rna glmy acts upstream of the srna glmz in the activation of glms expression and is subject to regulation by polyadenylation in escherichia coli
real-time kinetics of restriction–modification gene expression after entry into a new host cell
mitogen-induced recruitment of erk and msk to sre promoter complexes by ternary complex factor elk-
sequence homology and microhomology dominate chromosomal double-strand break repair in african trypanosomes
a new kinetic model reveals the synergistic effect of e-, p- and a-sites on +1 ribosomal frameshifting
a space-efficient and accurate method for mapping and aligning cdna sequences onto genomic sequence
determinants of a transcriptionally competent environment at the gm-csf promoter
the bacterial and mitochondrial ribosomal a-site molecular switches possess different conformational substates
autoregulation of the escherichia coli melr promoter: repression involves four molecules of melr
small ncrna transcriptome analysis from aspergillus fumigatus suggests a novel mechanism for regulation of protein synthesis
transforming growth factor-β-regulated mir-24 promotes skeletal muscle differentiation
the relationship of potential g-quadruplex sequences in cis -upstream regions of the human genome to sp1-binding elements
dissecting protein–rna recognition sites
human abasic endonuclease action on multilesion abasic clusters: implications for radiation-induced biological damage
recognition of trna leu by aquifex aeolicus leucyl-trna synthetase during the aminoacylation and editing steps
structure of the dna-binding domain of ngtrf1 reveals unique features of plant telomere-binding proteins
spontaneous symmetry breaking in genome evolution
intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis
the biological function of some human transcription factor binding motifs varies with position relative to the transcription start site
a bbp–mud2p heterodimer mediates branchpoint recognition and influences splicing substrate abundance in budding yeast
structural probing of the hiv-1 polypurine tract rna:dna hybrid using classic nucleic acid ligands
inhibition of hiv-1 by multiple sirnas expressed from a single microrna polycistron
presence and role of cytosine methylation in dna viruses of animals
distinct regions of atf/creb proteins atf1 and pcr1 control recombination hotspot ade6–m26 and the osmotic stress response
characterization of drosophila melanogaster jmjc+n histone demethylases
understanding how the v(d)j recombinase catalyzes transesterification: distinctions between dna cleavage and transposition
apoptotic signals induce specific degradation of ribosomal rna in yeast
pyrrole-imidazole hairpin polyamides with high affinity at 5‘–cgcg–3‘ dna sequence; influence of cytosine methylation on binding
tolerance for 8-oxoguanine but not thymine glycol in alignment-based gap filling of partially complementary double-strand break ends by dna polymerase in human nucl..
minimal components of the rna polymerase ii transcription apparatus determine the consensus tata box
differential stabilization of reaction intermediates: specificity checkpoints for m.ecori revealed by transient fluorescence and fluorescence lifetime studies
a study of the relationships between oligonucleotide properties and hybridization signal intensities from nimblegen microarray datasets
a polycomb group protein, phf1, is involved in the response to dna double-strand breaks in human cell
mismatched dntp incorporation by dna polymerase β does not proceed via globally different conformational pathways
a shared rna-binding site in the pet54 protein is required for translational activation and group i intron splicing in yeast mitochondria
transcriptional activation of the tumor suppressor and differentiation gene s100a2 by a novel p63-binding site
formation of the double helix: a mutational study
the poly(a) site sequence in hdv rna alters both extent and rate of self-cleavage of the antigenomic ribozyme
computational screen for spliceosomal rna genes aids in defining the phylogenetic distribution of major and minor spliceosomal components
transcriptional regulation of chondrogenesis by coactivator tip60 via chromatin association with sox9 and sox
using support vector machine combined with auto covariance to predict protein–protein interactions from protein sequences
dissection of the regulatory mechanism of a heat-shock responsive promoter in haloarchaea: a new paradigm for general transcription factor directed archaeal gene re..
lateral transfer of introns in the cryptophyte plastid genome
the major form of hepatitis c virus alternate reading frame protein is suppressed by core protein expression
overexpression of human mitochondrial valyl trna synthetase can partially restore levels of cognate mt-trna val carrying the pathogenic c25u mutation
the mrna encoding the yeast are-binding protein cth2 is generated by a novel 3‘ processing pathway
end-bridging is required for pol µ to efficiently promote repair of noncomplementary ends by nonhomologous end joining
multipride: automated batch development of quantitative real-time pcr primers
the three soxc proteins—sox4, sox11 and sox12—exhibit overlapping expression patterns and molecular properties
tfiib aptamers inhibit transcription by perturbing pic formation at distinct stages
copper sensing function of drosophila metal-responsive transcription factor-1 is mediated by a tetranuclear cu(i) cluster
structure and function of the regulatory c-terminal hrdc domain from deinococcus radiodurans recq
genome level analysis of rice mrna 3‘-end processing signals and alternative polyadenylation
a dual-tag microarray platform for high-performance nucleic acid and protein analyses
detecting cis -regulatory binding sites for cooperatively binding proteins
exalign: a new method for comparative analysis of exon–intron gene structures
uncovering signal transduction networks from high-throughput data by integer linear programming
dna bar coding and pyrosequencing to analyze adverse events in therapeutic gene transfer
the fidelity index provides a systematic quantitation of star activity of dna restriction endonucleases
identification of soluble protein fragments by gene fragmentation and genetic selection
r-coffee: a method for multiple alignment of non-coding rna
analysis of sirna specificity on targets with double-nucleotide mismatches
rapid one-step recombinational cloning
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