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核酸研究医学期刊2003年第12期封面 购买


l-nucleotides and 8-methylguanine of d(c1m8g2c3g4c5lg6lc7g8c9g10)2 act cooperatively to promote a left-handed helix under physiological salt conditions
unexpected correlations between gene expression and codon usage bias from microarray data for the whole escherichia coli k-12 genome
a novel approach to describe a u1 snrna binding site
exhaustive identification of interaction domains using a high-throughput method based on two-hybrid screening and pcr-convergence: molecular dissection of a kinetoc..
mastering seeds for genomic size nucleotide blast searches
molecular dynamics simulations of rna kissing-loop motifs reveal structural dynamics and formation of cation-binding pockets
transient xylr binding to the uas of the pseudomonas putida 54 promoter pu revealed with high intensity uv footprinting in vivo
an archaebacteria-derived glutamyl-trna synthetase and trna pair for unnatural amino acid mutagenesis of proteins in escherichia coli
dynamics of the metal-dependent transcription factor complex in vivo at the mouse metallothionein-i promoter
interleukin-6 represses the transcription of the ccaat/enhancer binding protein- gene in hepatoma cells by inhibiting its ability to autoactivate the proximal promo..
mutagenic stress modulates the dynamics of ctg repeat instability associated with myotonic dystrophy type
dynamic methylation of histone h3 at lysine 4 in transcriptional regulation by the androgen receptor
regulation of lysine biosynthesis and transport genes in bacteria: yet another rna riboswitch?
cleavage of dna without loss of genetic information by incorporation of a disaccharide nucleoside
conservation of dna curvature signals in regulatory regions of prokaryotic genes
solution structure and dna binding of the effector domain from the global regulator prra (rega) from rhodobacter sphaeroides: insights into dna binding specificity
a complex pathway for 3‘ processing of the yeast u3 snorna
ribosomal proteins rps0 and rps21 of saccharomyces cerevisiae have overlapping functions in the maturation of the 3‘ end of 18s rrna
the common and the distinctive features of the bulged-g motif based on a 1.04 å resolution rna structure
dna-pk is activated by nucleosomes and phosphorylates h2ax within the nucleosomes in an acetylation-dependent manner
functional characterization of helicobacter pylori dnab helicase
high mobility group a2 protein and its derivatives bind a specific region of the promoter of dna repair gene ercc1 and modulate its activity
two-metal ion mechanism of rna cleavage by hiv rnase h and mechanism-based design of selective hiv rnase h inhibitors
synergistic activation of the human orphan nuclear receptor shp gene promoter by basic helix-loop-helix protein e2a and orphan nuclear receptor sf-
the frog prince: a reconstructed transposon from rana pipiens with high transpositional activity in vertebrate cells
chromatin acetylation and remodeling at the cis promoter during stat5-induced transcription
computational identification of the spo0a-phosphate regulon that is essential for the cellular differentiation and development in gram-positive spore-forming bacteria
hairpin-duplex equilibrium reflected in the ab transition in an undecamer quasi-palindrome present in the locus control region of the human ß-globin gene cluster
mutagenesis of human dna polymerase : essential roles of tyr505 and phe506 for both dna polymerase and terminal transferase activities
a key role for the mrna leader structure in translational control of ribosomal protein s1 synthesis in -proteobacteria
structure-specific binding of the proto-oncogene protein dek to dna
genome-wide analysis of gene expression regulated by the hat cofactor trrap in conditional knockout cells
identifying cooperativity among transcription factors controlling the cell cycle in yeast
repair of single-strand dna interruptions by redundant pathways and its implication in cellular sensitivity to dna-damaging agents
improving gene annotation of complete viral genomes
tracking ecoki and dna fifty years on: a golden story full of surprises
in vitro characterization of a base pairing interaction between the primer binding site and the minimal packaging signal of avian leukosis virus genomic rna
hmg-d and histone h1 alter the local accessibility of nucleosomal dna
molecular genetic analysis of chloroplast gene promoters dependent on sig2, a nucleus-encoded sigma factor for the plastid-encoded rna polymerase, in arabidopsis th..
visualization and interpretation of protein networks in mycobacterium tuberculosis based on hierarchical clustering of genome-wide functional linkage maps
functional significance of intermediate cleavages in the 3‘ets of the pre-rrna from schizosaccharomyces pombe
molecular model of sars coronavirus polymerase: implications for biochemical functions and drug design
altered structural fluctuations in duplex rna versus dna: a conformational switch involving base pair opening
a novel allele of fission yeast rad11 that causes defects in dna repair and telomere length regulation
the base pairing properties of 8-aza-7-deaza-2‘-deoxyisoguanosine and 7-halogenated derivatives in oligonucleotide duplexes with parallel and antiparallel chain or..
effects of sequence on repeat expansion during dna replication
twist2, a novel add1/srebp1c interacting protein, represses the transcriptional activity of add1/srebp1c
a new, but old, nucleoside analog: the first synthesis of 1-deaza-2‘-deoxyguanosine and its properties as a nucleoside and as oligodeoxynucleotides
using electrostatic potentials to predict dna-binding sites on dna-binding proteins
the linker histone homolog hho1p from saccharomyces cerevisiae represents a winged helix-turn-helix fold as determined by nmr spectroscopy
a conserved chloramphenicol binding site at the entrance to the ribosomal peptide exit tunnel
substitutions at tyrosine 66 of escherichia coli uracil dna glycosylase lead to characterization of an efficient enzyme that is recalcitrant to product inhibition
repair of a minimal dna double-strand break by nhej requires dna-pkcs and is controlled by the atm/atr checkpoint
the role of dna dependent protein kinase in synapsis of dna ends
discovery and characterization of a thermostable bacteriophage rna ligase homologous to t4 rna ligase
residues 190-210 of human topoisomerase i are required for enzyme activity in vivo but not in vitro
transcription factor zbp-89 is required for stat1 constitutive expression
gene structure prediction in syntenic dna segments
a statistical sampling algorithm for rna secondary structure prediction
a novel maldi-tof based methodology for genotyping single nucleotide polymorphisms
a pcr primer bank for quantitative gene expression analysis
expression profiling via novel multiplex assay allows rapid assessment of gene regulation in defined signalling pathways
suppression of gene expression by a cell-permeable tet repressor
direct measurement of the melting temperature of supported dna by electrochemical method
validation of a novel, fully integrated and flexible microarray benchtop facility for gene expression profiling
improved detection of differentially expressed genes in microarray experiments through multiple scanning and image integration
real-time monitoring of nucleic acid ligation in homogenous solutions using molecular beacons
effect of g-1 on histidine trna microhelix conformation
the poly(a) binding protein hfq protects rna from rnase e and exoribonucleolytic degradation
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