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核酸研究医学期刊2003年第11期封面 购买


therapeutic modulation of endogenous gene function by agents with designed dna-sequence specificities
diversity of type ii restriction endonucleases that require two dna recognition sites
8-hydroxyguanine in a mutational hotspot of the c-ha-ras gene causes misreplication, action-at-a-distance mutagenesis and inhibition of replication
exegesis: a procedure to improve gene predictions and its use to find immunoglobulin superfamily proteins in the human and mouse genomes
identification of peptide inhibitors of pre-mrna splicing derived from the essential interaction domains of cdc5l and plrg
polq (pol ), a dna polymerase and dna-dependent atpase in human cells
transcriptional response to dna damage in the archaeon sulfolobus solfataricus
cold-sensitive mutants of taq dna polymerase provide a hot start for pcr
a role for c-myc in the regulation of ribosomal rna processing
inhibition of pre-mrna splicing by synthetic branched nucleic acids
gene positional changes relative to the nuclear substructure correlate with the proliferating status of hepatocytes during liver regeneration
dna mismatches and gc-rich motifs target transposition by the rag1/rag2 transposase
energetics of echinomycin binding to dna
poly(adp-ribose) polymerase-1 is a survival factor for radiation-exposed intestinal epithelial stem cells in vivo
ssdna-dependent colocalization of adeno-associated virus rep and herpes simplex virus icp8 in nuclear replication domains
splice site prediction with quadratic discriminant analysis using diversity measure
recognition of threosyl nucleotides by dna and rna polymerases
groove-binding unsymmetrical cyanine dyes for staining of dna: syntheses and characterization of the dna-binding
groove-binding unsymmetrical cyanine dyes for staining of dna: dissociation rates in free solution and electrophoresis gels
the fragile x syndrome repeats form rna hairpins that do not activate the interferon-inducible protein kinase, pkr, but are cut by dicer
automated identification of rna conformational motifs: theory and application to the hm lsu 23s rrna
repair of oxidative dna damage by amino acids
u2af modulates poly(a) length control by the poly(a)-limiting element
possible anti-recombinogenic role of blooms syndrome helicase in double-strand break processing
functional modules by relating protein interaction networks and gene expression
functional dissection of the mouse tyrosinase locus control region identifies a new putative boundary activity
transcription profiles of the bacterium mycoplasma pneumoniae grown at different temperatures
intrinsic differences between authentic and cryptic 5‘ splice sites
human efo1p exhibits acetyltransferase activity and is a unique combination of linker histone and ctf7p/eco1p chromatid cohesion establishment domains
characterisation of new substrate specificities of escherichia coli and saccharomyces cerevisiae ap endonucleases
matrix attachment region (mar) properties and abnormal expansion of at island minisatellites in fra16b fragile sites in leukemic cem cells
expanding the design horizon of antisense oligonucleotides with alpha-l-lna
triplex hydration: nanosecond molecular dynamics simulation of the solvated triplex formed by mixed sequences
roles of 5-substituents of trna wobble uridines in the recognition of purine-ending codons
comparative analysis of editosome proteins in trypanosomatids
a dna translocation motif in the bacterial transcription-repair coupling factor, mfd
kissing complex-mediated dimerisation of hiv-1 rna: coupling extended duplex formation to ribozyme cleavage
in vitro and in vivo modulations of benzophenanthrene-dna adducts by dna mismatch repair system
rnomics in escherichia coli detects new srna species and indicates parallel transcriptional output in bacteria
nucleotide sequence homology requirements of hiv-1-specific short hairpin rna
dna-protein cross-linking by trans-[ptcl2(e-iminoether)2]. a concept for activation of the trans geometry in platinum antitumor complexes
solution structures of stem-loop rnas that bind to the two n-terminal rna-binding domains of nucleolin
enhancement of dna, cdna synthesis and fidelity at high temperatures by a dimeric single-stranded dna-binding protein
nucleic acid binding properties of the nucleic acid chaperone domain of hepatitis delta antigen
site-selective in vivo targeting of cytosine-5 dna methylation by zinc-finger proteins
arginine/serine repeats are sufficient to constitute a splicing activation domain
identification of a new rna·rna interaction site for human telomerase rna (htr): structural implications for htr accumulation and a dyskeratosis congenita point mu..
the complete genome sequence and analysis of corynebacterium diphtheriae nctc1312
in vitro rnp assembly and methylation guide activity of an unusual box c/d rna, cis-acting archaeal pre-trnatrp
mononucleotide derivatives as ribosomal p-site substrates reveal an important contribution of the 2‘-oh to activity
identification of 13 novel human modification guide rnas
bidirectional replication from an internal ori site of the linear n15 plasmid prophage
deletion in a (t)8 microsatellite abrogates expression regulation by 3‘-utr
gene essentiality determines chromosome organisation in bacteria
deleterious mutation prediction in the secondary structure of rnas
p53 stimulates human topoisomerase i activity by modulating its dna binding
human let-7 stem-loop precursors harbor features of rnase iii cleavage products
molecular determinants of the hpa regulatory system of escherichia coli: the hpar repressor
host specificity of mollicutes oric plasmids: functional analysis of replication origin
silencing of toll pathway components by direct injection of double-stranded rna into drosophila adult flies
dna damage induces transcriptional activation of p73 by removing c-ebp repression on e2f
enzyme-specific profiles for genome annotation: priam
critical role of charged residues in helix 7 of the ligand binding domain in hepatocyte nuclear factor 4 dimerisation and transcriptional activity
left-handedly curved dna regulates accessibility to cis-dna elements in chromatin
molecular flip-flops formed by overlapping fis sites
identification of factors influencing strand bias in oligonucleotide-mediated recombination in escherichia coli
enhanced crossover scratchy: construction and high-throughput screening of a combinatorial library containing multiple non-homologous crossovers
inducible shrna expression for application in a prostate cancer mouse model
exploiting features of adenovirus replication to support mammalian kinase production
quantitative evaluation by minisequencing and microarrays reveals accurate multiplexed snp genotyping of whole genome amplified dna
short bioactive spiegelmers to migraine-associated calcitonin gene-related peptide rapidly identified by a novel approach: tailored-selex
regulation of cre recombinase by ligand-induced complementation of inactive fragments
dancer: a program for digital anatomical reconstruction of gene expression data
one step assembly of multiple dna fragments with a designed order and orientation in bacillus subtilis plasmid
efficient labeling of fission yeast schizosaccharomyces pombe with thymidine and budr
rapid purification of rna secondary structures
demonstration of preferential binding of sybr green i to specific dna fragments in real-time multiplex pcr
polylysine-coated mica can be used to observe systematic changes in the supercoiled dna conformation by scanning force microscopy in solution
sizing of single fluorescently stained dna fragments by scanning microscopy
direct measurement of lymphocyte receptor diversity
unidirectional cre-mediated genetic inversion in mice using the mutant loxp pair lox66/lox7
felines: a utility for extracting and examining est-defined introns and exons
global amplification of mrna by template-switching pcr: linearity and application to microarray analysis
thermodynamically balanced inside-out (tbio) pcr-based gene synthesis: a novel method of primer design for high-fidelity assembly of longer gene sequences
projector: automatic contig mapping for gap closure purposes
quick two-step rna ligation employing periodate oxidation
viral and microbial genotyping by a combination of multiplex competitive hybridization and specific extension followed by hybridization to generic tag arrays
high efficiency, site-specific excision of a marker gene by the phage p1 cre-loxp system in the yellow fever mosquito, aedes aegypti
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